RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Transmemebrane
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000152952	Gene ID	5352	Accession	9082
Symbol	PLOD2	Alias	LH2;TLH;BRKS2	Full Name	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Status	Confidence	Length	94355 bases	Strand	Minus strand
Position	3 : 146069371 - 146163725	RNA binding domain	2OG-FeII_Oxy
Summary	The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000419354	2OG-FeII_Oxy	PF03171	1.7e-05	1
ENSP00000420094	2OG-FeII_Oxy	PF03171	3.1e-05	1
ENSP00000516472	2OG-FeII_Oxy	PF03171	3.1e-05	1
ENSP00000419963	2OG-FeII_Oxy	PF03171	3.1e-05	1
ENSP00000516475	2OG-FeII_Oxy	PF03171	3.1e-05	1
ENSP00000353170	2OG-FeII_Oxy	PF03171	3.3e-05	1
ENSP00000515354	2OG-FeII_Oxy	PF03171	3.3e-05	1
ENSP00000282903	2OG-FeII_Oxy	PF03171	3.5e-05	1
ENSP00000515350	2OG-FeII_Oxy	PF03171	3.5e-05	1
ENSP00000515353	2OG-FeII_Oxy	PF03171	3.5e-05	1
ENSP00000515355	2OG-FeII_Oxy	PF03171	3.5e-05	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PLOD2-211	ENST00000703517	914	No protein	-
PLOD2-208	ENST00000480704	3862	98aa	ENSP00000419880
PLOD2-205	ENST00000469350	3511	709aa	ENSP00000419963
PLOD2-212	ENST00000703518	4502	758aa	ENSP00000515350
PLOD2-213	ENST00000703519	3575	No protein	-
PLOD2-214	ENST00000703520	3974	552aa	ENSP00000515351
PLOD2-215	ENST00000703521	4257	280aa	ENSP00000515352
PLOD2-204	ENST00000461497	3043	418aa	ENSP00000419354
PLOD2-201	ENST00000282903	3749	758aa	ENSP00000282903
PLOD2-216	ENST00000703522	4060	758aa	ENSP00000515353
PLOD2-217	ENST00000703523	3997	737aa	ENSP00000515354
PLOD2-202	ENST00000360060	3665	737aa	ENSP00000353170
PLOD2-218	ENST00000703524	3395	No protein	-
PLOD2-226	ENST00000706631	3960	No protein	-
PLOD2-219	ENST00000703525	5867	No protein	-
PLOD2-227	ENST00000706632	2375	No protein	-
PLOD2-220	ENST00000703526	2879	No protein	-
PLOD2-228	ENST00000706633	4481	No protein	-
PLOD2-229	ENST00000706634	4670	No protein	-
PLOD2-230	ENST00000706635	3536	702aa	ENSP00000516475
PLOD2-231	ENST00000706636	3836	280aa	ENSP00000516476
PLOD2-224	ENST00000706626	3572	699aa	ENSP00000516472
PLOD2-221	ENST00000703527	4330	758aa	ENSP00000515355
PLOD2-222	ENST00000703528	2117	485aa	ENSP00000515356
PLOD2-209	ENST00000494950	2908	703aa	ENSP00000420094
PLOD2-210	ENST00000495700	761	No protein	-
PLOD2-206	ENST00000475505	480	No protein	-
PLOD2-223	ENST00000703529	2165	No protein	-
PLOD2-207	ENST00000478436	3835	No protein	-
PLOD2-203	ENST00000460520	530	No protein	-
PLOD2-225	ENST00000706627	1558	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
3434	Cholesterol, HDL	3.54223048282432E-8	17903299
10898	Hip	5.0626450544479E-6	17903296
17280	Cholesterol, HDL	3.221e-005	19060910
85884	Fatty Acids	2E-7	23251661

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001666	involved_in response to hypoxia	1	IEP	Homo_sapiens(9606)	Process
GO:0005506	enables iron ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005783	is_active_in endoplasmic reticulum	1	IBA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006493	NOT involved_in protein O-linked glycosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0008475	enables procollagen-lysine 5-dioxygenase activity	3	IBA,IDA,ISS	Homo_sapiens(9606)	Function
GO:0017185	involved_in peptidyl-lysine hydroxylation	3	IBA,IDA,ISS	Homo_sapiens(9606)	Process
GO:0030867	located_in rough endoplasmic reticulum membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0031418	enables L-ascorbic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0033823	NOT enables procollagen glucosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0036211	involved_in protein modification process	1	TAS	Homo_sapiens(9606)	Process
GO:0046947	involved_in hydroxylysine biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component