RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000151846	Gene ID	5042	Accession	8556
Symbol	PABPC3	Alias	PABP3;tPABP;PABPL3	Full Name	poly(A) binding protein cytoplasmic 3
Status	Confidence	Length	3119 bases	Strand	Plus strand
Position	13 : 25096136 - 25099254	RNA binding domain	PABP , RRM_5 , RRM_1
Summary	Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000281589	RRM_1	PF00076	2.9e-88	1
ENSP00000281589	RRM_1	PF00076	2.9e-88	2
ENSP00000281589	RRM_1	PF00076	2.9e-88	3
ENSP00000281589	RRM_1	PF00076	2.9e-88	4
ENSP00000281589	PABP	PF00658	3.8e-29	5
ENSP00000281589	RRM_5	PF13893	4.8e-07	6

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32373524	New Insights Into the Complex Mutational Landscape of Sézary Syndrome.	Abu-Sayeef Mirza	2020-01-01	Frontiers in oncology
35041720	Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).	Mohadeseh M Zarei	2022-01-01	PloS one
35456240	Identification of Potentially Pathogenic Variants Associated with Recurrence in Medication-Related Osteonecrosis of the Jaw (MRONJ) Patients Using Whole-Exome Sequencing.	Songmi Kim	2022-04-12	Journal of clinical medicine
22400011	mRNA 3' end processing factors: a phylogenetic comparison.	K Sarah Darmon	2012-01-01	Comparative and functional genomics

Name	Transcript ID	bp	Protein	Translation ID
PABPC3-201	ENST00000281589	3119	631aa	ENSP00000281589

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
1599	Body Mass Index	3.69127265951175E-5	17903300
1609	Body Mass Index	9.1221293583299E-6	17903300
1621	Body Weight Changes	9.94212450016185E-5	17903300
1851	Body Mass Index	5.62533436854196E-5	17903300
1865	Body Mass Index	6.70008838343783E-6	17903300
1883	Body Weight Changes	3.72348892492269E-5	17903300
1991	Body Weight	4.803246198537E-5	17903300
2011	Body Weight	3.33930811104999E-5	17903300
7636	Glomerular Filtration Rate	1.43242652486927E-5	17903292

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000151846	homo_sapiens	ENSP00000313007	94.3396	92.1384	homo_sapiens	ENSP00000281589	95.0872	92.8685
ENSG00000151846	homo_sapiens	ENSP00000286070	32.7004	14.557	homo_sapiens	ENSP00000281589	24.5642	10.935
ENSG00000151846	homo_sapiens	ENSP00000294904	45.8128	25.3695	homo_sapiens	ENSP00000281589	29.477	16.3233
ENSG00000151846	homo_sapiens	ENSP00000352162	40.8719	21.5259	homo_sapiens	ENSP00000281589	23.7718	12.5198
ENSG00000151846	homo_sapiens	ENSP00000304405	31.7536	20.0632	homo_sapiens	ENSP00000281589	31.8542	20.1268
ENSG00000151846	homo_sapiens	ENSP00000358635	32.1027	21.1878	homo_sapiens	ENSP00000281589	31.6957	20.9192
ENSG00000151846	homo_sapiens	ENSP00000308012	75.6544	60.4712	homo_sapiens	ENSP00000281589	45.8003	36.6086
ENSG00000151846	homo_sapiens	ENSP00000385269	42.0245	22.6994	homo_sapiens	ENSP00000281589	21.7116	11.7274
ENSG00000151846	homo_sapiens	ENSP00000262031	45.4545	24.8157	homo_sapiens	ENSP00000281589	29.3185	16.0063
ENSG00000151846	homo_sapiens	ENSP00000386226	31.3953	14.6512	homo_sapiens	ENSP00000281589	21.3946	9.98415
ENSG00000151846	homo_sapiens	ENSP00000271628	32.783	20.283	homo_sapiens	ENSP00000281589	22.0285	13.6292
ENSG00000151846	homo_sapiens	ENSP00000311747	20.9268	12.2571	homo_sapiens	ENSP00000281589	22.187	12.9952
