Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000168806 Gene ID 9836 Accession 17558
Symbol LCMT2 Alias PPM2;TYW4 Full Name leucine carboxyl methyltransferase 2
Status Confidence Length 6934 bases Strand Minus strand
Position 15 : 43323649 - 43330582 RNA binding domain N.A.
Summary The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
LCMT2-201 ENST00000305641 6925 686aa ENSP00000307214
LCMT2-202 ENST00000567039 1545 39aa ENSP00000457403

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000168806homo_sapiensENSP0000038202148.203634.1317homo_sapiensENSP0000030721423.469416.6181

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000168806homo_sapiensENSP0000030721499.854299.2711pan_paniscusENSPPAP0000000147199.854299.2711
ENSG00000168806homo_sapiensENSP0000030721460.641450.8746ornithorhynchus_anatinusENSOANP0000004777662.182452.1674
ENSG00000168806homo_sapiensENSP0000030721448.979641.1079sarcophilus_harrisiiENSSHAP0000003836675.167863.0872
ENSG00000168806homo_sapiensENSP0000030721490.087582.3615dasypus_novemcinctusENSDNOP0000002871390.087582.3615
ENSG00000168806homo_sapiensENSP0000030721476.093370.1166erinaceus_europaeusENSEEUP0000000604576.204470.219
ENSG00000168806homo_sapiensENSP0000030721480.75874.4898echinops_telfairiENSETEP0000001602680.75874.4898
ENSG00000168806homo_sapiensENSP0000030721497.230395.481macaca_mulattaENSMMUP0000006488494.609992.9078
ENSG00000168806homo_sapiensENSP0000030721490.816383.965tursiops_truncatusENSTTRP0000001538890.816383.965
ENSG00000168806homo_sapiensENSP0000030721489.941782.6531vulpes_vulpesENSVVUP0000001322889.810882.5328
ENSG00000168806homo_sapiensENSP0000030721485.568577.8426mus_spretusMGP_SPRETEiJ_P005617285.568577.8426
ENSG00000168806homo_sapiensENSP0000030721489.067180.3207capra_hircusENSCHIP0000000187689.327580.5556
ENSG00000168806homo_sapiensENSP0000030721484.548176.0933loxodonta_africanaENSLAFP0000002275987.21878.4962
ENSG00000168806homo_sapiensENSP0000030721490.524883.6735ailuropoda_melanoleucaENSAMEP0000002019190.656983.7956
ENSG00000168806homo_sapiensENSP0000030721457.725952.3324oryctolagus_cuniculusENSOCUP0000002961789.795981.4059
ENSG00000168806homo_sapiensENSP0000030721491.253683.6735equus_caballusENSECAP0000006053289.942582.4713
ENSG00000168806homo_sapiensENSP0000030721489.650183.0904marmota_marmota_marmotaENSMMMP0000002141089.78183.2117
ENSG00000168806homo_sapiensENSP0000030721484.402375.8018cavia_porcellusENSCPOP0000000005181.549373.2394
ENSG00000168806homo_sapiensENSP0000030721491.253684.8397ursus_americanusENSUAMP0000003100191.386984.9635
ENSG00000168806homo_sapiensENSP0000030721469.387861.0787monodelphis_domesticaENSMODP0000004474476.404567.2552
ENSG00000168806homo_sapiensENSP0000030721490.816383.8192delphinapterus_leucasENSDLEP0000002409790.816383.8192
ENSG00000168806homo_sapiensENSP0000030721486.151677.9883mus_caroliMGP_CAROLIEiJ_P005407586.151677.9883
ENSG00000168806homo_sapiensENSP0000030721485.714377.8426mus_musculusENSMUSP0000010630285.714377.8426
ENSG00000168806homo_sapiensENSP0000030721488.046680.6122dipodomys_ordiiENSDORP0000001085788.046680.6122
ENSG00000168806homo_sapiensENSP0000030721489.650182.6531mustela_putorius_furoENSMPUP0000001971590.043983.0161
ENSG00000168806homo_sapiensENSP0000030721446.501543.0029vicugna_pacosENSVPAP0000000582446.569343.0657
ENSG00000168806homo_sapiensENSP0000030721497.667696.2099chlorocebus_sabaeusENSCSAP0000001924497.667696.2099
ENSG00000168806homo_sapiensENSP0000030721483.090477.1137tupaia_belangeriENSTBEP0000000869883.333377.3392
