Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000164362 Gene ID 7015 Accession 11730
Symbol TERT Alias TP2;TRT;CMM9;EST2;TCS1;hTRT;DKCA2;DKCB4;hEST2;PFBMFT1 Full Name telomerase reverse transcriptase
Status Confidence Length 41902 bases Strand Minus strand
Position 5 : 1253167 - 1295068 RNA binding domain Telomerase_RBD , RVT_1
Summary Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000425003 Telomerase_RBD PF12009 1.7e-40 1
ENSP00000334346 Telomerase_RBD PF12009 2.1e-40 1
ENSP00000309572 Telomerase_RBD PF12009 2.4e-40 1
ENSP00000309572 RVT_1 PF00078 7.2e-12 2
ENSP00000499759 Telomerase_RBD PF12009 7.9e-17 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31903880 Telomere-related Markers for Cancer. Xiaotian Yuan 2020-01-01 Current topics in medicinal chemistry
11809815 Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. J Tara Moriarty 2002-02-01 Molecular and cellular biology
37531400 Dynamics of TERT regulation via alternative splicing in stem cells and cancer cells. J Jeongjin Kim 2023-01-01 PloS one
33553693 Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer. Kumar Vikas Bhari 2021-07-01 Biochemistry and biophysics reports
32242127 Regulation of human telomerase in homeostasis and disease. M Caitlin Roake 2020-07-01 Nature reviews. Molecular cell biology
34474152 Post-transcriptional diversity in riboproteins and RNAs in aging and cancer. Jurandir Cruz 2021-11-01 Seminars in cancer biology
22244753 Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. A Karen Lewis 2012-01-11 Structure (London, England : 1993)
35477117 Functional interaction between compound heterozygous TERT mutations causes severe telomere biology disorder. Aram Niaz 2022-06-28 Blood advances
37009488 Proteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei. A Justin Davis 2023-01-01 Frontiers in cell and developmental biology
28441946 The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa. G Alvina Lai 2017-04-26 BMC evolutionary biology
23447707 A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Yasmin D'Souza 2013-05-01 Molecular biology of the cell
28264499 Current Insights to Regulation and Role of Telomerase in Human Diseases. Burak Mert Ozturk 2017-02-28 Antioxidants (Basel, Switzerland)
33046533 A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit. A Melissa Mefford 2020-11-20 Molecular and cellular biology
34083519 Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Gabrijela Dumbović 2021-06-03 Nature communications
25684364 A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Itamar Harel 2015-02-26 Cell
24957604 Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase. K Varuni Jamburuthugoda 2014-07-01 Nucleic acids research
27359343 Evolutionary perspectives of telomerase RNA structure and function. D Joshua Podlevsky 2016-08-02 RNA biology
23901009 Many disease-associated variants of hTERT retain high telomerase enzymatic activity. J Arthur Zaug 2013-10-01 Nucleic acids research
23299958 Finding the end: recruitment of telomerase to telomeres. Jayakrishnan Nandakumar 2013-02-01 Nature reviews. Molecular cell biology
31091669 Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer. T Andrew Ludlow 2019-05-14 Cancers
31892146 Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects. Esteban Rodríguez-Arce 2019-12-27 Molecules (Basel, Switzerland)
22093366 It all comes together at the ends: telomerase structure, function, and biogenesis. D Joshua Podlevsky 2012-02-01 Mutation research
21816660 Single-stranded DNA repeat synthesis by telomerase. Kathleen Collins 2011-10-01 Current opinion in chemical biology
27768860 Means to the ends: The role of telomeres and telomere processing machinery in metastasis. J Nathaniel Robinson 2016-12-01 Biochimica et biophysica acta
28375735 Single-Molecule Studies of Telomeres and Telomerase. W Joseph Parks 2017-05-22 Annual review of biophysics

Transcripts

Name Transcript ID bp Protein Translation ID