ENSG00000151846	homo_sapiens	ENSP00000348538	39.3305	25.1046	homo_sapiens	ENSP00000281589	14.897	9.50872
ENSG00000151846	homo_sapiens	ENSP00000360889	42.8962	22.4044	homo_sapiens	ENSP00000281589	24.8811	12.9952
ENSG00000151846	homo_sapiens	ENSP00000368341	40.678	25.4237	homo_sapiens	ENSP00000281589	15.2139	9.50872
ENSG00000151846	homo_sapiens	ENSP00000380479	43.1755	22.8412	homo_sapiens	ENSP00000281589	24.5642	12.9952
ENSG00000151846	homo_sapiens	ENSP00000463233	81.3513	67.5676	homo_sapiens	ENSP00000281589	47.7021	39.6197
ENSG00000151846	homo_sapiens	ENSP00000361949	78.4848	70	homo_sapiens	ENSP00000281589	82.0919	73.2171
ENSG00000151846	homo_sapiens	ENSP00000434359	29.517	15.7424	homo_sapiens	ENSP00000281589	26.149	13.9461
ENSG00000151846	homo_sapiens	ENSP00000373277	44.8513	25.1716	homo_sapiens	ENSP00000281589	31.0618	17.4326
ENSG00000151846	homo_sapiens	ENSP00000240185	36.4734	18.1159	homo_sapiens	ENSP00000281589	23.9303	11.8859
ENSG00000151846	homo_sapiens	ENSP00000217073	78.1906	66.0743	homo_sapiens	ENSP00000281589	76.7036	64.8177
ENSG00000151846	homo_sapiens	ENSP00000362621	84	72.5	homo_sapiens	ENSP00000281589	26.6244	22.9794
ENSG00000151846	homo_sapiens	ENSP00000362618	84	72.5	homo_sapiens	ENSP00000281589	26.6244	22.9794

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000151846	homo_sapiens	ENSP00000281589	94.9287	92.393	nomascus_leucogenys	ENSNLEP00000035525	94.9287	92.393
ENSG00000151846	homo_sapiens	ENSP00000281589	96.355	94.7702	pongo_abelii	ENSPPYP00000005945	95.5975	94.0252
ENSG00000151846	homo_sapiens	ENSP00000281589	98.8906	97.7813	pan_troglodytes	ENSPTRP00000041427	98.5782	97.4724
ENSG00000151846	homo_sapiens	ENSP00000281589	97.9398	96.8304	gorilla_gorilla	ENSGGOP00000043850	97.9398	96.8304
ENSG00000151846	homo_sapiens	ENSP00000281589	94.9287	92.2346	ornithorhynchus_anatinus	ENSOANP00000011633	94.1824	91.5094
ENSG00000151846	homo_sapiens	ENSP00000281589	41.5214	39.6197	dasypus_novemcinctus	ENSDNOP00000027441	92.2535	88.0282
ENSG00000151846	homo_sapiens	ENSP00000281589	69.7306	61.4897	dasypus_novemcinctus	ENSDNOP00000034210	77.193	68.0702
ENSG00000151846	homo_sapiens	ENSP00000281589	62.916	59.4295	echinops_telfairi	ENSETEP00000015606	90.2273	85.2273
ENSG00000151846	homo_sapiens	ENSP00000281589	90.6498	87.0048	callithrix_jacchus	ENSCJAP00000073289	89.9371	86.3208
ENSG00000151846	homo_sapiens	ENSP00000281589	95.4041	93.3439	cercocebus_atys	ENSCATP00000010037	95.5556	93.4921
ENSG00000151846	homo_sapiens	ENSP00000281589	96.1965	94.1363	macaca_mulatta	ENSMMUP00000027420	95.2904	93.2496
ENSG00000151846	homo_sapiens	ENSP00000281589	96.355	94.2948	macaca_nemestrina	ENSMNEP00000040023	96.355	94.2948
ENSG00000151846	homo_sapiens	ENSP00000281589	77.496	75.4358	papio_anubis	ENSPANP00000040758	95.3216	92.7875
ENSG00000151846	homo_sapiens	ENSP00000281589	96.038	93.9778	mandrillus_leucophaeus	ENSMLEP00000036181	96.1905	94.127
ENSG00000151846	homo_sapiens	ENSP00000281589	83.6767	77.3376	mus_spretus	MGP_SPRETEiJ_P0044575	82.1151	75.8942
ENSG00000151846	homo_sapiens	ENSP00000281589	82.2504	74.6434	mus_spretus	MGP_SPRETEiJ_P0048527	82.5119	74.8808