ENSG00000168806homo_sapiensENSP0000030721454.51949.5627mesocricetus_auratusENSMAUP000000233108577.2727
ENSG00000168806homo_sapiensENSP0000030721485.131277.2595rattus_norvegicusENSRNOP0000006099385.131277.2595
ENSG00000168806homo_sapiensENSP0000030721453.498547.9592microtus_ochrogasterENSMOCP0000001382183.409174.7727
ENSG00000168806homo_sapiensENSP0000030721486.588978.4257sorex_araneusENSSARP0000000075286.969378.7701
ENSG00000168806homo_sapiensENSP0000030721486.151679.8834peromyscus_maniculatus_bairdiiENSPEMP0000000944786.151679.8834
ENSG00000168806homo_sapiensENSP0000030721454.373248.688mus_spicilegusENSMSIP0000003412284.389175.5656
ENSG00000168806homo_sapiensENSP0000030721454.810549.8542cricetulus_griseus_chok1gshdENSCGRP0000100744785.454577.7273
ENSG00000168806homo_sapiensENSP0000030721489.941782.5073myotis_lucifugusENSMLUP0000000807890.07382.6277
ENSG00000168806homo_sapiensENSP0000030721478.425768.5131vombatus_ursinusENSVURP0001000825978.197768.314
ENSG00000168806homo_sapiensENSP0000030721489.358681.6327bos_taurusENSBTAP0000005531189.489181.7518
ENSG00000168806homo_sapiensENSP0000030721487.026279.5918heterocephalus_glaber_femaleENSHGLP0000002885087.280779.8246
ENSG00000168806homo_sapiensENSP0000030721489.941783.0904canis_lupus_dingoENSCAFP0002000407689.810882.9694
ENSG00000168806homo_sapiensENSP0000030721477.405368.3673phascolarctos_cinereusENSPCIP0000004314977.180268.1686
ENSG00000168806homo_sapiensENSP0000030721454.51950.5831nannospalax_galiliENSNGAP0000000716184.615478.5068
ENSG00000168806homo_sapiensENSP0000030721473.323666.4723chinchilla_lanigeraENSCLAP0000001722185.982977.9487
ENSG00000168806homo_sapiensENSP0000030721480.75872.8863cervus_hanglu_yarkandensisENSCHYP0000002625489.067580.3858
ENSG00000168806homo_sapiensENSP0000030721489.941781.7784catagonus_wagneriENSCWAP0000000394290.07381.8978
ENSG00000168806homo_sapiensENSP0000030721490.087582.9446ictidomys_tridecemlineatusENSSTOP0000002104290.21983.0657
ENSG00000168806homo_sapiensENSP0000030721489.795984.2566otolemur_garnettiiENSOGAP0000000011090.455284.8752
ENSG00000168806homo_sapiensENSP0000030721490.087583.5277urocitellus_parryiiENSUPAP0001001514390.21983.6496
ENSG00000168806homo_sapiensENSP0000030721484.985477.6968mus_pahariMGP_PahariEiJ_P006505285.233977.924
ENSG00000168806homo_sapiensENSP0000030721447.667630.3207ciona_intestinalisENSCINP0000001715847.391330.1449
ENSG00000168806homo_sapiensENSP0000030721427.259519.0962petromyzon_marinusENSPMAP0000000183755.162238.6431
ENSG00000168806homo_sapiensENSP0000030721456.559840.9621eptatretus_burgeriENSEBUP0000001919154.957539.8017
ENSG00000168806homo_sapiensENSP0000030721462.099146.0641callorhinchus_miliiENSCMIP0000003083165.237448.392
ENSG00000168806homo_sapiensENSP0000030721464.431546.5015latimeria_chalumnaeENSLACP0000000195164.150946.299
ENSG00000168806homo_sapiensENSP0000030721457.580243.0029lepisosteus_oculatusENSLOCP0000000491855.013941.0863
ENSG00000168806homo_sapiensENSP0000030721443.877632.6531clupea_harengusENSCHAP0000004493458.904143.8356
ENSG00000168806homo_sapiensENSP0000030721461.224544.0233danio_rerioENSDARP0000009911962.407144.8737
ENSG00000168806homo_sapiensENSP0000030721459.475242.7114carassius_auratusENSCARP000001328846043.0882
ENSG00000168806homo_sapiensENSP0000030721460.349945.0437astyanax_mexicanusENSAMXP000000154056044.7826
ENSG00000168806homo_sapiensENSP0000030721460.349944.4606ictalurus_punctatusENSIPUP000000354486044.2029
ENSG00000168806homo_sapiensENSP0000030721459.183743.7318esox_luciusENSELUP0000002887159.618244.0529
ENSG00000168806homo_sapiensENSP0000030721459.766844.898electrophorus_electricusENSEEEP0000003921158.238643.75
ENSG00000168806homo_sapiensENSP0000030721426.093318.0758salmo_salarENSSSAP0000015706350.852335.2273
ENSG00000168806homo_sapiensENSP000003072149.620997.58017salmo_truttaENSSTUP0000002672154.545542.9752
ENSG00000168806homo_sapiensENSP0000030721427.113717.6385salmo_truttaENSSTUP0000002587449.076531.9261
ENSG00000168806homo_sapiensENSP0000030721460.495646.2099fundulus_heteroclitusENSFHEP0000000097262.125747.4551
ENSG00000168806homo_sapiensENSP0000030721458.746444.898poecilia_reticulataENSPREP0000002971257.489343.9372
ENSG00000168806homo_sapiensENSP0000030721459.037944.898xiphophorus_maculatusENSXMAP0000000735757.774643.9372
ENSG00000168806homo_sapiensENSP0000030721436.297426.5306cyclopterus_lumpusENSCLMP0000503722953.091738.806
ENSG00000168806homo_sapiensENSP0000030721460.058344.7522oreochromis_niloticusENSONIP0000001734560.677545.2136
ENSG00000168806homo_sapiensENSP0000030721459.62144.7522haplochromis_burtoniENSHBUP0000000667760.50345.4142
ENSG00000168806homo_sapiensENSP0000030721459.475244.7522astatotilapia_callipteraENSACLP0000003534160.35545.4142
ENSG00000168806homo_sapiensENSP0000030721459.62144.7522sparus_aurataENSSAUP0001006166758.096643.608
ENSG00000168806homo_sapiensENSP0000030721459.62145.3353lates_calcariferENSLCAP0001001778760.058745.6681
ENSG00000168806homo_sapiensENSP0000030721454.227440.5248xenopus_tropicalisENSXETP0000009402859.424944.4089
ENSG00000168806homo_sapiensENSP000003072148.017496.85131chrysemys_picta_belliiENSCPBP0000000045064.705955.2941
ENSG00000168806homo_sapiensENSP0000030721427.113721.7201chrysemys_picta_belliiENSCPBP0000000040874.103659.3625
ENSG00000168806homo_sapiensENSP0000030721466.763852.4781sphenodon_punctatusENSSPUP0000001437166.666752.4017
ENSG00000168806homo_sapiensENSP0000030721450.145840.0875crocodylus_porosusENSCPRP0000502420765.774452.5813
ENSG00000168806homo_sapiensENSP0000030721464.577350.4373laticauda_laticaudataENSLLTP0000001922764.296150.2177
ENSG00000168806homo_sapiensENSP0000030721463.556950.7289notechis_scutatusENSNSUP0000000949063.556950.7289
ENSG00000168806homo_sapiensENSP0000030721463.556950.5831pseudonaja_textilisENSPTXP0000002270160.22147.9282
ENSG00000168806homo_sapiensENSP0000030721453.644340.9621anas_platyrhynchos_platyrhynchosENSAPLP0000000979741.770731.8956
ENSG00000168806homo_sapiensENSP0000030721461.370346.9388gallus_gallusENSGALP0001000223459.212445.2883
ENSG00000168806homo_sapiensENSP0000030721456.997141.8367meleagris_gallopavoENSMGAP0000001621866.837649.0598
ENSG00000168806homo_sapiensENSP0000030721458.163343.4402serinus_canariaENSSCAP0000000454568.321951.0274
ENSG00000168806homo_sapiensENSP0000030721464.577349.7085parus_majorENSPMJP0000000685463.46748.8539
ENSG00000168806homo_sapiensENSP0000030721439.358629.3003anolis_carolinensisENSACAP0000000012263.98147.6303
ENSG00000168806homo_sapiensENSP0000030721459.037944.4606neolamprologus_brichardiENSNBRP0000002122560.357745.4545
ENSG00000168806homo_sapiensENSP0000030721463.994250.2915naja_najaENSNNAP0000001240965.327451.3393
ENSG00000168806homo_sapiensENSP0000030721466.909652.3324podarcis_muralisENSPMRP0000000316359.302346.3824
ENSG00000168806homo_sapiensENSP0000030721460.204146.0641geospiza_fortisENSGFOP0000000461668.151852.1452
ENSG00000168806homo_sapiensENSP0000030721467.346951.312taeniopygia_guttataENSTGUP0000000063467.841451.6887
