RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000165806	Gene ID	840	Accession	1508
Symbol	CASP7	Alias	MCH3;CMH-1;LICE2;CASP-7;ICE-LAP3	Full Name	caspase 7
Status	Confidence	Length	51746 bases	Strand	Plus strand
Position	10 : 113679162 - 113730907	RNA binding domain	N.A.
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
24040159	Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.	Meng-Yun Wang	2013-01-01	PloS one

Name	Transcript ID	bp	Protein	Translation ID
CASP7-211	ENST00000621345	2467	303aa	ENSP00000480584
CASP7-206	ENST00000429617	834	222aa	ENSP00000400094
CASP7-205	ENST00000369331	2380	253aa	ENSP00000358337
CASP7-201	ENST00000345633	2659	303aa	ENSP00000298701
CASP7-204	ENST00000369321	2620	388aa	ENSP00000358327
CASP7-210	ENST00000614447	2555	253aa	ENSP00000478285
CASP7-203	ENST00000369318	2344	303aa	ENSP00000358324
CASP7-202	ENST00000369315	2421	303aa	ENSP00000358321
CASP7-212	ENST00000621607	2378	336aa	ENSP00000478999
CASP7-213	ENST00000672138	2351	302aa	ENSP00000500735
CASP7-207	ENST00000452490	2271	278aa	ENSP00000398107
CASP7-208	ENST00000468790	607	No protein	-
CASP7-209	ENST00000487232	799	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
30888	Erythrocyte Indices	3.0510000E-007	-
76243	Vitiligo	4E-8	22561518

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004190	enables aspartic-type endopeptidase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0004197	enables cysteine-type endopeptidase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005615	is_active_in extracellular space	1	TAS	Homo_sapiens(9606)	Component
GO:0005634	is_active_in nucleus	2	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006508	involved_in proteolysis	1	IDA	Homo_sapiens(9606)	Process
GO:0006915	involved_in apoptotic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0007507	involved_in heart development	1	IEA	Homo_sapiens(9606)	Process
GO:0008233	enables peptidase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0008234	enables cysteine-type peptidase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0009411	involved_in response to UV	1	IEA	Homo_sapiens(9606)	Process
GO:0016485	involved_in protein processing	1	IEA	Homo_sapiens(9606)	Process
GO:0030163	involved_in protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0032991	part_of protein-containing complex	1	IEA	Homo_sapiens(9606)	Component
GO:0042742	involved_in defense response to bacterium	1	IEA	Homo_sapiens(9606)	Process
GO:0044346	involved_in fibroblast apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0051146	involved_in striated muscle cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0051402	involved_in neuron apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0051604	involved_in protein maturation	1	IDA	Homo_sapiens(9606)	Process
GO:0070227	involved_in lymphocyte apoptotic process	1	ISS	Homo_sapiens(9606)	Process
GO:0071222	involved_in cellular response to lipopolysaccharide	1	IDA	Homo_sapiens(9606)	Process
GO:0072734	involved_in cellular response to staurosporine	1	IMP	Homo_sapiens(9606)	Process
GO:0097153	enables cysteine-type endopeptidase activity involved in apoptotic process	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0097194	involved_in execution phase of apoptosis	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0097200	enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	3	IBA,IDA,IMP	Homo_sapiens(9606)	Function
GO:1905686	involved_in positive regulation of plasma membrane repair	1	IEA	Homo_sapiens(9606)	Process