RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000157540	Gene ID	1859	Accession	3091
Symbol	DYRK1A	Alias	MNB;DYRK;HP86;MNBH;MRD7;DYRK1	Full Name	dual specificity tyrosine phosphorylation regulated kinase 1A
Status	Confidence	Length	160786 bases	Strand	Plus strand
Position	21 : 37365573 - 37526358	RNA binding domain	N.A.
Summary	This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]