ENSG00000168806homo_sapiensENSP0000030721459.912543.586erpetoichthys_calabaricusENSECRP0000001060458.297942.4113
ENSG00000168806homo_sapiensENSP0000030721413.556911.516kryptolebias_marmoratusENSKMAP0000000545463.265353.7415
ENSG00000168806homo_sapiensENSP0000030721423.323617.2012kryptolebias_marmoratusENSKMAP0000000542658.394243.0657
ENSG00000168806homo_sapiensENSP0000030721465.014651.6035salvator_merianaeENSSMRP0000000377255.061743.7037
ENSG00000168806homo_sapiensENSP0000030721454.664740.5248oryzias_javanicusENSOJAP0000000787752.228438.7187
ENSG00000168806homo_sapiensENSP0000030721457.434442.8571amphilophus_citrinellusENSACIP0000002643763.0447.04
ENSG00000168806homo_sapiensENSP0000030721459.183744.6064dicentrarchus_labraxENSDLAP0000506264358.333343.9655
ENSG00000168806homo_sapiensENSP0000030721452.040838.484amphiprion_perculaENSAPEP0000003110159.302343.8538
ENSG00000168806homo_sapiensENSP0000030721459.037944.6064amphiprion_perculaENSAPEP0000003375360.538145.7399
ENSG00000168806homo_sapiensENSP0000030721412.973810.7872oryzias_sinensisENSOSIP0000000368657.051347.4359
ENSG00000168806homo_sapiensENSP0000030721467.346953.0612pelodiscus_sinensisENSPSIP0000001379167.346953.0612
ENSG00000168806homo_sapiensENSP0000030721468.221655.2478gopherus_evgoodeiENSGEVP0000502340668.722555.6535
ENSG00000168806homo_sapiensENSP0000030721466.763854.0816chelonoidis_abingdoniiENSCABP0000000267368.154855.2083
ENSG00000168806homo_sapiensENSP0000030721456.41443.1487seriola_dumeriliENSSDUP0000002448561.624247.1338
ENSG00000168806homo_sapiensENSP0000030721459.912546.0641cottoperca_gobioENSCGOP0000000510560.70946.6765
ENSG00000168806homo_sapiensENSP0000030721460.204146.2099struthio_camelus_australisENSSCUP0000002459868.377552.4834
ENSG00000168806homo_sapiensENSP0000030721456.122443.1487anser_brachyrhynchusENSABRP0000000136565.924750.6849
ENSG00000168806homo_sapiensENSP0000030721459.766846.9388gasterosteus_aculeatusENSGACP0000001200061.469348.2759
ENSG00000168806homo_sapiensENSP0000030721460.641444.6064cynoglossus_semilaevisENSCSEP0000000435461.812845.4681
ENSG00000168806homo_sapiensENSP0000030721441.545230.3207poecilia_formosaENSPFOP0000000034147.579334.7245
ENSG00000168806homo_sapiensENSP0000030721460.495645.9184myripristis_murdjanENSMMDP0000505600060.495645.9184
ENSG00000168806homo_sapiensENSP0000030721458.454845.0437sander_luciopercaENSSLUP0000003887061.503147.3926
ENSG00000168806homo_sapiensENSP0000030721457.434443.1487strigops_habroptilaENSSHBP0000502173966.3349.8316
ENSG00000168806homo_sapiensENSP0000030721412.536410.7872amphiprion_ocellarisENSAOCP0000000458258.503450.3401
ENSG00000168806homo_sapiensENSP0000030721435.860125.656amphiprion_ocellarisENSAOCP0000002693953.362338.1779
ENSG00000168806homo_sapiensENSP0000030721446.938836.7347terrapene_carolina_triunguisENSTMTP0000002421262.645949.0272
ENSG00000168806homo_sapiensENSP0000030721459.912544.898betta_splendensENSBSLP0000005057561.619246.1769
ENSG00000168806homo_sapiensENSP0000030721459.62144.6064pygocentrus_nattereriENSPNAP0000001902760.058744.9339
ENSG00000168806homo_sapiensENSP0000030721459.329445.481anabas_testudineusENSATEP0000002859858.985545.2174
ENSG00000168806homo_sapiensENSP0000030721447.813430.1749ciona_savignyiENSCSAVP0000001452648.664730.7122
ENSG00000168806homo_sapiensENSP0000030721441.69122.3032saccharomyces_cerevisiaeYOL141W41.151122.0144
ENSG00000168806homo_sapiensENSP0000030721412.099110.7872seriola_lalandi_dorsalisENSSLDP0000002553256.462650.3401
