Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000160685 Gene ID 51043 Accession 18668
Symbol ZBTB7B Alias vGAF;CKROX;THPOK;ZFP67;ZBTB15;ZFP-67;c-KROX;hcKROX;ZNF857B Full Name zinc finger and BTB domain containing 7B
Status Confidence Length 15894 bases Strand Plus strand
Position 1 : 155002630 - 155018523 RNA binding domain zf-met
Summary This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000292176 zf-met PF12874 0.0011 1
ENSP00000357411 zf-met PF12874 0.0011 1
ENSP00000438647 zf-met PF12874 0.0011 1
ENSP00000406286 zf-met PF12874 0.0014 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ZBTB7B-203 ENST00000417934 4017 573aa ENSP00000406286
ZBTB7B-202 ENST00000368426 3594 539aa ENSP00000357411
ZBTB7B-205 ENST00000535420 3606 539aa ENSP00000438647
ZBTB7B-204 ENST00000483226 243 No protein -
ZBTB7B-201 ENST00000292176 2129 539aa ENSP00000292176

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
67688Body Mass Index3E-1025673412
67690Waist-Hip Ratio3E-1025673412
77679Body Height2E-825281659
77914Body Mass Index5E-1025673412
77916Waist-Hip Ratio5E-1025673412
82451Body Mass Index7E-1025673412
82453Waist-Hip Ratio7E-1025673412
92655Body Mass Index3E-1025673412
92657Waist-Hip Ratio3E-1025673412
104247Schizophrenia2E-626198764

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific1IBAHomo_sapiens(9606)Function
GO:0001217enables DNA-binding transcription repressor activity1ISSHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific1IEAHomo_sapiens(9606)Function
GO:0001865involved_in NK T cell differentiation1ISSHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0006366involved_in transcription by RNA polymerase II1TASHomo_sapiens(9606)Process
GO:0007398involved_in ectoderm development1TASHomo_sapiens(9606)Process
GO:0007595involved_in lactation1ISSHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression2IBA,ISSHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IEAHomo_sapiens(9606)Process
GO:0032740involved_in positive regulation of interleukin-17 production1ISSHomo_sapiens(9606)Process
GO:0032868involved_in response to insulin1ISSHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1ISSHomo_sapiens(9606)Function
GO:0042826enables histone deacetylase binding1IEAHomo_sapiens(9606)Function
GO:0043372involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation1ISSHomo_sapiens(9606)Process
GO:0043377involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation1ISSHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0046628involved_in positive regulation of insulin receptor signaling pathway1ISSHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051141involved_in negative regulation of NK T cell proliferation1ISSHomo_sapiens(9606)Process
GO:0090336involved_in positive regulation of brown fat cell differentiation1ISSHomo_sapiens(9606)Process
GO:0120162involved_in positive regulation of cold-induced thermogenesis1ISSHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:1990845involved_in adaptive thermogenesis1ISSHomo_sapiens(9606)Process
GO:2000320involved_in negative regulation of T-helper 17 cell differentiation1IEAHomo_sapiens(9606)Process
GO:2000640involved_in positive regulation of SREBP signaling pathway1ISSHomo_sapiens(9606)Process

Expression