RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000164078	Gene ID	4486	Accession	7381
Symbol	MST1R	Alias	RON;SEA;PTK8;CD136;NPCA3;CDw136;p185-Ron	Full Name	macrophage stimulating 1 receptor
Status	Confidence	Length	16872 bases	Strand	Minus strand
Position	3 : 49887002 - 49903873	RNA binding domain	N.A.
Summary	This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
MST1R-201	ENST00000296474	4772	1400aa	ENSP00000296474
MST1R-203	ENST00000411578	4683	1032aa	ENSP00000407926
MST1R-213	ENST00000621387	4449	1294aa	ENSP00000482642
MST1R-202	ENST00000344206	4198	1351aa	ENSP00000341325
MST1R-204	ENST00000434765	854	285aa	ENSP00000393294
MST1R-205	ENST00000440292	810	270aa	ENSP00000414792
MST1R-206	ENST00000463789	558	No protein	-
MST1R-210	ENST00000490053	341	No protein	-
MST1R-207	ENST00000467110	542	No protein	-
MST1R-208	ENST00000468525	2727	No protein	-
MST1R-209	ENST00000485044	1944	No protein	-
MST1R-211	ENST00000493535	1626	No protein	-
MST1R-212	ENST00000497001	1488	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001725	located_in stress fiber	1	IEA	Homo_sapiens(9606)	Component
GO:0004714	enables transmembrane receptor protein tyrosine kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005011	enables macrophage colony-stimulating factor receptor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005773	located_in vacuole	1	IEA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0006909	involved_in phagocytosis	1	IBA	Homo_sapiens(9606)	Process
GO:0006952	involved_in defense response	1	TAS	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0007169	involved_in transmembrane receptor protein tyrosine kinase signaling pathway	1	IBA	Homo_sapiens(9606)	Process
GO:0007275	involved_in multicellular organism development	1	IBA	Homo_sapiens(9606)	Process
GO:0007338	involved_in single fertilization	1	TAS	Homo_sapiens(9606)	Process
GO:0007399	involved_in nervous system development	1	IBA	Homo_sapiens(9606)	Process
GO:0008284	involved_in positive regulation of cell population proliferation	1	TAS	Homo_sapiens(9606)	Process
GO:0009615	involved_in response to virus	1	IDA	Homo_sapiens(9606)	Process
GO:0009986	located_in cell surface	1	HDA	Homo_sapiens(9606)	Component
GO:0016477	involved_in cell migration	1	IBA	Homo_sapiens(9606)	Process
GO:0019899	enables enzyme binding	1	IPI	Homo_sapiens(9606)	Function
GO:0033674	involved_in positive regulation of kinase activity	1	IBA	Homo_sapiens(9606)	Process
GO:0038145	involved_in macrophage colony-stimulating factor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0043235	part_of receptor complex	1	IBA	Homo_sapiens(9606)	Component
GO:0043406	involved_in positive regulation of MAP kinase activity	1	IDA	Homo_sapiens(9606)	Process
GO:0045087	involved_in innate immune response	1	IEA	Homo_sapiens(9606)	Process
GO:0051897	involved_in positive regulation of protein kinase B signaling	1	IDA	Homo_sapiens(9606)	Process