Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000167815 Gene ID 7001 Accession 9353
Symbol PRDX2 Alias PRP;TSA;PRX2;PTX1;TPX1;NKEFB;PRXII;TDPX1;NKEF-B;HEL-S-2a Full Name peroxiredoxin 2
Status Confidence Length 4981 bases Strand Minus strand
Position 19 : 12796820 - 12801800 RNA binding domain N.A.
Summary This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33017884 Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis. Yuan Zhang 2021-01-01 Cancer research and treatment

Transcripts

Name Transcript ID bp Protein Translation ID
PRDX2-202 ENST00000334482 784 136aa ENSP00000334063
PRDX2-203 ENST00000466174 1717 No protein -
PRDX2-201 ENST00000301522 925 198aa ENSP00000301522
PRDX2-206 ENST00000498785 505 No protein -
PRDX2-205 ENST00000478908 413 No protein -
PRDX2-204 ENST00000477555 699 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000167815homo_sapiensENSP0000036115290.452377.3869homo_sapiensENSP0000030152290.909177.7778
ENSG00000167815homo_sapiensENSP0000034202644.196429.4643homo_sapiensENSP000003015225033.3333
ENSG00000167815homo_sapiensENSP0000029851062.550homo_sapiensENSP0000030152280.808164.6465
ENSG00000167815homo_sapiensENSP0000036864660.885651.2915homo_sapiensENSP0000030152283.333370.202

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000167815homo_sapiensENSP0000030152282.323281.8182nomascus_leucogenysENSNLEP0000001554010099.3865
ENSG00000167815homo_sapiensENSP00000301522100100pan_paniscusENSPPAP00000022096100100
ENSG00000167815homo_sapiensENSP0000030152286.363686.3636pongo_abeliiENSPPYP0000001077196.610296.6102
ENSG00000167815homo_sapiensENSP00000301522100100pan_troglodytesENSPTRP00000017998100100
ENSG00000167815homo_sapiensENSP00000301522100100gorilla_gorillaENSGGOP00000021801100100
ENSG00000167815homo_sapiensENSP0000030152280.30373.2323ornithorhynchus_anatinusENSOANP0000004276279.572.5
ENSG00000167815homo_sapiensENSP0000030152294.949588.8889sarcophilus_harrisiiENSSHAP0000001837594.949588.8889
ENSG00000167815homo_sapiensENSP0000030152292.929387.8788notamacropus_eugeniiENSMEUP0000000546893.40188.3249
ENSG00000167815homo_sapiensENSP0000030152272.727368.1818dasypus_novemcinctusENSDNOP0000003161196.644390.604
ENSG00000167815homo_sapiensENSP0000030152265.151559.596erinaceus_europaeusENSEEUP0000000736866.494860.8247
ENSG00000167815homo_sapiensENSP0000030152299.494998.9899callithrix_jacchusENSCJAP0000000899399.494998.9899
ENSG00000167815homo_sapiensENSP00000301522100100cercocebus_atysENSCATP00000013126100100
ENSG00000167815homo_sapiensENSP00000301522100100macaca_fascicularisENSMFAP00000016962100100
ENSG00000167815homo_sapiensENSP0000030152271.717270.202macaca_fascicularisENSMFAP0000001691692.207890.2597
ENSG00000167815homo_sapiensENSP00000301522100100macaca_mulattaENSMMUP00000007512100100
ENSG00000167815homo_sapiensENSP0000030152295.959694.4444macaca_mulattaENSMMUP0000007853993.596192.1182
ENSG00000167815homo_sapiensENSP00000301522100100macaca_nemestrinaENSMNEP00000038464100100
ENSG00000167815homo_sapiensENSP00000301522100100papio_anubisENSPANP00000023169100100
ENSG00000167815homo_sapiensENSP00000301522100100mandrillus_leucophaeusENSMLEP00000001849100100
ENSG00000167815homo_sapiensENSP0000030152285.858681.8182tursiops_truncatusENSTTRP0000000336587.179583.0769
ENSG00000167815homo_sapiensENSP0000030152294.949593.4343vulpes_vulpesENSVVUP0000003333894.949593.4343
ENSG00000167815homo_sapiensENSP0000030152231.313117.6768mus_spretusMGP_SPRETEiJ_P008884730.845817.4129
ENSG00000167815homo_sapiensENSP0000030152288.888983.3333equus_asinusENSEASP0000504755172.727368.1818