TERT-204 ENST00000484238 2422 No protein -
TERT-206 ENST00000656021 5289 574aa ENSP00000499759
TERT-201 ENST00000310581 4039 1132aa ENSP00000309572
TERT-202 ENST00000334602 3210 1069aa ENSP00000334346
TERT-203 ENST00000460137 2992 795aa ENSP00000425003
TERT-207 ENST00000667927 493 No protein -
TERT-205 ENST00000503656 406 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
16434Pancreatic Neoplasms1.046E-0622523087
56341Glioma4.2800000E-009-
56342Glioma2.1630000E-008-
56741Lung Neoplasms4.2400000E-027-
56778Adenocarcinoma of lung2.6750000E-025-
57013Lung Diseases, Interstitial7.5983770E-014-
57014Lung Diseases, Interstitial8.9298720E-007-
60685Erythrocyte Indices1E-828017375
61774Leukemia, Lymphocytic, Chronic, B-Cell6E-826956414
63983Lung Diseases, Interstitial2E-1923583980
64075Glioma4E-1419578367
64599Melanoma7E-1228212542
65728Pancreatic Carcinoma2E-827579533
67029Breast Neoplasms3E-1427117709
67341Glioma4E-2026424050
68343Breast Neoplasms3E-1427117709
69229Breast Neoplasms5E-1223535733
69254Adenocarcinoma of lung2E-3127501781
70402Triple Negative Breast Neoplasms1E-724325915
71383Lung Neoplasms1E-2721725308
73602Lung Neoplasms4E-2723143601
74121Pancreatic Carcinoma1E-1325086665
74864Erythrocyte Count3E-628017375
76217Glioma1E-1421531791
76629Prostatic Neoplasms3E-2421743467
76831Ovarian Neoplasms9E-925581431
77307Breast Neoplasms3E-827117709
78062Idiopathic Pulmonary Fibrosis3E-818835860
79373Adenocarcinoma of lung3E-1120871597
80028Breast Neoplasms2E-1028171663
81692Breast Neoplasms5E-628171663
82448Breast Neoplasms2E-627117709
82959Glioma1E-1524908248
83768Thyroid Neoplasms3E-728195142
84220Glioma8E-726424050
85887Erythrocyte Count2E-1128017375
86938Adenocarcinoma of lung2E-1027197191
86939Breast Neoplasms2E-1027197191
86940Carcinoma, Non-Small-Cell Lung2E-1027197191
86941Lung Neoplasms2E-1027197191
86942Ovarian Neoplasms2E-1027197191
86943Prostatic Neoplasms2E-1027197191
86944Colorectal Neoplasms2E-1027197191
86945Carcinoma, Endometrioid2E-1027197191
87389Testicular Neoplasms5E-2423666240
88937Telomere4E-624465473
89637Prostatic Neoplasms3E-1125939597
89910Adenocarcinoma of lung3E-4022797724
91098Breast Neoplasms1E-827117709
91266Adenocarcinoma of lung2E-1019836008
92687Breast Neoplasms7E-923535729
92923Glioma7E-921827660
93077Adenocarcinoma of lung1E-827393504
94648Leukemia, Lymphocytic, Chronic, B-Cell6E-1028165464
95114Lung Neoplasms3E-927393504
95469Breast Neoplasms1E-1022037553
96404Breast Neoplasms8E-2827117709
97607Glioma2E-1719578367
98297Glioma4E-922886559
98368Glioblastoma6E-2426424050
98511Testicular Neoplasms8E-1520543847
98608Erythrocyte Count3E-820139978
105321Adenocarcinoma of lung2E-2220700438
106257Testicular Neoplasms1E-2320543847

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164362

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164362homo_sapiensENSP0000030957281.890580.7421nomascus_leucogenysENSNLEP0000001351294.303292.9807
ENSG00000164362homo_sapiensENSP0000030957291.607890.9894pan_paniscusENSPPAP0000001278199.711599.0385
ENSG00000164362homo_sapiensENSP0000030957248.586647.5265pongo_abeliiENSPPYP0000002523595.818893.7282
ENSG00000164362homo_sapiensENSP0000030957298.939998.4099pongo_abeliiENSPPYP0000001710898.939998.4099
ENSG00000164362homo_sapiensENSP0000030957267.226267.1378pan_troglodytesENSPTRP0000002863799.868899.7375
ENSG00000164362homo_sapiensENSP0000030957231.625431.0954pan_troglodytesENSPTRP0000006177799.444497.7778
ENSG00000164362homo_sapiensENSP0000030957299.646699.2049gorilla_gorillaENSGGOP0000000257099.646699.2049
ENSG00000164362homo_sapiensENSP0000030957267.844554.3286ornithorhynchus_anatinusENSOANP0000005030059.259347.4537
ENSG00000164362homo_sapiensENSP0000030957269.699654.5053sarcophilus_harrisiiENSSHAP0000003058658.271845.5687
ENSG00000164362homo_sapiensENSP0000030957239.222632.9505notamacropus_eugeniiENSMEUP0000000123143.873536.8577
ENSG00000164362homo_sapiensENSP0000030957275.441766.7845dasypus_novemcinctusENSDNOP0000003154272.866964.5051
ENSG00000164362homo_sapiensENSP0000030957240.547735.2473echinops_telfairiENSETEP0000001369375.742665.8416
ENSG00000164362homo_sapiensENSP0000030957290.989486.3958callithrix_jacchusENSCJAP0000007048991.882287.2435
ENSG00000164362homo_sapiensENSP0000030957293.639691.2544cercocebus_atysENSCATP0000002636194.3991.9858
ENSG00000164362homo_sapiensENSP0000030957289.57687.6325macaca_fascicularisENSMFAP0000002036394.063192.0223
ENSG00000164362homo_sapiensENSP0000030957297.261595.6714macaca_mulattaENSMMUP0000001434997.433695.8407
ENSG00000164362homo_sapiensENSP0000030957297.526595.8481macaca_nemestrinaENSMNEP0000003626297.526595.8481
ENSG00000164362homo_sapiensENSP0000030957290.547787.8975papio_anubisENSPANP0000003745989.912387.2807
ENSG00000164362homo_sapiensENSP0000030957231.272130.6537mandrillus_leucophaeusENSMLEP0000001513398.333396.3889
ENSG00000164362homo_sapiensENSP0000030957270.229762.5442tursiops_truncatusENSTTRP0000000363670.729562.9893
ENSG00000164362homo_sapiensENSP0000030957275.795167.9329vulpes_vulpesENSVVUP0000003054078.142170.0364
ENSG00000164362homo_sapiensENSP0000030957272.791562.1908mus_spretusMGP_SPRETEiJ_P003653273.244462.5778
ENSG00000164362homo_sapiensENSP0000030957284.187376.6784equus_asinusENSEASP0000502722584.41176.8822
ENSG00000164362homo_sapiensENSP0000030957277.561869.8763capra_hircusENSCHIP0000000399978.183470.4363
ENSG00000164362homo_sapiensENSP0000030957277.915269.523loxodonta_africanaENSLAFP0000001094380.695372.0037
ENSG00000164362homo_sapiensENSP0000030957279.328671.5548panthera_leoENSPLOP0000000523880.828172.9073
ENSG00000164362homo_sapiensENSP0000030957280.565473.8516ailuropoda_melanoleucaENSAMEP0000001117681.355974.5763
ENSG00000164362homo_sapiensENSP0000030957277.650269.8763bos_indicus_hybridENSBIXP0000504334379.475671.519
ENSG00000164362homo_sapiensENSP0000030957284.010676.4134equus_caballusENSECAP0000000128082.623875.152
ENSG00000164362homo_sapiensENSP0000030957279.41771.8198canis_lupus_familiarisENSCAFP0084503611177.70170.2679
ENSG00000164362homo_sapiensENSP0000030957279.240371.3781panthera_pardusENSPPRP0000001311380.738172.7273
ENSG00000164362homo_sapiensENSP0000030957268.286259.8057marmota_marmota_marmotaENSMMMP0000001841871.113262.2815
ENSG00000164362homo_sapiensENSP0000030957281.007172.9682balaenoptera_musculusENSBMSP0001001913381.366573.2919
ENSG00000164362homo_sapiensENSP0000030957271.643162.9859cavia_porcellusENSCPOP0000001403079.66670.0393
ENSG00000164362homo_sapiensENSP0000030957276.413468.7279felis_catusENSFCAP0000006079066.436259.7542
ENSG00000164362homo_sapiensENSP0000030957280.830473.6749ursus_americanusENSUAMP0000001762381.915874.6643
ENSG00000164362homo_sapiensENSP0000030957267.756252.2085monodelphis_domesticaENSMODP0000003699060.204146.3893
ENSG00000164362homo_sapiensENSP0000030957280.565472.2615monodon_monocerosENSMMNP0001500692180.922872.5821
ENSG00000164362homo_sapiensENSP0000030957279.94771.9081sus_scrofaENSSSCP0000001813580.088572.0354
ENSG00000164362homo_sapiensENSP0000030957280.830473.5866microcebus_murinusENSMICP0000000992183.257575.7962
ENSG00000164362homo_sapiensENSP0000030957271.554861.4841octodon_degusENSODEP0000002498078.488467.4419
ENSG00000164362homo_sapiensENSP0000030957265.10654.0636jaculus_jaculusENSJJAP0000001193172.610860.2956
ENSG00000164362homo_sapiensENSP0000030957277.826970.4064ovis_aries_rambouilletENSOARP0002001355978.450670.9706
ENSG00000164362homo_sapiensENSP0000030957254.505347.7032ochotona_princepsENSOPRP0000000569964.20456.1915
ENSG00000164362homo_sapiensENSP0000030957272.349864.3993delphinapterus_leucasENSDLEP0000000492768.079860.5985
ENSG00000164362homo_sapiensENSP0000030957280.565472.4382physeter_catodonENSPCTP0000500200381.355973.149
ENSG00000164362homo_sapiensENSP0000030957272.968262.2792mus_caroliMGP_CAROLIEiJ_P003486173.422262.6667
ENSG00000164362homo_sapiensENSP0000030957272.614861.9258mus_musculusENSMUSP0000002210473.26262.4777
