Functions and Diseases

RBP Type Canonical_RBPs
Diseases SARS-COV-2
Drug N.A.
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000164346 Gene ID 10412 Accession 30728
Symbol NSA2 Alias HCLG1;TINP1;CDK105;HCL-G1;HUSSY29;HUSSY-29 Full Name NSA2 ribosome biogenesis factor
Status Confidence Length 13123 bases Strand Plus strand
Position 5 : 74766991 - 74780113 RNA binding domain Ribosomal_S8e
Summary This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000483484 Ribosomal_S8e PF01201 2.7e-44 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25404745 A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. Jochen Baßler 2014-11-24 The Journal of cell biology

Transcripts

Name Transcript ID bp Protein Translation ID
NSA2-201 ENST00000296802 1199 189aa ENSP00000296802
NSA2-203 ENST00000514918 645 No protein -
NSA2-205 ENST00000610426 4337 260aa ENSP00000483484
NSA2-202 ENST00000513356 797 No protein -
NSA2-204 ENST00000515524 448 98aa ENSP00000427266

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164346

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164346homo_sapiensENSP0000048348499.615498.8462nomascus_leucogenysENSNLEP0000000611398.479197.7186
ENSG00000164346homo_sapiensENSP0000048348410099.2308nomascus_leucogenysENSNLEP0000004196510099.2308
ENSG00000164346homo_sapiensENSP00000483484100100pan_paniscusENSPPAP00000039933100100
ENSG00000164346homo_sapiensENSP00000483484100100pongo_abeliiENSPPYP00000023551100100
ENSG00000164346homo_sapiensENSP0000048348410099.6154pan_troglodytesENSPTRP0000006217199.616999.2337
ENSG00000164346homo_sapiensENSP00000483484100100gorilla_gorillaENSGGOP00000051519100100
ENSG00000164346homo_sapiensENSP0000048348493.076991.1538ornithorhynchus_anatinusENSOANP0000003627389.629687.7778
ENSG00000164346homo_sapiensENSP00000483484100100sarcophilus_harrisiiENSSHAP00000020816100100
ENSG00000164346homo_sapiensENSP0000048348410099.6154dasypus_novemcinctusENSDNOP0000003295878.787978.4848
ENSG00000164346homo_sapiensENSP0000048348498.846298.0769echinops_telfairiENSETEP0000000335898.846298.0769
ENSG00000164346homo_sapiensENSP00000483484100100callithrix_jacchusENSCJAP00000031064100100
ENSG00000164346homo_sapiensENSP0000048348410099.6154cercocebus_atysENSCATP0000000868310099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154macaca_fascicularisENSMFAP0000000283210099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.2308macaca_mulattaENSMMUP0000005863610099.2308
ENSG00000164346homo_sapiensENSP0000048348410099.6154macaca_nemestrinaENSMNEP0000003882810099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154papio_anubisENSPANP0000000111410099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154mandrillus_leucophaeusENSMLEP0000002175810099.6154
ENSG00000164346homo_sapiensENSP0000048348495.769293.8462loxodonta_africanaENSLAFP0000002303697.647195.6863
ENSG00000164346homo_sapiensENSP0000048348410099.6154oryctolagus_cuniculusENSOCUP0000000564710099.6154
ENSG00000164346homo_sapiensENSP0000048348487.692387.3077oryctolagus_cuniculusENSOCUP0000003571799.563399.1266
ENSG00000164346homo_sapiensENSP0000048348499.230897.6923oryctolagus_cuniculusENSOCUP0000002071876.106274.9263
ENSG00000164346homo_sapiensENSP0000048348410099.6154marmota_marmota_marmotaENSMMMP0000000188810099.6154
ENSG00000164346homo_sapiensENSP00000483484100100cavia_porcellusENSCPOP00000022071100100
ENSG00000164346homo_sapiensENSP0000048348499.615499.6154monodelphis_domesticaENSMODP00000050867100100
ENSG00000164346homo_sapiensENSP0000048348498.076998.0769bison_bison_bisonENSBBBP0000002496498.076998.0769
ENSG00000164346homo_sapiensENSP00000483484100100microcebus_murinusENSMICP00000023326100100
ENSG00000164346homo_sapiensENSP0000048348497.692396.5385microcebus_murinusENSMICP0000004478997.692396.5385
