RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000171621	Gene ID	80176	Accession	30628
Symbol	SPSB1	Alias	SSB1;SSB-1	Full Name	splA/ryanodine receptor domain and SOCS box containing 1
Status	Confidence	Length	76639 bases	Strand	Plus strand
Position	1 : 9292894 - 9369532	RNA binding domain	SPRY
Summary	Enables ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000330221	SPRY	PF00622	1.6e-18	1
ENSP00000350573	SPRY	PF00622	1.6e-18	1
ENSP00000366616	SPRY	PF00622	1.6e-18	1
ENSP00000409235	SPRY	PF00622	3.9e-12	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
SPSB1-201	ENST00000328089	3106	273aa	ENSP00000330221
SPSB1-204	ENST00000450402	822	202aa	ENSP00000409235
SPSB1-202	ENST00000357898	1439	273aa	ENSP00000350573
SPSB1-203	ENST00000377399	1007	273aa	ENSP00000366616

Gene Model

Click here to download ENSG00000171621's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
27784	Blood Glucose	5.1390000E-005	-
75244	Dental Caries	5E-7	23064961
95862	Cognition	1E-6	28093568
101785	Vaccine Potency	4E-6	22658931
104896	Arthritis, Rheumatoid	5E-8	22491018
104897	Drug Resistance	5E-8	22491018

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000171621's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	2	IDA,IEA	Homo_sapiens(9606)	Process
GO:0019005	part_of SCF ubiquitin ligase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:1990756	enables ubiquitin ligase-substrate adaptor activity	1	IPI	Homo_sapiens(9606)	Function

Expression