Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerFlavivirusesSARS-COV-2Dengue
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000165280 Gene ID 7415 Accession 12666
Symbol VCP Alias p97;TERA;CDC48;FTDALS6 Full Name valosin containing protein
Status Confidence Length 18741 bases Strand Minus strand
Position 9 : 35053928 - 35072668 RNA binding domain N.A.
Summary This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34396115 TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain. Jasmine Harley 2021-01-01 Brain communications
33693641 Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis. E Giulia Tyzack 2021-08-17 Brain : a journal of neurology
26287246 Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS. Francesca Navone 2015-08-06 Cells
37269429 CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer. Chong Wang 2023-06-03 Discover. Oncology
34595747 Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS. Colombine Verzat 2022-02-01 Neuropathology and applied neurobiology
36180233 Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis. Marija M Petrić 2022-10-01 Genome research
34706979 Pathological phase transitions in ALS-FTD impair dynamic RNA-protein granules. B Natalia Nedelsky 2022-01-01 RNA (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
VCP-221 ENST00000679902 6033 772aa ENSP00000506338
VCP-212 ENST00000678650 4362 761aa ENSP00000503426
VCP-210 ENST00000678018 4480 43aa ENSP00000503811
VCP-218 ENST00000679800 4561 No protein -
VCP-209 ENST00000677257 4404 804aa ENSP00000504354
VCP-211 ENST00000678465 4451 334aa ENSP00000504259
VCP-233 ENST00000681537 1303 76aa ENSP00000505847
VCP-201 ENST00000358901 3746 806aa ENSP00000351777
VCP-203 ENST00000448530 3849 761aa ENSP00000392088
VCP-217 ENST00000679647 2895 733aa ENSP00000506216
VCP-231 ENST00000681335 3077 754aa ENSP00000505230
VCP-202 ENST00000417448 3382 761aa ENSP00000399456
VCP-229 ENST00000680916 3264 694aa ENSP00000505769
VCP-216 ENST00000679599 5506 No protein -
VCP-219 ENST00000679862 3159 760aa ENSP00000504990
VCP-235 ENST00000681690 4691 No protein -
VCP-213 ENST00000679204 2987 458aa ENSP00000503131
VCP-208 ENST00000676836 3597 No protein -
VCP-207 ENST00000493886 2942 No protein -
VCP-205 ENST00000479300 1159 No protein -
VCP-204 ENST00000466100 508 No protein -
VCP-206 ENST00000480327 2162 No protein -
VCP-230 ENST00000681125 441 47aa ENSP00000505052
VCP-227 ENST00000680834 709 237aa ENSP00000506387
VCP-224 ENST00000680520 463 77aa ENSP00000505308
VCP-236 ENST00000681789 364 50aa ENSP00000505142
VCP-226 ENST00000680731 436 77aa ENSP00000505497
VCP-234 ENST00000681562 328 110aa ENSP00000505893
VCP-222 ENST00000680079 809 56aa ENSP00000506523
VCP-215 ENST00000679449 321 107aa ENSP00000506658
VCP-228 ENST00000680900 306 102aa ENSP00000505674
VCP-232 ENST00000681386 462 55aa ENSP00000505509
VCP-220 ENST00000679901 458 No protein -
VCP-214 ENST00000679392 271 No protein -
VCP-225 ENST00000680575 510 No protein -
VCP-223 ENST00000680108 415 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000165280homo_sapiensENSP0000030549451.261632.9349homo_sapiensENSP0000035177747.890830.7692
ENSG00000165280homo_sapiensENSP0000028170148.247733.7617homo_sapiensENSP0000035177751.240735.8561
ENSG00000165280homo_sapiensENSP0000027400850.391934.7144homo_sapiensENSP0000035177755.831338.4615
ENSG00000165280homo_sapiensENSP0000030351134.795920.9184homo_sapiensENSP0000035177742.307725.4342
ENSG00000165280homo_sapiensENSP0000024863328.137217.537homo_sapiensENSP0000035177744.789127.9156

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000165280homo_sapiensENSP0000035177799.503799.3797nomascus_leucogenysENSNLEP0000000574299.257499.1337
ENSG00000165280homo_sapiensENSP00000351777100100pan_paniscusENSPPAP00000035908100100
ENSG00000165280homo_sapiensENSP00000351777100100pongo_abeliiENSPPYP00000021408100100
ENSG00000165280homo_sapiensENSP00000351777100100pan_troglodytesENSPTRP00000035748100100
ENSG00000165280homo_sapiensENSP00000351777100100gorilla_gorillaENSGGOP00000003146100100
ENSG00000165280homo_sapiensENSP0000035177799.131598.8834ornithorhynchus_anatinusENSOANP0000004268597.677397.4328
ENSG00000165280homo_sapiensENSP0000035177799.751999.6278sarcophilus_harrisiiENSSHAP0000002853599.751999.6278
