RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000163344	Gene ID	10654	Accession	9141
Symbol	PMVK	Alias	PMK;PMKA;PMKASE;POROK1;HUMPMKI	Full Name	phosphomevalonate kinase
Status	Confidence	Length	11980 bases	Strand	Minus strand
Position	1 : 154924740 - 154936719	RNA binding domain	N.A.
Summary	This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PMVK-201	ENST00000368467	1002	192aa	ENSP00000357452

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004631	enables phosphomevalonate kinase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005777	NOT located_in peroxisome	2	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006695	involved_in cholesterol biosynthetic process	3	IBA,IDA,TAS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016126	involved_in sterol biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0016310	involved_in phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0019287	involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	2	IBA,IEA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0070723	involved_in response to cholesterol	1	IEP	Homo_sapiens(9606)	Process