ENSG00000164346homo_sapiensENSP0000048348485.769285.3846octodon_degusENSODEP0000000145496.120795.6897
ENSG00000164346homo_sapiensENSP0000048348499.230898.4615octodon_degusENSODEP0000002541599.230898.4615
ENSG00000164346homo_sapiensENSP00000483484100100ochotona_princepsENSOPRP00000001717100100
ENSG00000164346homo_sapiensENSP0000048348499.615499.2308aotus_nancymaaeENSANAP0000000416010099.6139
ENSG00000164346homo_sapiensENSP0000048348479.615476.9231aotus_nancymaaeENSANAP0000000838496.279193.0233
ENSG00000164346homo_sapiensENSP00000483484100100saimiri_boliviensis_boliviensisENSSBOP00000033312100100
ENSG00000164346homo_sapiensENSP00000483484100100chlorocebus_sabaeusENSCSAP00000018005100100
ENSG00000164346homo_sapiensENSP0000048348485.384683.0769camelus_dromedariusENSCDRP0000502609794.871892.3077
ENSG00000164346homo_sapiensENSP0000048348433.461532.6923carlito_syrichtaENSTSYP0000003322595.604493.4066
ENSG00000164346homo_sapiensENSP0000048348499.230899.2308prolemur_simusENSPSMP0000001879499.230899.2308
ENSG00000164346homo_sapiensENSP0000048348410099.6154microtus_ochrogasterENSMOCP0000001222810099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154cricetulus_griseus_chok1gshdENSCGRP0000101108710099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154vombatus_ursinusENSVURP0001002459710099.6154
ENSG00000164346homo_sapiensENSP0000048348499.230898.8462heterocephalus_glaber_femaleENSHGLP0000000034299.613999.2278
ENSG00000164346homo_sapiensENSP0000048348410099.6154rhinopithecus_bietiENSRBIP0000002798410099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154sciurus_vulgarisENSSVLP0000500810310099.6154
ENSG00000164346homo_sapiensENSP0000048348499.230898.8462phascolarctos_cinereusENSPCIP0000001296899.230898.8462
ENSG00000164346homo_sapiensENSP00000483484100100procavia_capensisENSPCAP00000014364100100
ENSG00000164346homo_sapiensENSP00000483484100100chinchilla_lanigeraENSCLAP00000014752100100
ENSG00000164346homo_sapiensENSP0000048348492.307792.3077cebus_imitatorENSCCAP00000003011100100
ENSG00000164346homo_sapiensENSP0000048348410099.6154urocitellus_parryiiENSUPAP0001000672110099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154rhinopithecus_roxellanaENSRROP0000002842410099.6154
ENSG00000164346homo_sapiensENSP0000048348410099.6154propithecus_coquereliENSPCOP0000001032410099.6154
ENSG00000164346homo_sapiensENSP0000048348486.538569.2308caenorhabditis_elegansW09C5.1.186.872669.4981
ENSG00000164346homo_sapiensENSP0000048348487.307774.6154drosophila_melanogasterFBpp030403187.644874.9035
ENSG00000164346homo_sapiensENSP000004834849586.9231ciona_intestinalisENSCINP000000360969586.9231
ENSG00000164346homo_sapiensENSP000004834849587.6923eptatretus_burgeriENSEBUP000000152229587.6923
ENSG00000164346homo_sapiensENSP0000048348498.461595.3846callorhinchus_miliiENSCMIP0000004355298.461595.3846
ENSG00000164346homo_sapiensENSP0000048348499.615496.9231latimeria_chalumnaeENSLACP0000000476899.615496.9231
ENSG00000164346homo_sapiensENSP0000048348498.846295.7692lepisosteus_oculatusENSLOCP0000000648498.846295.7692
ENSG00000164346homo_sapiensENSP0000048348498.076992.6923clupea_harengusENSCHAP0000005756478.947474.613
ENSG00000164346homo_sapiensENSP000004834848075.7692clupea_harengusENSCHAP0000005722994.545589.5455
ENSG00000164346homo_sapiensENSP0000048348498.461594.6154danio_rerioENSDARP0000000303698.461594.6154
ENSG00000164346homo_sapiensENSP0000048348492.692387.6923carassius_auratusENSCARP0000008277291.984787.0229
ENSG00000164346homo_sapiensENSP0000048348498.846295carassius_auratusENSCARP0000010736698.846295
ENSG00000164346homo_sapiensENSP0000048348498.461594.6154carassius_auratusENSCARP0000001897393.772990.1099
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385astyanax_mexicanusENSAMXP0000004483699.230896.5385
ENSG00000164346homo_sapiensENSP0000048348499.230894.2308ictalurus_punctatusENSIPUP0000000945399.230894.2308
ENSG00000164346homo_sapiensENSP0000048348498.461593.8462esox_luciusENSELUP0000002702698.461593.8462
ENSG00000164346homo_sapiensENSP0000048348498.846294.6154electrophorus_electricusENSEEEP0000001294398.846294.6154
ENSG00000164346homo_sapiensENSP0000048348497.692392.6923oncorhynchus_kisutchENSOKIP0000508813397.31892.3372
ENSG00000164346homo_sapiensENSP0000048348498.076993.0769oncorhynchus_kisutchENSOKIP0000507228898.076993.0769
ENSG00000164346homo_sapiensENSP0000048348493.846286.9231oncorhynchus_mykissENSOMYP0000000074382.432476.3513
ENSG00000164346homo_sapiensENSP0000048348497.692392.6923oncorhynchus_mykissENSOMYP0000012234395.849190.9434
ENSG00000164346homo_sapiensENSP0000048348493.076986.9231salmo_salarENSSSAP0000016025590.298584.3284
ENSG00000164346homo_sapiensENSP0000048348498.076993.0769salmo_salarENSSSAP0000008747298.076993.0769
ENSG00000164346homo_sapiensENSP0000048348498.076993.0769salmo_truttaENSSTUP0000008105898.076993.0769
ENSG00000164346homo_sapiensENSP0000048348497.692392.6923salmo_truttaENSSTUP0000004922287.586283.1034
ENSG00000164346homo_sapiensENSP0000048348498.461593.4615gadus_morhuaENSGMOP0000004795298.461593.4615
ENSG00000164346homo_sapiensENSP0000048348474.230868.0769gadus_morhuaENSGMOP0000000337987.330380.0905
ENSG00000164346homo_sapiensENSP0000048348499.230895fundulus_heteroclitusENSFHEP0000002457499.230895
ENSG00000164346homo_sapiensENSP0000048348492.307788.8462poecilia_reticulataENSPREP0000003110499.173695.4545
ENSG00000164346homo_sapiensENSP0000048348499.230895.3846xiphophorus_maculatusENSXMAP0000000075999.230895.3846
ENSG00000164346homo_sapiensENSP0000048348499.230895oryzias_latipesENSORLP0000000419899.230895
ENSG00000164346homo_sapiensENSP0000048348498.846295.3846oreochromis_niloticusENSONIP0000002806398.846295.3846
ENSG00000164346homo_sapiensENSP0000048348494.230889.2308haplochromis_burtoniENSHBUP0000000940484.192479.7251
ENSG00000164346homo_sapiensENSP0000048348494.230889.2308astatotilapia_callipteraENSACLP0000004077384.192479.7251
ENSG00000164346homo_sapiensENSP0000048348498.461593.4615sparus_aurataENSSAUP0001003613188.888984.375
ENSG00000164346homo_sapiensENSP0000048348499.230895lates_calcariferENSLCAP0001004443499.230895
ENSG00000164346homo_sapiensENSP0000048348410097.6923xenopus_tropicalisENSXETP0000001107410097.6923
ENSG00000164346homo_sapiensENSP0000048348499.615497.6923chrysemys_picta_belliiENSCPBP0000000104899.615497.6923
ENSG00000164346homo_sapiensENSP0000048348492.692391.1538sphenodon_punctatusENSSPUP0000000077099.586897.9339
ENSG00000164346homo_sapiensENSP0000048348499.615495.3846crocodylus_porosusENSCPRP0000500080999.615495.3846
ENSG00000164346homo_sapiensENSP0000048348498.461596.1538laticauda_laticaudataENSLLTP0000002162398.841796.5251
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385notechis_scutatusENSNSUP0000001425999.230896.5385
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385pseudonaja_textilisENSPTXP0000000359699.230896.5385
ENSG00000164346homo_sapiensENSP0000048348498.076996.1538anas_platyrhynchos_platyrhynchosENSAPLP0000002239771.629270.2247
ENSG00000164346homo_sapiensENSP0000048348499.230896.1538gallus_gallusENSGALP0001001442397.727394.697
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385meleagris_gallopavoENSMGAP0000000535897.727395.0758
ENSG00000164346homo_sapiensENSP0000048348492.692390serinus_canariaENSSCAP0000000618893.050290.3475
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385parus_majorENSPMJP0000002177599.230896.5385
