Welcome to
RBP World!
Functions and Diseases
| RBP Type | Canonical_RBPs |
| Diseases | N.A. |
| Drug | Drug |
| Main interacting RNAs | N.A. |
| Moonlighting functions | Metabolic enzyme |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000168918 | Gene ID | 3635 | Accession | 6079 |
| Symbol | INPP5D | Alias | SHIP;SHIP1;SHIP-1;hp51CN;SIP-145;p150Ship | Full Name | inositol polyphosphate-5-phosphatase D |
| Status | Confidence | Length | 147937 bases | Strand | Plus strand |
| Position | 2 : 233059967 - 233207903 | RNA binding domain | Exo_endo_phos | ||
| Summary | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020] | ||||
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| INPP5D-201 | ENST00000359570 | 5274 | 1188aa | ENSP00000352575 |
| INPP5D-205 | ENST00000451407 | 2545 | No protein | - |
| INPP5D-204 | ENST00000445964 | 4902 | 1189aa | ENSP00000405338 |
| INPP5D-207 | ENST00000467393 | 431 | No protein | - |
| INPP5D-209 | ENST00000474278 | 568 | No protein | - |
| INPP5D-214 | ENST00000496402 | 569 | No protein | - |
| INPP5D-202 | ENST00000415617 | 3628 | 810aa | ENSP00000397421 |
| INPP5D-212 | ENST00000493078 | 401 | No protein | - |
| INPP5D-208 | ENST00000472517 | 527 | No protein | - |
| INPP5D-213 | ENST00000493632 | 958 | No protein | - |
| INPP5D-210 | ENST00000480983 | 439 | No protein | - |
| INPP5D-206 | ENST00000465281 | 568 | No protein | - |
| INPP5D-203 | ENST00000417661 | 588 | 130aa | ENSP00000414835 |
| INPP5D-211 | ENST00000491070 | 528 | 43aa | ENSP00000473280 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0004439 | enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0004445 | enables inositol-polyphosphate 5-phosphatase activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005829 | is_active_in cytosol | 3 | IBA,IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005856 | located_in cytoskeleton | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0005886 | located_in plasma membrane | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0006661 | involved_in phosphatidylinositol biosynthetic process | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0006796 | involved_in phosphate-containing compound metabolic process | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0006915 | involved_in apoptotic process | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0007165 | involved_in signal transduction | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0008340 | involved_in determination of adult lifespan | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0009968 | involved_in negative regulation of signal transduction | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0016064 | involved_in immunoglobulin mediated immune response | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0016314 | enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0017124 | enables SH3 domain binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0030889 | involved_in negative regulation of B cell proliferation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0032715 | involved_in negative regulation of interleukin-6 production | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0034485 | enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0035556 | involved_in intracellular signal transduction | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0043065 | involved_in positive regulation of apoptotic process | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0045121 | located_in membrane raft | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0045579 | involved_in positive regulation of B cell differentiation | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0045648 | involved_in positive regulation of erythrocyte differentiation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0045656 | involved_in negative regulation of monocyte differentiation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0045659 | involved_in negative regulation of neutrophil differentiation | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0045671 | involved_in negative regulation of osteoclast differentiation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0045779 | involved_in negative regulation of bone resorption | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0046856 | involved_in phosphatidylinositol dephosphorylation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0050776 | involved_in regulation of immune response | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0050777 | involved_in negative regulation of immune response | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0050852 | involved_in T cell receptor signaling pathway | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0052658 | enables inositol-1,4,5-trisphosphate 5-phosphatase activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0052659 | enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | 1 | IEA | Homo_sapiens(9606) | Function |