RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000164068	Gene ID	63891	Accession	21148
Symbol	RNF123	Alias	KPC1;FP1477	Full Name	ring finger protein 123
Status	Confidence	Length	31992 bases	Strand	Plus strand
Position	3 : 49689538 - 49721529	RNA binding domain	SPRY
Summary	The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000394369	SPRY	PF00622	9.5e-26	1
ENSP00000328287	SPRY	PF00622	2.2e-25	1
ENSP00000392443	SPRY	PF00622	2.8e-22	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
RNF123-202	ENST00000432042	2670	762aa	ENSP00000392443
RNF123-207	ENST00000457726	4506	721aa	ENSP00000394369
RNF123-206	ENST00000454491	531	76aa	ENSP00000408490
RNF123-204	ENST00000443204	481	68aa	ENSP00000390856
RNF123-201	ENST00000327697	4255	1314aa	ENSP00000328287
RNF123-209	ENST00000486102	4564	No protein	-
RNF123-210	ENST00000487805	5882	No protein	-
RNF123-214	ENST00000629802	207	68aa	ENSP00000487104
RNF123-211	ENST00000494005	557	No protein	-
RNF123-208	ENST00000469978	889	No protein	-
RNF123-203	ENST00000433785	1555	426aa	ENSP00000416156
RNF123-205	ENST00000444689	442	25aa	ENSP00000413794
RNF123-212	ENST00000497099	606	No protein	-
RNF123-213	ENST00000498376	746	No protein	-

Gene Model

Click here to download ENSG00000164068's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
74570	Education	5E-9	25201988

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000164068's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004842	enables ubiquitin-protein transferase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	3	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IEA	Homo_sapiens(9606)	Process
GO:0031965	located_in nuclear membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0051603	involved_in proteolysis involved in protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0051604	involved_in protein maturation	1	IDA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	1	IDA	Homo_sapiens(9606)	Function

Expression