ENSG00000164346homo_sapiensENSP0000048348499.615498.0769anolis_carolinensisENSACAP0000004005294.871893.4066
ENSG00000164346homo_sapiensENSP0000048348498.846295.3846neolamprologus_brichardiENSNBRP0000001175198.846295.3846
ENSG00000164346homo_sapiensENSP0000048348499.230896.9231naja_najaENSNNAP0000000916299.230896.9231
ENSG00000164346homo_sapiensENSP000004834847065.7692podarcis_muralisENSPMRP0000002657881.614376.6816
ENSG00000164346homo_sapiensENSP0000048348498.846296.1538geospiza_fortisENSGFOP0000001829148.859347.5285
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385taeniopygia_guttataENSTGUP0000000621599.230896.5385
ENSG00000164346homo_sapiensENSP0000048348499.615495.7692erpetoichthys_calabaricusENSECRP0000002393099.615495.7692
ENSG00000164346homo_sapiensENSP0000048348499.615494.2308kryptolebias_marmoratusENSKMAP0000001777699.615494.2308
ENSG00000164346homo_sapiensENSP0000048348499.615498.0769salvator_merianaeENSSMRP0000000730299.615498.0769
ENSG00000164346homo_sapiensENSP0000048348494.615490oryzias_javanicusENSOJAP0000002504996.470691.7647
ENSG00000164346homo_sapiensENSP0000048348492.307788.4615amphilophus_citrinellusENSACIP0000000427899.173695.0413
ENSG00000164346homo_sapiensENSP0000048348497.692392.6923dicentrarchus_labraxENSDLAP0000508076886.986382.5342
ENSG00000164346homo_sapiensENSP0000048348498.846295amphiprion_perculaENSAPEP0000000051194.833991.1439
ENSG00000164346homo_sapiensENSP0000048348499.230894.6154oryzias_sinensisENSOSIP0000001057699.230894.6154
ENSG00000164346homo_sapiensENSP0000048348499.615497.6923pelodiscus_sinensisENSPSIP0000001443499.615497.6923
ENSG00000164346homo_sapiensENSP0000048348499.615498.0769gopherus_evgoodeiENSGEVP0000500337799.615498.0769
ENSG00000164346homo_sapiensENSP0000048348493.461590.7692chelonoidis_abingdoniiENSCABP0000001941294.921992.1875
ENSG00000164346homo_sapiensENSP0000048348499.230894.6154seriola_dumeriliENSSDUP0000002949999.230894.6154
ENSG00000164346homo_sapiensENSP0000048348498.076992.3077cottoperca_gobioENSCGOP0000001083898.076992.3077
ENSG00000164346homo_sapiensENSP0000048348498.846295.7692struthio_camelus_australisENSSCUP0000002597799.227896.139
ENSG00000164346homo_sapiensENSP0000048348499.230897.6923anser_brachyrhynchusENSABRP0000000036899.230897.6923
ENSG00000164346homo_sapiensENSP0000048348497.692392.3077gasterosteus_aculeatusENSGACP0000002097697.692392.3077
ENSG00000164346homo_sapiensENSP0000048348492.307788.4615cynoglossus_semilaevisENSCSEP0000002062199.173695.0413
ENSG00000164346homo_sapiensENSP0000048348499.230895poecilia_formosaENSPFOP0000001252299.230895
ENSG00000164346homo_sapiensENSP0000048348499.230895.7692myripristis_murdjanENSMMDP0000504697799.230895.7692
ENSG00000164346homo_sapiensENSP0000048348499.230894.2308sander_luciopercaENSSLUP0000005456099.230894.2308
ENSG00000164346homo_sapiensENSP0000048348499.615496.9231strigops_habroptilaENSSHBP0000502525299.615496.9231
ENSG00000164346homo_sapiensENSP0000048348499.230895.3846amphiprion_ocellarisENSAOCP0000002624599.230895.3846
ENSG00000164346homo_sapiensENSP0000048348499.615497.6923terrapene_carolina_triunguisENSTMTP0000001491499.615497.6923
ENSG00000164346homo_sapiensENSP0000048348497.692392.6923hucho_huchoENSHHUP0000000055878.88274.8447
ENSG00000164346homo_sapiensENSP0000048348494.230886.9231hucho_huchoENSHHUP0000003195692.105384.9624
ENSG00000164346homo_sapiensENSP0000048348499.230893.4615betta_splendensENSBSLP0000002904499.613993.8224
ENSG00000164346homo_sapiensENSP0000048348499.230896.9231pygocentrus_nattereriENSPNAP0000001067999.230896.9231
ENSG00000164346homo_sapiensENSP0000048348499.615494.2308anabas_testudineusENSATEP0000001572199.615494.2308
ENSG00000164346homo_sapiensENSP0000048348477.307762.3077saccharomyces_cerevisiaeYER126C77.011562.069
