RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	DataSet_02_10

Description

Ensembl ID	ENSG00000165819	Gene ID	56339	Accession	17563
Symbol	METTL3	Alias		Full Name
Status	Confidence	Length	13208 bases	Strand	Minus strand
Position	14 : 21498133 - 21511340	RNA binding domain	MT-A70
Summary

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000298717	MT-A70	PF05063	6.3e-60	1

Showing 1 to 1 of 1 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y

Showing 1 to 2 of 2 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
30602712	Modulation of Bacterial sRNAs Activity by Epigenetic Modifications: Inputs from the Eukaryotic miRNAs.	Brice Felden	2018-12-31	Genes
31104845	Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.	Y Leslie Beh	2019-06-13	Cell
34505967	METTL3-Mediated lncRNA m⁶A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein.	Yidan Song	2021-12-01	Stem cell reviews and reports
36553579	The Role of the m⁶A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis.	E Jacqueline Mermoud	2022-12-08	Genes
37370798	Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression.	Gwenola Bougras-Cartron	2023-06-14	Cancers
37492710	m⁶A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes.	Tamara Kleinbielen	2023-09-01	Genes & diseases

Showing 1 to 6 of 6 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
METTL3-201	ENST00000298717	1980	580aa	ENSP00000298717
METTL3-202	ENST00000367606	802	No protein	-
METTL3-203	ENST00000377543	563	9aa	ENSP00000366766
METTL3-204	ENST00000396522	2523	No protein	-
METTL3-205	ENST00000536201	1592	No protein	-
METTL3-206	ENST00000537163	2030	153aa	ENSP00000442407
METTL3-207	ENST00000538267	1553	No protein	-
METTL3-208	ENST00000539760	1462	336aa	ENSP00000440598
METTL3-209	ENST00000542054	975	No protein	-
METTL3-210	ENST00000543235	2124	258aa	ENSP00000445523

Showing 1 to 10 of 14 entries

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Gene Model

Click here to download ENSG00000165819's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
7974	Uric Acid	3.7073475692404E-5	17903292
8001	Uric Acid	1.19773350512812E-5	17903292
107077	homoharringtonine	9E-7	25628645
107078	Cell Survival	9E-7	25628645

Showing 1 to 4 of 4 entries

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000165819's PPI file

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000165819	homo_sapiens	ENSP00000298717	100	100	nomascus_leucogenys	ENSNLEP00000017753	100	100
ENSG00000165819	homo_sapiens	ENSP00000298717	100	99.8276	pan_paniscus	ENSPPAP00000032353	100	99.8276
ENSG00000165819	homo_sapiens	ENSP00000298717	99.8276	99.8276	pongo_abelii	ENSPPYP00000006369	99.8276	99.8276
ENSG00000165819	homo_sapiens	ENSP00000298717	100	100	pan_troglodytes	ENSPTRP00000010396	100	100
ENSG00000165819	homo_sapiens	ENSP00000298717	100	100	gorilla_gorilla	ENSGGOP00000005830	100	100
ENSG00000165819	homo_sapiens	ENSP00000298717	92.4138	90.1724	ornithorhynchus_anatinus	ENSOANP00000037673	93.5428	91.274
ENSG00000165819	homo_sapiens	ENSP00000298717	94.1379	92.931	sarcophilus_harrisii	ENSSHAP00000010417	89.2157	88.0719
ENSG00000165819	homo_sapiens	ENSP00000298717	80.8621	79.4828	notamacropus_eugenii	ENSMEUP00000009606	82.8622	81.4488
ENSG00000165819	homo_sapiens	ENSP00000298717	82.4138	82.069	choloepus_hoffmanni	ENSCHOP00000000635	94.0945	93.7008
ENSG00000165819	homo_sapiens	ENSP00000298717	97.5862	96.8966	dasypus_novemcinctus	ENSDNOP00000023997	97.4182	96.7298

Showing 1 to 10 of 195 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0080009	involved_in mRNA methylation	4	IBA,IDA,IMP,NAS	Homo_sapiens(9606)	Process
GO:0001734	enables mRNA (N6-adenosine)-methyltransferase activity	3	IBA,IDA,IMP	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0036396	part_of RNA N6-methyladenosine methyltransferase complex	3	IBA,IDA,IPI	Homo_sapiens(9606)	Component
GO:0000398	involved_in mRNA splicing, via spliceosome	2	IMP,ISS	Homo_sapiens(9606)	Process
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0046982	enables protein heterodimerization activity	2	IDA,IPI	Homo_sapiens(9606)	Function
GO:0001510	involved_in RNA methylation	1	IMP	Homo_sapiens(9606)	Process
GO:0003729	enables mRNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function

Showing 1 to 10 of 40 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression