RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000154582	Gene ID	6921	Accession	11617
Symbol	ELOC	Alias	SIII;TCEB1	Full Name	elongin C
Status	Confidence	Length	33139 bases	Strand	Minus strand
Position	8 : 73939169 - 73972307	RNA binding domain	N.A.
Summary	This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ELOC-209	ENST00000602840	2780	65aa	ENSP00000473408
ELOC-206	ENST00000520242	2015	112aa	ENSP00000428171
ELOC-202	ENST00000518127	1943	112aa	ENSP00000428334
ELOC-215	ENST00000692141	5877	No protein	-
ELOC-214	ENST00000688584	1911	96aa	ENSP00000509989
ELOC-210	ENST00000622804	1992	112aa	ENSP00000478121
ELOC-213	ENST00000687224	2032	112aa	ENSP00000509184
ELOC-212	ENST00000685938	1709	133aa	ENSP00000509885
ELOC-205	ENST00000520210	1451	96aa	ENSP00000430224
ELOC-201	ENST00000284811	683	112aa	ENSP00000284811
ELOC-211	ENST00000685250	659	No protein	-
ELOC-204	ENST00000519487	765	135aa	ENSP00000429596
ELOC-207	ENST00000522337	816	112aa	ENSP00000429906
ELOC-208	ENST00000523815	719	112aa	ENSP00000428074
ELOC-203	ENST00000519082	634	89aa	ENSP00000429789

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
42630	Platelet Function Tests	2.5766400E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001222	enables transcription corepressor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	TAS	Homo_sapiens(9606)	Process
GO:0006367	involved_in transcription initiation at RNA polymerase II promoter	1	IDA	Homo_sapiens(9606)	Process
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	2	IDA,IEA	Homo_sapiens(9606)	Process
GO:0030674	enables protein-macromolecule adaptor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0031462	part_of Cul2-RING ubiquitin ligase complex	1	ISS	Homo_sapiens(9606)	Component
GO:0031466	part_of Cul5-RING ubiquitin ligase complex	1	IDA	Homo_sapiens(9606)	Component
GO:0070449	part_of elongin complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0140958	involved_in target-directed miRNA degradation	1	IMP	Homo_sapiens(9606)	Process