ENSG00000165280homo_sapiensENSP0000035177792.183692.0596notamacropus_eugeniiENSMEUP0000000590992.87592.75
ENSG00000165280homo_sapiensENSP0000035177798.387197.8908choloepus_hoffmanniENSCHOP0000000068999.249198.7484
ENSG00000165280homo_sapiensENSP00000351777100100dasypus_novemcinctusENSDNOP00000011282100100
ENSG00000165280homo_sapiensENSP0000035177776.302776.3027erinaceus_europaeusENSEEUP0000000089076.302776.3027
ENSG00000165280homo_sapiensENSP0000035177764.640264.6402echinops_telfairiENSETEP0000001019364.640264.6402
ENSG00000165280homo_sapiensENSP00000351777100100cercocebus_atysENSCATP00000008392100100
ENSG00000165280homo_sapiensENSP00000351777100100macaca_fascicularisENSMFAP00000013931100100
ENSG00000165280homo_sapiensENSP0000035177799.503799.5037macaca_mulattaENSMMUP0000002658297.448497.4484
ENSG00000165280homo_sapiensENSP0000035177784.739581.8859macaca_nemestrinaENSMNEP0000002609989.048286.0495
ENSG00000165280homo_sapiensENSP00000351777100100papio_anubisENSPANP00000019119100100
ENSG00000165280homo_sapiensENSP00000351777100100mandrillus_leucophaeusENSMLEP00000023388100100
ENSG00000165280homo_sapiensENSP0000035177798.387198.3871tursiops_truncatusENSTTRP0000000589599.748499.7484
ENSG00000165280homo_sapiensENSP0000035177797.890897.6427vulpes_vulpesENSVVUP0000003740494.040593.8021
ENSG00000165280homo_sapiensENSP00000351777100100mus_spretusMGP_SPRETEiJ_P0064367100100
ENSG00000165280homo_sapiensENSP0000035177799.131599.1315equus_asinusENSEASP0000504196098.036898.0368
ENSG00000165280homo_sapiensENSP0000035177799.007498.8834capra_hircusENSCHIP0000001921397.794197.6716
ENSG00000165280homo_sapiensENSP0000035177799.379799.2556loxodonta_africanaENSLAFP0000000612999.875399.7506
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759panthera_leoENSPLOP0000001934599.875999.8759
ENSG00000165280homo_sapiensENSP0000035177799.379799.3797ailuropoda_melanoleucaENSAMEP0000003984394.792994.7929
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759bos_indicus_hybridENSBIXP0000500501099.875999.8759
ENSG00000165280homo_sapiensENSP00000351777100100oryctolagus_cuniculusENSOCUP00000005566100100
ENSG00000165280homo_sapiensENSP0000035177799.627899.6278equus_caballusENSECAP0000003886499.875699.8756
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759canis_lupus_familiarisENSCAFP0084500781899.875999.8759
ENSG00000165280homo_sapiensENSP0000035177797.890897.8908panthera_pardusENSPPRP0000000716099.873499.8734
ENSG00000165280homo_sapiensENSP0000035177799.255699.2556marmota_marmota_marmotaENSMMMP0000000860699.255699.2556
ENSG00000165280homo_sapiensENSP0000035177799.751999.7519balaenoptera_musculusENSBMSP0001000617299.751999.7519
ENSG00000165280homo_sapiensENSP00000351777100100cavia_porcellusENSCPOP00000033093100100
ENSG00000165280homo_sapiensENSP0000035177794.292894.2928felis_catusENSFCAP0000000103299.868699.8686
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759ursus_americanusENSUAMP0000003171499.875999.8759
ENSG00000165280homo_sapiensENSP0000035177799.751999.5037monodelphis_domesticaENSMODP0000000969999.751999.5037
ENSG00000165280homo_sapiensENSP0000035177797.890897.8908bison_bison_bisonENSBBBP0000000718599.873499.8734
ENSG00000165280homo_sapiensENSP0000035177799.751999.7519monodon_monocerosENSMMNP0001502273799.751999.7519
ENSG00000165280homo_sapiensENSP0000035177796.40296.0298sus_scrofaENSSSCP0000007347493.727493.3655
ENSG00000165280homo_sapiensENSP00000351777100100microcebus_murinusENSMICP00000004998100100
ENSG00000165280homo_sapiensENSP0000035177799.751999.6278octodon_degusENSODEP0000001986199.751999.6278
ENSG00000165280homo_sapiensENSP00000351777100100jaculus_jaculusENSJJAP00000006683100100
ENSG00000165280homo_sapiensENSP0000035177799.007498.8834ovis_aries_rambouilletENSOARP0002000220297.794197.6716
ENSG00000165280homo_sapiensENSP0000035177794.292894.2928ursus_maritimusENSUMAP0000000837499.868699.8686
ENSG00000165280homo_sapiensENSP0000035177794.789194.4169ochotona_princepsENSOPRP0000000980699.738999.3473
ENSG00000165280homo_sapiensENSP0000035177796.774296.5261delphinapterus_leucasENSDLEP0000002971896.177695.9309
ENSG00000165280homo_sapiensENSP0000035177799.751999.7519physeter_catodonENSPCTP0000500051399.751999.7519
ENSG00000165280homo_sapiensENSP00000351777100100mus_caroliMGP_CAROLIEiJ_P0061903100100