ENSG00000164362homo_sapiensENSP0000030957279.063671.0247mustela_putorius_furoENSMPUP0000000884780.413372.2372
ENSG00000164362homo_sapiensENSP0000030957289.134384.5406aotus_nancymaaeENSANAP0000002861792.146187.3973
ENSG00000164362homo_sapiensENSP0000030957287.102582.5088saimiri_boliviensis_boliviensisENSSBOP0000002835589.963585.219
ENSG00000164362homo_sapiensENSP0000030957297.261595.583chlorocebus_sabaeusENSCSAP0000001340397.261595.583
ENSG00000164362homo_sapiensENSP0000030957272.173161.2191mesocricetus_auratusENSMAUP0000000623173.869862.6582
ENSG00000164362homo_sapiensENSP0000030957280.123772.0848phocoena_sinusENSPSNP0000000318080.479172.4046
ENSG00000164362homo_sapiensENSP0000030957280.742172.9682camelus_dromedariusENSCDRP0000501031280.528672.7753
ENSG00000164362homo_sapiensENSP0000030957277.120168.7279carlito_syrichtaENSTSYP0000003275380.983372.1707
ENSG00000164362homo_sapiensENSP0000030957241.872836.7491panthera_tigris_altaicaENSPTIP0000000707373.261264.2968
ENSG00000164362homo_sapiensENSP0000030957272.526562.8092rattus_norvegicusENSRNOP0000007697172.977863.2
ENSG00000164362homo_sapiensENSP0000030957225.706723.8516prolemur_simusENSPSMP0000001447281.284975.419
ENSG00000164362homo_sapiensENSP0000030957271.996560.424microtus_ochrogasterENSMOCP0000000266471.869560.3175
ENSG00000164362homo_sapiensENSP0000030957273.586663.0742peromyscus_maniculatus_bairdiiENSPEMP0000001361774.242463.6364
ENSG00000164362homo_sapiensENSP0000030957256.272149.3816bos_mutusENSBMUP0000002652851.704545.3734
ENSG00000164362homo_sapiensENSP0000030957273.056562.1908mus_spicilegusENSMSIP0000002002373.511162.5778
ENSG00000164362homo_sapiensENSP0000030957273.939963.0742cricetulus_griseus_chok1gshdENSCGRP0000101072574.136463.2418
ENSG00000164362homo_sapiensENSP0000030957266.872859.4523pteropus_vampyrusENSPVAP0000000000766.991159.5575
ENSG00000164362homo_sapiensENSP0000030957278.003569.523myotis_lucifugusENSMLUP0000001141280.565771.8066
ENSG00000164362homo_sapiensENSP0000030957268.639653.8869vombatus_ursinusENSVURP0001002835060.232647.2868
ENSG00000164362homo_sapiensENSP0000030957278.356970.9364rhinolophus_ferrumequinumENSRFEP0001000298881.078673.4004
ENSG00000164362homo_sapiensENSP0000030957273.939965.8127neovison_visonENSNVIP0000003166170.872163.0821
ENSG00000164362homo_sapiensENSP0000030957278.356970.4064bos_taurusENSBTAP0000001668578.844470.8444
ENSG00000164362homo_sapiensENSP0000030957227.915224.5583heterocephalus_glaber_femaleENSHGLP0000000952076.328567.1498
ENSG00000164362homo_sapiensENSP0000030957297.084896.0247rhinopithecus_bietiENSRBIP0000001644294.173193.1448
ENSG00000164362homo_sapiensENSP0000030957279.41771.8198canis_lupus_dingoENSCAFP0002002935580.196372.5245
ENSG00000164362homo_sapiensENSP0000030957277.915269.788sciurus_vulgarisENSSVLP0000500954379.963771.6228
ENSG00000164362homo_sapiensENSP0000030957269.876354.682phascolarctos_cinereusENSPCIP0000000027158.723145.954
ENSG00000164362homo_sapiensENSP0000030957256.360450.3534procavia_capensisENSPCAP0000001023058.318152.1024
ENSG00000164362homo_sapiensENSP0000030957275.971768.1095nannospalax_galiliENSNGAP0000000045276.308868.4117
ENSG00000164362homo_sapiensENSP0000030957278.356970.4064bos_grunniensENSBGRP0000001244371.187863.9647
ENSG00000164362homo_sapiensENSP0000030957264.752656.0954chinchilla_lanigeraENSCLAP0000000878675.801465.667
ENSG00000164362homo_sapiensENSP0000030957277.208568.7279cervus_hanglu_yarkandensisENSCHYP0000003047669.365161.746
ENSG00000164362homo_sapiensENSP0000030957243.462938.3392catagonus_wagneriENSCWAP0000000031783.81673.9353
ENSG00000164362homo_sapiensENSP0000030957277.385268.9929ictidomys_tridecemlineatusENSSTOP0000001904681.186372.3818
ENSG00000164362homo_sapiensENSP0000030957281.802174.47otolemur_garnettiiENSOGAP0000001745681.874574.5358
ENSG00000164362homo_sapiensENSP0000030957291.961187.6325cebus_imitatorENSCCAP0000002630992.863588.4924
ENSG00000164362homo_sapiensENSP0000030957278.268669.9647urocitellus_parryiiENSUPAP0001001416680.472371.9346
