Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq DataSet_01_216 DataSet_01_218 DataSet_02_24

Description

Ensembl ID ENSG00000169813 Gene ID 3185 Accession 5039
Symbol HNRNPF Alias HNRPF;mcs94-1;OK/SW-cl.23 Full Name heterogeneous nuclear ribonucleoprotein F
Status Confidence Length 23570 bases Strand Minus strand
Position 10 : 43385617 - 43409186 RNA binding domain zf-RNPHF , RRM_1
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000338477 RRM_1 PF00076 7.5e-27 1
ENSP00000338477 RRM_1 PF00076 7.5e-27 2
ENSP00000338477 zf-RNPHF PF08080 1.6e-23 3
ENSP00000348345 RRM_1 PF00076 7.5e-27 1
ENSP00000348345 RRM_1 PF00076 7.5e-27 2
ENSP00000348345 zf-RNPHF PF08080 1.6e-23 3
ENSP00000349573 RRM_1 PF00076 7.5e-27 1
ENSP00000349573 RRM_1 PF00076 7.5e-27 2
ENSP00000349573 zf-RNPHF PF08080 1.6e-23 3
ENSP00000400433 RRM_1 PF00076 7.5e-27 1
ENSP00000400433 RRM_1 PF00076 7.5e-27 2
ENSP00000400433 zf-RNPHF PF08080 1.6e-23 3
ENSP00000438061 RRM_1 PF00076 7.5e-27 1
ENSP00000438061 RRM_1 PF00076 7.5e-27 2
ENSP00000438061 zf-RNPHF PF08080 1.6e-23 3
ENSP00000507787 RRM_1 PF00076 7.5e-27 1
ENSP00000507787 RRM_1 PF00076 7.5e-27 2
ENSP00000507787 zf-RNPHF PF08080 1.6e-23 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27618485 A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage. Zhihong Xue 2016-10-06 Molecular cell
32873578 The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing. Xavier Rambout 2020-09-01 Genes & development
36291863 Tumor-Associated Macrophages Promote Metastasis of Oral Squamous Cell Carcinoma via CCL13 Regulated by Stress Granule. Zhixin Liu 2022-10-17 Cancers
29269483 RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF. Huilin Huang 2017-11-15 Genes & development
35809850 Single-Cell Quantitative Proteomic Analysis of Human Oocyte Maturation Revealed High Heterogeneity in In Vitro-Matured Oocytes. Yueshuai Guo 2022-08-01 Molecular & cellular proteomics : MCP
36831678 Molecular Insight into Drug Resistance Mechanism Conferred by Aberrant PIK3CD Splice Variant in African American Prostate Cancer. Siyoung Ha 2023-02-20 Cancers
31831626 Control of noncoding RNA production and histone levels by a 5' tRNA fragment. Ana Boskovic 2020-01-01 Genes & development
33637716 The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis. Fang Zheng 2021-02-26 Nature communications
29507424 CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. J Nicholas Kramer 2018-04-01 Nature genetics

Transcripts

Name Transcript ID bp Protein Translation ID
HNRNPF-204 ENST00000443950 2755 415aa ENSP00000400433
HNRNPF-207 ENST00000544000 2676 415aa ENSP00000438061
HNRNPF-203 ENST00000357065 2617 415aa ENSP00000349573
HNRNPF-202 ENST00000356053 2670 415aa ENSP00000348345
HNRNPF-208 ENST00000682386 2569 415aa ENSP00000507787
HNRNPF-201 ENST00000337970 2186 415aa ENSP00000338477
HNRNPF-205 ENST00000477108 636 98aa ENSP00000490768
HNRNPF-206 ENST00000498176 715 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000169813homo_sapiensENSP0000040573827.019118.649homo_sapiensENSP0000050778744.337330.6024
ENSG00000169813homo_sapiensENSP0000036192779.955570.1559homo_sapiensENSP0000050778786.50675.9036
ENSG00000169813homo_sapiensENSP0000037708281.06972.1604homo_sapiensENSP0000050778787.710878.0723
