Functions and Diseases

RBP Type Canonical_RBPs
Diseases CHIKVSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengue
Drug N.A.
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations Stress granucleP-bodyNucleoli rim
BulkPerturb-seq DataSet_01_117 DataSet_01_12

Description

Ensembl ID ENSG00000165732 Gene ID 9188 Accession 2744
Symbol DDX21 Alias RH;GUA;GURDB;II/Gu;RHII/Gu;RH-II/GU;gu-alpha;RH-II/GuA Full Name DExD-box helicase 21
Status Confidence Length 28934 bases Strand Plus strand
Position 10 : 68956135 - 68985068 RNA binding domain ResIII , DEAD , GUCT
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression