RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligaseTF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000167967	Gene ID	1877	Accession	3121
Symbol	E4F1	Alias	E4F	Full Name	E4F transcription factor 1
Status	Confidence	Length	12163 bases	Strand	Plus strand
Position	16 : 2223580 - 2235742	RNA binding domain	zf-met
Summary	The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000454652	zf-met	PF12874	0.0007	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
E4F1-206	ENST00000565090	2028	607aa	ENSP00000456760
E4F1-201	ENST00000301727	2548	784aa	ENSP00000301727
E4F1-204	ENST00000564139	2493	654aa	ENSP00000457672
E4F1-202	ENST00000562589	817	208aa	ENSP00000456005
E4F1-207	ENST00000565413	940	272aa	ENSP00000454652
E4F1-209	ENST00000569796	5931	No protein	-
E4F1-203	ENST00000563643	793	No protein	-
E4F1-205	ENST00000564930	297	No protein	-
E4F1-208	ENST00000567111	691	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0000977	enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0001227	enables DNA-binding transcription repressor activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0003700	enables DNA-binding transcription factor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IEA	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	IEA	Homo_sapiens(9606)	Component
GO:0006260	involved_in DNA replication	1	IEA	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0009794	involved_in regulation of mitotic cell cycle, embryonic	1	IEA	Homo_sapiens(9606)	Process
GO:0010564	involved_in regulation of cell cycle process	1	IDA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IEA	Homo_sapiens(9606)	Process
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0016740	enables transferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0035497	enables cAMP response element binding	1	IDA	Homo_sapiens(9606)	Function
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0051726	involved_in regulation of cell cycle	1	TAS	Homo_sapiens(9606)	Process
GO:0061629	enables RNA polymerase II-specific DNA-binding transcription factor binding	1	IPI	Homo_sapiens(9606)	Function