RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000170145	Gene ID	23235	Accession	21680
Symbol	SIK2	Alias	QIK;SIK-2;SNF1LK2;LOH11CR1I	Full Name	salt inducible kinase 2
Status	Confidence	Length	128407 bases	Strand	Plus strand
Position	11 : 111602449 - 111730855	RNA binding domain	N.A.
Summary	Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
SIK2-201	ENST00000304987	9622	926aa	ENSP00000305976
SIK2-202	ENST00000533868	544	No protein	-

Gene Model

Click here to download ENSG00000170145's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
27682	Coronary Disease	2.7920000E-005	-
57828	Myocardial Infarction	2.2430000E-005	-
103499	Cholangitis, Sclerosing	5E-7	27992413

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000170145's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000287	enables magnesium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0005789	is_active_in endoplasmic reticulum membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0046626	involved_in regulation of insulin receptor signaling pathway	1	ISS	Homo_sapiens(9606)	Process
GO:0046777	involved_in protein autophosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IDA	Homo_sapiens(9606)	Function

Expression