Functions and Diseases

RBP Type Canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000172922 Gene ID 84153 Accession 24116
Symbol RNASEH2C Alias AGS3;AYP1 Full Name ribonuclease H2 subunit C
Status Confidence Length 5724 bases Strand Minus strand
Position 11 : 65715080 - 65720803 RNA binding domain RNase_H2_suC
Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000308193 RNase_H2_suC PF08615 1.3e-27 1
ENSP00000432081 RNase_H2_suC PF08615 1.3e-27 1
ENSP00000435717 RNase_H2_suC PF08615 1.3e-27 1
ENSP00000493695 RNase_H2_suC PF08615 1.3e-27 1
ENSP00000432897 RNase_H2_suC PF08615 6.2e-27 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
29273853 Antisense transcription regulates the expression of sense gene via alternative polyadenylation. Ting Shen 2018-06-01 Protein & cell
19015152 Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Hyongi Chon 2009-01-01 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
RNASEH2C-211 ENST00000644198 1807 No protein -
RNASEH2C-213 ENST00000646597 1082 No protein -
RNASEH2C-212 ENST00000645835 1596 No protein -
RNASEH2C-207 ENST00000534482 3311 164aa ENSP00000432081
RNASEH2C-201 ENST00000308418 2645 164aa ENSP00000308193
RNASEH2C-209 ENST00000643214 2643 No protein -
RNASEH2C-205 ENST00000531596 2085 164aa ENSP00000435717
RNASEH2C-203 ENST00000528220 2798 No protein -
RNASEH2C-210 ENST00000644142 1750 164aa ENSP00000493695
RNASEH2C-208 ENST00000642430 1909 No protein -
RNASEH2C-206 ENST00000533698 710 No protein -
RNASEH2C-202 ENST00000527610 835 247aa ENSP00000432897
RNASEH2C-204 ENST00000530192 576 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
102974Acne Vulgaris3E-1124927181

