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RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | Disease |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | Kinase |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000157540 | Gene ID | 1859 | Accession | 3091 |
| Symbol | DYRK1A | Alias | MNB;DYRK;HP86;MNBH;MRD7;DYRK1 | Full Name | dual specificity tyrosine phosphorylation regulated kinase 1A |
| Status | Confidence | Length | 160786 bases | Strand | Plus strand |
| Position | 21 : 37365573 - 37526358 | RNA binding domain | N.A. | ||
| Summary | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 34785661 | Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. | H Ines Kaltheuner | 2021-11-16 | Nature communications |
| 37310920 | DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner. | S Madison Strine | 2023-06-01 | PLoS biology |
| 37469393 | Dyrk1a Phosphorylation of α-Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson's Disease. | Yuxuan Yong | 2023-01-01 | Parkinson's disease |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| DYRK1A-219 | ENST00000646523 | 2153 | 605aa | ENSP00000495632 |
| DYRK1A-222 | ENST00000647425 | 2737 | 754aa | ENSP00000496748 |
| DYRK1A-221 | ENST00000647188 | 17024 | 754aa | ENSP00000494572 |
| DYRK1A-223 | ENST00000647504 | 5591 | 725aa | ENSP00000495571 |
| DYRK1A-214 | ENST00000644942 | 3137 | 763aa | ENSP00000494544 |
| DYRK1A-201 | ENST00000338785 | 5518 | 584aa | ENSP00000342690 |
| DYRK1A-210 | ENST00000643624 | 2881 | 754aa | ENSP00000493627 |
| DYRK1A-209 | ENST00000643551 | 525 | 110aa | ENSP00000494698 |
| DYRK1A-204 | ENST00000426672 | 693 | 181aa | ENSP00000412269 |
| DYRK1A-203 | ENST00000398960 | 2782 | 763aa | ENSP00000381932 |
| DYRK1A-220 | ENST00000646548 | 17562 | 754aa | ENSP00000495908 |
| DYRK1A-205 | ENST00000455097 | 364 | 23aa | ENSP00000398483 |
| DYRK1A-212 | ENST00000643854 | 1456 | 400aa | ENSP00000493653 |
| DYRK1A-215 | ENST00000645424 | 1654 | 525aa | ENSP00000494897 |
| DYRK1A-207 | ENST00000642309 | 1709 | 400aa | ENSP00000495596 |
| DYRK1A-216 | ENST00000645774 | 1764 | 519aa | ENSP00000494536 |
| DYRK1A-202 | ENST00000398956 | 1590 | 529aa | ENSP00000381929 |
| DYRK1A-206 | ENST00000462274 | 1233 | No protein | - |
| DYRK1A-208 | ENST00000643355 | 1866 | No protein | - |
| DYRK1A-211 | ENST00000643808 | 1117 | No protein | - |
| DYRK1A-213 | ENST00000644367 | 796 | No protein | - |
| DYRK1A-217 | ENST00000646224 | 1735 | No protein | - |
| DYRK1A-218 | ENST00000646351 | 4543 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 18993 | Transferrin | 1.318e-005 | - |
| 19002 | Transferrin | 4.515e-006 | - |
| 19003 | Transferrin | 3.95e-005 | - |
| 21289 | Conscience | 3.603e-005 | - |
| 21301 | Conscience | 6.12e-005 | - |
| 21307 | Conscience | 3.448e-005 | - |
| 21932 | Personality | 3.665e-007 | - |
| 21950 | Personality | 9.278e-007 | - |
| 21953 | Personality | 4.853e-007 | - |
| 22181 | Thyrotropin | 5.59e-005 | - |
| 59171 | Cryptorchidism | 9.9300000E-005 | - |
| 74104 | HIV-1 | 5E-6 | 21364930 |
| 80679 | Immunoglobulins | 5E-6 | 23382691 |
| 103776 | Metabolic Syndrome X | 6E-6 | 20694148 |
| 103777 | Waist-Hip Ratio | 6E-6 | 20694148 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0003713 | enables transcription coactivator activity | 1 | IBA | Homo_sapiens(9606) | Function |
| GO:0004672 | enables protein kinase activity | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0004674 | enables protein serine/threonine kinase activity | 5 | IBA,IGI,ISS,NAS,TAS | Homo_sapiens(9606) | Function |
| GO:0004712 | enables protein serine/threonine/tyrosine kinase activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0004713 | enables protein tyrosine kinase activity | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0004715 | enables non-membrane spanning protein tyrosine kinase activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005524 | enables ATP binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0005634 | is_active_in nucleus | 4 | IBA,IDA,ISS | Homo_sapiens(9606) | Component |
| GO:0005654 | located_in nucleoplasm | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0005737 | located_in cytoplasm | 3 | IDA,ISS,TAS | Homo_sapiens(9606) | Component |
| GO:0005856 | colocalizes_with cytoskeleton | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0006338 | involved_in chromatin remodeling | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0006357 | involved_in regulation of transcription by RNA polymerase II | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0006468 | involved_in protein phosphorylation | 2 | ISS,TAS | Homo_sapiens(9606) | Process |
| GO:0007399 | involved_in nervous system development | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0007623 | involved_in circadian rhythm | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0008353 | enables RNA polymerase II CTD heptapeptide repeat kinase activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0016607 | located_in nuclear speck | 2 | ISS,TAS | Homo_sapiens(9606) | Component |
| GO:0018105 | involved_in peptidyl-serine phosphorylation | 3 | IBA,IGI,ISS | Homo_sapiens(9606) | Process |
| GO:0018107 | involved_in peptidyl-threonine phosphorylation | 2 | IBA,ISS | Homo_sapiens(9606) | Process |
| GO:0018108 | acts_upstream_of_or_within peptidyl-tyrosine phosphorylation | 2 | IDA,ISS | Homo_sapiens(9606) | Process |
| GO:0030424 | located_in axon | 1 | ISS | Homo_sapiens(9606) | Component |
| GO:0030425 | located_in dendrite | 1 | ISS | Homo_sapiens(9606) | Component |
| GO:0031115 | involved_in negative regulation of microtubule polymerization | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0033120 | involved_in positive regulation of RNA splicing | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0034205 | involved_in amyloid-beta formation | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0036289 | involved_in peptidyl-serine autophosphorylation | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0038083 | involved_in peptidyl-tyrosine autophosphorylation | 2 | IDA,TAS | Homo_sapiens(9606) | Process |
| GO:0042802 | enables identical protein binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0043518 | involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0043621 | enables protein self-association | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0045893 | involved_in positive regulation of DNA-templated transcription | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0046777 | involved_in protein autophosphorylation | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0048025 | involved_in negative regulation of mRNA splicing, via spliceosome | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0048156 | enables tau protein binding | 2 | ISS,NAS | Homo_sapiens(9606) | Function |
| GO:0050321 | enables tau-protein kinase activity | 1 | NAS | Homo_sapiens(9606) | Function |
| GO:0090310 | involved_in negative regulation of DNA methylation-dependent heterochromatin formation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0090312 | involved_in positive regulation of protein deacetylation | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0106310 | enables protein serine kinase activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0140857 | enables histone H3T45 kinase activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:1990904 | part_of ribonucleoprotein complex | 1 | IEA | Homo_sapiens(9606) | Component |