RBP Type	Canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000170748	Gene ID	27288	Accession	17886
Symbol	RBMXL2	Alias	HNRPGT;HNRNPGT;HNRNPG-T	Full Name	RBMX like 2
Status	Confidence	Length	2151 bases	Strand	Plus strand
Position	11 : 7088998 - 7091148	RNA binding domain	RBM1CTR , RRM_1
Summary	This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000304139	RRM_1	PF00076	1.6e-21	1
ENSP00000304139	RBM1CTR	PF08081	2e-18	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
34927545	Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases.	Saad Aldalaqan	2022-02-01	Cell cycle (Georgetown, Tex.)
30674417	An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.	Ingrid Ehrmann	2019-01-24	eLife

Name	Transcript ID	bp	Protein	Translation ID
RBMXL2-201	ENST00000306904	2151	392aa	ENSP00000304139

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
31663	Platelet Count	9.0540000E-005	-
42842	Platelet Function Tests	1.5418500E-005	-
98189	Arachidonic Acid	9E-6	26584805

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000170748	homo_sapiens	ENSP00000417451	26.8041	24.0862	homo_sapiens	ENSP00000304139	72.9592	65.5612
ENSG00000170748	homo_sapiens	ENSP00000295971	13.6594	8.4317	homo_sapiens	ENSP00000304139	20.6633	12.7551
ENSG00000170748	homo_sapiens	ENSP00000478691	38.4164	25.2199	homo_sapiens	ENSP00000304139	33.4184	21.9388
ENSG00000170748	homo_sapiens	ENSP00000445366	16.9972	11.0482	homo_sapiens	ENSP00000304139	15.3061	9.94898
ENSG00000170748	homo_sapiens	ENSP00000341826	36.0215	22.043	homo_sapiens	ENSP00000304139	34.1837	20.9184
ENSG00000170748	homo_sapiens	ENSP00000350090	40.3125	25.3125	homo_sapiens	ENSP00000304139	32.9082	20.6633
ENSG00000170748	homo_sapiens	ENSP00000493805	41.25	25.3125	homo_sapiens	ENSP00000304139	33.6735	20.6633
ENSG00000170748	homo_sapiens	ENSP00000376309	34.9206	24.3386	homo_sapiens	ENSP00000304139	33.6735	23.4694
ENSG00000170748	homo_sapiens	ENSP00000284073	31.7073	22.561	homo_sapiens	ENSP00000304139	26.5306	18.8776
ENSG00000170748	homo_sapiens	ENSP00000310471	22.8412	14.7632	homo_sapiens	ENSP00000304139	20.9184	13.5204
ENSG00000170748	homo_sapiens	ENSP00000309166	21.978	14.011	homo_sapiens	ENSP00000304139	20.4082	13.0102
ENSG00000170748	homo_sapiens	ENSP00000498248	75.8974	69.4872	homo_sapiens	ENSP00000304139	75.5102	69.1327
ENSG00000170748	homo_sapiens	ENSP00000359645	79.5396	73.6573	homo_sapiens	ENSP00000304139	79.3367	73.4694
ENSG00000170748	homo_sapiens	ENSP00000401371	22.2798	12.1762	homo_sapiens	ENSP00000304139	21.9388	11.9898
ENSG00000170748	homo_sapiens	ENSP00000257552	28.1768	19.8895	homo_sapiens	ENSP00000304139	26.0204	18.3673
ENSG00000170748	homo_sapiens	ENSP00000281722	15.9475	8.63039	homo_sapiens	ENSP00000304139	21.6837	11.7347
ENSG00000170748	homo_sapiens	ENSP00000352956	12.5285	7.74487	homo_sapiens	ENSP00000304139	14.0306	8.67347
ENSG00000170748	homo_sapiens	ENSP00000362936	21.2544	11.4983	homo_sapiens	ENSP00000304139	15.5612	8.41837
ENSG00000170748	homo_sapiens	ENSP00000313199	26.4789	17.1831	homo_sapiens	ENSP00000304139	23.9796	15.5612
ENSG00000170748	homo_sapiens	ENSP00000253363	12.4528	8.30189	homo_sapiens	ENSP00000304139	16.8367	11.2245