ENSG00000164346homo_sapiensENSP0000048348498.846293.8462seriola_lalandi_dorsalisENSSLDP0000001926398.467493.4866
ENSG00000164346homo_sapiensENSP0000048348498.846293.8462labrus_bergyltaENSLBEP0000002670498.846293.8462
ENSG00000164346homo_sapiensENSP0000048348458.076950.3846labrus_bergyltaENSLBEP0000000000478.238367.8756
ENSG00000164346homo_sapiensENSP0000048348498.846295.3846pundamilia_nyerereiENSPNYP0000000257798.846295.3846
ENSG00000164346homo_sapiensENSP0000048348499.230895.3846mastacembelus_armatusENSMAMP0000004141399.230895.3846
ENSG00000164346homo_sapiensENSP0000048348499.230895.3846stegastes_partitusENSSPAP0000000670499.230895.3846
ENSG00000164346homo_sapiensENSP0000048348499.230895.3846stegastes_partitusENSSPAP0000001873199.230895.3846
ENSG00000164346homo_sapiensENSP0000048348497.692392.6923oncorhynchus_tshawytschaENSOTSP0000505081897.31892.3372
ENSG00000164346homo_sapiensENSP0000048348498.076993.0769oncorhynchus_tshawytschaENSOTSP0000508531598.076993.0769
ENSG00000164346homo_sapiensENSP0000048348492.692387.6923acanthochromis_polyacanthusENSAPOP0000000428392.337287.3563
ENSG00000164346homo_sapiensENSP0000048348491.923190aquila_chrysaetos_chrysaetosENSACCP0002001541949.380248.3471
ENSG00000164346homo_sapiensENSP0000048348499.615495.3846nothobranchius_furzeriENSNFUP0001503689699.615495.3846
ENSG00000164346homo_sapiensENSP0000048348498.846295cyprinodon_variegatusENSCVAP0000000827798.846295
ENSG00000164346homo_sapiensENSP0000048348498.461594.2308denticeps_clupeoidesENSDCDP0000001597498.461594.2308
ENSG00000164346homo_sapiensENSP0000048348499.230894.6154larimichthys_croceaENSLCRP0000501331599.230894.6154
ENSG00000164346homo_sapiensENSP0000048348494.615490takifugu_rubripesENSTRUP0000005406392.134887.6404
ENSG00000164346homo_sapiensENSP0000048348492.692390.3846ficedula_albicollisENSFALP0000001052799.17796.7078
ENSG00000164346homo_sapiensENSP0000048348497.307791.5385hippocampus_comesENSHCOP0000000643094.756689.1386
ENSG00000164346homo_sapiensENSP0000048348493.076988.0769cyprinus_carpio_carpioENSCCRP0000017687490.636785.7678
ENSG00000164346homo_sapiensENSP0000048348498.461594.2308cyprinus_carpio_carpioENSCCRP0000007360798.461594.2308
ENSG00000164346homo_sapiensENSP0000048348499.230896.5385coturnix_japonicaENSCJPP0000500182499.230896.5385
ENSG00000164346homo_sapiensENSP0000048348499.230895poecilia_latipinnaENSPLAP0000002669099.230895
ENSG00000164346homo_sapiensENSP0000048348498.461594.2308sinocyclocheilus_grahamiENSSGRP0000004946598.461594.2308
ENSG00000164346homo_sapiensENSP0000048348491.538588.0769sinocyclocheilus_grahamiENSSGRP0000009370998.347194.6281
ENSG00000164346homo_sapiensENSP0000048348498.846295.3846maylandia_zebraENSMZEP0000500574898.846295.3846
ENSG00000164346homo_sapiensENSP0000048348499.615495.7692tetraodon_nigroviridisENSTNIP0000001643499.615495.7692
ENSG00000164346homo_sapiensENSP0000048348498.846295.3846paramormyrops_kingsleyaeENSPKIP0000000003298.846295.3846
ENSG00000164346homo_sapiensENSP0000048348492.692388.0769scleropages_formosusENSSFOP0001502518488.278483.8828
ENSG00000164346homo_sapiensENSP0000048348450.769244.6154leptobrachium_leishanenseENSLLEP0000000409172.527563.7363
ENSG00000164346homo_sapiensENSP0000048348498.846294.2308scophthalmus_maximusENSSMAP0000001753598.846294.2308
ENSG00000164346homo_sapiensENSP0000048348499.230895oryzias_melastigmaENSOMEP0000002981299.230895

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000460involved_in maturation of 5.8S rRNA1IBAHomo_sapiens(9606)Process
GO:0000470involved_in maturation of LSU-rRNA1IBAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005730located_in nucleolus1IEAHomo_sapiens(9606)Component
GO:0030687part_of preribosome, large subunit precursor1IBAHomo_sapiens(9606)Component

Expression