ENSG00000168806homo_sapiensENSP0000030721434.985425.656seriola_lalandi_dorsalisENSSLDP0000002552156.603841.5094
ENSG00000168806homo_sapiensENSP0000030721460.204146.2099labrus_bergyltaENSLBEP0000002816960.824746.6863
ENSG00000168806homo_sapiensENSP0000030721452.478139.0671pundamilia_nyerereiENSPNYP0000002037159.210544.0789
ENSG00000168806homo_sapiensENSP0000030721460.787245.6268mastacembelus_armatusENSMAMP0000001799561.595346.2334
ENSG00000168806homo_sapiensENSP0000030721458.017544.0233stegastes_partitusENSSPAP0000002230860.394545.827
ENSG00000168806homo_sapiensENSP0000030721454.373240.8163acanthochromis_polyacanthusENSAPOP0000001836659.967845.0161
ENSG00000168806homo_sapiensENSP0000030721454.810541.1079aquila_chrysaetos_chrysaetosENSACCP0002001595967.504550.6284
ENSG00000168806homo_sapiensENSP0000030721459.912543.8776nothobranchius_furzeriENSNFUP0001501376457.482542.0979
ENSG00000168806homo_sapiensENSP0000030721411.5169.76676cyprinodon_variegatusENSCVAP0000001691454.109645.8904
ENSG00000168806homo_sapiensENSP0000030721423.906717.7843cyprinodon_variegatusENSCVAP0000001689855.972741.6382
ENSG00000168806homo_sapiensENSP0000030721456.268241.5452denticeps_clupeoidesENSDCDP0000001458257.611942.5373
ENSG00000168806homo_sapiensENSP0000030721458.746445.3353larimichthys_croceaENSLCRP0000500881059.792346.1424
ENSG00000168806homo_sapiensENSP0000030721458.600644.6064takifugu_rubripesENSTRUP0000003910158.85844.8023
ENSG00000168806homo_sapiensENSP0000030721467.492751.7493ficedula_albicollisENSFALP0000000857767.296551.5988
ENSG00000168806homo_sapiensENSP0000030721411.22457.72595hippocampus_comesENSHCOP0000001912866.379345.6897
ENSG00000168806homo_sapiensENSP0000030721412.682210.4956hippocampus_comesENSHCOP0000000296461.702151.0638
ENSG00000168806homo_sapiensENSP0000030721460.058343.0029cyprinus_carpio_carpioENSCCRP0000014788560.588243.3824
ENSG00000168806homo_sapiensENSP0000030721466.472351.0204coturnix_japonicaENSCJPP0000500563067.256651.6224
ENSG00000168806homo_sapiensENSP0000030721459.183744.4606poecilia_latipinnaENSPLAP0000000133157.917343.5093
ENSG00000168806homo_sapiensENSP0000030721457.871741.2536sinocyclocheilus_grahamiENSSGRP0000011249159.342342.3019
ENSG00000168806homo_sapiensENSP0000030721436.443127.551sinocyclocheilus_grahamiENSSGRP0000001222955.432441.9069
ENSG00000168806homo_sapiensENSP0000030721459.475244.7522maylandia_zebraENSMZEP0000502861060.35545.4142
ENSG00000168806homo_sapiensENSP0000030721458.017542.7114tetraodon_nigroviridisENSTNIP0000000949659.491843.7967
ENSG00000168806homo_sapiensENSP0000030721459.62144.4606paramormyrops_kingsleyaeENSPKIP0000001262260.413645.0517
ENSG00000168806homo_sapiensENSP0000030721459.766845.481scleropages_formosusENSSFOP0001503679760.294145.8824
ENSG00000168806homo_sapiensENSP0000030721459.037944.0233leptobrachium_leishanenseENSLLEP0000001928161.178245.6193
ENSG00000168806homo_sapiensENSP0000030721458.454844.0233scophthalmus_maximusENSSMAP0000002622359.144544.5428
ENSG00000168806homo_sapiensENSP0000030721458.30943.8776oryzias_melastigmaENSOMEP0000003353452.35639.3979

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737located_in cytoplasm1TASHomo_sapiens(9606)Component
GO:0006400involved_in tRNA modification1TASHomo_sapiens(9606)Process
GO:0008175enables tRNA methyltransferase activity2IBA,TASHomo_sapiens(9606)Function
GO:0030488involved_in tRNA methylation1IBAHomo_sapiens(9606)Process
GO:0031591involved_in wybutosine biosynthetic process1IBAHomo_sapiens(9606)Process

Expression