ENSG00000170748	homo_sapiens	ENSP00000363109	14.5051	8.70307	homo_sapiens	ENSP00000304139	21.6837	13.0102
ENSG00000170748	homo_sapiens	ENSP00000316042	33.4426	23.2787	homo_sapiens	ENSP00000304139	26.0204	18.1122
ENSG00000170748	homo_sapiens	ENSP00000318195	13.3803	7.60563	homo_sapiens	ENSP00000304139	24.2347	13.7755
ENSG00000170748	homo_sapiens	ENSP00000394902	21.8667	12	homo_sapiens	ENSP00000304139	20.9184	11.4796
ENSG00000170748	homo_sapiens	ENSP00000351108	28.9157	18.6747	homo_sapiens	ENSP00000304139	24.4898	15.8163
ENSG00000170748	homo_sapiens	ENSP00000261741	9.79167	5.20833	homo_sapiens	ENSP00000304139	23.9796	12.7551
ENSG00000170748	homo_sapiens	ENSP00000233078	32.4324	21.8673	homo_sapiens	ENSP00000304139	33.6735	22.7041
ENSG00000170748	homo_sapiens	ENSP00000372127	47.1774	38.1048	homo_sapiens	ENSP00000304139	59.6939	48.2143
ENSG00000170748	homo_sapiens	ENSP00000372105	47.1774	38.1048	homo_sapiens	ENSP00000304139	59.6939	48.2143
ENSG00000170748	homo_sapiens	ENSP00000372484	47.379	38.3064	homo_sapiens	ENSP00000304139	59.949	48.4694
ENSG00000170748	homo_sapiens	ENSP00000372154	46.9758	38.1048	homo_sapiens	ENSP00000304139	59.4388	48.2143
ENSG00000170748	homo_sapiens	ENSP00000250831	46.9758	38.1048	homo_sapiens	ENSP00000304139	59.4388	48.2143
ENSG00000170748	homo_sapiens	ENSP00000307155	46.9758	38.1048	homo_sapiens	ENSP00000304139	59.4388	48.2143
ENSG00000170748	homo_sapiens	ENSP00000295470	21.9048	14.2857	homo_sapiens	ENSP00000304139	23.4694	15.3061
ENSG00000170748	homo_sapiens	ENSP00000466025	37.3737	29.2929	homo_sapiens	ENSP00000304139	28.3163	22.1939
ENSG00000170748	homo_sapiens	ENSP00000365950	66.879	53.5032	homo_sapiens	ENSP00000304139	26.7857	21.4286

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000170748	homo_sapiens	ENSP00000304139	97.449	96.6837	nomascus_leucogenys	ENSNLEP00000022085	97.201	96.4377
ENSG00000170748	homo_sapiens	ENSP00000304139	99.2347	98.7245	pan_troglodytes	ENSPTRP00000005794	99.2347	98.7245
ENSG00000170748	homo_sapiens	ENSP00000304139	98.7245	98.2143	gorilla_gorilla	ENSGGOP00000034227	98.7245	98.2143
ENSG00000170748	homo_sapiens	ENSP00000304139	71.1735	68.3673	dasypus_novemcinctus	ENSDNOP00000024110	90	86.4516
ENSG00000170748	homo_sapiens	ENSP00000304139	72.1939	69.6429	echinops_telfairi	ENSETEP00000004569	72.9381	70.3608
ENSG00000170748	homo_sapiens	ENSP00000304139	97.1939	96.1735	macaca_mulatta	ENSMMUP00000060072	96.7005	95.6853
ENSG00000170748	homo_sapiens	ENSP00000304139	96.9388	95.9184	macaca_nemestrina	ENSMNEP00000000968	96.4467	95.4315
ENSG00000170748	homo_sapiens	ENSP00000304139	96.9388	95.9184	papio_anubis	ENSPANP00000011538	96.4467	95.4315
ENSG00000170748	homo_sapiens	ENSP00000304139	67.602	64.0306	tursiops_truncatus	ENSTTRP00000003036	69.1906	65.5352
ENSG00000170748	homo_sapiens	ENSP00000304139	17.602	17.3469	vulpes_vulpes	ENSVVUP00000039218	78.4091	77.2727
ENSG00000170748	homo_sapiens	ENSP00000304139	85.7143	79.8469	mus_spretus	MGP_SPRETEiJ_P0084793	87.2727	81.2987
ENSG00000170748	homo_sapiens	ENSP00000304139	80.6122	77.551	equus_asinus	ENSEASP00005038149	79.597	76.5743
