Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations >Nucleoplasm<>Cytosol<
BulkPerturb-seq

Description

Ensembl ID ENSG00000157554 Gene ID 2078 Accession 3446
Symbol ERG Alias p55;erg-3 Full Name ETS transcription factor ERG
Status Confidence Length 281754 bases Strand Minus strand
Position 21 : 38380027 - 38661780 RNA binding domain N.A.
Summary This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ERG-203 ENST00000398905 4806 455aa ENSP00000381877
ERG-204 ENST00000398907 4809 456aa ENSP00000381879
ERG-202 ENST00000398897 4651 363aa ENSP00000381871
ERG-206 ENST00000398911 4914 462aa ENSP00000381882
ERG-208 ENST00000417133 5023 486aa ENSP00000414150
ERG-205 ENST00000398910 4954 463aa ENSP00000381881
ERG-201 ENST00000288319 4904 479aa ENSP00000288319
ERG-210 ENST00000453032 1595 387aa ENSP00000396268
ERG-207 ENST00000398919 1868 486aa ENSP00000381891
ERG-213 ENST00000481609 970 No protein -
ERG-215 ENST00000492833 938 No protein -
ERG-211 ENST00000468474 1454 No protein -
ERG-212 ENST00000473107 560 No protein -
ERG-214 ENST00000485493 1626 No protein -
ERG-209 ENST00000442448 5034 462aa ENSP00000394694

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
14828Hemoglobin A, Glycosylated7.036E-0519875614
14829Hemoglobin A, Glycosylated5.777E-0519875614
19086Blood Vessels1.96e-005-
19518Blood Pressure1.314e-005-
27846Blood Glucose4.4920000E-005-
28090Blood Glucose9.5570000E-005-
31269Hematocrit8.5310000E-005-
31273Hematocrit5.4090000E-005-
31745Erythrocyte Count2.3250000E-006-
31761Erythrocyte Count1.1150000E-005-
38018Platelet Function Tests2.2900000E-006-
45870Platelet Function Tests3.3485700E-005-
47691Intelligence Tests5.5500900E-007-
47692Intelligence Tests2.5909800E-006-
48465Child Development Disorders, Pervasive3.9768600E-007-
48466Child Development Disorders, Pervasive2.7584100E-006-
50021Child Development Disorders, Pervasive2.2841000E-005-
51384Child Development Disorders, Pervasive3.7698000E-006-
52075Child Development Disorders, Pervasive9.5000000E-005-
52295Child Development Disorders, Pervasive7.5000000E-005-
57743Plaque, Atherosclerotic2.4040000E-00521909108
73696Intelligence1E-625383866
77846Basophils2E-1821738478
85675Multiple Sclerosis2E-727386562
91573Aortic Aneurysm, Abdominal6E-927899403
103879Anxiety Disorders6E-626989097
103880Cognitive Therapy6E-626989097

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific2IBA,ISAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific1IMPHomo_sapiens(9606)Function
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation1TASHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0030154involved_in cell differentiation1IBAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II2IDA,IMPHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component

Expression