RBP Type	Non-canonical_RBPs
Diseases	Cancer Disease
Drug	Drug
Main interacting RNAs	ncRNA
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000164342	Gene ID	7098	Accession	11849
Symbol	TLR3	Alias	CD283;IIAE2;IMD83	Full Name	toll like receptor 3
Status	Confidence	Length	19163 bases	Strand	Plus strand
Position	4 : 186068911 - 186088073	RNA binding domain	N.A.
Summary	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]