ENSG00000164362homo_sapiensENSP0000030957274.646666.5194moschus_moschiferusENSMMSP0000002476676.748468.3924
ENSG00000164362homo_sapiensENSP0000030957297.084896.1131rhinopithecus_roxellanaENSRROP0000001689297.084896.1131
ENSG00000164362homo_sapiensENSP0000030957273.144962.8975mus_pahariMGP_PahariEiJ_P002652673.663.2889
ENSG00000164362homo_sapiensENSP0000030957254.240349.8233propithecus_coquereliENSPCOP0000002543282.195475.502
ENSG00000164362homo_sapiensENSP0000030957225.353423.5866propithecus_coquereliENSPCOP0000000277686.969780.9091
ENSG00000164362homo_sapiensENSP0000030957219.87638.83392caenorhabditis_elegansDY3.4a.340.10717.8253
ENSG00000164362homo_sapiensENSP0000030957232.508817.9329ciona_intestinalisENSCINP0000001842040.70822.4558
ENSG00000164362homo_sapiensENSP0000030957253.356939.1343eptatretus_burgeriENSEBUP0000000992847.335434.7179
ENSG00000164362homo_sapiensENSP0000030957258.038943.4629callorhinchus_miliiENSCMIP0000004813655.349641.449
ENSG00000164362homo_sapiensENSP0000030957237.632527.1201latimeria_chalumnaeENSLACP0000000782243.737231.5195
ENSG00000164362homo_sapiensENSP0000030957253.091937.2792lepisosteus_oculatusENSLOCP0000000416756.912939.9621
ENSG00000164362homo_sapiensENSP0000030957247.968234.364clupea_harengusENSCHAP0000000257050.138535.9187
ENSG00000164362homo_sapiensENSP0000030957246.466431.8021danio_rerioENSDARP0000012498847.905332.7869
ENSG00000164362homo_sapiensENSP0000030957224.73517.7562carassius_auratusENSCARP0000012883745.826532.8969
ENSG00000164362homo_sapiensENSP0000030957246.113132.8622carassius_auratusENSCARP0000001574151.226736.5064
ENSG00000164362homo_sapiensENSP0000030957243.992929.417astyanax_mexicanusENSAMXP0000004076447.930732.05
ENSG00000164362homo_sapiensENSP0000030957245.31831.2721ictalurus_punctatusENSIPUP0000003398046.763932.2698
ENSG00000164362homo_sapiensENSP0000030957248.851635.0707esox_luciusENSELUP0000001572448.981435.1639
ENSG00000164362homo_sapiensENSP0000030957246.378133.2155electrophorus_electricusENSEEEP0000003518449.43535.4049
ENSG00000164362homo_sapiensENSP0000030957249.381636.0424oncorhynchus_kisutchENSOKIP0000501134243.603731.8253
ENSG00000164362homo_sapiensENSP0000030957249.558336.2191oncorhynchus_mykissENSOMYP0000013612047.461934.687
ENSG00000164362homo_sapiensENSP0000030957247.438234.0989salmo_salarENSSSAP0000005845346.253233.2472
ENSG00000164362homo_sapiensENSP0000030957249.646636.3074salmo_truttaENSSTUP0000008773442.511331.0893
ENSG00000164362homo_sapiensENSP0000030957249.293334.629gadus_morhuaENSGMOP0000006563550.681235.604
ENSG00000164362homo_sapiensENSP0000030957249.381634.894fundulus_heteroclitusENSFHEP0000002062150.818235.9091
ENSG00000164362homo_sapiensENSP0000030957249.293334.1873poecilia_reticulataENSPREP0000002766550.819735.2459
ENSG00000164362homo_sapiensENSP0000030957249.381634.7173xiphophorus_maculatusENSXMAP0000001643250.957235.825
ENSG00000164362homo_sapiensENSP0000030957248.586634.0989oryzias_latipesENSORLP0000001746750.458735.4128
ENSG00000164362homo_sapiensENSP0000030957248.851635.5124cyclopterus_lumpusENSCLMP0000501445250.920837.0166
ENSG00000164362homo_sapiensENSP0000030957248.144933.8339oreochromis_niloticusENSONIP0000004018446.700932.8192
ENSG00000164362homo_sapiensENSP0000030957247.526533.2155haplochromis_burtoniENSHBUP0000003246649.63134.6863
ENSG00000164362homo_sapiensENSP0000030957248.233233.7456astatotilapia_callipteraENSACLP0000000647649.86334.8858
ENSG00000164362homo_sapiensENSP0000030957248.409934.5406sparus_aurataENSSAUP0001001043649.369435.2252
ENSG00000164362homo_sapiensENSP0000030957247.526533.8339lates_calcariferENSLCAP0001005361648.909134.8182
ENSG00000164362homo_sapiensENSP0000030957260.600744.3463xenopus_tropicalisENSXETP0000003411355.636740.7137
ENSG00000164362homo_sapiensENSP0000030957265.017750.3534chrysemys_picta_belliiENSCPBP0000002237154.437942.1598
ENSG00000164362homo_sapiensENSP0000030957260.247345.6714sphenodon_punctatusENSSPUP0000000543861.220846.4093