ENSG00000167815homo_sapiensENSP0000030152270.20264.6465capra_hircusENSCHIP0000001861175.956369.9454
ENSG00000167815homo_sapiensENSP0000030152254.545554.5455loxodonta_africanaENSLAFP0000000715796.428696.4286
ENSG00000167815homo_sapiensENSP0000030152295.959694.9495panthera_leoENSPLOP0000001988595.959694.9495
ENSG00000167815homo_sapiensENSP0000030152295.959694.4444ailuropoda_melanoleucaENSAMEP0000001296195.959694.4444
ENSG00000167815homo_sapiensENSP0000030152290.40482.8283bos_indicus_hybridENSBIXP0000502041580.630673.8739
ENSG00000167815homo_sapiensENSP0000030152289.393983.8384equus_caballusENSECAP0000000945676.956572.1739
ENSG00000167815homo_sapiensENSP0000030152294.949593.4343canis_lupus_familiarisENSCAFP0084502233394.949593.4343
ENSG00000167815homo_sapiensENSP0000030152295.959694.9495panthera_pardusENSPPRP0000001864995.959694.9495
ENSG00000167815homo_sapiensENSP0000030152247.979844.9495marmota_marmota_marmotaENSMMMP0000002698676.612971.7742
ENSG00000167815homo_sapiensENSP0000030152296.464694.9495marmota_marmota_marmotaENSMMMP0000002383196.464694.9495
ENSG00000167815homo_sapiensENSP0000030152295.454592.4242balaenoptera_musculusENSBMSP0001000797995.454592.4242
ENSG00000167815homo_sapiensENSP0000030152295.959692.9293cavia_porcellusENSCPOP0000001736195.959692.9293
ENSG00000167815homo_sapiensENSP0000030152295.959694.9495felis_catusENSFCAP0000000043895.959694.9495
ENSG00000167815homo_sapiensENSP0000030152295.959694.4444ursus_americanusENSUAMP0000002515695.959694.4444
ENSG00000167815homo_sapiensENSP0000030152293.434387.3737monodelphis_domesticaENSMODP0000005324093.434387.3737
ENSG00000167815homo_sapiensENSP0000030152294.949589.899bison_bison_bisonENSBBBP0000002393894.472489.4472
ENSG00000167815homo_sapiensENSP0000030152295.454592.4242monodon_monocerosENSMMNP0001500660295.454592.4242
ENSG00000167815homo_sapiensENSP0000030152295.454591.9192sus_scrofaENSSSCP0000003928379.746876.7933
ENSG00000167815homo_sapiensENSP0000030152235.353531.3131sus_scrofaENSSSCP0000007535358.823552.1008
ENSG00000167815homo_sapiensENSP0000030152294.949591.9192microcebus_murinusENSMICP0000005048495.431592.3858
ENSG00000167815homo_sapiensENSP0000030152295.959693.4343octodon_degusENSODEP0000001353395.959693.4343
ENSG00000167815homo_sapiensENSP0000030152296.464695.9596jaculus_jaculusENSJJAP0000001388196.464695.9596
ENSG00000167815homo_sapiensENSP0000030152291.414185.3535jaculus_jaculusENSJJAP0000000186194.270888.0208
ENSG00000167815homo_sapiensENSP0000030152236.363632.8283ovis_aries_rambouilletENSOARP000200129187265
ENSG00000167815homo_sapiensENSP0000030152295.959694.4444ursus_maritimusENSUMAP0000000816795.959694.4444
ENSG00000167815homo_sapiensENSP0000030152296.969794.9495ochotona_princepsENSOPRP0000000440696.969794.9495
ENSG00000167815homo_sapiensENSP0000030152295.454592.4242delphinapterus_leucasENSDLEP0000001430495.454592.4242
ENSG00000167815homo_sapiensENSP0000030152294.949591.9192physeter_catodonENSPCTP0000502618894.949591.9192
ENSG00000167815homo_sapiensENSP0000030152296.969793.9394mus_caroliMGP_CAROLIEiJ_P008534796.969793.9394
ENSG00000167815homo_sapiensENSP0000030152296.969793.4343mus_musculusENSMUSP0000010535696.969793.4343
ENSG00000167815homo_sapiensENSP0000030152287.878884.8485dipodomys_ordiiENSDORP0000000845581.308478.5047
ENSG00000167815homo_sapiensENSP0000030152295.959694.9495mustela_putorius_furoENSMPUP0000000455695.477494.4724
ENSG00000167815homo_sapiensENSP0000030152210099.4949aotus_nancymaaeENSANAP0000001719410099.4949
ENSG00000167815homo_sapiensENSP0000030152299.494998.9899saimiri_boliviensis_boliviensisENSSBOP0000003715799.494998.9899