ENSG00000165280homo_sapiensENSP00000351777100100mus_musculusENSMUSP00000030164100100
ENSG00000165280homo_sapiensENSP00000351777100100dipodomys_ordiiENSDORP00000027394100100
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759mustela_putorius_furoENSMPUP0000000455299.875999.8759
ENSG00000165280homo_sapiensENSP0000035177799.627899.6278aotus_nancymaaeENSANAP0000003175798.527698.5276
ENSG00000165280homo_sapiensENSP00000351777100100saimiri_boliviensis_boliviensisENSSBOP00000037614100100
ENSG00000165280homo_sapiensENSP0000035177752.481452.4814vicugna_pacosENSVPAP0000000301399.764299.7642
ENSG00000165280homo_sapiensENSP00000351777100100chlorocebus_sabaeusENSCSAP00000006492100100
ENSG00000165280homo_sapiensENSP0000035177793.548493.4243tupaia_belangeriENSTBEP0000000402095.685395.5584
ENSG00000165280homo_sapiensENSP0000035177799.751999.5037mesocricetus_auratusENSMAUP0000000163499.014898.7685
ENSG00000165280homo_sapiensENSP0000035177799.751999.7519phocoena_sinusENSPSNP0000002643399.751999.7519
ENSG00000165280homo_sapiensENSP0000035177799.007498.8834camelus_dromedariusENSCDRP0000501168696.727396.6061
ENSG00000165280homo_sapiensENSP00000351777100100carlito_syrichtaENSTSYP00000008855100100
ENSG00000165280homo_sapiensENSP0000035177799.503799.5037panthera_tigris_altaicaENSPTIP0000001313099.627399.6273
ENSG00000165280homo_sapiensENSP0000035177710099.8759rattus_norvegicusENSRNOP0000004012110099.8759
ENSG00000165280homo_sapiensENSP00000351777100100prolemur_simusENSPSMP00000007311100100
ENSG00000165280homo_sapiensENSP00000351777100100microtus_ochrogasterENSMOCP00000011420100100
ENSG00000165280homo_sapiensENSP0000035177799.255699.2556sorex_araneusENSSARP00000011151100100
ENSG00000165280homo_sapiensENSP0000035177799.379799.3797peromyscus_maniculatus_bairdiiENSPEMP0000001893599.379799.3797
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759bos_mutusENSBMUP0000003124299.875999.8759
ENSG00000165280homo_sapiensENSP0000035177799.875999.7519mus_spicilegusENSMSIP0000003786779.624179.5252
ENSG00000165280homo_sapiensENSP00000351777100100cricetulus_griseus_chok1gshdENSCGRP00001026162100100
ENSG00000165280homo_sapiensENSP0000035177799.255699.2556pteropus_vampyrusENSPVAP0000000861699.875299.8752
ENSG00000165280homo_sapiensENSP0000035177710099.8759myotis_lucifugusENSMLUP0000000561410099.8759
ENSG00000165280homo_sapiensENSP0000035177799.751999.6278vombatus_ursinusENSVURP0001001976299.751999.6278
ENSG00000165280homo_sapiensENSP00000351777100100rhinolophus_ferrumequinumENSRFEP00010011085100100
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759neovison_visonENSNVIP0000003120099.875999.8759
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759bos_taurusENSBTAP0000001997099.875999.8759
ENSG00000165280homo_sapiensENSP00000351777100100heterocephalus_glaber_femaleENSHGLP00000009769100100
ENSG00000165280homo_sapiensENSP00000351777100100rhinopithecus_bietiENSRBIP00000002365100100
ENSG00000165280homo_sapiensENSP0000035177798.387198.139canis_lupus_dingoENSCAFP0002002033588.901388.6771
ENSG00000165280homo_sapiensENSP00000351777100100sciurus_vulgarisENSSVLP00005027669100100
ENSG00000165280homo_sapiensENSP0000035177799.751999.6278phascolarctos_cinereusENSPCIP0000002920399.751999.6278
ENSG00000165280homo_sapiensENSP0000035177795.533595.5335procavia_capensisENSPCAP0000000075495.652295.6522
ENSG00000165280homo_sapiensENSP0000035177710099.8759nannospalax_galiliENSNGAP0000001064210099.8759
ENSG00000165280homo_sapiensENSP0000035177797.642797.6427bos_grunniensENSBGRP0000002155199.873199.8731
ENSG00000165280homo_sapiensENSP0000035177799.875999.5037chinchilla_lanigeraENSCLAP0000000390094.483694.1315
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759cervus_hanglu_yarkandensisENSCHYP0000003995188.754188.7541
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759catagonus_wagneriENSCWAP0000001380399.875999.8759
ENSG00000165280homo_sapiensENSP00000351777100100ictidomys_tridecemlineatusENSSTOP00000013606100100
ENSG00000165280homo_sapiensENSP0000035177799.751999.7519otolemur_garnettiiENSOGAP00000007713100100
ENSG00000165280homo_sapiensENSP0000035177799.627899.6278cebus_imitatorENSCCAP0000002598599.504399.5043
ENSG00000165280homo_sapiensENSP0000035177799.007498.8834urocitellus_parryiiENSUPAP0001002327697.435997.3138