ENSG00000164362homo_sapiensENSP0000030957262.014148.2332crocodylus_porosusENSCPRP0000502035055.188742.9245
ENSG00000164362homo_sapiensENSP0000030957259.452343.8163laticauda_laticaudataENSLLTP0000001695553.668339.5534
ENSG00000164362homo_sapiensENSP0000030957262.014145.8481notechis_scutatusENSNSUP0000001362753.91739.8618
ENSG00000164362homo_sapiensENSP0000030957259.452343.8163pseudonaja_textilisENSPTXP0000000566753.582839.4904
ENSG00000164362homo_sapiensENSP0000030957262.985947.0848anas_platyrhynchos_platyrhynchosENSAPLP0000001778852.932439.5694
ENSG00000164362homo_sapiensENSP0000030957262.897548.3216gallus_gallusENSGALP0001001098852.4340.2798
ENSG00000164362homo_sapiensENSP0000030957259.36445.4947meleagris_gallopavoENSMGAP0000001722253.545841.0359
ENSG00000164362homo_sapiensENSP0000030957259.62945.318serinus_canariaENSSCAP0000000787152.447639.8601
ENSG00000164362homo_sapiensENSP0000030957262.014146.5548parus_majorENSPMJP0000001834146.093234.6028
ENSG00000164362homo_sapiensENSP0000030957262.897546.2014anolis_carolinensisENSACAP0000000140753.373339.2054
ENSG00000164362homo_sapiensENSP0000030957248.233233.8339neolamprologus_brichardiENSNBRP0000002665449.86334.9772
ENSG00000164362homo_sapiensENSP0000030957259.010643.2862naja_najaENSNNAP0000000137352.889938.7965
ENSG00000164362homo_sapiensENSP0000030957264.31148.0565podarcis_muralisENSPMRP0000001779651.485138.4724
ENSG00000164362homo_sapiensENSP0000030957256.537143.0212geospiza_fortisENSGFOP0000000943353.200340.4821
ENSG00000164362homo_sapiensENSP0000030957262.367547.5265taeniopygia_guttataENSTGUP0000002380352.568940.0596
ENSG00000164362homo_sapiensENSP0000030957258.745642.3145erpetoichthys_calabaricusENSECRP0000001867053.157538.2894
ENSG00000164362homo_sapiensENSP0000030957249.204933.6572kryptolebias_marmoratusENSKMAP0000002933450.452934.5109
ENSG00000164362homo_sapiensENSP0000030957262.632547.2615salvator_merianaeENSSMRP0000001989756.225242.4266
ENSG00000164362homo_sapiensENSP0000030957248.144933.3039oryzias_javanicusENSOJAP0000002965350.13834.6826
ENSG00000164362homo_sapiensENSP0000030957247.879933.7456amphilophus_citrinellusENSACIP0000002258849.362534.7905
ENSG00000164362homo_sapiensENSP0000030957248.321634.4523dicentrarchus_labraxENSDLAP0000503208449.817935.5191
ENSG00000164362homo_sapiensENSP0000030957248.409933.6572amphiprion_perculaENSAPEP0000000155949.413934.3553
ENSG00000164362homo_sapiensENSP0000030957261.219146.9081pelodiscus_sinensisENSPSIP0000001412655.175242.2771
ENSG00000164362homo_sapiensENSP0000030957264.57649.5583gopherus_evgoodeiENSGEVP0000500287655.336942.4678
ENSG00000164362homo_sapiensENSP0000030957264.045948.8516chelonoidis_abingdoniiENSCABP0000000880254.924241.8939
ENSG00000164362homo_sapiensENSP0000030957249.911735.5124seriola_dumeriliENSSDUP0000000249050.992836.2816
ENSG00000164362homo_sapiensENSP0000030957248.939934.7173cottoperca_gobioENSCGOP000000110565035.4693
ENSG00000164362homo_sapiensENSP0000030957258.127243.9046anser_brachyrhynchusENSABRP0000002278154.067440.8381
ENSG00000164362homo_sapiensENSP0000030957248.939935.159gasterosteus_aculeatusENSGACP0000001223850.045235.953
ENSG00000164362homo_sapiensENSP0000030957245.31831.1837cynoglossus_semilaevisENSCSEP0000001511850.097734.4727
ENSG00000164362homo_sapiensENSP0000030957248.144933.5689poecilia_formosaENSPFOP0000001505250.184234.9908
ENSG00000164362homo_sapiensENSP0000030957249.911734.8057myripristis_murdjanENSMMDP0000501057550.809435.4317
ENSG00000164362homo_sapiensENSP0000030957248.763334.9823sander_luciopercaENSSLUP0000004979349.864535.7724
ENSG00000164362homo_sapiensENSP0000030957262.455847.9682strigops_habroptilaENSSHBP0000500541353.23840.8886
ENSG00000164362homo_sapiensENSP0000030957248.321633.6572amphiprion_ocellarisENSAOCP0000001975249.368234.3863
ENSG00000164362homo_sapiensENSP0000030957265.017750.1767terrapene_carolina_triunguisENSTMTP0000001151354.357541.9498
ENSG00000164362homo_sapiensENSP0000030957245.229732.4205hucho_huchoENSHHUP0000006813349.805435.7004