ENSG00000167815homo_sapiensENSP0000030152244.444443.4343vicugna_pacosENSVPAP0000000301655.696254.4304
ENSG00000167815homo_sapiensENSP00000301522100100chlorocebus_sabaeusENSCSAP00000002859100100
ENSG00000167815homo_sapiensENSP0000030152232.323231.8182tupaia_belangeriENSTBEP0000001096357.142956.25
ENSG00000167815homo_sapiensENSP0000030152297.474796.4646mesocricetus_auratusENSMAUP0000000423397.474796.4646
ENSG00000167815homo_sapiensENSP0000030152295.454592.4242phocoena_sinusENSPSNP0000000968195.454592.4242
ENSG00000167815homo_sapiensENSP0000030152295.959692.4242camelus_dromedariusENSCDRP0000503262895.959692.4242
ENSG00000167815homo_sapiensENSP0000030152297.474796.4646carlito_syrichtaENSTSYP0000001672397.474796.4646
ENSG00000167815homo_sapiensENSP0000030152295.959694.9495panthera_tigris_altaicaENSPTIP0000001416795.959694.9495
ENSG00000167815homo_sapiensENSP0000030152296.969793.9394rattus_norvegicusENSRNOP0000000479996.969793.9394
ENSG00000167815homo_sapiensENSP0000030152284.848581.8182prolemur_simusENSPSMP0000003534690.810887.5676
ENSG00000167815homo_sapiensENSP0000030152281.313177.2727prolemur_simusENSPSMP0000003681991.477386.9318
ENSG00000167815homo_sapiensENSP0000030152288.383885.3535prolemur_simusENSPSMP0000002558192.105388.9474
ENSG00000167815homo_sapiensENSP0000030152283.838479.798prolemur_simusENSPSMP0000000488181.773477.8325
ENSG00000167815homo_sapiensENSP0000030152294.444490.9091microtus_ochrogasterENSMOCP0000000354294.444490.9091
ENSG00000167815homo_sapiensENSP0000030152297.474795.9596microtus_ochrogasterENSMOCP0000002426796.595
ENSG00000167815homo_sapiensENSP0000030152269.69767.1717sorex_araneusENSSARP0000000013669.69767.1717
ENSG00000167815homo_sapiensENSP0000030152296.969795.9596peromyscus_maniculatus_bairdiiENSPEMP0000000073896.969795.9596
ENSG00000167815homo_sapiensENSP0000030152294.949589.899bos_mutusENSBMUP0000001945694.472489.4472
ENSG00000167815homo_sapiensENSP0000030152273.737469.697mus_spicilegusENSMSIP0000002877890.123585.1852
ENSG00000167815homo_sapiensENSP0000030152243.434343.4343mus_spicilegusENSMSIP0000002963890.526390.5263
ENSG00000167815homo_sapiensENSP0000030152296.969793.4343mus_spicilegusENSMSIP0000001598396.969793.4343
ENSG00000167815homo_sapiensENSP0000030152246.464643.9394cricetulus_griseus_chok1gshdENSCGRP0000100632891.089186.1386
ENSG00000167815homo_sapiensENSP0000030152296.969793.9394pteropus_vampyrusENSPVAP0000001385896.969793.9394
ENSG00000167815homo_sapiensENSP0000030152295.454590.404myotis_lucifugusENSMLUP0000001157195.454590.404
ENSG00000167815homo_sapiensENSP0000030152294.444488.8889vombatus_ursinusENSVURP0001001631294.444488.8889
ENSG00000167815homo_sapiensENSP0000030152296.464692.9293rhinolophus_ferrumequinumENSRFEP0001003245396.464692.9293
ENSG00000167815homo_sapiensENSP0000030152295.959694.4444neovison_visonENSNVIP0000000466995.959694.4444
ENSG00000167815homo_sapiensENSP0000030152294.949589.899bos_taurusENSBTAP0000001599694.472489.4472
ENSG00000167815homo_sapiensENSP0000030152299.494999.4949rhinopithecus_bietiENSRBIP0000003288699.494999.4949
ENSG00000167815homo_sapiensENSP0000030152286.363682.3232canis_lupus_dingoENSCAFP0002000636661.956559.058
ENSG00000167815homo_sapiensENSP0000030152296.464694.9495sciurus_vulgarisENSSVLP0000502108296.464694.9495
ENSG00000167815homo_sapiensENSP0000030152294.444488.8889phascolarctos_cinereusENSPCIP0000001846594.444488.8889
ENSG00000167815homo_sapiensENSP0000030152293.939491.4141procavia_capensisENSPCAP0000001426495.876393.299
ENSG00000167815homo_sapiensENSP0000030152297.474794.9495nannospalax_galiliENSNGAP0000002414997.474794.9495