ENSG00000165280homo_sapiensENSP0000035177799.875999.8759moschus_moschiferusENSMMSP0000001838499.875999.8759
ENSG00000165280homo_sapiensENSP0000035177790.694889.5782rhinopithecus_roxellanaENSRROP0000001903396.949695.756
ENSG00000165280homo_sapiensENSP00000351777100100mus_pahariMGP_PahariEiJ_P0057627100100
ENSG00000165280homo_sapiensENSP00000351777100100propithecus_coquereliENSPCOP00000016734100100
ENSG00000165280homo_sapiensENSP0000035177789.3379.0323caenorhabditis_elegansC41C4.8.188.888978.642
ENSG00000165280homo_sapiensENSP0000035177789.454178.1638caenorhabditis_elegansC06A1.1.189.122477.8739
ENSG00000165280homo_sapiensENSP0000035177791.687382.5062drosophila_melanogasterFBpp011181889.467380.5085
ENSG00000165280homo_sapiensENSP0000035177791.811484.2432ciona_intestinalisENSCINP0000001459891.245483.7238
ENSG00000165280homo_sapiensENSP0000035177751.116648.263petromyzon_marinusENSPMAP0000000551492.376787.2197
ENSG00000165280homo_sapiensENSP0000035177722.332521.464petromyzon_marinusENSPMAP0000000166395.238191.5344
ENSG00000165280homo_sapiensENSP0000035177739.702238.4615petromyzon_marinusENSPMAP0000000884695.808492.8144
ENSG00000165280homo_sapiensENSP0000035177780.893376.3027eptatretus_burgeriENSEBUP0000001993491.83186.6197
ENSG00000165280homo_sapiensENSP0000035177798.511296.2779callorhinchus_miliiENSCMIP0000002036098.511296.2779
ENSG00000165280homo_sapiensENSP0000035177792.183689.0819latimeria_chalumnaeENSLACP0000001393792.75989.638
ENSG00000165280homo_sapiensENSP0000035177798.883497.2705lepisosteus_oculatusENSLOCP0000000796098.883497.2705
ENSG00000165280homo_sapiensENSP0000035177795.905793.1762clupea_harengusENSCHAP0000004310892.023889.4048
ENSG00000165280homo_sapiensENSP0000035177798.759396.7742danio_rerioENSDARP0000001204898.759396.7742
ENSG00000165280homo_sapiensENSP0000035177798.511295.7816carassius_auratusENSCARP0000009095698.389195.6629
ENSG00000165280homo_sapiensENSP0000035177798.26395.9057carassius_auratusENSCARP0000013438797.297394.9631
ENSG00000165280homo_sapiensENSP0000035177798.635296.5261ictalurus_punctatusENSIPUP0000001153698.635296.5261
ENSG00000165280homo_sapiensENSP0000035177797.890895.0372esox_luciusENSELUP0000006509097.648594.802
ENSG00000165280homo_sapiensENSP0000035177797.270594.7891esox_luciusENSELUP0000006846796.314593.8575
ENSG00000165280homo_sapiensENSP0000035177798.883496.7742electrophorus_electricusENSEEEP0000004738898.883496.7742
ENSG00000165280homo_sapiensENSP0000035177797.766795.0372oncorhynchus_kisutchENSOKIP0000500175897.524794.802
ENSG00000165280homo_sapiensENSP0000035177797.642794.5409oncorhynchus_kisutchENSOKIP0000510528195.975692.9268
ENSG00000165280homo_sapiensENSP0000035177794.789192.5558oncorhynchus_kisutchENSOKIP0000511414991.937489.7714
ENSG00000165280homo_sapiensENSP0000035177797.890895.1613oncorhynchus_kisutchENSOKIP0000508492088.452985.9865
ENSG00000165280homo_sapiensENSP0000035177797.766795.0372oncorhynchus_mykissENSOMYP0000006185297.524794.802
ENSG00000165280homo_sapiensENSP0000035177797.890895.1613oncorhynchus_mykissENSOMYP0000008595988.452985.9865
ENSG00000165280homo_sapiensENSP0000035177797.642795.2854oncorhynchus_mykissENSOMYP0000002581596.092893.7729
ENSG00000165280homo_sapiensENSP0000035177795.781693.3002salmo_salarENSSSAP0000000548485.587683.3703
ENSG00000165280homo_sapiensENSP0000035177791.687388.4615salmo_salarENSSSAP0000017656785.631582.6188
ENSG00000165280homo_sapiensENSP0000035177797.766794.7891salmo_salarENSSSAP0000008027494.711591.8269
ENSG00000165280homo_sapiensENSP0000035177797.642795.2854salmo_salarENSSSAP0000015894793.136190.8876
ENSG00000165280homo_sapiensENSP0000035177797.394594.665salmo_truttaENSSTUP0000009116896.083293.3904
ENSG00000165280homo_sapiensENSP0000035177793.548491.067salmo_truttaENSSTUP0000011523789.976187.5895
ENSG00000165280homo_sapiensENSP0000035177797.642795.2854salmo_truttaENSSTUP0000008214997.642795.2854
ENSG00000165280homo_sapiensENSP0000035177797.766794.665salmo_truttaENSSTUP0000003695395.515292.4848
ENSG00000165280homo_sapiensENSP0000035177797.766795.1613gadus_morhuaENSGMOP0000002927497.766795.1613
ENSG00000165280homo_sapiensENSP0000035177798.014995.6576fundulus_heteroclitusENSFHEP0000002757798.014995.6576
ENSG00000165280homo_sapiensENSP0000035177792.92890.8189poecilia_reticulataENSPREP0000000290598.423196.1892
