RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzymeTransmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000154269	Gene ID	5169	Accession	3358
Symbol	ENPP3	Alias	B10;NPP3;PDNP3;CD203c;PD-IBETA	Full Name	ectonucleotide pyrophosphatase/phosphodiesterase 3
Status	Confidence	Length	118977 bases	Strand	Plus strand
Position	6 : 131628442 - 131747418	RNA binding domain	Endonuclease_NS
Summary	The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000350265	Endonuclease_NS	PF01223	8.9e-06	1
ENSP00000406261	Endonuclease_NS	PF01223	8.9e-06	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
39749	Platelet Function Tests	1.0655200E-005	-
84856	Lung Neoplasms	2E-6	28044437
84857	Body Mass Index	2E-6	28044437
86830	Fenofibrate	5E-6	23149075

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002276	involved_in basophil activation involved in immune response	1	ISS	Homo_sapiens(9606)	Process
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004528	enables phosphodiesterase I activity	1	IMP	Homo_sapiens(9606)	Function
GO:0005509	enables calcium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0006220	involved_in pyrimidine nucleotide metabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0006796	involved_in phosphate-containing compound metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0009143	involved_in nucleoside triphosphate catabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0009897	located_in external side of plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0016324	located_in apical plasma membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0030505	NOT involved_in inorganic diphosphate transport	1	IDA	Homo_sapiens(9606)	Process
GO:0033007	involved_in negative regulation of mast cell activation involved in immune response	1	ISS	Homo_sapiens(9606)	Process
GO:0046034	involved_in ATP metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0047429	enables nucleoside triphosphate diphosphatase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0048471	located_in perinuclear region of cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0050728	involved_in negative regulation of inflammatory response	1	ISS	Homo_sapiens(9606)	Process
GO:0055062	involved_in phosphate ion homeostasis	1	IEA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0070667	involved_in negative regulation of mast cell proliferation	1	ISS	Homo_sapiens(9606)	Process