ENSG00000167815homo_sapiensENSP0000030152285.353579.2929bos_grunniensENSBGRP0000001007969.262364.3443
ENSG00000167815homo_sapiensENSP0000030152296.464693.4343chinchilla_lanigeraENSCLAP0000002032996.464693.4343
ENSG00000167815homo_sapiensENSP0000030152267.171760.101cervus_hanglu_yarkandensisENSCHYP0000000571779.640771.2575
ENSG00000167815homo_sapiensENSP0000030152297.474794.4444catagonus_wagneriENSCWAP0000000049297.474794.4444
ENSG00000167815homo_sapiensENSP0000030152237.878833.3333catagonus_wagneriENSCWAP0000000076364.655256.8966
ENSG00000167815homo_sapiensENSP0000030152296.969795.4545ictidomys_tridecemlineatusENSSTOP0000002194896.969795.4545
ENSG00000167815homo_sapiensENSP0000030152289.89987.8788ictidomys_tridecemlineatusENSSTOP0000002705094.680992.5532
ENSG00000167815homo_sapiensENSP0000030152292.929388.8889otolemur_garnettiiENSOGAP0000002245892.929388.8889
ENSG00000167815homo_sapiensENSP0000030152297.474795.4545otolemur_garnettiiENSOGAP0000001810197.474795.4545
ENSG00000167815homo_sapiensENSP0000030152210099.4949cebus_imitatorENSCCAP0000000214310099.4949
ENSG00000167815homo_sapiensENSP0000030152260.606156.5657urocitellus_parryiiENSUPAP0001002745689.552283.5821
ENSG00000167815homo_sapiensENSP0000030152296.969795.4545urocitellus_parryiiENSUPAP0001000974696.969795.4545
ENSG00000167815homo_sapiensENSP0000030152239.89933.8384moschus_moschiferusENSMMSP0000001086273.148162.037
ENSG00000167815homo_sapiensENSP00000301522100100rhinopithecus_roxellanaENSRROP00000022319100100
ENSG00000167815homo_sapiensENSP0000030152236.868733.3333mus_pahariMGP_PahariEiJ_P005361637.244933.6735
ENSG00000167815homo_sapiensENSP0000030152294.949592.4242propithecus_coquereliENSPCOP0000002265995.431592.8934
ENSG00000167815homo_sapiensENSP0000030152248.484831.3131drosophila_melanogasterFBpp008735443.636428.1818
ENSG00000167815homo_sapiensENSP0000030152248.484831.3131drosophila_melanogasterFBpp008735643.636428.1818
ENSG00000167815homo_sapiensENSP0000030152248.484830.8081drosophila_melanogasterFBpp008740643.636427.7273
ENSG00000167815homo_sapiensENSP0000030152276.262665.1515eptatretus_burgeriENSEBUP0000001372766.228156.5789
ENSG00000167815homo_sapiensENSP0000030152244.444437.3737latimeria_chalumnaeENSLACP0000000052080.733967.8899
ENSG00000167815homo_sapiensENSP0000030152249.494942.4242oncorhynchus_kisutchENSOKIP0000504955269.014159.1549
ENSG00000167815homo_sapiensENSP0000030152290.909180.303poecilia_reticulataENSPREP0000000070191.370680.7107
ENSG00000167815homo_sapiensENSP0000030152291.414180.303xiphophorus_maculatusENSXMAP0000003451076.050466.8067
ENSG00000167815homo_sapiensENSP0000030152287.878875.2525xenopus_tropicalisENSXETP0000007904764.68455.3903
ENSG00000167815homo_sapiensENSP0000030152282.828374.7475chrysemys_picta_belliiENSCPBP0000003424388.648780
ENSG00000167815homo_sapiensENSP0000030152291.414184.8485sphenodon_punctatusENSSPUP0000002009959.150354.902
ENSG00000167815homo_sapiensENSP0000030152287.373776.2626laticauda_laticaudataENSLLTP0000000884287.373776.2626
ENSG00000167815homo_sapiensENSP0000030152287.373776.2626notechis_scutatusENSNSUP0000000325087.373776.2626
ENSG00000167815homo_sapiensENSP0000030152287.373776.2626notechis_scutatusENSNSUP0000001408587.373776.2626
ENSG00000167815homo_sapiensENSP0000030152287.373776.2626pseudonaja_textilisENSPTXP0000001119587.373776.2626
ENSG00000167815homo_sapiensENSP0000030152288.888975.7576anolis_carolinensisENSACAP0000000330988.888975.7576
ENSG00000167815homo_sapiensENSP0000030152286.363675.2525naja_najaENSNNAP0000000451586.363675.2525
