RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000165458	Gene ID	3636	Accession	6080
Symbol	INPPL1	Alias	OPSMD;SHIP2	Full Name	inositol polyphosphate phosphatase like 1
Status	Confidence	Length	15447 bases	Strand	Plus strand
Position	11 : 72223701 - 72239147	RNA binding domain	Exo_endo_phos
Summary	The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000444619	Exo_endo_phos	PF03372	2.1e-11	1
ENSP00000298229	Exo_endo_phos	PF03372	3.2e-11	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
30252095	Monitored eCLIP: high accuracy mapping of RNA-protein interactions.	Rémi Hocq	2018-11-30	Nucleic acids research

Name	Transcript ID	bp	Protein	Translation ID
INPPL1-209	ENST00000540973	375	22aa	ENSP00000440904
INPPL1-213	ENST00000543234	275	17aa	ENSP00000440512
INPPL1-201	ENST00000298229	4789	1258aa	ENSP00000298229
INPPL1-211	ENST00000541544	530	No protein	-
INPPL1-207	ENST00000538751	4656	1016aa	ENSP00000444619
INPPL1-208	ENST00000540329	741	127aa	ENSP00000440018
INPPL1-204	ENST00000537656	550	33aa	ENSP00000444630
INPPL1-206	ENST00000538339	505	No protein	-
INPPL1-205	ENST00000537755	535	No protein	-
INPPL1-214	ENST00000544806	547	No protein	-
INPPL1-210	ENST00000541303	1238	No protein	-
INPPL1-215	ENST00000545355	1124	No protein	-
INPPL1-203	ENST00000535985	353	41aa	ENSP00000437852
INPPL1-212	ENST00000541752	856	197aa	ENSP00000441094
INPPL1-202	ENST00000320683	717	149aa	ENSP00000321775

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000922	located_in spindle pole	1	IEA	Homo_sapiens(9606)	Component
GO:0001958	involved_in endochondral ossification	1	IMP	Homo_sapiens(9606)	Process
GO:0002376	involved_in immune system process	1	IEA	Homo_sapiens(9606)	Process
GO:0003779	enables actin binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004445	enables inositol-polyphosphate 5-phosphatase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	ISS	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0006006	involved_in glucose metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006661	involved_in phosphatidylinositol biosynthetic process	1	TAS	Homo_sapiens(9606)	Process
GO:0006897	involved_in endocytosis	1	IMP	Homo_sapiens(9606)	Process
GO:0007015	involved_in actin filament organization	1	IMP	Homo_sapiens(9606)	Process
GO:0007155	involved_in cell adhesion	1	TAS	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0009791	involved_in post-embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0009925	located_in basal plasma membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0010629	involved_in negative regulation of gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	ISS	Homo_sapiens(9606)	Component
GO:0017124	enables SH3 domain binding	1	IEA	Homo_sapiens(9606)	Function
GO:0030027	located_in lamellipodium	1	IEA	Homo_sapiens(9606)	Component
GO:0030175	located_in filopodium	1	IEA	Homo_sapiens(9606)	Component
GO:0032868	involved_in response to insulin	1	IEA	Homo_sapiens(9606)	Process
GO:0034485	enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0042169	enables SH2 domain binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043569	involved_in negative regulation of insulin-like growth factor receptor signaling pathway	1	IBA	Homo_sapiens(9606)	Process
GO:0046856	involved_in phosphatidylinositol dephosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0050776	involved_in regulation of immune response	1	IBA	Homo_sapiens(9606)	Process
GO:0097178	involved_in ruffle assembly	1	IEA	Homo_sapiens(9606)	Process