RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-OC43FlavivirusesRVSARS-COV-2SINVDengueZika
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucleFibrillar center
BulkPerturb-seq	DataSet_01_295 DataSet_01_62 DataSet_02_47

Description

Ensembl ID	ENSG00000161813	Gene ID	113251	Accession	24320
Symbol	LARP4	Alias	PP13296	Full Name	La ribonucleoprotein 4
Status	Confidence	Length	87622 bases	Strand	Plus strand
Position	12 : 50392383 - 50480004	RNA binding domain	La
Summary	Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytosol. Colocalizes with cytoplasmic stress granule; cytosolic small ribosomal subunit; and polysome. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000293618	La	PF05383	1.8e-16	1
ENSP00000340901	La	PF05383	1.9e-16	1
ENSP00000381490	La	PF05383	2e-16	1
ENSP00000415464	La	PF05383	2e-16	1
ENSP00000428516	La	PF05383	6.5e-10	1
ENSP00000429077	La	PF05383	2e-16	1
ENSP00000429781	La	PF05383	9.5e-17	1
ENSP00000430851	La	PF05383	8e-17	1
ENSP00000446966	La	PF05383	1.5e-17	1
ENSP00000447408	La	PF05383	2.5e-14	1
ENSP00000448756	La	PF05383	3.5e-17	1

Showing 1 to 11 of 11 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29431736	RICK_PMID29431736_Hela_human	Hela	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
29636419	CARIC_PMID29636419_Hela_human	Hela	Xichen Bao	2018 Apr 24	doi: 10.1073/pnas.1718406115.?Epub 2018 Apr 10
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115

Showing 1 to 10 of 31 entries

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Pubmed ID	Title	Author	Time	Journal
No data available in table

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
LARP4-201	ENST00000293618	6296	653aa	ENSP00000293618
LARP4-202	ENST00000347328	3621	653aa	ENSP00000340901
LARP4-203	ENST00000398473	6441	724aa	ENSP00000381490
LARP4-204	ENST00000429001	4000	730aa	ENSP00000415464
LARP4-205	ENST00000517559	559	84aa	ENSP00000428516
LARP4-206	ENST00000518444	2853	723aa	ENSP00000429077
LARP4-207	ENST00000518561	1578	375aa	ENSP00000430851
LARP4-208	ENST00000520064	2068	491aa	ENSP00000429631
LARP4-209	ENST00000521120	987	No protein	-
LARP4-210	ENST00000522085	1577	445aa	ENSP00000429781

Showing 1 to 10 of 18 entries

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Gene Model

Click here to download ENSG00000161813's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
75370	Colorectal Neoplasms	3E-6	23300701

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000161813's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000161813	homo_sapiens	ENSP00000428589	21.3504	11.9526	homo_sapiens	ENSP00000381490	32.3204	18.0939
ENSG00000161813	homo_sapiens	ENSP00000260956	31.3725	15.4412	homo_sapiens	ENSP00000381490	17.6796	8.70166
ENSG00000161813	homo_sapiens	ENSP00000326128	52.8455	36.5854	homo_sapiens	ENSP00000381490	53.8674	37.2928
ENSG00000161813	homo_sapiens	ENSP00000299213	27.2912	15.0713	homo_sapiens	ENSP00000381490	18.5083	10.221
ENSG00000161813	homo_sapiens	ENSP00000344950	27.6632	14.433	homo_sapiens	ENSP00000381490	22.2376	11.6022
ENSG00000161813	homo_sapiens	ENSP00000321997	24.6171	14.0044	homo_sapiens	ENSP00000381490	31.0773	17.6796

Showing 1 to 6 of 6 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000161813	homo_sapiens	ENSP00000381490	98.0663	97.7901	nomascus_leucogenys	ENSNLEP00000029173	98.2019	97.9253
ENSG00000161813	homo_sapiens	ENSP00000381490	92.9558	92.5414	pan_paniscus	ENSPPAP00000023946	96.9741	96.5418
ENSG00000161813	homo_sapiens	ENSP00000381490	98.895	97.9282	pongo_abelii	ENSPPYP00000005151	98.0822	97.1233
ENSG00000161813	homo_sapiens	ENSP00000381490	99.4475	99.1713	pan_troglodytes	ENSPTRP00000058410	99.4475	99.1713
ENSG00000161813	homo_sapiens	ENSP00000381490	92.8177	91.2983	gorilla_gorilla	ENSGGOP00000014862	97.1098	95.5202
ENSG00000161813	homo_sapiens	ENSP00000381490	76.2431	66.5746	ornithorhynchus_anatinus	ENSOANP00000052536	66.7473	58.283
ENSG00000161813	homo_sapiens	ENSP00000381490	85.4972	76.3812	sarcophilus_harrisii	ENSSHAP00000025417	85.0275	75.9615
ENSG00000161813	homo_sapiens	ENSP00000381490	46.547	40.884	notamacropus_eugenii	ENSMEUP00000015104	51.372	45.122
ENSG00000161813	homo_sapiens	ENSP00000381490	57.3204	54.6961	choloepus_hoffmanni	ENSCHOP00000009289	57.6389	55
ENSG00000161813	homo_sapiens	ENSP00000381490	93.3702	89.3646	dasypus_novemcinctus	ENSDNOP00000031049	93.2414	89.2414

Showing 1 to 10 of 313 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003730	enables mRNA 3-UTR binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005829	is_active_in cytosol	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0045727	involved_in positive regulation of translation	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0006412	involved_in translation	1	IEA	Homo_sapiens(9606)	Process
GO:0007010	involved_in cytoskeleton organization	1	IMP	Homo_sapiens(9606)	Process
GO:0008143	enables poly(A) binding	1	IDA	Homo_sapiens(9606)	Function
GO:0010494	colocalizes_with cytoplasmic stress granule	1	IDA	Homo_sapiens(9606)	Component
GO:0010608	involved_in post-transcriptional regulation of gene expression	1	IDA	Homo_sapiens(9606)	Process

Showing 1 to 10 of 12 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression