RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	DataSet_02_40

Description

Ensembl ID	ENSG00000156976	Gene ID	1974	Accession	3284
Symbol	EIF4A2	Alias	DDX2B;EIF4A;EIF4F;BM-010;NEDHSS;eIF4A-II;eIF-4A-II	Full Name	eukaryotic translation initiation factor 4A2
Status	Confidence	Length	6693 bases	Strand	Plus strand
Position	3 : 186783205 - 186789897	RNA binding domain	ResIII , DEAD
Summary	Enables ATP hydrolysis activity. Involved in negative regulation of RNA-directed 5'-3' RNA polymerase activity. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000326381	DEAD	PF00270	3.2e-43	1
ENSP00000326381	ResIII	PF04851	4.7e-07	2
ENSP00000398370	DEAD	PF00270	3.2e-43	1
ENSP00000398370	ResIII	PF04851	4.7e-07	2
ENSP00000413529	DEAD	PF00270	2.5e-43	1
ENSP00000413529	ResIII	PF04851	3.6e-07	2
ENSP00000415878	DEAD	PF00270	1.3e-06	1
ENSP00000462571	DEAD	PF00270	1.2e-14	1
ENSP00000462571	ResIII	PF04851	5.2e-05	2

Showing 1 to 9 of 9 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_HeLa	HeLa	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y

Showing 1 to 10 of 12 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
23867391	Downregulation of EIF4A2 in non-small-cell lung cancer associates with poor prognosis.	Xi Shaoyan	2013-11-01	Clinical lung cancer
27009120	miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning.	Duygu Kuzuoğlu-Öztürk	2016-06-01	The EMBO journal
27160682	Sumoylation of eIF4A2 affects stress granule formation.	Jirapas Jongjitwimol	2016-06-15	Journal of cell science
31180491	DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.	A Hedda Meijer	2019-09-05	Nucleic acids research
31791371	eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR.	Ania Wilczynska	2019-12-02	Genome biology
32575790	General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation.	Leo Shen	2020-06-20	International journal of molecular sciences
32766783	Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.	Jutta Steinberger	2020-09-25	Nucleic acids research
35781533	The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.	Lina Liu	2022-07-04	Nature communications
36528028	Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.	S Maimuna Paul	2023-01-05	American journal of human genetics

Showing 1 to 9 of 9 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
EIF4A2-201	ENST00000323963	1886	407aa	ENSP00000326381
EIF4A2-202	ENST00000425053	1977	362aa	ENSP00000413529
EIF4A2-203	ENST00000426808	1751	96aa	ENSP00000392686
EIF4A2-204	ENST00000429589	1005	96aa	ENSP00000388237
EIF4A2-205	ENST00000440191	1889	408aa	ENSP00000398370
EIF4A2-206	ENST00000441007	480	57aa	ENSP00000407504
EIF4A2-207	ENST00000443963	1729	97aa	ENSP00000402313
EIF4A2-208	ENST00000445596	600	98aa	ENSP00000415878
EIF4A2-209	ENST00000461021	575	No protein	-
EIF4A2-210	ENST00000465032	578	No protein	-

Showing 1 to 10 of 27 entries

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Gene Model

Click here to download ENSG00000156976's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
88025	Adiponectin	7E-7	24105470

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000156976	rs266719	3	186783859	Adiponectin levels	24105470	0.13	EFO_0004502

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000156976's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000156976	homo_sapiens	ENSP00000379475	51.4019	33.8785	homo_sapiens	ENSP00000326381	54.0541	35.6265
ENSG00000156976	homo_sapiens	ENSP00000385536	27.1605	18.7929	homo_sapiens	ENSP00000326381	48.6486	33.6609
ENSG00000156976	homo_sapiens	ENSP00000263239	29.1045	17.0149	homo_sapiens	ENSP00000326381	47.9115	28.0098
ENSG00000156976	homo_sapiens	ENSP00000497641	80.5353	67.1533	homo_sapiens	ENSP00000326381	81.3268	67.8133
ENSG00000156976	homo_sapiens	ENSP00000482680	26.7974	15.9477	homo_sapiens	ENSP00000326381	50.3685	29.9754
ENSG00000156976	homo_sapiens	ENSP00000293831	96.3054	89.9015	homo_sapiens	ENSP00000326381	96.0688	89.6806
ENSG00000156976	homo_sapiens	ENSP00000306117	53.1381	35.1464	homo_sapiens	ENSP00000326381	62.4079	41.2776
ENSG00000156976	homo_sapiens	ENSP00000288071	53.2359	35.6994	homo_sapiens	ENSP00000326381	62.6536	42.0147
ENSG00000156976	homo_sapiens	ENSP00000481495	22.9336	13.1548	homo_sapiens	ENSP00000326381	48.403	27.7641
ENSG00000156976	homo_sapiens	ENSP00000416534	19.9612	12.2093	homo_sapiens	ENSP00000326381	50.6143	30.9582

Showing 1 to 10 of 38 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000156976	homo_sapiens	ENSP00000326381	99.5086	99.5086	nomascus_leucogenys	ENSNLEP00000008099	99.5086	99.5086
ENSG00000156976	homo_sapiens	ENSP00000326381	100	100	pan_paniscus	ENSPPAP00000003559	100	100
ENSG00000156976	homo_sapiens	ENSP00000326381	97.543	96.8059	pongo_abelii	ENSPPYP00000035935	97.066	96.3325
ENSG00000156976	homo_sapiens	ENSP00000326381	100	100	pan_troglodytes	ENSPTRP00000027042	99.7549	99.7549
ENSG00000156976	homo_sapiens	ENSP00000326381	100	100	gorilla_gorilla	ENSGGOP00000005745	100	100
ENSG00000156976	homo_sapiens	ENSP00000326381	99.5086	98.7715	ornithorhynchus_anatinus	ENSOANP00000054875	97.3558	96.6346
ENSG00000156976	homo_sapiens	ENSP00000326381	99.7543	99.0172	sarcophilus_harrisii	ENSSHAP00000028916	99.7543	99.0172
ENSG00000156976	homo_sapiens	ENSP00000326381	95.5774	94.8403	notamacropus_eugenii	ENSMEUP00000010692	96.0494	95.3086
ENSG00000156976	homo_sapiens	ENSP00000326381	79.6069	78.8698	choloepus_hoffmanni	ENSCHOP00000012415	80.597	79.8507
ENSG00000156976	homo_sapiens	ENSP00000326381	61.9165	61.9165	erinaceus_europaeus	ENSEEUP00000007820	90.3226	90.3226

Showing 1 to 10 of 212 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002183	involved_in cytoplasmic translational initiation	1	IBA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003724	enables RNA helicase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0003743	enables translation initiation factor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004386	enables helicase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006413	involved_in translational initiation	1	NAS	Homo_sapiens(9606)	Process
GO:0006446	involved_in regulation of translational initiation	1	TAS	Homo_sapiens(9606)	Process

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression