Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000169375 Gene ID 25942 Accession 19353
Symbol SIN3A Alias WITKOS;DEL15Q24;CHR15DELq24 Full Name SIN3 transcription regulator family member A
Status Confidence Length 86464 bases Strand Minus strand
Position 15 : 75369379 - 75455842 RNA binding domain N.A.
Summary The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
28416772 DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer. Shasha Zhou 2017-05-23 Oncotarget
34050002 R-Loop-Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin. Maryam Safari 2021-08-01 Molecular cancer research : MCR
35073971 Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming. Jiabao Feng 2022-01-24 Stem cell research & therapy

Transcripts

Name Transcript ID bp Protein Translation ID
SIN3A-202 ENST00000394947 6723 1273aa ENSP00000378402
SIN3A-219 ENST00000704310 5342 1278aa ENSP00000515832
SIN3A-201 ENST00000360439 5050 1273aa ENSP00000353622
SIN3A-220 ENST00000704311 3628 239aa ENSP00000515833
SIN3A-206 ENST00000565264 5170 1273aa ENSP00000454296
SIN3A-205 ENST00000564778 4778 1273aa ENSP00000455204
SIN3A-203 ENST00000394949 4930 1273aa ENSP00000378403
SIN3A-217 ENST00000704304 4936 84aa ENSP00000515828
SIN3A-221 ENST00000704312 4923 1273aa ENSP00000515834
SIN3A-218 ENST00000704305 3989 84aa ENSP00000515829
SIN3A-216 ENST00000704302 3287 922aa ENSP00000515826
SIN3A-207 ENST00000566640 944 No protein -
SIN3A-215 ENST00000570124 593 No protein -
SIN3A-213 ENST00000570021 600 No protein -
SIN3A-204 ENST00000562776 590 142aa ENSP00000455072
SIN3A-211 ENST00000568431 565 130aa ENSP00000454750
SIN3A-208 ENST00000567289 4078 156aa ENSP00000455834
SIN3A-214 ENST00000570115 554 123aa ENSP00000455662
SIN3A-210 ENST00000568309 549 107aa ENSP00000455644
SIN3A-209 ENST00000568190 567 98aa ENSP00000456997
SIN3A-212 ENST00000568919 455 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
80576Death, Sudden, Cardiac3E-621658281

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000118part_of histone deacetylase complex1IDAHomo_sapiens(9606)Component
GO:0000122involved_in negative regulation of transcription by RNA polymerase II3IBA,IMP,NASHomo_sapiens(9606)Process
GO:0000776located_in kinetochore1IEAHomo_sapiens(9606)Component
GO:0000785part_of chromatin1IBAHomo_sapiens(9606)Component
GO:0001701involved_in in utero embryonic development1IEAHomo_sapiens(9606)Process
GO:0002218involved_in activation of innate immune response1IMPHomo_sapiens(9606)Process
GO:0002230involved_in positive regulation of defense response to virus by host1IMPHomo_sapiens(9606)Process
GO:0002244involved_in hematopoietic progenitor cell differentiation1IEAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IEAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IMPHomo_sapiens(9606)Function
GO:0003714enables transcription corepressor activity2IBA,IMPHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus3IDA,ISS,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IEAHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1IEAHomo_sapiens(9606)Process
GO:0008104involved_in protein localization1IEAHomo_sapiens(9606)Process
GO:0010817involved_in regulation of hormone levels1IEAHomo_sapiens(9606)Process
GO:0010971involved_in positive regulation of G2/M transition of mitotic cell cycle1IEAHomo_sapiens(9606)Process
GO:0016580part_of Sin3 complex3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0017053part_of transcription repressor complex1IEAHomo_sapiens(9606)Component
GO:0021895involved_in cerebral cortex neuron differentiation1ISSHomo_sapiens(9606)Process
GO:0030336involved_in negative regulation of cell migration1NASHomo_sapiens(9606)Process
GO:0030512involved_in negative regulation of transforming growth factor beta receptor signaling pathway1NASHomo_sapiens(9606)Process
GO:0030516involved_in regulation of axon extension1ISSHomo_sapiens(9606)Process
GO:0031453involved_in positive regulation of heterochromatin formation1IMPHomo_sapiens(9606)Process
GO:0042754involved_in negative regulation of circadian rhythm1ISSHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043619involved_in regulation of transcription from RNA polymerase II promoter in response to oxidative stress1IEAHomo_sapiens(9606)Process
GO:0045666involved_in positive regulation of neuron differentiation1ISSHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1ISSHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IMPHomo_sapiens(9606)Process
GO:0048511involved_in rhythmic process1IEAHomo_sapiens(9606)Process
GO:0051595involved_in response to methylglyoxal1IEAHomo_sapiens(9606)Process
GO:0061629enables RNA polymerase II-specific DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0071333involved_in cellular response to glucose stimulus1IEAHomo_sapiens(9606)Process
GO:0140416enables transcription regulator inhibitor activity1IDAHomo_sapiens(9606)Function
GO:1900181involved_in negative regulation of protein localization to nucleus1IMPHomo_sapiens(9606)Process
GO:1902455involved_in negative regulation of stem cell population maintenance1NASHomo_sapiens(9606)Process
GO:1902459involved_in positive regulation of stem cell population maintenance1NASHomo_sapiens(9606)Process
GO:1903351involved_in cellular response to dopamine1IEAHomo_sapiens(9606)Process
GO:2000678involved_in negative regulation of transcription regulatory region DNA binding1IMPHomo_sapiens(9606)Process

Expression