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000172922

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000172922homo_sapiensENSP0000030819395.731792.0732nomascus_leucogenysENSNLEP0000003289663.562861.1336
ENSG00000172922homo_sapiensENSP0000030819397.56195.1219pan_paniscusENSPPAP0000003984664.777363.1579
ENSG00000172922homo_sapiensENSP0000030819395.731792.6829pongo_abeliiENSPPYP0000003523263.562861.5385
ENSG00000172922homo_sapiensENSP0000030819397.56195.1219pan_troglodytesENSPTRP0000008250964.777363.1579
ENSG00000172922homo_sapiensENSP0000030819346.341535.9756ornithorhynchus_anatinusENSOANP0000004003041.304332.0652
ENSG00000172922homo_sapiensENSP0000030819355.487842.0732notamacropus_eugeniiENSMEUP0000000567360.666746
ENSG00000172922homo_sapiensENSP0000030819345.731742.6829choloepus_hoffmanniENSCHOP0000001129445.731742.6829
ENSG00000172922homo_sapiensENSP0000030819384.146376.8293dasypus_novemcinctusENSDNOP0000002288281.176574.1176
ENSG00000172922homo_sapiensENSP0000030819357.926853.0488echinops_telfairiENSETEP0000001628274.218867.9688
ENSG00000172922homo_sapiensENSP0000030819343.292739.6341echinops_telfairiENSETEP0000001239867.61961.9048
ENSG00000172922homo_sapiensENSP0000030819389.634185.9756callithrix_jacchusENSCJAP0000007514469.339666.5094
ENSG00000172922homo_sapiensENSP0000030819395.121993.2927macaca_fascicularisENSMFAP0000003772595.705593.865
ENSG00000172922homo_sapiensENSP0000030819394.512293.2927macaca_mulattaENSMMUP0000002133494.512293.2927
ENSG00000172922homo_sapiensENSP0000030819395.121993.9024macaca_mulattaENSMMUP0000002608495.121993.9024
ENSG00000172922homo_sapiensENSP0000030819395.121993.9024macaca_nemestrinaENSMNEP0000003556595.121993.9024
ENSG00000172922homo_sapiensENSP0000030819392.682989.6341papio_anubisENSPANP0000000675961.788659.7561
ENSG00000172922homo_sapiensENSP0000030819357.926853.0488tursiops_truncatusENSTTRP0000001604857.926853.0488
ENSG00000172922homo_sapiensENSP0000030819380.487874.3902vulpes_vulpesENSVVUP0000003788163.157958.3732
ENSG00000172922homo_sapiensENSP0000030819382.317175equus_asinusENSEASP0000504968281.325374.0964
ENSG00000172922homo_sapiensENSP0000030819378.658568.9024capra_hircusENSCHIP0000001155478.181868.4848
ENSG00000172922homo_sapiensENSP0000030819380.487871.3415loxodonta_africanaENSLAFP0000001311078.106569.2308
ENSG00000172922homo_sapiensENSP0000030819381.097675panthera_leoENSPLOP0000000911281.595175.4601
ENSG00000172922homo_sapiensENSP0000030819385.975679.2683ailuropoda_melanoleucaENSAMEP0000001832282.456176.0234
ENSG00000172922homo_sapiensENSP0000030819379.878172.561equus_caballusENSECAP0000007404174.431867.6136
ENSG00000172922homo_sapiensENSP0000030819383.536676.8293canis_lupus_familiarisENSCAFP0084502552781.547675
ENSG00000172922homo_sapiensENSP0000030819381.707375.6098panthera_pardusENSPPRP0000000480982.208676.0736
ENSG00000172922homo_sapiensENSP0000030819379.878170.7317marmota_marmota_marmotaENSMMMP0000002409075.722567.052
ENSG00000172922homo_sapiensENSP0000030819381.707376.2195balaenoptera_musculusENSBMSP0001001317878.362673.0994
ENSG00000172922homo_sapiensENSP0000030819377.43964.0244cavia_porcellusENSCPOP0000001233476.969763.6364
ENSG00000172922homo_sapiensENSP0000030819381.707375felis_catusENSFCAP0000005414559.555654.6667
ENSG00000172922homo_sapiensENSP0000030819384.756178.0488ursus_americanusENSUAMP0000002688381.286674.8538
ENSG00000172922homo_sapiensENSP0000030819358.536647.561monodelphis_domesticaENSMODP0000001193050.793741.2698
ENSG00000172922homo_sapiensENSP0000030819370.731761.5854bison_bison_bisonENSBBBP0000001165071.165661.9632
ENSG00000172922homo_sapiensENSP0000030819377.43968.9024bison_bison_bisonENSBBBP0000002785477.914169.3252
ENSG00000172922homo_sapiensENSP0000030819381.097675monodon_monocerosENSMMNP0001503003977.777871.9298
ENSG00000172922homo_sapiensENSP0000030819379.878175.6098sus_scrofaENSSSCP0000007959678.443174.2515
ENSG00000172922homo_sapiensENSP0000030819385.365980.4878microcebus_murinusENSMICP0000000808285.365980.4878
ENSG00000172922homo_sapiensENSP0000030819378.048866.4634octodon_degusENSODEP0000002433377.108465.6627
ENSG00000172922homo_sapiensENSP0000030819381.097673.7805jaculus_jaculusENSJJAP0000001789281.097673.7805
ENSG00000172922homo_sapiensENSP0000030819377.43967.6829ovis_aries_rambouilletENSOARP0002002680676.969767.2727
ENSG00000172922homo_sapiensENSP0000030819382.926876.2195ursus_maritimusENSUMAP0000001466279.532273.0994
ENSG00000172922homo_sapiensENSP0000030819379.878173.7805delphinapterus_leucasENSDLEP0000000426046.953443.3692
ENSG00000172922homo_sapiensENSP0000030819382.317176.2195physeter_catodonENSPCTP0000502688778.947473.0994
ENSG00000172922homo_sapiensENSP0000030819375.609864.6341mus_caroliMGP_CAROLIEiJ_P004763974.698863.8554
ENSG00000172922homo_sapiensENSP0000030819364.024456.7073mus_musculusENSMUSP0000015844862.555.3571
