RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000169567	Gene ID	3094	Accession	4912
Symbol	HINT1	Alias	HINT;NMAN;PKCI-1;PRKCNH1	Full Name	histidine triad nucleotide binding protein 1
Status	Confidence	Length	9967 bases	Strand	Minus strand
Position	5 : 131155383 - 131165349	RNA binding domain	DcpS_C
Summary	This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000304229	DcpS_C	PF11969	3.2e-20	1
ENSP00000502350	DcpS_C	PF11969	3.2e-11	1
ENSP00000424974	DcpS_C	PF11969	3.6e-11	1
ENSP00000427008	DcpS_C	PF11969	5.6e-11	1
ENSP00000427499	DcpS_C	PF11969	5.6e-11	1
ENSP00000502370	DcpS_C	PF11969	5.6e-11	1
ENSP00000426860	DcpS_C	PF11969	6.1e-11	1
ENSP00000430909	DcpS_C	PF11969	8.7e-11	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
HINT1-211	ENST00000675100	598	109aa	ENSP00000502350
HINT1-213	ENST00000675372	3080	65aa	ENSP00000502792
HINT1-201	ENST00000304043	852	126aa	ENSP00000304229
HINT1-212	ENST00000675135	902	No protein	-
HINT1-207	ENST00000511475	1032	103aa	ENSP00000427008
HINT1-206	ENST00000508495	825	78aa	ENSP00000424974
HINT1-215	ENST00000676117	988	No protein	-
HINT1-205	ENST00000508488	1070	103aa	ENSP00000427499
HINT1-210	ENST00000520028	1038	91aa	ENSP00000430909
HINT1-209	ENST00000513345	1064	65aa	ENSP00000421608
HINT1-214	ENST00000675491	3527	103aa	ENSP00000502370
HINT1-204	ENST00000506908	3628	78aa	ENSP00000426860
HINT1-208	ENST00000513012	3504	65aa	ENSP00000422444
HINT1-203	ENST00000506207	479	No protein	-
HINT1-202	ENST00000504202	619	65aa	ENSP00000425260

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000118	part_of histone deacetylase complex	1	IDA	Homo_sapiens(9606)	Component
GO:0000166	enables nucleotide binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005080	enables protein kinase C binding	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0005856	located_in cytoskeleton	1	TAS	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0006355	involved_in regulation of DNA-templated transcription	1	IMP	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0009154	involved_in purine ribonucleotide catabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0016787	enables hydrolase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0016926	involved_in protein desumoylation	1	IMP	Homo_sapiens(9606)	Process
GO:0016929	enables deSUMOylase activity	1	IMP	Homo_sapiens(9606)	Function
GO:0043530	enables adenosine 5-monophosphoramidase activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0050850	involved_in positive regulation of calcium-mediated signaling	1	IEA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0072332	involved_in intrinsic apoptotic signaling pathway by p53 class mediator	1	IMP	Homo_sapiens(9606)	Process