ENSG00000169813homo_sapiensENSP0000041874825.383516.5969homo_sapiensENSP0000050778743.855428.6747
ENSG00000169813homo_sapiensENSP0000026586668.208156.9364homo_sapiensENSP0000050778756.867547.4699
ENSG00000169813homo_sapiensENSP0000042980715.68438.99101homo_sapiensENSP0000050778737.831321.6867
ENSG00000169813homo_sapiensENSP0000025479943.7531.0417homo_sapiensENSP0000050778750.602435.9036
ENSG00000169813homo_sapiensENSP0000036322817.3828.90558homo_sapiensENSP0000050778739.036120

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000169813homo_sapiensENSP0000050778799.75999.5181nomascus_leucogenysENSNLEP0000002294999.75999.5181
ENSG00000169813homo_sapiensENSP00000507787100100pongo_abeliiENSPPYP00000033783100100
ENSG00000169813homo_sapiensENSP00000507787100100pan_troglodytesENSPTRP00000050686100100
ENSG00000169813homo_sapiensENSP0000050778791.325390.8434gorilla_gorillaENSGGOP0000001058994.044793.5484
ENSG00000169813homo_sapiensENSP0000050778748.915741.6867dasypus_novemcinctusENSDNOP0000002013160.59751.6418
ENSG00000169813homo_sapiensENSP0000050778798.554298.0723callithrix_jacchusENSCJAP0000001530198.792398.3092
ENSG00000169813homo_sapiensENSP00000507787100100macaca_fascicularisENSMFAP00000062831100100
ENSG00000169813homo_sapiensENSP00000507787100100macaca_mulattaENSMMUP00000075935100100
ENSG00000169813homo_sapiensENSP0000050778710099.759papio_anubisENSPANP0000001081610099.759
ENSG00000169813homo_sapiensENSP00000507787100100mandrillus_leucophaeusENSMLEP00000005252100100
ENSG00000169813homo_sapiensENSP0000050778798.554297.8313vulpes_vulpesENSVVUP0000002908898.792398.0676
ENSG00000169813homo_sapiensENSP0000050778798.795297.5904equus_asinusENSEASP0000505510799.033897.8261
ENSG00000169813homo_sapiensENSP0000050778776.144670.3614capra_hircusENSCHIP0000002677385.405478.9189
ENSG00000169813homo_sapiensENSP0000050778797.349495.1807loxodonta_africanaENSLAFP0000000036297.349495.1807
ENSG00000169813homo_sapiensENSP0000050778725.783122.6506panthera_leoENSPLOP0000000979689.166778.3333
ENSG00000169813homo_sapiensENSP0000050778714.698812.7711ailuropoda_melanoleucaENSAMEP0000003003666.304357.6087
ENSG00000169813homo_sapiensENSP0000050778791.325389.8795bos_indicus_hybridENSBIXP0000502172596.930995.3964
ENSG00000169813homo_sapiensENSP0000050778794.939893.253oryctolagus_cuniculusENSOCUP0000002408494.939893.253
ENSG00000169813homo_sapiensENSP0000050778798.795297.5904equus_caballusENSECAP0000006939699.033897.8261
ENSG00000169813homo_sapiensENSP0000050778798.554297.8313canis_lupus_familiarisENSCAFP0084503766398.792398.0676
ENSG00000169813homo_sapiensENSP0000050778798.554297.8313panthera_pardusENSPPRP0000002888798.792398.0676
ENSG00000169813homo_sapiensENSP0000050778775.903673.012marmota_marmota_marmotaENSMMMP0000000300991.304387.8261
ENSG00000169813homo_sapiensENSP0000050778797.349495.9036balaenoptera_musculusENSBMSP0001002003197.349495.9036
ENSG00000169813homo_sapiensENSP0000050778798.313397.5904cavia_porcellusENSCPOP0000001643598.313397.5904
ENSG00000169813homo_sapiensENSP0000050778798.554297.8313felis_catusENSFCAP0000002406698.792398.0676
ENSG00000169813homo_sapiensENSP0000050778713.49412.2892ursus_americanusENSUAMP0000002993064.367858.6207
