RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000162433	Gene ID	205	Accession	363
Symbol	AK4	Alias	AK3;AK4;AK3L1;AK3L2	Full Name	adenylate kinase 4
Status	Confidence	Length	84597 bases	Strand	Plus strand
Position	1 : 65147549 - 65232145	RNA binding domain	ADK_lid
Summary	This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000448458	ADK_lid	PF05191	2.6e-14	1
ENSP00000322175	ADK_lid	PF05191	3.9e-14	1
ENSP00000378743	ADK_lid	PF05191	3.9e-14	1
ENSP00000445912	ADK_lid	PF05191	3.9e-14	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
AK4-206	ENST00000497030	834	No protein	-
AK4-203	ENST00000470888	1043	No protein	-
AK4-208	ENST00000546702	1335	171aa	ENSP00000448458
AK4-201	ENST00000327299	6845	223aa	ENSP00000322175
AK4-204	ENST00000474968	928	No protein	-
AK4-205	ENST00000479060	867	No protein	-
AK4-207	ENST00000545314	6887	223aa	ENSP00000445912
AK4-202	ENST00000395334	6998	223aa	ENSP00000378743

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
21568	Emotions	4.988e-005	-
81826	Venous Thromboembolism	4E-10	23509962

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002082	involved_in regulation of oxidative phosphorylation	1	IMP	Homo_sapiens(9606)	Process
GO:0004017	NOT enables adenylate kinase activity	2	IDA	Homo_sapiens(9606)	Function
GO:0004550	enables nucleoside diphosphate kinase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005525	enables GTP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005759	is_active_in mitochondrial matrix	3	IBA,ISS,TAS	Homo_sapiens(9606)	Component
GO:0006172	involved_in ADP biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0009142	involved_in nucleoside triphosphate biosynthetic process	1	IBA	Homo_sapiens(9606)	Process
GO:0009188	involved_in ribonucleoside diphosphate biosynthetic process	1	IMP	Homo_sapiens(9606)	Process
GO:0015949	involved_in nucleobase-containing small molecule interconversion	1	TAS	Homo_sapiens(9606)	Process
GO:0016310	involved_in phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0046033	involved_in AMP metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0046034	involved_in ATP metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046039	involved_in GTP metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046899	NOT enables nucleoside triphosphate adenylate kinase activity	2	IDA	Homo_sapiens(9606)	Function
GO:0046940	involved_in nucleoside monophosphate phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0050145	enables nucleoside monophosphate kinase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0071456	acts_upstream_of cellular response to hypoxia	2	IMP	Homo_sapiens(9606)	Process