Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000154548 Gene ID 135295 Accession 21220
Symbol SRSF12 Alias SFRS19;SRrp35;SFRS13B Full Name serine and arginine rich splicing factor 12
Status Confidence Length 22113 bases Strand Minus strand
Position 6 : 89095959 - 89118071 RNA binding domain RRM_1
Summary Enables RNA binding activity. Involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000414302 RRM_1 PF00076 1e-18 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34316707 A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. Muhammad Sohail 2021-06-01 NAR cancer

Transcripts

Name Transcript ID bp Protein Translation ID

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000154548homo_sapiensENSP0000042019564.122153.0534homo_sapiensENSP0000041430264.367853.2567
ENSG00000154548homo_sapiensENSP0000048014039.361727.6596homo_sapiensENSP0000041430242.528729.8851
ENSG00000154548homo_sapiensENSP0000035308953.846238.914homo_sapiensENSP0000041430245.593932.9502

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000154548homo_sapiensENSP0000041430290.804690.8046nomascus_leucogenysENSNLEP0000004033998.340298.3402
ENSG00000154548homo_sapiensENSP0000041430293.869792.3372pan_paniscusENSPPAP0000003764992.80391.2879
ENSG00000154548homo_sapiensENSP0000041430299.616999.6169pongo_abeliiENSPPYP0000001884999.616999.6169
ENSG00000154548homo_sapiensENSP00000414302100100pan_troglodytesENSPTRP00000031459100100
ENSG00000154548homo_sapiensENSP0000041430292.337291.954gorilla_gorillaENSGGOP0000005198394.509894.1176
ENSG00000154548homo_sapiensENSP0000041430221.455919.9234ornithorhynchus_anatinusENSOANP0000005196378.873273.2394
ENSG00000154548homo_sapiensENSP0000041430286.973281.2261sarcophilus_harrisiiENSSHAP0000004405391.532385.4839
ENSG00000154548homo_sapiensENSP0000041430261.302755.9387notamacropus_eugeniiENSMEUP0000001343765.843660.0823
ENSG00000154548homo_sapiensENSP0000041430272.413871.6475choloepus_hoffmanniENSCHOP0000001232294.974993.9698
ENSG00000154548homo_sapiensENSP0000041430262.06961.3027dasypus_novemcinctusENSDNOP0000003456497.590496.3855
ENSG00000154548homo_sapiensENSP0000041430296.934995.4023erinaceus_europaeusENSEEUP0000001003696.564995.0382
ENSG00000154548homo_sapiensENSP0000041430265.517264.3678echinops_telfairiENSETEP0000000111471.848770.5882
ENSG00000154548homo_sapiensENSP0000041430271.647568.9655callithrix_jacchusENSCJAP0000008248166.077763.6042
ENSG00000154548homo_sapiensENSP00000414302100100cercocebus_atysENSCATP00000012955100100
ENSG00000154548homo_sapiensENSP00000414302100100macaca_fascicularisENSMFAP00000061194100100
ENSG00000154548homo_sapiensENSP0000041430299.233799.2337macaca_mulattaENSMMUP0000001959897.003797.0037
ENSG00000154548homo_sapiensENSP00000414302100100macaca_nemestrinaENSMNEP00000013421100100
ENSG00000154548homo_sapiensENSP0000041430299.616999.6169papio_anubisENSPANP0000001877199.236699.2366
ENSG00000154548homo_sapiensENSP0000041430290.421590.4215mandrillus_leucophaeusENSMLEP0000003616497.925397.9253
ENSG00000154548homo_sapiensENSP0000041430292.337291.954tursiops_truncatusENSTTRP0000000345491.984791.6031
ENSG00000154548homo_sapiensENSP0000041430291.187790.0383vulpes_vulpesENSVVUP0000001393894.820793.6255
ENSG00000154548homo_sapiensENSP0000041430293.103489.6552mus_spretusMGP_SPRETEiJ_P006412293.103489.6552
ENSG00000154548homo_sapiensENSP0000041430262.452162.069equus_asinusENSEASP0000505335598.192897.5904
ENSG00000154548homo_sapiensENSP0000041430297.31896.9349capra_hircusENSCHIP0000001302896.946696.5649
ENSG00000154548homo_sapiensENSP0000041430289.655289.272loxodonta_africanaENSLAFP0000000457497.095496.6805
ENSG00000154548homo_sapiensENSP0000041430221.455919.9234panthera_leoENSPLOP0000001379681.159475.3623
ENSG00000154548homo_sapiensENSP0000041430290.804690.4215ailuropoda_melanoleucaENSAMEP0000000043490.45890.0763
ENSG00000154548homo_sapiensENSP0000041430298.084397.7011bos_indicus_hybridENSBIXP0000504666198.084397.7011
ENSG00000154548homo_sapiensENSP0000041430262.06960.9195oryctolagus_cuniculusENSOCUP0000000081797.590495.7831
ENSG00000154548homo_sapiensENSP0000041430281.992380.8429equus_caballusENSECAP0000001661246.120745.4741
ENSG00000154548homo_sapiensENSP0000041430291.95491.5709canis_lupus_familiarisENSCAFP0084500904381.355981.017
ENSG00000154548homo_sapiensENSP0000041430297.701197.318panthera_pardusENSPPRP0000002741997.701197.318
ENSG00000154548homo_sapiensENSP0000041430288.122688.1226marmota_marmota_marmotaENSMMMP0000001081897.457697.4576
ENSG00000154548homo_sapiensENSP0000041430262.452161.6858balaenoptera_musculusENSBMSP0001001404598.192896.988
ENSG00000154548homo_sapiensENSP0000041430288.888988.1226cavia_porcellusENSCPOP0000000980997.071196.2343
ENSG00000154548homo_sapiensENSP0000041430271.647569.7318felis_catusENSFCAP0000005451943.589742.4242
ENSG00000154548homo_sapiensENSP0000041430285.823879.6935monodelphis_domesticaENSMODP0000002279790.688384.2105
ENSG00000154548homo_sapiensENSP0000041430288.505788.1226bison_bison_bisonENSBBBP0000001321591.666791.2698
ENSG00000154548homo_sapiensENSP0000041430262.452162.069monodon_monocerosENSMMNP0001503021798.192897.5904
ENSG00000154548homo_sapiensENSP0000041430298.084397.7011sus_scrofaENSSSCP0000004765197.709997.3282
ENSG00000154548homo_sapiensENSP0000041430298.467497.318microcebus_murinusENSMICP0000001934398.467497.318
ENSG00000154548homo_sapiensENSP0000041430293.486691.954octodon_degusENSODEP0000001235993.486691.954
ENSG00000154548homo_sapiensENSP0000041430294.252993.8697ovis_aries_rambouilletENSOARP0002001589694.980794.5946
ENSG00000154548homo_sapiensENSP0000041430289.655288.8889ursus_maritimusENSUMAP0000001428889.31388.5496
ENSG00000154548homo_sapiensENSP0000041430287.356384.6743ochotona_princepsENSOPRP0000001465595.397592.4686
ENSG00000154548homo_sapiensENSP0000041430298.467498.0843delphinapterus_leucasENSDLEP0000002653698.091697.7099
ENSG00000154548homo_sapiensENSP0000041430298.850698.4674physeter_catodonENSPCTP0000501718998.850698.4674
ENSG00000154548homo_sapiensENSP0000041430292.720388.8889mus_caroliMGP_CAROLIEiJ_P006169192.720388.8889
ENSG00000154548homo_sapiensENSP0000041430263.601559.7701mus_musculusENSMUSP0000006793962.40658.6466
ENSG00000154548homo_sapiensENSP0000041430261.685861.3027mustela_putorius_furoENSMPUP0000000926996.98896.3855
ENSG00000154548homo_sapiensENSP0000041430298.084398.0843aotus_nancymaaeENSANAP0000001050993.430793.4307
ENSG00000154548homo_sapiensENSP0000041430289.27289.272saimiri_boliviensis_boliviensisENSSBOP0000003243892.094992.0949
ENSG00000154548homo_sapiensENSP0000041430292.720391.5709vicugna_pacosENSVPAP0000000387992.366491.2214
ENSG00000154548homo_sapiensENSP0000041430299.616999.6169chlorocebus_sabaeusENSCSAP0000001335999.236699.2366
ENSG00000154548homo_sapiensENSP0000041430286.206984.6743tupaia_belangeriENSTBEP0000000749394.142392.4686
ENSG00000154548homo_sapiensENSP0000041430223.754822.6054mesocricetus_auratusENSMAUP0000000838091.176586.7647
ENSG00000154548homo_sapiensENSP0000041430298.850698.4674phocoena_sinusENSPSNP0000000757475.882475.5882
ENSG00000154548homo_sapiensENSP0000041430262.452161.6858camelus_dromedariusENSCDRP0000502611498.192896.988