ENSG00000165280homo_sapiensENSP0000035177798.014995.5335xiphophorus_maculatusENSXMAP0000000751998.014995.5335
ENSG00000165280homo_sapiensENSP0000035177797.642795.0372oryzias_latipesENSORLP0000001064496.68394.1032
ENSG00000165280homo_sapiensENSP0000035177797.890894.9132cyclopterus_lumpusENSCLMP0000504761397.407494.4444
ENSG00000165280homo_sapiensENSP0000035177797.518695.1613oreochromis_niloticusENSONIP0000004846396.323593.9951
ENSG00000165280homo_sapiensENSP0000035177798.13995.7816haplochromis_burtoniENSHBUP0000000867398.13995.7816
ENSG00000165280homo_sapiensENSP0000035177798.13995.7816astatotilapia_callipteraENSACLP0000000349398.13995.7816
ENSG00000165280homo_sapiensENSP0000035177798.13995.6576sparus_aurataENSSAUP0001003084598.13995.6576
ENSG00000165280homo_sapiensENSP0000035177791.935588.7097lates_calcariferENSLCAP0001006053384.977181.9954
ENSG00000165280homo_sapiensENSP0000035177799.131597.5186xenopus_tropicalisENSXETP0000009632999.254797.6398
ENSG00000165280homo_sapiensENSP0000035177799.007498.3871chrysemys_picta_belliiENSCPBP0000002520696.144695.5422
ENSG00000165280homo_sapiensENSP0000035177799.255698.263sphenodon_punctatusENSSPUP0000001440799.255698.263
ENSG00000165280homo_sapiensENSP0000035177796.526196.0298crocodylus_porosusENSCPRP0000502214695.69595.2029
ENSG00000165280homo_sapiensENSP0000035177799.007498.3871laticauda_laticaudataENSLLTP0000000862697.080396.472
ENSG00000165280homo_sapiensENSP0000035177799.379798.6352notechis_scutatusENSNSUP0000001590799.379798.6352
ENSG00000165280homo_sapiensENSP0000035177799.379798.7593pseudonaja_textilisENSPTXP0000001747299.379798.7593
ENSG00000165280homo_sapiensENSP0000035177799.627898.7593anas_platyrhynchos_platyrhynchosENSAPLP0000000413893.918193.0994
ENSG00000165280homo_sapiensENSP0000035177799.379798.7593gallus_gallusENSGALP0001001542294.235393.6471
ENSG00000165280homo_sapiensENSP0000035177799.379798.263gallus_gallusENSGALP0001001883594.569193.5065
ENSG00000165280homo_sapiensENSP0000035177799.627898.8834meleagris_gallopavoENSMGAP0000000215799.627898.8834
ENSG00000165280homo_sapiensENSP0000035177763.151462.2829meleagris_gallopavoENSMGAP0000000929894.962793.6567
ENSG00000165280homo_sapiensENSP0000035177792.183690.8189serinus_canariaENSSCAP0000002165298.541197.0822
ENSG00000165280homo_sapiensENSP0000035177787.344985.4839serinus_canariaENSSCAP0000000401987.780585.9102
ENSG00000165280homo_sapiensENSP0000035177799.751999.0074parus_majorENSPMJP0000000619799.751999.0074
ENSG00000165280homo_sapiensENSP0000035177799.379798.6352anolis_carolinensisENSACAP0000001165199.256598.513
ENSG00000165280homo_sapiensENSP0000035177798.13995.7816neolamprologus_brichardiENSNBRP0000000609298.13995.7816
ENSG00000165280homo_sapiensENSP0000035177799.379798.3871naja_najaENSNNAP0000002584686.221785.3606
ENSG00000165280homo_sapiensENSP0000035177799.503798.7593podarcis_muralisENSPMRP0000002062999.503798.7593
ENSG00000165280homo_sapiensENSP0000035177790.198590.0744geospiza_fortisENSGFOP0000001331110099.8624
ENSG00000165280homo_sapiensENSP0000035177799.255698.5112geospiza_fortisENSGFOP0000000419897.205396.4763
ENSG00000165280homo_sapiensENSP0000035177799.751999.0074taeniopygia_guttataENSTGUP0000000182599.751999.0074
ENSG00000165280homo_sapiensENSP0000035177798.883496.5261erpetoichthys_calabaricusENSECRP0000001048098.760896.4064
ENSG00000165280homo_sapiensENSP0000035177798.13995.0372kryptolebias_marmoratusENSKMAP0000001817598.13995.0372
ENSG00000165280homo_sapiensENSP0000035177799.503799.0074salvator_merianaeENSSMRP0000002610099.503799.0074
ENSG00000165280homo_sapiensENSP0000035177785.73282.134oryzias_javanicusENSOJAP0000004582992.133388.2667
ENSG00000165280homo_sapiensENSP0000035177792.92890.9429amphilophus_citrinellusENSACIP0000002646898.423196.3206
ENSG00000165280homo_sapiensENSP0000035177797.642795.1613dicentrarchus_labraxENSDLAP0000504879896.092893.6508
ENSG00000165280homo_sapiensENSP0000035177798.13995.6576amphiprion_perculaENSAPEP0000002979198.13995.6576
ENSG00000165280homo_sapiensENSP0000035177797.890895.2854oryzias_sinensisENSOSIP0000004306797.769595.1673
ENSG00000165280homo_sapiensENSP0000035177792.307791.5633pelodiscus_sinensisENSPSIP0000000232297.509896.7235
ENSG00000165280homo_sapiensENSP0000035177799.379798.6352gopherus_evgoodeiENSGEVP0000501568269.470968.9506