ENSG00000170748	homo_sapiens	ENSP00000304139	85.7143	81.8878	capra_hircus	ENSCHIP00000002273	85.0633	81.2658
ENSG00000170748	homo_sapiens	ENSP00000304139	77.0408	74.2347	loxodonta_africana	ENSLAFP00000026253	86.2857	83.1429
ENSG00000170748	homo_sapiens	ENSP00000304139	84.949	80.8673	panthera_leo	ENSPLOP00000008324	84.5178	80.4569
ENSG00000170748	homo_sapiens	ENSP00000304139	86.2245	82.1429	bos_indicus_hybrid	ENSBIXP00005037583	85.3535	81.3131
ENSG00000170748	homo_sapiens	ENSP00000304139	25.2551	24.4898	oryctolagus_cuniculus	ENSOCUP00000041756	67.3469	65.3061
ENSG00000170748	homo_sapiens	ENSP00000304139	80.3571	75.7653	equus_caballus	ENSECAP00000063564	71.1061	67.0429
ENSG00000170748	homo_sapiens	ENSP00000304139	84.949	80.8673	panthera_pardus	ENSPPRP00000028994	84.5178	80.4569
ENSG00000170748	homo_sapiens	ENSP00000304139	80.102	76.5306	balaenoptera_musculus	ENSBMSP00010030342	81.5584	77.9221
ENSG00000170748	homo_sapiens	ENSP00000304139	85.2041	80.6122	felis_catus	ENSFCAP00000048227	84.7716	80.203
ENSG00000170748	homo_sapiens	ENSP00000304139	17.3469	17.0918	ursus_americanus	ENSUAMP00000001281	94.4444	93.0556
ENSG00000170748	homo_sapiens	ENSP00000304139	17.0918	15.051	bison_bison_bison	ENSBBBP00000027767	88.1579	77.6316
ENSG00000170748	homo_sapiens	ENSP00000304139	79.5918	75.7653	monodon_monoceros	ENSMMNP00015029260	81.4621	77.5457
ENSG00000170748	homo_sapiens	ENSP00000304139	34.4388	31.3776	sus_scrofa	ENSSSCP00000076887	78.9474	71.9298
ENSG00000170748	homo_sapiens	ENSP00000304139	64.5408	59.949	octodon_degus	ENSODEP00000001299	81.3505	75.5627
ENSG00000170748	homo_sapiens	ENSP00000304139	85.7143	81.8878	ovis_aries_rambouillet	ENSOARP00020010750	85.0633	81.2658
ENSG00000170748	homo_sapiens	ENSP00000304139	18.3673	16.5816	ursus_maritimus	ENSUMAP00000026488	90	81.25
ENSG00000170748	homo_sapiens	ENSP00000304139	79.8469	75.7653	delphinapterus_leucas	ENSDLEP00000011426	81.7232	77.5457
ENSG00000170748	homo_sapiens	ENSP00000304139	78.8265	74.7449	physeter_catodon	ENSPCTP00005007015	81.9629	77.7188
ENSG00000170748	homo_sapiens	ENSP00000304139	85.7143	79.8469	mus_caroli	MGP_CAROLIEiJ_P0081410	87.2727	81.2987
ENSG00000170748	homo_sapiens	ENSP00000304139	85.7143	79.8469	mus_musculus	ENSMUSP00000095739	87.2727	81.2987
ENSG00000170748	homo_sapiens	ENSP00000304139	17.0918	17.0918	dipodomys_ordii	ENSDORP00000024335	77.907	77.907
ENSG00000170748	homo_sapiens	ENSP00000304139	61.4796	58.4184	mustela_putorius_furo	ENSMPUP00000010354	87.3188	82.971
ENSG00000170748	homo_sapiens	ENSP00000304139	90.3061	87.2449	chlorocebus_sabaeus	ENSCSAP00000004728	89.8477	86.802
ENSG00000170748	homo_sapiens	ENSP00000304139	96.1735	95.1531	chlorocebus_sabaeus	ENSCSAP00000018843	95.9288	94.9109
ENSG00000170748	homo_sapiens	ENSP00000304139	69.6429	64.5408	mesocricetus_auratus	ENSMAUP00000024519	87.2204	80.8307
ENSG00000170748	homo_sapiens	ENSP00000304139	20.4082	18.6224	panthera_tigris_altaica	ENSPTIP00000020766	73.3945	66.9725
ENSG00000170748	homo_sapiens	ENSP00000304139	85.4592	79.3367	rattus_norvegicus	ENSRNOP00000088340	86.7876	80.5699