ENSG00000154548homo_sapiensENSP0000041430289.655288.8889carlito_syrichtaENSTSYP0000000117795.121994.3089
ENSG00000154548homo_sapiensENSP0000041430261.302760.9195panthera_tigris_altaicaENSPTIP0000000845996.385595.7831
ENSG00000154548homo_sapiensENSP0000041430294.252990.8046rattus_norvegicusENSRNOP0000008846265.079462.6984
ENSG00000154548homo_sapiensENSP0000041430298.084396.9349prolemur_simusENSPSMP0000001477197.709996.5649
ENSG00000154548homo_sapiensENSP0000041430293.869791.1877microtus_ochrogasterENSMOCP0000000720493.869791.1877
ENSG00000154548homo_sapiensENSP0000041430289.655289.6552sorex_araneusENSSARP0000000706497.095497.0954
ENSG00000154548homo_sapiensENSP0000041430224.137921.0728peromyscus_maniculatus_bairdiiENSPEMP0000002501267.741959.1398
ENSG00000154548homo_sapiensENSP0000041430288.505788.1226bos_mutusENSBMUP0000002810991.666791.2698
ENSG00000154548homo_sapiensENSP0000041430261.302758.2375mus_spicilegusENSMSIP0000001433260.150457.1429
ENSG00000154548homo_sapiensENSP0000041430264.367860.5364cricetulus_griseus_chok1gshdENSCGRP0000100245065.62561.7188
ENSG00000154548homo_sapiensENSP0000041430289.655289.272pteropus_vampyrusENSPVAP0000000098797.597.0833
ENSG00000154548homo_sapiensENSP0000041430289.27288.8889myotis_lucifugusENSMLUP0000000141694.33293.9271
ENSG00000154548homo_sapiensENSP0000041430250.957945.2107vombatus_ursinusENSVURP0001000825286.928177.1242
ENSG00000154548homo_sapiensENSP0000041430262.452161.6858rhinolophus_ferrumequinumENSRFEP0001000182498.192896.988
ENSG00000154548homo_sapiensENSP0000041430261.685861.3027neovison_visonENSNVIP0000000288396.98896.3855
ENSG00000154548homo_sapiensENSP0000041430298.084397.7011bos_taurusENSBTAP0000005390598.084397.7011
ENSG00000154548homo_sapiensENSP0000041430261.685860.5364heterocephalus_glaber_femaleENSHGLP0000004446296.98895.1807
ENSG00000154548homo_sapiensENSP0000041430292.337291.954rhinopithecus_bietiENSRBIP0000001170997.967597.561
ENSG00000154548homo_sapiensENSP0000041430298.084397.7011canis_lupus_dingoENSCAFP0002002016298.084397.7011
ENSG00000154548homo_sapiensENSP0000041430262.452162.069sciurus_vulgarisENSSVLP0000501839098.192897.5904
ENSG00000154548homo_sapiensENSP0000041430286.973281.2261phascolarctos_cinereusENSPCIP0000002915391.532385.4839
ENSG00000154548homo_sapiensENSP0000041430277.394675.8621procavia_capensisENSPCAP0000000931177.692376.1538
ENSG00000154548homo_sapiensENSP0000041430294.252990.8046nannospalax_galiliENSNGAP0000001919194.615491.1538
ENSG00000154548homo_sapiensENSP0000041430298.084397.7011bos_grunniensENSBGRP0000003724198.084397.7011
ENSG00000154548homo_sapiensENSP0000041430290.038389.6552chinchilla_lanigeraENSCLAP0000002024098.326497.908
ENSG00000154548homo_sapiensENSP0000041430288.888988.8889cervus_hanglu_yarkandensisENSCHYP0000002475389.575389.5753
ENSG00000154548homo_sapiensENSP0000041430297.31896.5517catagonus_wagneriENSCWAP0000001437096.946696.1832
ENSG00000154548homo_sapiensENSP0000041430298.084397.318ictidomys_tridecemlineatusENSSTOP0000000640397.709996.9466
ENSG00000154548homo_sapiensENSP0000041430288.888986.9732otolemur_garnettiiENSOGAP0000000573996.666794.5833
ENSG00000154548homo_sapiensENSP0000041430298.084398.0843cebus_imitatorENSCCAP0000002998893.430793.4307
ENSG00000154548homo_sapiensENSP0000041430262.06961.6858urocitellus_parryiiENSUPAP0001002167297.590496.988
ENSG00000154548homo_sapiensENSP0000041430297.701196.9349moschus_moschiferusENSMMSP0000001449197.701196.9349
ENSG00000154548homo_sapiensENSP0000041430299.233799.2337rhinopithecus_roxellanaENSRROP00000024305100100
ENSG00000154548homo_sapiensENSP0000041430293.486689.6552mus_pahariMGP_PahariEiJ_P005735593.486689.6552
ENSG00000154548homo_sapiensENSP0000041430297.701196.5517propithecus_coquereliENSPCOP0000000045097.328296.1832
ENSG00000154548homo_sapiensENSP0000041430250.957940.2299ciona_intestinalisENSCINP0000003456458.590346.2555
ENSG00000154548homo_sapiensENSP0000041430245.593936.0153eptatretus_burgeriENSEBUP0000001201661.979248.9583
ENSG00000154548homo_sapiensENSP0000041430265.517259.0038latimeria_chalumnaeENSLACP0000000492162.637456.4103
ENSG00000154548homo_sapiensENSP0000041430221.072818.3908danio_rerioENSDARP0000015026491.666780
ENSG00000154548homo_sapiensENSP0000041430221.072817.6245carassius_auratusENSCARP0000010858277.464864.7887
ENSG00000154548homo_sapiensENSP0000041430226.436820.6897carassius_auratusENSCARP0000009264176.666760
ENSG00000154548homo_sapiensENSP0000041430221.455918.3908astyanax_mexicanusENSAMXP0000003931481.159469.5652
ENSG00000154548homo_sapiensENSP0000041430224.521120.3065ictalurus_punctatusENSIPUP0000003443060.952450.4762
ENSG00000154548homo_sapiensENSP0000041430224.521121.4559esox_luciusENSELUP0000005576559.813152.3364
ENSG00000154548homo_sapiensENSP0000041430225.287419.1571electrophorus_electricusENSEEEP0000002002758.928644.6429
ENSG00000154548homo_sapiensENSP0000041430220.689716.8582gadus_morhuaENSGMOP000000128559073.3333
ENSG00000154548homo_sapiensENSP0000041430227.586221.4559gadus_morhuaENSGMOP0000004326262.06948.2759
ENSG00000154548homo_sapiensENSP0000041430221.839117.2414fundulus_heteroclitusENSFHEP0000002991151.351440.5405
ENSG00000154548homo_sapiensENSP0000041430221.455918.3908cyclopterus_lumpusENSCLMP0000501867476.712365.7534
ENSG00000154548homo_sapiensENSP0000041430224.521120.3065oreochromis_niloticusENSONIP0000008014559.259349.0741
ENSG00000154548homo_sapiensENSP0000041430277.394670.4981xenopus_tropicalisENSXETP0000001185179.841972.7273
ENSG00000154548homo_sapiensENSP0000041430221.455919.9234sphenodon_punctatusENSSPUP0000002107383.582177.6119
ENSG00000154548homo_sapiensENSP0000041430254.02344.0613laticauda_laticaudataENSLLTP0000002260479.213564.6067
ENSG00000154548homo_sapiensENSP0000041430254.02344.0613notechis_scutatusENSNSUP0000002419879.213564.6067
ENSG00000154548homo_sapiensENSP0000041430275.095863.9847pseudonaja_textilisENSPTXP0000001132083.760771.3675
ENSG00000154548homo_sapiensENSP0000041430270.114959.387anolis_carolinensisENSACAP0000004016773.262
ENSG00000154548homo_sapiensENSP0000041430221.839118.7739neolamprologus_brichardiENSNBRP0000001370081.428670
ENSG00000154548homo_sapiensENSP0000041430275.095863.9847naja_najaENSNNAP0000000445183.760771.3675
ENSG00000154548homo_sapiensENSP0000041430252.873646.3602podarcis_muralisENSPMRP0000000684078.857169.1429
ENSG00000154548homo_sapiensENSP0000041430245.210739.4636kryptolebias_marmoratusENSKMAP0000000082165.555657.2222
ENSG00000154548homo_sapiensENSP0000041430280.459870.8812salvator_merianaeENSSMRP0000002255282.031272.2656
ENSG00000154548homo_sapiensENSP0000041430221.072818.3908oryzias_javanicusENSOJAP0000001166380.882470.5882
ENSG00000154548homo_sapiensENSP0000041430221.839118.7739amphilophus_citrinellusENSACIP0000000188981.428670
ENSG00000154548homo_sapiensENSP0000041430221.839119.1571amphilophus_citrinellusENSACIP0000002406983.823573.5294
ENSG00000154548homo_sapiensENSP0000041430249.808439.0805amphiprion_perculaENSAPEP0000000685861.032947.8873
ENSG00000154548homo_sapiensENSP0000041430220.689718.0077amphiprion_perculaENSAPEP0000002269079.411869.1176