ENSG00000169813homo_sapiensENSP0000050778714.939812.7711ursus_americanusENSUAMP0000001158969.662959.5506
ENSG00000169813homo_sapiensENSP0000050778798.072396.8675bison_bison_bisonENSBBBP0000000349898.309297.1014
ENSG00000169813homo_sapiensENSP0000050778797.108495.6627monodon_monocerosENSMMNP0001502612996.87595.4327
ENSG00000169813homo_sapiensENSP0000050778765.301259.5181sus_scrofaENSSSCP0000001938678.09871.1816
ENSG00000169813homo_sapiensENSP0000050778787.469981.4458microcebus_murinusENSMICP0000001719986.223380.285
ENSG00000169813homo_sapiensENSP0000050778786.50680.241microcebus_murinusENSMICP0000001802787.56181.2195
ENSG00000169813homo_sapiensENSP0000050778792.771190.1205octodon_degusENSODEP0000000307294.362791.6667
ENSG00000169813homo_sapiensENSP0000050778798.313397.5904octodon_degusENSODEP0000002592798.313397.5904
ENSG00000169813homo_sapiensENSP0000050778776.626573.494jaculus_jaculusENSJJAP0000000067386.885283.3333
ENSG00000169813homo_sapiensENSP0000050778783.614580.9639jaculus_jaculusENSJJAP0000002212892.287289.3617
ENSG00000169813homo_sapiensENSP0000050778769.156662.8916jaculus_jaculusENSJJAP0000001098585.671677.9104
ENSG00000169813homo_sapiensENSP0000050778791.325387.2289jaculus_jaculusENSJJAP0000001512693.120488.9435
ENSG00000169813homo_sapiensENSP0000050778785.783184.5783jaculus_jaculusENSJJAP0000001085195.956994.6092
ENSG00000169813homo_sapiensENSP0000050778779.75973.253ovis_aries_rambouilletENSOARP0002003168886.649279.5812
ENSG00000169813homo_sapiensENSP0000050778714.939812.7711ursus_maritimusENSUMAP0000002007969.662959.5506
ENSG00000169813homo_sapiensENSP0000050778713.49412.2892ursus_maritimusENSUMAP0000001226364.367858.6207
ENSG00000169813homo_sapiensENSP0000050778797.108495.6627delphinapterus_leucasENSDLEP0000000949596.87595.4327
ENSG00000169813homo_sapiensENSP0000050778797.831396.3855physeter_catodonENSPCTP0000503156497.831396.3855
ENSG00000169813homo_sapiensENSP0000050778799.036198.0723mus_musculusENSMUSP0000013002399.036198.0723
ENSG00000169813homo_sapiensENSP0000050778798.072396.6265dipodomys_ordiiENSDORP0000002600698.072396.6265
ENSG00000169813homo_sapiensENSP0000050778791.807287.9518dipodomys_ordiiENSDORP0000000507894.540990.5707
ENSG00000169813homo_sapiensENSP0000050778796.385593.7349dipodomys_ordiiENSDORP0000001650596.385593.7349
ENSG00000169813homo_sapiensENSP0000050778792.771190.1205dipodomys_ordiiENSDORP0000000775096.0193.2668
ENSG00000169813homo_sapiensENSP0000050778795.421794.4578mustela_putorius_furoENSMPUP0000001717498.019897.0297
ENSG00000169813homo_sapiensENSP0000050778797.590496.8675aotus_nancymaaeENSANAP0000003108899.753799.0148
ENSG00000169813homo_sapiensENSP0000050778799.75999.5181saimiri_boliviensis_boliviensisENSSBOP0000000408799.75999.5181
ENSG00000169813homo_sapiensENSP0000050778767.710861.4458tupaia_belangeriENSTBEP0000001398774.338667.4603
ENSG00000169813homo_sapiensENSP0000050778799.036198.0723mesocricetus_auratusENSMAUP0000000580499.036198.0723
ENSG00000169813homo_sapiensENSP0000050778797.108495.6627phocoena_sinusENSPSNP0000001429196.87595.4327
ENSG00000169813homo_sapiensENSP0000050778714.939814.4578camelus_dromedariusENSCDRP0000502477386.111183.3333
ENSG00000169813homo_sapiensENSP0000050778799.277198.3133carlito_syrichtaENSTSYP0000002660399.277198.3133
ENSG00000169813homo_sapiensENSP0000050778786.74783.6145carlito_syrichtaENSTSYP0000002023490.452387.1859
ENSG00000169813homo_sapiensENSP0000050778798.554297.8313panthera_tigris_altaicaENSPTIP0000000823598.792398.0676
ENSG00000169813homo_sapiensENSP0000050778774.457872.0482rattus_norvegicusENSRNOP0000008325491.964388.9881
ENSG00000169813homo_sapiensENSP0000050778799.036198.0723rattus_norvegicusENSRNOP0000007959799.036198.0723
ENSG00000169813homo_sapiensENSP0000050778798.554298.3133prolemur_simusENSPSMP0000002809898.554298.3133
ENSG00000169813homo_sapiensENSP0000050778798.795297.3494microtus_ochrogasterENSMOCP0000001586398.795297.3494
ENSG00000169813homo_sapiensENSP0000050778798.554297.1084sorex_araneusENSSARP0000000909898.792397.343
ENSG00000169813homo_sapiensENSP0000050778799.036198.0723peromyscus_maniculatus_bairdiiENSPEMP0000003464599.036198.0723
ENSG00000169813homo_sapiensENSP0000050778798.554297.5904peromyscus_maniculatus_bairdiiENSPEMP0000003348498.554297.5904
ENSG00000169813homo_sapiensENSP0000050778715.421715.4217peromyscus_maniculatus_bairdiiENSPEMP0000002909895.522495.5224
ENSG00000169813homo_sapiensENSP0000050778785.060280.4819bos_mutusENSBMUP0000003384589.141484.3434
ENSG00000169813homo_sapiensENSP0000050778716.144616.1446mus_spicilegusENSMSIP0000000254594.366294.3662
ENSG00000169813homo_sapiensENSP0000050778722.168722.1687mus_spicilegusENSMSIP0000000255598.924798.9247
ENSG00000169813homo_sapiensENSP0000050778716.626516.6265mus_spicilegusENSMSIP0000000558397.183197.1831
ENSG00000169813homo_sapiensENSP0000050778799.036198.0723cricetulus_griseus_chok1gshdENSCGRP0000101575599.036198.0723
ENSG00000169813homo_sapiensENSP0000050778797.590496.6265pteropus_vampyrusENSPVAP0000001097797.826196.8599
ENSG00000169813homo_sapiensENSP0000050778797.349494.9398myotis_lucifugusENSMLUP0000000662097.349494.9398
ENSG00000169813homo_sapiensENSP0000050778797.108495.1807rhinolophus_ferrumequinumENSRFEP0001001620796.87594.9519
ENSG00000169813homo_sapiensENSP0000050778798.554297.8313neovison_visonENSNVIP0000002586598.792398.0676
ENSG00000169813homo_sapiensENSP0000050778783.614579.2771bos_taurusENSBTAP0000002733287.848183.2911
ENSG00000169813homo_sapiensENSP0000050778798.072397.3494heterocephalus_glaber_femaleENSHGLP0000004165198.309297.5845
ENSG00000169813homo_sapiensENSP0000050778789.156685.5422heterocephalus_glaber_femaleENSHGLP0000005833293.434389.6465
ENSG00000169813homo_sapiensENSP0000050778715.662715.6627sciurus_vulgarisENSSVLP0000501984991.549391.5493
ENSG00000169813homo_sapiensENSP0000050778716.867516.3855sciurus_vulgarisENSSVLP0000502589795.890493.1507
ENSG00000169813homo_sapiensENSP0000050778797.108494.6988procavia_capensisENSPCAP0000001224697.108494.6988
ENSG00000169813homo_sapiensENSP0000050778775.421769.1566nannospalax_galiliENSNGAP0000000637289.428682
ENSG00000169813homo_sapiensENSP0000050778799.036197.5904nannospalax_galiliENSNGAP0000000708899.036197.5904
ENSG00000169813homo_sapiensENSP0000050778782.650679.2771nannospalax_galiliENSNGAP0000001212292.452888.6792
ENSG00000169813homo_sapiensENSP0000050778788.674787.4699bos_grunniensENSBGRP0000003925898.133396.8
ENSG00000169813homo_sapiensENSP0000050778798.313397.5904chinchilla_lanigeraENSCLAP0000000733998.313397.5904