ENSG00000172922homo_sapiensENSP000003081937571.9512dipodomys_ordiiENSDORP0000002392474.545571.5152
ENSG00000172922homo_sapiensENSP0000030819384.146377.439mustela_putorius_furoENSMPUP0000001153780.232673.8372
ENSG00000172922homo_sapiensENSP0000030819389.024484.1463aotus_nancymaaeENSANAP0000002948960.580957.2614
ENSG00000172922homo_sapiensENSP0000030819393.902490.8537saimiri_boliviensis_boliviensisENSSBOP0000003736394.478591.411
ENSG00000172922homo_sapiensENSP0000030819372.56166.4634vicugna_pacosENSVPAP0000000611179.333372.6667
ENSG00000172922homo_sapiensENSP0000030819396.341595.1219chlorocebus_sabaeusENSCSAP0000000424696.341595.1219
ENSG00000172922homo_sapiensENSP0000030819378.658570.1219mesocricetus_auratusENSMAUP0000001748677.710869.2771
ENSG00000172922homo_sapiensENSP0000030819381.707376.2195phocoena_sinusENSPSNP0000001496078.362673.0994
ENSG00000172922homo_sapiensENSP0000030819377.43971.3415camelus_dromedariusENSCDRP0000500627879.874273.5849
ENSG00000172922homo_sapiensENSP0000030819352.43948.7805carlito_syrichtaENSTSYP0000002470151.807248.1928
ENSG00000172922homo_sapiensENSP0000030819380.487873.7805panthera_tigris_altaicaENSPTIP0000001115780.981674.2331
ENSG00000172922homo_sapiensENSP0000030819373.780562.1951rattus_norvegicusENSRNOP0000002809762.051352.3077
ENSG00000172922homo_sapiensENSP0000030819382.317178.0488prolemur_simusENSPSMP0000003326984.37580
ENSG00000172922homo_sapiensENSP0000030819376.829367.6829microtus_ochrogasterENSMOCP0000001343176.363667.2727
ENSG00000172922homo_sapiensENSP0000030819377.43968.9024peromyscus_maniculatus_bairdiiENSPEMP0000002071776.50668.0723
ENSG00000172922homo_sapiensENSP0000030819376.219566.4634bos_mutusENSBMUP0000000126557.077649.7717
ENSG00000172922homo_sapiensENSP0000030819375.609865.2439mus_spicilegusENSMSIP0000000150074.698864.4578
ENSG00000172922homo_sapiensENSP0000030819378.048869.5122cricetulus_griseus_chok1gshdENSCGRP0000101451977.108468.6747
ENSG00000172922homo_sapiensENSP0000030819381.707374.3902pteropus_vampyrusENSPVAP0000001598981.212173.9394
ENSG00000172922homo_sapiensENSP0000030819381.097673.1707myotis_lucifugusENSMLUP0000000799080.120572.2892
ENSG00000172922homo_sapiensENSP0000030819356.097644.5122vombatus_ursinusENSVURP0001000185064.788751.4085
ENSG00000172922homo_sapiensENSP0000030819381.707372.561rhinolophus_ferrumequinumENSRFEP0001000507679.289970.4142
ENSG00000172922homo_sapiensENSP0000030819384.146376.8293neovison_visonENSNVIP0000001986083.636476.3636
ENSG00000172922homo_sapiensENSP0000030819378.048868.9024bos_taurusENSBTAP0000000732777.575868.4848
ENSG00000172922homo_sapiensENSP0000030819381.707368.9024heterocephalus_glaber_femaleENSHGLP0000001881081.707368.9024
ENSG00000172922homo_sapiensENSP0000030819394.512290.8537rhinopithecus_bietiENSRBIP0000003267563.008160.5691
ENSG00000172922homo_sapiensENSP0000030819383.536676.8293canis_lupus_dingoENSCAFP0002001899081.547675
ENSG00000172922homo_sapiensENSP0000030819381.097673.7805sciurus_vulgarisENSSVLP0000501191076.878669.9422
ENSG00000172922homo_sapiensENSP0000030819380.487873.1707procavia_capensisENSPCAP0000000735176.744269.7674
ENSG00000172922homo_sapiensENSP0000030819365.243956.7073nannospalax_galiliENSNGAP0000002110672.297362.8378
ENSG00000172922homo_sapiensENSP0000030819373.170764.6341bos_grunniensENSBGRP0000003451677.922168.8312
ENSG00000172922homo_sapiensENSP0000030819378.658564.6341chinchilla_lanigeraENSCLAP0000002408378.181864.2424
ENSG00000172922homo_sapiensENSP0000030819375.609864.0244cervus_hanglu_yarkandensisENSCHYP0000000753462.944253.2995
ENSG00000172922homo_sapiensENSP0000030819378.048871.3415catagonus_wagneriENSCWAP0000001279974.418668.0233
ENSG00000172922homo_sapiensENSP0000030819379.268370.1219ictidomys_tridecemlineatusENSSTOP0000002388975.144566.474
ENSG00000172922homo_sapiensENSP0000030819386.585483.5366otolemur_garnettiiENSOGAP0000001265483.529480.5882
ENSG00000172922homo_sapiensENSP0000030819393.292790.8537cebus_imitatorENSCCAP0000001532793.86591.411
ENSG00000172922homo_sapiensENSP0000030819379.268370.1219urocitellus_parryiiENSUPAP0001001159875.144566.474
ENSG00000172922homo_sapiensENSP0000030819376.219567.6829moschus_moschiferusENSMMSP0000002272775.757667.2727
ENSG00000172922homo_sapiensENSP0000030819394.512290.8537rhinopithecus_roxellanaENSRROP0000004378363.008160.5691
ENSG00000172922homo_sapiensENSP000003081937564.6341mus_pahariMGP_PahariEiJ_P002065075.460165.0307
ENSG00000172922homo_sapiensENSP0000030819382.926879.2683propithecus_coquereliENSPCOP0000001840082.926879.2683

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IEAHomo_sapiens(9606)Component
GO:0006298involved_in mismatch repair1NASHomo_sapiens(9606)Process
GO:0006401involved_in RNA catabolic process2IBA,IDAHomo_sapiens(9606)Process
GO:0032299part_of ribonuclease H2 complex3IBA,IDA,IPIHomo_sapiens(9606)Component

Expression