Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000160007 Gene ID 2909 Accession 4591
Symbol ARHGAP35 Alias GRF-1;GRLF1;P190A;P190-A;p190RhoGAP;p190ARhoGAP Full Name Rho GTPase activating protein 35
Status Confidence Length 144081 bases Strand Plus strand
Position 19 : 46860997 - 47005077 RNA binding domain FF
Summary The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000500409 FF PF01846 1.9e-07 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ARHGAP35-205 ENST00000672722 9290 1499aa ENSP00000500409
ARHGAP35-206 ENST00000700035 7426 No protein -
ARHGAP35-201 ENST00000595822 2977 No protein -
ARHGAP35-202 ENST00000596593 346 No protein -
ARHGAP35-203 ENST00000598548 572 No protein -
ARHGAP35-204 ENST00000599284 931 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
64356Cisplatin7E-621844884

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001843involved_in neural tube closure1IEAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003924enables GTPase activity1IEAHomo_sapiens(9606)Function
GO:0005096enables GTPase activator activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005525enables GTP binding1IEAHomo_sapiens(9606)Function
GO:0005543enables phospholipid binding1IDAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IEAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IEAHomo_sapiens(9606)Component
GO:0007266involved_in Rho protein signal transduction1IBAHomo_sapiens(9606)Process
GO:0007411involved_in axon guidance1ISSHomo_sapiens(9606)Process
GO:0007413involved_in axonal fasciculation1ISSHomo_sapiens(9606)Process
GO:0008064involved_in regulation of actin polymerization or depolymerization1ISSHomo_sapiens(9606)Process
GO:0008360involved_in regulation of cell shape1IEAHomo_sapiens(9606)Process
GO:0008361involved_in regulation of cell size1IBAHomo_sapiens(9606)Process
GO:0010976involved_in positive regulation of neuron projection development1ISSHomo_sapiens(9606)Process
GO:0015629located_in actin cytoskeleton1IEAHomo_sapiens(9606)Component
GO:0016477involved_in cell migration1ISSHomo_sapiens(9606)Process
GO:0021955involved_in central nervous system neuron axonogenesis1ISSHomo_sapiens(9606)Process
GO:0030879involved_in mammary gland development1ISSHomo_sapiens(9606)Process
GO:0030900involved_in forebrain development1IEAHomo_sapiens(9606)Process
GO:0030950involved_in establishment or maintenance of actin cytoskeleton polarity1ISSHomo_sapiens(9606)Process
GO:0031668involved_in cellular response to extracellular stimulus1ISSHomo_sapiens(9606)Process
GO:0032794enables GTPase activating protein binding1IEAHomo_sapiens(9606)Function
GO:0032956involved_in regulation of actin cytoskeleton organization1ISSHomo_sapiens(9606)Process
GO:0035024acts_upstream_of_or_within negative regulation of Rho protein signal transduction1ISSHomo_sapiens(9606)Process
GO:0036064located_in ciliary basal body1ISSHomo_sapiens(9606)Component
GO:0043010involved_in camera-type eye development1IEAHomo_sapiens(9606)Process
GO:0043116involved_in negative regulation of vascular permeability1IEAHomo_sapiens(9606)Process
GO:0043547involved_in positive regulation of GTPase activity1IEAHomo_sapiens(9606)Process
GO:0044319involved_in wound healing, spreading of cells1ISSHomo_sapiens(9606)Process
GO:0044877enables protein-containing complex binding1IEAHomo_sapiens(9606)Function
GO:0045724involved_in positive regulation of cilium assembly1ISSHomo_sapiens(9606)Process
GO:0050770involved_in regulation of axonogenesis2IBA,ISSHomo_sapiens(9606)Process
GO:0051056involved_in regulation of small GTPase mediated signal transduction1TASHomo_sapiens(9606)Process
GO:0097485involved_in neuron projection guidance1ISSHomo_sapiens(9606)Process

Expression