Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases FlavivirusesSARS-COV-2Dengue
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000170312 Gene ID 983 Accession 1722
Symbol CDK1 Alias CDC2;CDC28A;P34CDC2 Full Name cyclin dependent kinase 1
Status Confidence Length 16522 bases Strand Plus strand
Position 10 : 60778331 - 60794852 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
CDK1-207 ENST00000519078 723 189aa ENSP00000430665
CDK1-205 ENST00000475504 1720 No protein -
CDK1-201 ENST00000316629 1733 240aa ENSP00000325970
CDK1-208 ENST00000519760 276 No protein -
CDK1-203 ENST00000395284 1889 297aa ENSP00000378699
CDK1-204 ENST00000448257 1948 297aa ENSP00000397973
CDK1-202 ENST00000373809 1613 240aa ENSP00000362915
CDK1-206 ENST00000487784 598 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
12872Schizophrenia7.66E-5-
28881monocyte chemoattractant protein 1 (66-77)3.0210000E-007-
31463Erythrocyte Indices4.7800000E-006-
31616Erythrocyte Count1.9170000E-006-
41144Platelet Function Tests1.0919900E-005-
42146Platelet Function Tests4.0905577E-006-
64532Cocaine-Related Disorders5E-623958962
65606Cocaine-Related Disorders3E-623958962
87713Reading3E-623738518

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000086involved_in G2/M transition of mitotic cell cycle3IBA,NAS,TASHomo_sapiens(9606)Process
GO:0000226involved_in microtubule cytoskeleton organization1TASHomo_sapiens(9606)Process
GO:0000307part_of cyclin-dependent protein kinase holoenzyme complex1IDAHomo_sapiens(9606)Component
GO:0000781located_in chromosome, telomeric region1HDAHomo_sapiens(9606)Component
GO:0001618enables virus receptor activity1IEAHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IEAHomo_sapiens(9606)Function
GO:0004672enables protein kinase activity1IDAHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity2IDA,TASHomo_sapiens(9606)Function
GO:0004693enables cyclin-dependent protein serine/threonine kinase activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1TASHomo_sapiens(9606)Component
GO:0005759colocalizes_with mitochondrial matrix1IDAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005876located_in spindle microtubule1IDAHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1TASHomo_sapiens(9606)Process
GO:0006281involved_in DNA repair1TASHomo_sapiens(9606)Process
GO:0006338involved_in chromatin remodeling1IEAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0007095involved_in mitotic G2 DNA damage checkpoint signaling1IBAHomo_sapiens(9606)Process
GO:0007098involved_in centrosome cycle1TASHomo_sapiens(9606)Process
GO:0007344involved_in pronuclear fusion1TASHomo_sapiens(9606)Process
GO:0008353enables RNA polymerase II CTD heptapeptide repeat kinase activity1IDAHomo_sapiens(9606)Function
GO:0009410involved_in response to xenobiotic stimulus1IEAHomo_sapiens(9606)Process
GO:0009636involved_in response to toxic substance1IEAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IEAHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IEAHomo_sapiens(9606)Process
GO:0010971involved_in positive regulation of G2/M transition of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:0014038involved_in regulation of Schwann cell differentiation1TASHomo_sapiens(9606)Process
GO:0014075involved_in response to amine1IEAHomo_sapiens(9606)Process
GO:0014823involved_in response to activity1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016301enables kinase activity1IDAHomo_sapiens(9606)Function
GO:0016477involved_in cell migration1TASHomo_sapiens(9606)Process
GO:0016579involved_in protein deubiquitination1TASHomo_sapiens(9606)Process
GO:0018105involved_in peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0018107involved_in peptidyl-threonine phosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0030261involved_in chromosome condensation1IEAHomo_sapiens(9606)Process
GO:0030332enables cyclin binding2IDA,IPIHomo_sapiens(9606)Function
GO:0030496located_in midbody1IDAHomo_sapiens(9606)Component
GO:0030544enables Hsp70 protein binding1IEAHomo_sapiens(9606)Function
GO:0030855involved_in epithelial cell differentiation1IEPHomo_sapiens(9606)Process
GO:0031100involved_in animal organ regeneration1IEAHomo_sapiens(9606)Process
GO:0034501involved_in protein localization to kinetochore1IDAHomo_sapiens(9606)Process
GO:0035173enables histone kinase activity1IDAHomo_sapiens(9606)Function
GO:0042307involved_in positive regulation of protein import into nucleus1IEAHomo_sapiens(9606)Process
GO:0042752involved_in regulation of circadian rhythm1IMPHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0045471involved_in response to ethanol1IEAHomo_sapiens(9606)Process
GO:0045740involved_in positive regulation of DNA replication1IEAHomo_sapiens(9606)Process
GO:0045995involved_in regulation of embryonic development1TASHomo_sapiens(9606)Process
GO:0046686involved_in response to cadmium ion1IEAHomo_sapiens(9606)Process
GO:0046688involved_in response to copper ion1IEAHomo_sapiens(9606)Process
GO:0046718involved_in viral entry into host cell1IEAHomo_sapiens(9606)Process
GO:0048144involved_in fibroblast proliferation1IEAHomo_sapiens(9606)Process
GO:0048511involved_in rhythmic process1IEAHomo_sapiens(9606)Process
GO:0048678involved_in response to axon injury1IEAHomo_sapiens(9606)Process
GO:0051301involved_in cell division1IEAHomo_sapiens(9606)Process
GO:0055015involved_in ventricular cardiac muscle cell development1IEAHomo_sapiens(9606)Process
GO:0060045involved_in positive regulation of cardiac muscle cell proliferation1IEAHomo_sapiens(9606)Process
GO:0062033involved_in positive regulation of mitotic sister chromatid segregation1IDAHomo_sapiens(9606)Process
GO:0065003involved_in protein-containing complex assembly1IEAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070301involved_in cellular response to hydrogen peroxide1IEAHomo_sapiens(9606)Process
GO:0070371involved_in ERK1 and ERK2 cascade1TASHomo_sapiens(9606)Process
GO:0071407involved_in cellular response to organic cyclic compound1IEAHomo_sapiens(9606)Process
GO:0072686located_in mitotic spindle1IDAHomo_sapiens(9606)Component
GO:0090166involved_in Golgi disassembly1ISSHomo_sapiens(9606)Process
GO:0097125part_of cyclin B1-CDK1 complex2IMP,IPIHomo_sapiens(9606)Component
GO:0097472enables cyclin-dependent protein kinase activity1IDAHomo_sapiens(9606)Function
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1900182involved_in positive regulation of protein localization to nucleus1IMPHomo_sapiens(9606)Process
GO:1902850involved_in microtubule cytoskeleton organization involved in mitosis1IDAHomo_sapiens(9606)Process
GO:1905448involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport1IMPHomo_sapiens(9606)Process

Expression