RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000153048	Gene ID	23589	Accession	17150
Symbol	CARHSP1	Alias	CSDC1;CRHSP24;CRHSP-24	Full Name	calcium regulated heat stable protein 1
Status	Confidence	Length	16071 bases	Strand	Minus strand
Position	16 : 8852942 - 8869012	RNA binding domain	CSD
Summary	Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule and cytosol. Predicted to be active in cytoplasm. Predicted to colocalize with cytoplasmic exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000311847	CSD	PF00313	1.4e-11	1
ENSP00000379838	CSD	PF00313	1.4e-11	1
ENSP00000455016	CSD	PF00313	1.1e-11	1
ENSP00000455284	CSD	PF00313	1.4e-11	1
ENSP00000455522	CSD	PF00313	1.3e-10	1
ENSP00000455855	CSD	PF00313	1.4e-11	1
ENSP00000456909	CSD	PF00313	7.3e-10	1
ENSP00000457864	CSD	PF00313	1.8e-10	1
ENSP00000460812	CSD	PF00313	6.2e-08	1
ENSP00000478055	CSD	PF00313	1.4e-11	1
ENSP00000480144	CSD	PF00313	1.4e-11	1
ENSP00000480542	CSD	PF00313	1.4e-11	1
ENSP00000481550	CSD	PF00313	1.4e-11	1
ENSP00000483591	CSD	PF00313	1.4e-11	1

Showing 1 to 14 of 14 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21

Showing 1 to 1 of 1 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
26899994	miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1.	Xiaoyi Li	2016-02-22	Scientific reports
34290231	Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.	Guo-Dong Zhu	2021-07-21	Cell death & disease
35955908	Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening.	N Rosette Tamaddondoust	2022-08-07	International journal of molecular sciences

Showing 1 to 3 of 3 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
CARHSP1-201	ENST00000311052	2709	147aa	ENSP00000311847
CARHSP1-202	ENST00000396593	3026	147aa	ENSP00000379838
CARHSP1-203	ENST00000561530	729	147aa	ENSP00000455284
CARHSP1-204	ENST00000562586	578	No protein	-
CARHSP1-205	ENST00000562843	843	94aa	ENSP00000460812
CARHSP1-206	ENST00000563815	1913	No protein	-
CARHSP1-207	ENST00000565287	556	131aa	ENSP00000455016
CARHSP1-208	ENST00000567554	598	147aa	ENSP00000455855
CARHSP1-209	ENST00000567626	350	No protein	-
CARHSP1-210	ENST00000567908	565	125aa	ENSP00000455522

Showing 1 to 10 of 20 entries

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Gene Model

Click here to download ENSG00000153048's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
54671	Creatine Kinase	4.3400000E-005	-
54672	Creatine Kinase	2.5950000E-005	-

Showing 1 to 2 of 2 entries

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000153048	rs138031402	16	8866468	Intracranial aneurysm	29531279	4.2953296	EFO_0003870

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000153048's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000153048	homo_sapiens	ENSP00000302485	68.6274	60.1307	homo_sapiens	ENSP00000311847	71.4286	62.585

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000153048	homo_sapiens	ENSP00000311847	99.3197	97.9592	nomascus_leucogenys	ENSNLEP00000012279	99.3197	97.9592
ENSG00000153048	homo_sapiens	ENSP00000311847	100	100	pan_paniscus	ENSPPAP00000011839	100	100
ENSG00000153048	homo_sapiens	ENSP00000311847	99.3197	97.2789	pongo_abelii	ENSPPYP00000008012	74.8718	73.3333
ENSG00000153048	homo_sapiens	ENSP00000311847	100	100	pan_troglodytes	ENSPTRP00000013237	100	100
ENSG00000153048	homo_sapiens	ENSP00000311847	100	100	gorilla_gorilla	ENSGGOP00000035231	100	100
ENSG00000153048	homo_sapiens	ENSP00000311847	65.3061	59.8639	ornithorhynchus_anatinus	ENSOANP00000048508	47.2906	43.3498
ENSG00000153048	homo_sapiens	ENSP00000311847	94.5578	87.7551	sarcophilus_harrisii	ENSSHAP00000031541	94.5578	87.7551
ENSG00000153048	homo_sapiens	ENSP00000311847	94.5578	88.4354	notamacropus_eugenii	ENSMEUP00000014997	94.5578	88.4354
ENSG00000153048	homo_sapiens	ENSP00000311847	68.0272	65.3061	choloepus_hoffmanni	ENSCHOP00000000356	67.5676	64.8649
ENSG00000153048	homo_sapiens	ENSP00000311847	95.9184	93.1973	dasypus_novemcinctus	ENSDNOP00000026101	88.6792	86.1635

Showing 1 to 10 of 200 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003730	enables mRNA 3-UTR binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0043488	involved_in regulation of mRNA stability	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0000932	located_in P-body	1	IEA	Homo_sapiens(9606)	Component
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	ISS	Homo_sapiens(9606)	Component
GO:0019902	enables phosphatase binding	1	NAS	Homo_sapiens(9606)	Function
GO:0035556	involved_in intracellular signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0043186	located_in P granule	1	ISS	Homo_sapiens(9606)	Component

Showing 1 to 9 of 9 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression