RBPWorld - a comprehensive database of RNA Binding Proteins

Welcome to

RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000168291	Gene ID	5162	Accession	8808
Symbol	PDHB	Alias	PDHBD;PHE1B;E1beta;PDHE1B;PDHE1-B	Full Name	pyruvate dehydrogenase E1 subunit beta
Status	Confidence	Length	6228 bases	Strand	Minus strand
Position	3 : 58427630 - 58433857	RNA binding domain	N.A.
Summary	The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
PDHB-201	ENST00000302746	1507	359aa	ENSP00000307241
PDHB-202	ENST00000383714	1478	341aa	ENSP00000373220
PDHB-204	ENST00000469364	1616	251aa	ENSP00000419580
PDHB-210	ENST00000485460	1397	341aa	ENSP00000417267
PDHB-207	ENST00000479945	4459	No protein	-
PDHB-206	ENST00000474765	1503	350aa	ENSP00000418448
PDHB-203	ENST00000461692	1535	No protein	-
PDHB-208	ENST00000480626	710	No protein	-
PDHB-209	ENST00000482894	581	No protein	-
PDHB-205	ENST00000469827	586	No protein	-

Gene Model

Click here to download ENSG00000168291's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
83838	Hepcidins	7E-7	27846281

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000168291's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004739	enables pyruvate dehydrogenase (acetyl-transferring) activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	HDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0005967	part_of mitochondrial pyruvate dehydrogenase complex	3	IBA,IPI,ISS	Homo_sapiens(9606)	Component
GO:0006006	involved_in glucose metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006086	involved_in acetyl-CoA biosynthetic process from pyruvate	4	IBA,IC,IDA,ISS	Homo_sapiens(9606)	Process
GO:0006099	involved_in tricarboxylic acid cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0034604	contributes_to pyruvate dehydrogenase (NAD+) activity	1	IDA	Homo_sapiens(9606)	Function
GO:0045254	part_of pyruvate dehydrogenase complex	1	IDA	Homo_sapiens(9606)	Component

Expression