ENSG00000167815homo_sapiensENSP0000030152287.878879.2929podarcis_muralisENSPMRP0000001615484.05875.8454
ENSG00000167815homo_sapiensENSP0000030152290.909176.7677erpetoichthys_calabaricusENSECRP0000002474590.909176.7677
ENSG00000167815homo_sapiensENSP0000030152290.909178.7879salvator_merianaeENSSMRP0000000528090.909178.7879
ENSG00000167815homo_sapiensENSP0000030152255.050547.9798pelodiscus_sinensisENSPSIP0000001338075.694465.9722
ENSG00000167815homo_sapiensENSP0000030152288.888982.8283gopherus_evgoodeiENSGEVP0000502701288.888982.8283
ENSG00000167815homo_sapiensENSP0000030152264.141451.0101chelonoidis_abingdoniiENSCABP0000001348467.553253.7234
ENSG00000167815homo_sapiensENSP0000030152291.919278.7879cynoglossus_semilaevisENSCSEP0000002226392.385879.1878
ENSG00000167815homo_sapiensENSP0000030152290.909180.303poecilia_formosaENSPFOP0000001283290.909180.303
ENSG00000167815homo_sapiensENSP0000030152279.292973.7374terrapene_carolina_triunguisENSTMTP0000002502785.326179.3478
ENSG00000167815homo_sapiensENSP0000030152290.909178.2828takifugu_rubripesENSTRUP0000005380490.909178.2828
ENSG00000167815homo_sapiensENSP0000030152290.909180.303poecilia_latipinnaENSPLAP000000200298070.6667
ENSG00000167815homo_sapiensENSP0000030152283.838472.7273paramormyrops_kingsleyaeENSPKIP0000002786875.113165.1584

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002357involved_in defense response to tumor cell1IMPHomo_sapiens(9606)Process
GO:0002536involved_in respiratory burst involved in inflammatory response1IEAHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737located_in cytoplasm1TASHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0006979involved_in response to oxidative stress3IBA,IMP,NASHomo_sapiens(9606)Process
GO:0008379enables thioredoxin peroxidase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0010310involved_in regulation of hydrogen peroxide metabolic process1IEAHomo_sapiens(9606)Process
GO:0016209enables antioxidant activity2IDA,NASHomo_sapiens(9606)Function
GO:0019430involved_in removal of superoxide radicals2IBA,IDAHomo_sapiens(9606)Process
GO:0030194involved_in positive regulation of blood coagulation1IEAHomo_sapiens(9606)Process
GO:0031665involved_in negative regulation of lipopolysaccharide-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0032088involved_in negative regulation of NF-kappaB transcription factor activity1IEAHomo_sapiens(9606)Process
GO:0032496involved_in response to lipopolysaccharide1IEAHomo_sapiens(9606)Process
GO:0033554involved_in cellular response to stress1IBAHomo_sapiens(9606)Process
GO:0034599involved_in cellular response to oxidative stress1IDAHomo_sapiens(9606)Process
GO:0042098involved_in T cell proliferation1IEAHomo_sapiens(9606)Process
GO:0042744involved_in hydrogen peroxide catabolic process2IBA,TASHomo_sapiens(9606)Process
GO:0042981involved_in regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043029involved_in T cell homeostasis1IEAHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0043410involved_in positive regulation of MAPK cascade1IEAHomo_sapiens(9606)Process
GO:0045321involved_in leukocyte activation1IBAHomo_sapiens(9606)Process
GO:0045454involved_in cell redox homeostasis1IBAHomo_sapiens(9606)Process
GO:0045581involved_in negative regulation of T cell differentiation1IEAHomo_sapiens(9606)Process
GO:0048538involved_in thymus development1IEAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0097191involved_in extrinsic apoptotic signaling pathway1IEAHomo_sapiens(9606)Process
GO:2001240involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand1IEAHomo_sapiens(9606)Process

Expression