ENSG00000164362homo_sapiensENSP0000030957249.381635.0707betta_splendensENSBSLP0000000857449.777435.3517
ENSG00000164362homo_sapiensENSP0000030957244.434630.7421pygocentrus_nattereriENSPNAP0000000357847.904833.1429
ENSG00000164362homo_sapiensENSP0000030957249.028334.7173anabas_testudineusENSATEP0000005192950.090335.4693
ENSG00000164362homo_sapiensENSP0000030957230.742116.3428saccharomyces_cerevisiaeYLR318W39.366520.9276
ENSG00000164362homo_sapiensENSP0000030957249.73535.6007seriola_lalandi_dorsalisENSSLDP0000001019750.812336.3718
ENSG00000164362homo_sapiensENSP0000030957249.4734.1873labrus_bergyltaENSLBEP0000003150750.541534.9278
ENSG00000164362homo_sapiensENSP0000030957247.438232.8622pundamilia_nyerereiENSPNYP0000000096849.266134.1284
ENSG00000164362homo_sapiensENSP0000030957249.204934.4523mastacembelus_armatusENSMAMP0000000915050.180235.1351
ENSG00000164362homo_sapiensENSP0000030957249.028334.4523stegastes_partitusENSSPAP0000002719650.135535.2304
ENSG00000164362homo_sapiensENSP0000030957249.116633.8339acanthochromis_polyacanthusENSAPOP0000001729250.135334.5356
ENSG00000164362homo_sapiensENSP0000030957263.162548.3216aquila_chrysaetos_chrysaetosENSACCP0002000352553.799941.1588
ENSG00000164362homo_sapiensENSP0000030957249.204934.4523cyprinodon_variegatusENSCVAP0000002845651.054135.747
ENSG00000164362homo_sapiensENSP0000030957246.378131.9788denticeps_clupeoidesENSDCDP0000004270350.529434.8412
ENSG00000164362homo_sapiensENSP0000030957249.381635.0707larimichthys_croceaENSLCRP0000503293350.542535.8951
ENSG00000164362homo_sapiensENSP0000030957248.498233.4806takifugu_rubripesENSTRUP0000003630551.117335.2886
ENSG00000164362homo_sapiensENSP0000030957258.657244.523ficedula_albicollisENSFALP0000002792053.162540.3523
ENSG00000164362homo_sapiensENSP0000030957245.671431.8905hippocampus_comesENSHCOP0000000502248.544633.8967
ENSG00000164362homo_sapiensENSP0000030957246.731433.7456cyprinus_carpio_carpioENSCCRP0000012979649.578335.8013
ENSG00000164362homo_sapiensENSP0000030957247.084833.6572cyprinus_carpio_carpioENSCCRP0000017900951.004836.4593
ENSG00000164362homo_sapiensENSP0000030957262.720848.2332coturnix_japonicaENSCJPP0000501819152.827440.625
ENSG00000164362homo_sapiensENSP0000030957249.116634.2756poecilia_latipinnaENSPLAP0000001589650.683735.3692
ENSG00000164362homo_sapiensENSP0000030957248.233233.7456maylandia_zebraENSMZEP0000501509049.86334.8858
ENSG00000164362homo_sapiensENSP0000030957247.261532.6855tetraodon_nigroviridisENSTNIP0000000107349.263434.07
ENSG00000164362homo_sapiensENSP0000030957249.204935.8657paramormyrops_kingsleyaeENSPKIP0000000581052.946838.5932
ENSG00000164362homo_sapiensENSP0000030957246.996532.4205scleropages_formosusENSSFOP0001501923151.40135.4589
ENSG00000164362homo_sapiensENSP0000030957257.950542.3145leptobrachium_leishanenseENSLLEP0000004119352.733138.5048
ENSG00000164362homo_sapiensENSP0000030957249.116634.9823scophthalmus_maximusENSSMAP0000003390751.386336.5989
ENSG00000164362homo_sapiensENSP0000030957247.438232.0671oryzias_melastigmaENSOMEP0000001151649.447533.4254
ENSG00000164362homo_sapiensENSP0000030957237.455825.265oryzias_melastigmaENSOMEP0000000584852.410435.3523

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000049enables tRNA binding1IDAHomo_sapiens(9606)Function
GO:0000333part_of telomerase catalytic core complex4IBA,IDA,IMP,IPIHomo_sapiens(9606)Component
GO:0000723involved_in telomere maintenance1TASHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region2IC,IDAHomo_sapiens(9606)Component
GO:0000783part_of nuclear telomere cap complex1ICHomo_sapiens(9606)Component
GO:0001172involved_in RNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0001223enables transcription coactivator binding1IPIHomo_sapiens(9606)Function
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003720enables telomerase activity2IDA,TASHomo_sapiens(9606)Function
GO:0003721enables telomerase RNA reverse transcriptase activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IPIHomo_sapiens(9606)Function