ENSG00000154548homo_sapiensENSP0000041430252.107342.9119seriola_dumeriliENSSDUP0000001121245.791237.7104
ENSG00000154548homo_sapiensENSP0000041430222.605417.2414cottoperca_gobioENSCGOP0000003987677.631659.2105
ENSG00000154548homo_sapiensENSP0000041430223.754818.7739sander_luciopercaENSSLUP0000005165675.609859.7561
ENSG00000154548homo_sapiensENSP0000041430222.605420.3065strigops_habroptilaENSSHBP0000500636076.623468.8312
ENSG00000154548homo_sapiensENSP0000041430228.352520.6897amphiprion_ocellarisENSAOCP0000000606057.812542.1875
ENSG00000154548homo_sapiensENSP0000041430221.839118.3908pygocentrus_nattereriENSPNAP0000002477586.363672.7273
ENSG00000154548homo_sapiensENSP0000041430223.754819.9234anabas_testudineusENSATEP0000005625465.263254.7368
ENSG00000154548homo_sapiensENSP0000041430222.605419.1571anabas_testudineusENSATEP0000000494181.944469.4444
ENSG00000154548homo_sapiensENSP0000041430252.490439.8467ciona_savignyiENSCSAVP0000000861860.619546.0177
ENSG00000154548homo_sapiensENSP0000041430220.306518.0077seriola_lalandi_dorsalisENSSLDP0000000041872.602764.3836
ENSG00000154548homo_sapiensENSP0000041430220.306518.0077seriola_lalandi_dorsalisENSSLDP0000000342786.885277.0492
ENSG00000154548homo_sapiensENSP0000041430221.072817.6245labrus_bergyltaENSLBEP0000001638983.333369.697
ENSG00000154548homo_sapiensENSP0000041430220.689718.7739mastacembelus_armatusENSMAMP0000001198581.818274.2424
ENSG00000154548homo_sapiensENSP0000041430221.072818.7739mastacembelus_armatusENSMAMP0000001128363.218456.3218
ENSG00000154548homo_sapiensENSP0000041430221.839118.7739stegastes_partitusENSSPAP0000000238081.428670
ENSG00000154548homo_sapiensENSP0000041430221.839119.1571acanthochromis_polyacanthusENSAPOP0000002091289.062578.125
ENSG00000154548homo_sapiensENSP0000041430221.455919.9234aquila_chrysaetos_chrysaetosENSACCP0002001214036.12933.5484
ENSG00000154548homo_sapiensENSP0000041430221.839119.1571larimichthys_croceaENSLCRP0000506574970.370461.7284
ENSG00000154548homo_sapiensENSP0000041430221.839118.3908takifugu_rubripesENSTRUP0000008397078.082265.7534
ENSG00000154548homo_sapiensENSP0000041430221.839117.6245hippocampus_comesENSHCOP0000000443383.823567.6471
ENSG00000154548homo_sapiensENSP0000041430224.137918.7739hippocampus_comesENSHCOP0000002152772.413856.3218
ENSG00000154548homo_sapiensENSP0000041430244.444436.7816cyprinus_carpio_carpioENSCCRP0000017083071.604959.2593
ENSG00000154548homo_sapiensENSP0000041430221.839119.1571paramormyrops_kingsleyaeENSPKIP0000001302964.044956.1798
ENSG00000154548homo_sapiensENSP0000041430275.095869.7318leptobrachium_leishanenseENSLLEP0000003354977.470471.9368
ENSG00000154548homo_sapiensENSP0000041430220.689717.2414scophthalmus_maximusENSSMAP0000003026867.556.25

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000244involved_in spliceosomal tri-snRNP complex assembly1NASHomo_sapiens(9606)Process
GO:0000381involved_in regulation of alternative mRNA splicing, via spliceosome1IDAHomo_sapiens(9606)Process
GO:0000395involved_in mRNA 5-splice site recognition1IDAHomo_sapiens(9606)Process
GO:0000398involved_in mRNA splicing, via spliceosome1IBAHomo_sapiens(9606)Process
GO:0003723enables RNA binding3HDA,IBA,NASHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm2ISS,TASHomo_sapiens(9606)Component
GO:0016607is_active_in nuclear speck1IBAHomo_sapiens(9606)Component
GO:0048025involved_in negative regulation of mRNA splicing, via spliceosome1ISSHomo_sapiens(9606)Process
GO:0050733enables RS domain binding1NASHomo_sapiens(9606)Function
GO:0051082enables unfolded protein binding1NASHomo_sapiens(9606)Function

Expression