Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000166333 Gene ID 3611 Accession 6040
Symbol ILK Alias P59;ILK-1;ILK-2;p59ILK;HEL-S-28 Full Name integrin linked kinase
Status Confidence Length 7167 bases Strand Plus strand
Position 11 : 6603708 - 6610874 RNA binding domain N.A.
Summary This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ILK-212 ENST00000532063 1617 318aa ENSP00000434492
ILK-207 ENST00000526711 1594 40aa ENSP00000479932
ILK-215 ENST00000537806 1801 483aa ENSP00000439606
ILK-203 ENST00000420936 1692 452aa ENSP00000403487
ILK-205 ENST00000526114 851 36aa ENSP00000432617
ILK-211 ENST00000530016 1696 No protein -
ILK-201 ENST00000299421 1759 452aa ENSP00000299421
ILK-208 ENST00000527121 891 36aa ENSP00000436062
ILK-210 ENST00000528995 1559 391aa ENSP00000435323
ILK-213 ENST00000534565 574 No protein -
ILK-202 ENST00000396751 2074 452aa ENSP00000379975
ILK-216 ENST00000627400 111 36aa ENSP00000487498
ILK-206 ENST00000526318 596 111aa ENSP00000480597
ILK-204 ENST00000524735 566 No protein -
ILK-209 ENST00000528784 947 No protein -
ILK-214 ENST00000534706 790 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17753Alcoholism8.6268e-00522978509

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000902acts_upstream_of_or_within cell morphogenesis1IMPHomo_sapiens(9606)Process
GO:0001658involved_in branching involved in ureteric bud morphogenesis1IEAHomo_sapiens(9606)Process
GO:0001725colocalizes_with stress fiber1IBAHomo_sapiens(9606)Component
GO:0001934involved_in positive regulation of protein phosphorylation1IMPHomo_sapiens(9606)Process
GO:0003151involved_in outflow tract morphogenesis1IEAHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IEAHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion3HDA,IBA,IDAHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0007160involved_in cell-matrix adhesion1IBAHomo_sapiens(9606)Process
GO:0007229involved_in integrin-mediated signaling pathway2IBA,IDAHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1IEAHomo_sapiens(9606)Process
GO:0009967involved_in positive regulation of signal transduction1IMPHomo_sapiens(9606)Process
GO:0010761involved_in fibroblast migration1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0018105involved_in peptidyl-serine phosphorylation1IEAHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0021675involved_in nerve development1IEAHomo_sapiens(9606)Process
GO:0022011involved_in myelination in peripheral nervous system1IEAHomo_sapiens(9606)Process
GO:0030017located_in sarcomere1IEAHomo_sapiens(9606)Component
GO:0030027located_in lamellipodium1IEAHomo_sapiens(9606)Component
GO:0030030involved_in cell projection organization1IEAHomo_sapiens(9606)Process
GO:0030513involved_in positive regulation of BMP signaling pathway1IEAHomo_sapiens(9606)Process
GO:0033209involved_in tumor necrosis factor-mediated signaling pathway1IMPHomo_sapiens(9606)Process
GO:0034446involved_in substrate adhesion-dependent cell spreading2IBA,IMPHomo_sapiens(9606)Process
GO:0042327involved_in positive regulation of phosphorylation1IMPHomo_sapiens(9606)Process
GO:0043491involved_in protein kinase B signaling1IEAHomo_sapiens(9606)Process
GO:0045197involved_in establishment or maintenance of epithelial cell apical/basal polarity1IEAHomo_sapiens(9606)Process
GO:0045669involved_in positive regulation of osteoblast differentiation1IEAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IMPHomo_sapiens(9606)Process
GO:0061351involved_in neural precursor cell proliferation1IEAHomo_sapiens(9606)Process
GO:0070527involved_in platelet aggregation1HMPHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway1IMPHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1900026involved_in positive regulation of substrate adhesion-dependent cell spreading1IGIHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:2000178involved_in negative regulation of neural precursor cell proliferation1IEAHomo_sapiens(9606)Process

Expression