ENSG00000151846	homo_sapiens	ENSP00000281589	61.8067	47.7021	equus_asinus	ENSEASP00005020531	65.6566	50.6734
ENSG00000151846	homo_sapiens	ENSP00000281589	62.7575	48.8114	equus_caballus	ENSECAP00000023392	66.443	51.6779
ENSG00000151846	homo_sapiens	ENSP00000281589	48.1775	36.1331	ursus_americanus	ENSUAMP00000029130	70.5336	52.9002
ENSG00000151846	homo_sapiens	ENSP00000281589	90.8082	86.5293	microcebus_murinus	ENSMICP00000027955	90.9524	86.6667
ENSG00000151846	homo_sapiens	ENSP00000281589	67.0365	60.0634	jaculus_jaculus	ENSJJAP00000017768	83.2677	74.6063
ENSG00000151846	homo_sapiens	ENSP00000281589	82.4089	74.4849	jaculus_jaculus	ENSJJAP00000010743	83.6013	75.5627
ENSG00000151846	homo_sapiens	ENSP00000281589	84.1521	78.13	mus_caroli	MGP_CAROLIEiJ_P0042697	82.5816	76.6719
ENSG00000151846	homo_sapiens	ENSP00000281589	82.7258	75.1189	mus_caroli	MGP_CAROLIEiJ_P0046607	82.9889	75.3577
ENSG00000151846	homo_sapiens	ENSP00000281589	82.4089	74.9604	mus_musculus	ENSMUSP00000066639	82.8026	75.3185
ENSG00000151846	homo_sapiens	ENSP00000281589	84.1521	77.9715	mus_musculus	ENSMUSP00000050792	82.5816	76.5163
ENSG00000151846	homo_sapiens	ENSP00000281589	95.0872	92.71	dipodomys_ordii	ENSDORP00000013100	94.3396	91.9811
ENSG00000151846	homo_sapiens	ENSP00000281589	80.5071	75.9113	aotus_nancymaae	ENSANAP00000017680	83.9669	79.1736
ENSG00000151846	homo_sapiens	ENSP00000281589	75.2773	71.1569	aotus_nancymaae	ENSANAP00000036652	85.1255	80.466
ENSG00000151846	homo_sapiens	ENSP00000281589	79.3978	74.3265	saimiri_boliviensis_boliviensis	ENSSBOP00000007693	85.0594	79.6265
ENSG00000151846	homo_sapiens	ENSP00000281589	34.8653	26.4659	vicugna_pacos	ENSVPAP00000010248	66.6667	50.6061
ENSG00000151846	homo_sapiens	ENSP00000281589	82.4089	76.7036	mesocricetus_auratus	ENSMAUP00000003008	81.5047	75.8621
ENSG00000151846	homo_sapiens	ENSP00000281589	84.7861	77.496	mesocricetus_auratus	ENSMAUP00000019802	84.9206	77.619
ENSG00000151846	homo_sapiens	ENSP00000281589	54.3582	52.9319	camelus_dromedarius	ENSCDRP00005012707	92.4528	90.027
ENSG00000151846	homo_sapiens	ENSP00000281589	83.9937	78.7639	rattus_norvegicus	ENSRNOP00000023319	82.4261	77.2939
ENSG00000151846	homo_sapiens	ENSP00000281589	71.3154	64.8177	rattus_norvegicus	ENSRNOP00000019468	83.7989	76.1639
ENSG00000151846	homo_sapiens	ENSP00000281589	83.2013	75.5943	microtus_ochrogaster	ENSMOCP00000001743	83.8658	76.1981
ENSG00000151846	homo_sapiens	ENSP00000281589	83.8352	78.4469	peromyscus_maniculatus_bairdii	ENSPEMP00000029297	82.1429	76.8634
ENSG00000151846	homo_sapiens	ENSP00000281589	84.6276	78.4469	peromyscus_maniculatus_bairdii	ENSPEMP00000012969	85.0318	78.8217
ENSG00000151846	homo_sapiens	ENSP00000281589	83.0428	76.8621	mus_spicilegus	ENSMSIP00000016569	81.493	75.4277
ENSG00000151846	homo_sapiens	ENSP00000281589	82.0919	74.9604	mus_spicilegus	ENSMSIP00000014254	82.6156	75.4386
ENSG00000151846	homo_sapiens	ENSP00000281589	83.0428	77.6545	cricetulus_griseus_chok1gshd	ENSCGRP00001005982	82.2606	76.9231
ENSG00000151846	homo_sapiens	ENSP00000281589	72.2662	58.7956	myotis_lucifugus	ENSMLUP00000017881	72.8435	59.2652
ENSG00000151846	homo_sapiens	ENSP00000281589	39.1442	38.1933	heterocephalus_glaber_female	ENSHGLP00000004140	89.4928	87.3188