ENSG00000170748	homo_sapiens	ENSP00000304139	20.1531	17.3469	prolemur_simus	ENSPSMP00000014350	68.6957	59.1304
ENSG00000170748	homo_sapiens	ENSP00000304139	20.4082	18.3673	microtus_ochrogaster	ENSMOCP00000010916	77.6699	69.9029
ENSG00000170748	homo_sapiens	ENSP00000304139	49.2347	45.4082	sorex_araneus	ENSSARP00000010957	50.6562	46.7192
ENSG00000170748	homo_sapiens	ENSP00000304139	19.898	18.1122	peromyscus_maniculatus_bairdii	ENSPEMP00000011391	78.7879	71.7172
ENSG00000170748	homo_sapiens	ENSP00000304139	19.1327	18.1122	bos_mutus	ENSBMUP00000012471	93.75	88.75
ENSG00000170748	homo_sapiens	ENSP00000304139	85.7143	79.8469	mus_spicilegus	ENSMSIP00000017067	87.2727	81.2987
ENSG00000170748	homo_sapiens	ENSP00000304139	86.2245	80.6122	cricetulus_griseus_chok1gshd	ENSCGRP00001005800	87.5648	81.8653
ENSG00000170748	homo_sapiens	ENSP00000304139	82.1429	78.3163	rhinolophus_ferrumequinum	ENSRFEP00010006152	81.9338	78.1171
ENSG00000170748	homo_sapiens	ENSP00000304139	49.4898	45.1531	neovison_vison	ENSNVIP00000016876	75.4864	68.8716
ENSG00000170748	homo_sapiens	ENSP00000304139	86.7347	82.6531	bos_taurus	ENSBTAP00000056096	85.8586	81.8182
ENSG00000170748	homo_sapiens	ENSP00000304139	74.2347	69.1327	heterocephalus_glaber_female	ENSHGLP00000048854	78.6487	73.2432
ENSG00000170748	homo_sapiens	ENSP00000304139	88.5204	86.4796	rhinopithecus_bieti	ENSRBIP00000007880	96.1219	93.9058
ENSG00000170748	homo_sapiens	ENSP00000304139	82.9082	79.0816	canis_lupus_dingo	ENSCAFP00020012274	83.1202	79.2839
ENSG00000170748	homo_sapiens	ENSP00000304139	85.4592	82.6531	sciurus_vulgaris	ENSSVLP00005006801	87.013	84.1558
ENSG00000170748	homo_sapiens	ENSP00000304139	84.4388	80.102	bos_grunniens	ENSBGRP00000008610	78.436	74.4076
ENSG00000170748	homo_sapiens	ENSP00000304139	56.3776	51.7857	chinchilla_lanigera	ENSCLAP00000024575	81.25	74.6324
ENSG00000170748	homo_sapiens	ENSP00000304139	17.8571	15.8163	cervus_hanglu_yarkandensis	ENSCHYP00000030987	83.3333	73.8095
ENSG00000170748	homo_sapiens	ENSP00000304139	20.6633	18.6224	cervus_hanglu_yarkandensis	ENSCHYP00000016055	81	73
ENSG00000170748	homo_sapiens	ENSP00000304139	17.8571	15.051	catagonus_wagneri	ENSCWAP00000007410	78.6517	66.2921
ENSG00000170748	homo_sapiens	ENSP00000304139	87.7551	85.9694	otolemur_garnettii	ENSOGAP00000022253	87.5318	85.7506
ENSG00000170748	homo_sapiens	ENSP00000304139	87.2449	84.4388	cebus_imitator	ENSCCAP00000026112	81.0427	78.436
ENSG00000170748	homo_sapiens	ENSP00000304139	14.5408	13.0102	urocitellus_parryii	ENSUPAP00010001409	77.027	68.9189
ENSG00000170748	homo_sapiens	ENSP00000304139	85.4592	82.1429	moschus_moschiferus	ENSMMSP00000024640	85.2417	81.9338
ENSG00000170748	homo_sapiens	ENSP00000304139	85.4592	79.5918	mus_pahari	MGP_PahariEiJ_P0018225	87.013	81.039

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000398	involved_in mRNA splicing, via spliceosome	1	IBA	Homo_sapiens(9606)	Process
GO:0003729	enables mRNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005689	part_of U12-type spliceosomal complex	1	IBA	Homo_sapiens(9606)	Component
GO:0017069	enables snRNA binding	1	IBA	Homo_sapiens(9606)	Function