GO:0003964enables RNA-directed DNA polymerase activity2IDA,TASHomo_sapiens(9606)Function
GO:0003968enables RNA-dependent RNA polymerase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005697part_of telomerase holoenzyme complex4IDA,IPI,NAS,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus2IDA,NASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IEAHomo_sapiens(9606)Component
GO:0006278involved_in RNA-templated DNA biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0007004involved_in telomere maintenance via telomerase4IBA,IDA,IMP,NASHomo_sapiens(9606)Process
GO:0007005involved_in mitochondrion organization1IDAHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IDAHomo_sapiens(9606)Process
GO:0016605colocalizes_with PML body1IDAHomo_sapiens(9606)Component
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0022616involved_in DNA strand elongation1IDAHomo_sapiens(9606)Process
GO:0030177involved_in positive regulation of Wnt signaling pathway1IGIHomo_sapiens(9606)Process
GO:0030422involved_in siRNA processing1IDAHomo_sapiens(9606)Process
GO:0031379part_of RNA-directed RNA polymerase complex1IPIHomo_sapiens(9606)Component
GO:0031647involved_in regulation of protein stability2IDA,IMPHomo_sapiens(9606)Process
GO:0032092involved_in positive regulation of protein binding1IDAHomo_sapiens(9606)Process
GO:0042162enables telomeric DNA binding1IBAHomo_sapiens(9606)Function
GO:0042635involved_in positive regulation of hair cycle1ISSHomo_sapiens(9606)Process
GO:0042645located_in mitochondrial nucleoid1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity2IDA,IPIHomo_sapiens(9606)Function
GO:0043524involved_in negative regulation of neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0045766involved_in positive regulation of angiogenesis1IEAHomo_sapiens(9606)Process
GO:0046326involved_in positive regulation of glucose import1IEAHomo_sapiens(9606)Process
GO:0046686involved_in response to cadmium ion1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051000involved_in positive regulation of nitric-oxide synthase activity1IDAHomo_sapiens(9606)Process
GO:0051087enables protein-folding chaperone binding1IPIHomo_sapiens(9606)Function
GO:0070034enables telomerase RNA binding3IBA,IDA,IPIHomo_sapiens(9606)Function
GO:0070200involved_in establishment of protein localization to telomere1IDAHomo_sapiens(9606)Process
GO:0071456involved_in cellular response to hypoxia1IMPHomo_sapiens(9606)Process
GO:0071897involved_in DNA biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0090399involved_in replicative senescence1IMPHomo_sapiens(9606)Process
GO:0098680enables template-free RNA nucleotidyltransferase1IDAHomo_sapiens(9606)Function
GO:0140745involved_in siRNA transcription1IDAHomo_sapiens(9606)Process
GO:1900087involved_in positive regulation of G1/S transition of mitotic cell cycle1IEAHomo_sapiens(9606)Process
GO:1902895involved_in positive regulation of miRNA transcription1IMPHomo_sapiens(9606)Process
GO:1903620involved_in positive regulation of transdifferentiation1IEAHomo_sapiens(9606)Process
GO:1904707involved_in positive regulation of vascular associated smooth muscle cell proliferation1IEAHomo_sapiens(9606)Process
GO:1904751involved_in positive regulation of protein localization to nucleolus1IDAHomo_sapiens(9606)Process
GO:1904754involved_in positive regulation of vascular associated smooth muscle cell migration1IEAHomo_sapiens(9606)Process
GO:1990572part_of TERT-RMRP complex2IDA,IPIHomo_sapiens(9606)Component
GO:2000352involved_in negative regulation of endothelial cell apoptotic process1IEAHomo_sapiens(9606)Process
GO:2000648involved_in positive regulation of stem cell proliferation1ISSHomo_sapiens(9606)Process
GO:2000773involved_in negative regulation of cellular senescence2IDA,IMPHomo_sapiens(9606)Process
GO:2001240involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand1IMPHomo_sapiens(9606)Process

Expression