ENSG00000151846	homo_sapiens	ENSP00000281589	95.0872	92.71	rhinopithecus_bieti	ENSRBIP00000020833	95.2381	92.8571
ENSG00000151846	homo_sapiens	ENSP00000281589	81.9334	75.1189	nannospalax_galili	ENSNGAP00000014829	81.5457	74.7634
ENSG00000151846	homo_sapiens	ENSP00000281589	81.9334	74.8019	nannospalax_galili	ENSNGAP00000001322	82.194	75.0397
ENSG00000151846	homo_sapiens	ENSP00000281589	87.4802	81.775	otolemur_garnettii	ENSOGAP00000021369	85.9813	80.3738
ENSG00000151846	homo_sapiens	ENSP00000281589	79.8732	74.3265	cebus_imitator	ENSCCAP00000027761	86.1538	80.1709
ENSG00000151846	homo_sapiens	ENSP00000281589	66.2441	62.599	cebus_imitator	ENSCCAP00000021366	85.4806	80.7771
ENSG00000151846	homo_sapiens	ENSP00000281589	95.0872	92.71	rhinopithecus_roxellana	ENSRROP00000026262	95.2381	92.8571
ENSG00000151846	homo_sapiens	ENSP00000281589	42.7892	39.1442	mus_pahari	MGP_PahariEiJ_P0054988	74.7922	68.4211
ENSG00000151846	homo_sapiens	ENSP00000281589	80.6656	72.7417	mus_pahari	MGP_PahariEiJ_P0039195	80.6656	72.7417
ENSG00000151846	homo_sapiens	ENSP00000281589	91.1252	85.8954	propithecus_coquereli	ENSPCOP00000004836	91.4149	86.1685
ENSG00000151846	homo_sapiens	ENSP00000281589	8.71632	7.92393	callorhinchus_milii	ENSCMIP00000003022	93.2203	84.7458
ENSG00000151846	homo_sapiens	ENSP00000281589	93.8193	90.3328	latimeria_chalumnae	ENSLACP00000004944	88.6228	85.3293
ENSG00000151846	homo_sapiens	ENSP00000281589	92.71	87.1632	lepisosteus_oculatus	ENSLOCP00000011833	91.4062	85.9375
ENSG00000151846	homo_sapiens	ENSP00000281589	90.1743	84.3106	clupea_harengus	ENSCHAP00000025064	88.9062	83.125
ENSG00000151846	homo_sapiens	ENSP00000281589	16.4818	10.1426	carassius_auratus	ENSCARP00000017321	59.4286	36.5714
ENSG00000151846	homo_sapiens	ENSP00000281589	90.3328	84.1521	astyanax_mexicanus	ENSAMXP00000050925	89.9054	83.7539
ENSG00000151846	homo_sapiens	ENSP00000281589	44.691	32.9636	ictalurus_punctatus	ENSIPUP00000029435	54.1267	39.9232
ENSG00000151846	homo_sapiens	ENSP00000281589	34.8653	27.4168	ictalurus_punctatus	ENSIPUP00000036236	66.0661	51.952
ENSG00000151846	homo_sapiens	ENSP00000281589	17.2742	13.6292	ictalurus_punctatus	ENSIPUP00000014692	61.9318	48.8636
ENSG00000151846	homo_sapiens	ENSP00000281589	67.3534	60.8558	esox_lucius	ENSELUP00000046174	83.0078	75
ENSG00000151846	homo_sapiens	ENSP00000281589	90.4913	84.6276	lates_calcarifer	ENSLCAP00010030427	91.6533	85.7143
ENSG00000151846	homo_sapiens	ENSP00000281589	93.8193	90.8082	chrysemys_picta_bellii	ENSCPBP00000007323	93.5229	90.5213
ENSG00000151846	homo_sapiens	ENSP00000281589	93.8193	91.1252	laticauda_laticaudata	ENSLLTP00000009330	93.2283	90.5512
ENSG00000151846	homo_sapiens	ENSP00000281589	93.5024	90.8082	notechis_scutatus	ENSNSUP00000016921	92.9134	90.2362
ENSG00000151846	homo_sapiens	ENSP00000281589	93.5024	90.8082	pseudonaja_textilis	ENSPTXP00000001309	92.9134	90.2362
ENSG00000151846	homo_sapiens	ENSP00000281589	94.2948	91.1252	anas_platyrhynchos_platyrhynchos	ENSAPLP00000000885	93.4066	90.2669
ENSG00000151846	homo_sapiens	ENSP00000281589	94.2948	91.1252	gallus_gallus	ENSGALP00010015549	88.1481	85.1852