ENSG00000165280homo_sapiensENSP0000035177799.007498.3871chelonoidis_abingdoniiENSCABP0000000915996.144695.5422
ENSG00000165280homo_sapiensENSP0000035177798.13995.6576seriola_dumeriliENSSDUP0000002016398.13995.6576
ENSG00000165280homo_sapiensENSP0000035177798.014995.2854cottoperca_gobioENSCGOP0000002912498.014995.2854
ENSG00000165280homo_sapiensENSP0000035177797.394596.5261struthio_camelus_australisENSSCUP0000002513194.464593.6221
ENSG00000165280homo_sapiensENSP0000035177791.687390.5707anser_brachyrhynchusENSABRP0000001191397.880896.6887
ENSG00000165280homo_sapiensENSP0000035177797.890895.1613gasterosteus_aculeatusENSGACP0000001277097.890895.1613
ENSG00000165280homo_sapiensENSP0000035177798.014995.1613cynoglossus_semilaevisENSCSEP0000002101998.014995.1613
ENSG00000165280homo_sapiensENSP0000035177798.014995.0372cynoglossus_semilaevisENSCSEP0000001835198.014995.0372
ENSG00000165280homo_sapiensENSP0000035177797.890895.4094poecilia_formosaENSPFOP0000001672797.890895.4094
ENSG00000165280homo_sapiensENSP0000035177797.890895.6576myripristis_murdjanENSMMDP0000502327197.167594.9507
ENSG00000165280homo_sapiensENSP0000035177798.13995.0372sander_luciopercaENSSLUP0000005600498.13995.0372
ENSG00000165280homo_sapiensENSP0000035177770.471569.8511strigops_habroptilaENSSHBP0000502376194.666793.8333
ENSG00000165280homo_sapiensENSP0000035177794.168793.4243strigops_habroptilaENSSHBP0000501112099.737298.9488
ENSG00000165280homo_sapiensENSP0000035177798.13995.6576amphiprion_ocellarisENSAOCP0000000992598.13995.6576
ENSG00000165280homo_sapiensENSP0000035177799.503798.8834terrapene_carolina_triunguisENSTMTP0000001277799.503798.8834
ENSG00000165280homo_sapiensENSP0000035177797.518695.1613hucho_huchoENSHHUP0000003893796.323593.9951
ENSG00000165280homo_sapiensENSP0000035177796.650193.7965hucho_huchoENSHHUP0000003252696.410993.5644
ENSG00000165280homo_sapiensENSP0000035177797.890895.1613hucho_huchoENSHHUP0000004999597.890895.1613
ENSG00000165280homo_sapiensENSP0000035177797.270594.0447hucho_huchoENSHHUP0000000538696.909893.6959
ENSG00000165280homo_sapiensENSP0000035177797.890895.2854betta_splendensENSBSLP0000001762797.167594.5813
ENSG00000165280homo_sapiensENSP0000035177789.454187.3449pygocentrus_nattereriENSPNAP0000000423698.767196.4384
ENSG00000165280homo_sapiensENSP0000035177798.014995.5335anabas_testudineusENSATEP0000004965598.014995.5335
ENSG00000165280homo_sapiensENSP0000035177792.183684.8635ciona_savignyiENSCSAVP0000001823389.302982.2115
ENSG00000165280homo_sapiensENSP0000035177790.942988.2134seriola_lalandi_dorsalisENSSLDP0000000194689.499486.8132
ENSG00000165280homo_sapiensENSP0000035177798.13995.4094labrus_bergyltaENSLBEP0000001966198.13995.4094
ENSG00000165280homo_sapiensENSP0000035177798.13995.7816pundamilia_nyerereiENSPNYP0000002430198.13995.7816
ENSG00000165280homo_sapiensENSP0000035177797.642795.4094mastacembelus_armatusENSMAMP0000003691296.32894.1248
ENSG00000165280homo_sapiensENSP0000035177798.13995.6576stegastes_partitusENSSPAP0000002267298.13995.6576
ENSG00000165280homo_sapiensENSP0000035177797.890895.1613oncorhynchus_tshawytschaENSOTSP0000506753996.33793.6508
ENSG00000165280homo_sapiensENSP0000035177797.766795.0372oncorhynchus_tshawytschaENSOTSP0000500437597.524794.802
ENSG00000165280homo_sapiensENSP0000035177797.518694.4169oncorhynchus_tshawytschaENSOTSP0000508420989.216886.3791
ENSG00000165280homo_sapiensENSP0000035177795.037292.5558oncorhynchus_tshawytschaENSOTSP0000509730090.973988.5986
ENSG00000165280homo_sapiensENSP0000035177798.13995.6576acanthochromis_polyacanthusENSAPOP0000000931698.13995.6576
ENSG00000165280homo_sapiensENSP0000035177799.751999.0074aquila_chrysaetos_chrysaetosENSACCP0002002231199.751999.0074
ENSG00000165280homo_sapiensENSP0000035177796.277993.0521nothobranchius_furzeriENSNFUP0001504842192.712189.6057
ENSG00000165280homo_sapiensENSP0000035177798.13995.2854cyprinodon_variegatusENSCVAP0000000987498.13995.2854
ENSG00000165280homo_sapiensENSP0000035177798.26396.1538denticeps_clupeoidesENSDCDP0000001680898.019895.9158
ENSG00000165280homo_sapiensENSP0000035177798.13995.4094larimichthys_croceaENSLCRP0000500088797.89695.1733
ENSG00000165280homo_sapiensENSP0000035177795.905793.1762takifugu_rubripesENSTRUP0000004551694.383491.6972
ENSG00000165280homo_sapiensENSP0000035177799.255698.6352ficedula_albicollisENSFALP0000001020098.887598.2695