ENSG00000169813homo_sapiensENSP0000050778764.337358.0723cervus_hanglu_yarkandensisENSCHYP0000003662185.852177.492
ENSG00000169813homo_sapiensENSP0000050778798.072397.1084catagonus_wagneriENSCWAP0000002931198.309297.343
ENSG00000169813homo_sapiensENSP0000050778798.795298.3133ictidomys_tridecemlineatusENSSTOP0000001720598.795298.3133
ENSG00000169813homo_sapiensENSP0000050778789.638687.9518ictidomys_tridecemlineatusENSSTOP0000002752593.702891.9395
ENSG00000169813homo_sapiensENSP0000050778784.337382.4096ictidomys_tridecemlineatusENSSTOP0000003045092.105390
ENSG00000169813homo_sapiensENSP0000050778794.939891.8072otolemur_garnettiiENSOGAP0000001230294.711591.5865
ENSG00000169813homo_sapiensENSP0000050778794.216993.494otolemur_garnettiiENSOGAP0000001562198.241297.4874
ENSG00000169813homo_sapiensENSP0000050778781.204879.759cebus_imitatorENSCCAP0000002172193.351891.6898
ENSG00000169813homo_sapiensENSP0000050778799.518199.2771cebus_imitatorENSCCAP0000002727199.518199.2771
ENSG00000169813homo_sapiensENSP0000050778798.554298.3133urocitellus_parryiiENSUPAP0001002805898.554298.3133
ENSG00000169813homo_sapiensENSP0000050778798.072396.8675moschus_moschiferusENSMMSP0000002724998.309297.1014
ENSG00000169813homo_sapiensENSP00000507787100100rhinopithecus_roxellanaENSRROP00000000384100100
ENSG00000169813homo_sapiensENSP0000050778798.072396.8675mus_pahariMGP_PahariEiJ_P007061998.072396.8675
ENSG00000169813homo_sapiensENSP0000050778738.795226.0241caenorhabditis_elegansY73B6BL.33a.126.393417.7049
ENSG00000169813homo_sapiensENSP0000050778737.108419.759caenorhabditis_elegansY106G6D.7.116.24478.64979
ENSG00000169813homo_sapiensENSP0000050778736.144622.8916caenorhabditis_elegansZK1067.6a.124.271815.3722
ENSG00000169813homo_sapiensENSP0000050778754.939836.6265drosophila_melanogasterFBpp042843438.907825.9386
ENSG00000169813homo_sapiensENSP0000050778742.168725.5422drosophila_melanogasterFBpp008647918.097210.9617
ENSG00000169813homo_sapiensENSP0000050778731.566318.5542ciona_intestinalisENSCINP0000000212512.1867.16279
ENSG00000169813homo_sapiensENSP0000050778741.686726.0241ciona_intestinalisENSCINP0000003370423.4114.6143
ENSG00000169813homo_sapiensENSP0000050778731.807216.6265ciona_savignyiENSCSAVP0000000158712.80316.69253
ENSG00000169813homo_sapiensENSP0000050778733.01225.0602ciona_savignyiENSCSAVP0000001845149.103937.276
ENSG00000169813homo_sapiensENSP0000050778741.927726.2651ciona_savignyiENSCSAVP0000000345825.25415.82

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000398involved_in mRNA splicing, via spliceosome1ICHomo_sapiens(9606)Process
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0003727enables single-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1TASHomo_sapiens(9606)Component
GO:0005654is_active_in nucleoplasm3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1TASHomo_sapiens(9606)Component
GO:0006396involved_in RNA processing1TASHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0043484involved_in regulation of RNA splicing3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0045202located_in synapse1IEAHomo_sapiens(9606)Component
GO:0071013part_of catalytic step 2 spliceosome1IDAHomo_sapiens(9606)Component
GO:1990904part_of ribonucleoprotein complex1IBAHomo_sapiens(9606)Component

Expression