RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000156110	Gene ID	132	Accession	257
Symbol	ADK	Alias	AK	Full Name	adenosine kinase
Status	Confidence	Length	558762 bases	Strand	Plus strand
Position	10 : 74151202 - 74709963	RNA binding domain	N.A.
Summary	This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ADK-209	ENST00000672429	1249	305aa	ENSP00000500292
ADK-205	ENST00000539909	1992	362aa	ENSP00000443965
ADK-201	ENST00000286621	1622	347aa	ENSP00000286621
ADK-204	ENST00000478611	443	37aa	ENSP00000500114
ADK-214	ENST00000673352	2494	294aa	ENSP00000500056
ADK-213	ENST00000673310	3212	229aa	ENSP00000500097
ADK-202	ENST00000372734	1993	345aa	ENSP00000361819
ADK-211	ENST00000672920	1622	99aa	ENSP00000500141
ADK-208	ENST00000672394	1791	270aa	ENSP00000500390
ADK-212	ENST00000673027	1188	327aa	ENSP00000500201
ADK-206	ENST00000541550	1752	356aa	ENSP00000438321
ADK-210	ENST00000672604	731	179aa	ENSP00000499911
ADK-203	ENST00000467840	603	No protein	-
ADK-207	ENST00000661461	379	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
4944	Cholesterol, LDL	3.40063589262047E-6	17903299
4959	Cholesterol, LDL	6.2515746639416E-6	17903299
73953	Tooth Eruption	2E-8	23704328
74680	Odontogenesis	8E-16	23704328
83148	Interleukin-2 Receptor alpha Subunit	8E-6	26293465
102153	Tooth Eruption	6E-18	21931568
106796	Hypospadias	1E-7	25108383

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0004001	enables adenosine kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004136	enables deoxyadenosine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0006144	involved_in purine nucleobase metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0006166	involved_in purine ribonucleoside salvage	1	IEA	Homo_sapiens(9606)	Process
GO:0006175	involved_in dATP biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0009156	involved_in ribonucleoside monophosphate biosynthetic process	1	TAS	Homo_sapiens(9606)	Process
GO:0016310	involved_in phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0032263	involved_in GMP salvage	1	IEA	Homo_sapiens(9606)	Process
GO:0044209	involved_in AMP salvage	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0106383	involved_in dAMP salvage	1	IEA	Homo_sapiens(9606)	Process