ENSG00000151846	homo_sapiens	ENSP00000281589	85.5784	82.7258	meleagris_gallopavo	ENSMGAP00000012874	94.0767	90.9408
ENSG00000151846	homo_sapiens	ENSP00000281589	85.5784	82.7258	serinus_canaria	ENSSCAP00000005525	93.913	90.7826
ENSG00000151846	homo_sapiens	ENSP00000281589	94.1363	91.2837	anolis_carolinensis	ENSACAP00000016286	93.3962	90.566
ENSG00000151846	homo_sapiens	ENSP00000281589	93.0269	90.3328	naja_naja	ENSNNAP00000014858	92.8797	90.1899
ENSG00000151846	homo_sapiens	ENSP00000281589	93.6609	90.8082	podarcis_muralis	ENSPMRP00000032361	90.5054	87.7488
ENSG00000151846	homo_sapiens	ENSP00000281589	86.6878	83.0428	geospiza_fortis	ENSGFOP00000019377	91.9328	88.0672
ENSG00000151846	homo_sapiens	ENSP00000281589	91.1252	86.5293	erpetoichthys_calabaricus	ENSECRP00000027705	90.5512	85.9843
ENSG00000151846	homo_sapiens	ENSP00000281589	94.4532	91.6006	salvator_merianae	ENSSMRP00000027436	93.7107	90.8805
ENSG00000151846	homo_sapiens	ENSP00000281589	94.1363	91.4422	pelodiscus_sinensis	ENSPSIP00000003942	93.3962	90.7233
ENSG00000151846	homo_sapiens	ENSP00000281589	94.2948	91.4422	gopherus_evgoodei	ENSGEVP00005012803	93.5535	90.7233
ENSG00000151846	homo_sapiens	ENSP00000281589	94.2948	91.4422	chelonoidis_abingdonii	ENSCABP00000012863	93.5535	90.7233
ENSG00000151846	homo_sapiens	ENSP00000281589	79.7147	77.1791	struthio_camelus_australis	ENSSCUP00000012861	94.3715	91.3696
ENSG00000151846	homo_sapiens	ENSP00000281589	88.748	85.2615	anser_brachyrhynchus	ENSABRP00000004074	89.172	85.6688
ENSG00000151846	homo_sapiens	ENSP00000281589	93.9778	90.6498	strigops_habroptila	ENSSHBP00005001790	93.0926	89.7959
ENSG00000151846	homo_sapiens	ENSP00000281589	94.2948	91.2837	terrapene_carolina_triunguis	ENSTMTP00000002518	93.5535	90.566
ENSG00000151846	homo_sapiens	ENSP00000281589	94.2948	91.1252	aquila_chrysaetos_chrysaetos	ENSACCP00020001837	93.4066	90.2669
ENSG00000151846	homo_sapiens	ENSP00000281589	87.7971	83.6767	ficedula_albicollis	ENSFALP00000006100	92.4875	88.1469
ENSG00000151846	homo_sapiens	ENSP00000281589	16.1648	10.1426	cyprinus_carpio_carpio	ENSCCRP00000163535	56.6667	35.5556
ENSG00000151846	homo_sapiens	ENSP00000281589	86.8463	83.6767	coturnix_japonica	ENSCJPP00005000791	93.039	89.6435
ENSG00000151846	homo_sapiens	ENSP00000281589	86.5293	78.7639	scleropages_formosus	ENSSFOP00015010223	86.1199	78.3912
ENSG00000151846	homo_sapiens	ENSP00000281589	90.6498	84.7861	scleropages_formosus	ENSSFOP00015004255	90.0787	84.252
ENSG00000151846	homo_sapiens	ENSP00000281589	42.9477	41.5214	leptobrachium_leishanense	ENSLLEP00000040766	94.0972	90.9722

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003730	enables mRNA 3-UTR binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	NAS	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0008143	enables poly(A) binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0008266	enables poly(U) RNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0010494	is_active_in cytoplasmic stress granule	1	IBA	Homo_sapiens(9606)	Component
GO:0016071	involved_in mRNA metabolic process	1	NAS	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:1990904	part_of ribonucleoprotein complex	1	IBA	Homo_sapiens(9606)	Component