ENSG00000165280homo_sapiensENSP0000035177797.890894.7891hippocampus_comesENSHCOP0000001259997.890894.7891
ENSG00000165280homo_sapiensENSP0000035177798.387196.402cyprinus_carpio_carpioENSCCRP0000012792997.660195.6897
ENSG00000165280homo_sapiensENSP0000035177798.511296.1538cyprinus_carpio_carpioENSCCRP0000017418897.54395.2088
ENSG00000165280homo_sapiensENSP0000035177799.379798.6352coturnix_japonicaENSCJPP0000500628696.389995.6679
ENSG00000165280homo_sapiensENSP0000035177797.890895.4094poecilia_latipinnaENSPLAP0000002029597.890895.4094
ENSG00000165280homo_sapiensENSP0000035177766.253164.268sinocyclocheilus_grahamiENSSGRP0000004659598.706195.7486
ENSG00000165280homo_sapiensENSP0000035177785.980182.2581sinocyclocheilus_grahamiENSSGRP0000010806191.184287.2368
ENSG00000165280homo_sapiensENSP0000035177798.13995.7816maylandia_zebraENSMZEP0000502261898.13995.7816
ENSG00000165280homo_sapiensENSP0000035177797.766795.2854tetraodon_nigroviridisENSTNIP0000001846398.009995.5224
ENSG00000165280homo_sapiensENSP0000035177798.759396.8983paramormyrops_kingsleyaeENSPKIP0000004008994.874893.087
ENSG00000165280homo_sapiensENSP0000035177798.883496.6501paramormyrops_kingsleyaeENSPKIP0000003548798.883496.6501
ENSG00000165280homo_sapiensENSP0000035177796.650194.9132scleropages_formosusENSSFOP0001506169294.768993.0657
ENSG00000165280homo_sapiensENSP0000035177798.511296.5261scleropages_formosusENSSFOP0001505287394.636592.7294
ENSG00000165280homo_sapiensENSP0000035177798.635297.1464leptobrachium_leishanenseENSLLEP0000000166898.148196.6667
ENSG00000165280homo_sapiensENSP0000035177722.084419.4789leptobrachium_leishanenseENSLLEP0000003674876.724167.6724
ENSG00000165280homo_sapiensENSP0000035177798.014995.1613scophthalmus_maximusENSSMAP0000004620397.893495.0434
ENSG00000165280homo_sapiensENSP0000035177798.014995.5335oryzias_melastigmaENSOMEP0000000348898.014995.5335

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000502part_of proteasome complex1IDAHomo_sapiens(9606)Component
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005634located_in nucleus4HDA,IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,NASHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1IDAHomo_sapiens(9606)Component
GO:0005789is_active_in endoplasmic reticulum membrane3IDA,TASHomo_sapiens(9606)Component
GO:0005811located_in lipid droplet1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1NASHomo_sapiens(9606)Process
GO:0006302involved_in double-strand break repair1IDAHomo_sapiens(9606)Process
GO:0006734involved_in NADH metabolic process1IMPHomo_sapiens(9606)Process
GO:0006888involved_in endoplasmic reticulum to Golgi vesicle-mediated transport1IEAHomo_sapiens(9606)Process
GO:0006914involved_in autophagy1IMPHomo_sapiens(9606)Process
GO:0006919involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process1ISSHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IDAHomo_sapiens(9606)Process
GO:0008289enables lipid binding1IEAHomo_sapiens(9606)Function
GO:0010494located_in cytoplasmic stress granule1IDAHomo_sapiens(9606)Component
GO:0010498involved_in proteasomal protein catabolic process1IMPHomo_sapiens(9606)Process
GO:0010918involved_in positive regulation of mitochondrial membrane potential1IMPHomo_sapiens(9606)Process
GO:0016236involved_in macroautophagy1IMPHomo_sapiens(9606)Process
GO:0016567involved_in protein ubiquitination2IDA,NASHomo_sapiens(9606)Process
GO:0016887enables ATP hydrolysis activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0019079involved_in viral genome replication1IMPHomo_sapiens(9606)Process
GO:0019903enables protein phosphatase binding1IPIHomo_sapiens(9606)Function
GO:0019904enables protein domain specific binding1IPIHomo_sapiens(9606)Function
GO:0019985involved_in translesion synthesis1IMPHomo_sapiens(9606)Process
GO:0030433involved_in ubiquitin-dependent ERAD pathway5IBA,IDA,IMP,ISO,TASHomo_sapiens(9606)Process
GO:0030968involved_in endoplasmic reticulum unfolded protein response1TASHomo_sapiens(9606)Process
GO:0030970involved_in retrograde protein transport, ER to cytosol4IBA,IDA,IMP,ISOHomo_sapiens(9606)Process
GO:0031334involved_in positive regulation of protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0031593enables polyubiquitin modification-dependent protein binding2IBA,IDAHomo_sapiens(9606)Function
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0032436involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0032510involved_in endosome to lysosome transport via multivesicular body sorting pathway1IMPHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0034098part_of VCP-NPL4-UFD1 AAA ATPase complex4IBA,IPI,ISS,TASHomo_sapiens(9606)Component
GO:0034605involved_in cellular response to heat1IMPHomo_sapiens(9606)Process
GO:0034774located_in secretory granule lumen1TASHomo_sapiens(9606)Component
GO:0035578located_in azurophil granule lumen1TASHomo_sapiens(9606)Component
GO:0035617involved_in stress granule disassembly1IMPHomo_sapiens(9606)Process
GO:0035800enables deubiquitinase activator activity1IDAHomo_sapiens(9606)Function
GO:0035861located_in site of double-strand break1IDAHomo_sapiens(9606)Component
GO:0036297involved_in interstrand cross-link repair1ISSHomo_sapiens(9606)Process
GO:0036435enables K48-linked polyubiquitin modification-dependent protein binding1IEAHomo_sapiens(9606)Function
GO:0036503involved_in ERAD pathway2IDA,IMPHomo_sapiens(9606)Process
GO:0036513part_of Derlin-1 retrotranslocation complex1IDAHomo_sapiens(9606)Component
GO:0042288enables MHC class I protein binding1IEAHomo_sapiens(9606)Function
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042981involved_in regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0043161involved_in proteasome-mediated ubiquitin-dependent protein catabolic process2IMP,NASHomo_sapiens(9606)Process
GO:0043231located_in intracellular membrane-bounded organelle1ISSHomo_sapiens(9606)Component
GO:0043531enables ADP binding1IEAHomo_sapiens(9606)Function
GO:0044389enables ubiquitin-like protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0045184involved_in establishment of protein localization1TASHomo_sapiens(9606)Process
GO:0045732involved_in positive regulation of protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0045879involved_in negative regulation of smoothened signaling pathway1IMPHomo_sapiens(9606)Process
GO:0046034involved_in ATP metabolic process1IEAHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0050807involved_in regulation of synapse organization1IEAHomo_sapiens(9606)Process
GO:0051228involved_in mitotic spindle disassembly1IBAHomo_sapiens(9606)Process
GO:0061857involved_in endoplasmic reticulum stress-induced pre-emptive quality control1IMPHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070842involved_in aggresome assembly1IEAHomo_sapiens(9606)Process
GO:0071712involved_in ER-associated misfolded protein catabolic process2IBA,IMPHomo_sapiens(9606)Process
GO:0072389involved_in flavin adenine dinucleotide catabolic process1IMPHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway1IDAHomo_sapiens(9606)Process
GO:0097352involved_in autophagosome maturation2IBA,IMPHomo_sapiens(9606)Process
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0106300involved_in protein-DNA covalent cross-linking repair1IDAHomo_sapiens(9606)Process
GO:0120186involved_in negative regulation of protein localization to chromatin1IDAHomo_sapiens(9606)Process
GO:0140036enables ubiquitin-dependent protein binding1IDAHomo_sapiens(9606)Function
GO:1903006involved_in positive regulation of protein K63-linked deubiquitination1IDAHomo_sapiens(9606)Process
GO:1903007involved_in positive regulation of Lys63-specific deubiquitinase activity1IDAHomo_sapiens(9606)Process
GO:1903715involved_in regulation of aerobic respiration1IMPHomo_sapiens(9606)Process
GO:1903843involved_in cellular response to arsenite ion1IMPHomo_sapiens(9606)Process
GO:1903862involved_in positive regulation of oxidative phosphorylation1IMPHomo_sapiens(9606)Process
GO:1904288enables BAT3 complex binding1IPIHomo_sapiens(9606)Function
GO:1904813located_in ficolin-1-rich granule lumen1TASHomo_sapiens(9606)Component
GO:1904949part_of ATPase complex1IEAHomo_sapiens(9606)Component
GO:1905634involved_in regulation of protein localization to chromatin1IDAHomo_sapiens(9606)Process
GO:1990381enables ubiquitin-specific protease binding1IPIHomo_sapiens(9606)Function
GO:1990730part_of VCP-NSFL1C complex2ISO,ISSHomo_sapiens(9606)Component
GO:2001171involved_in positive regulation of ATP biosynthetic process1IMPHomo_sapiens(9606)Process

Expression