Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000150593 Gene ID 27250 Accession 8763
Symbol PDCD4 Alias H731 Full Name programmed cell death 4
Status Confidence Length 28212 bases Strand Plus strand
Position 10 : 110871795 - 110900006 RNA binding domain MA3
Summary This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000376816 MA3 PF02847 9.2e-47 1
ENSP00000376816 MA3 PF02847 9.2e-47 2
ENSP00000280154 MA3 PF02847 9.9e-47 1
ENSP00000280154 MA3 PF02847 9.9e-47 2
ENSP00000394668 MA3 PF02847 1.2e-10 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27647131 miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4. Yanqing Liu 2016-10-01 Protein & cell
25190455 An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4. Olesja Fehler 2014-01-01 Nucleic acids research
26501070 Translation, Pdcd4 and eIF4A. Abhiruchi Biyanee 2015-01-01 Oncoscience
25820028 Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA. Johanna Ohnheiser 2015-07-01 Biochimica et biophysica acta
34925466 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes. Yogita Chhichholiya 2021-01-01 Frontiers in genetics
31692513 Programmed cell death 4 (PDCD4) as a novel prognostic marker for papillary thyroid carcinoma. Francesca Galuppini 2019-01-01 Cancer management and research
24041411 The unique evolution of the programmed cell death 4 protein in plants. Shijun Cheng 2013-09-16 BMC evolutionary biology
26026468 Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. Zhike Chen 2015-07-01 Breast cancer research and treatment
35943670 High Expression of circ_0001821 Promoted Colorectal Cancer Progression Through miR-600/ISOC1 Axis. Cheng Li 2023-02-01 Biochemical genetics
30365117 MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation. Yiwei Wang 2019-01-01 International journal of molecular medicine
35795053 Dissecting the Roles of PDCD4 in Breast Cancer. Qian Cai 2022-01-01 Frontiers in oncology
28849168 MicroRNA‑503 serves an oncogenic role in laryngeal squamous cell carcinoma via targeting programmed cell death protein 4. Yu Shuang 2017-10-01 Molecular medicine reports
32843616 IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas. Qing Wang 2020-08-26 Signal transduction and targeted therapy
30496290 A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability. Mahdieh Jadaliha 2018-11-01 PLoS genetics
25016284 microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion. Amit Bera 2014-10-15 Experimental cell research
12894233 The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Maret Böhm 2003-07-31 Oncogene
31952347 Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy. M Manirujjaman 2020-01-15 Cells
21779451 Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions. Lena Wedeken 2010-03-01 Genes & cancer
34917890 p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. Clarissa Braun 2021-12-01 Cell stress
23536002 Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46. N Kumar 2013-01-14 Oncogenesis
31075975 Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions. Sachiko Matsuhashi 2019-05-09 International journal of molecular sciences
34606825 Discovery of a novel role of tumor suppressor PDCD4 in stimulation of translation termination. Ekaterina Shuvalova 2021-11-01 The Journal of biological chemistry

Transcripts

Name Transcript ID bp Protein Translation ID
PDCD4-202 ENST00000393104 3697 458aa ENSP00000376816
PDCD4-205 ENST00000467574 735 No protein -
PDCD4-208 ENST00000483670 774 No protein -
PDCD4-201 ENST00000280154 3481 469aa ENSP00000280154
PDCD4-203 ENST00000444997 819 231aa ENSP00000394668
PDCD4-210 ENST00000492932 813 No protein -
PDCD4-206 ENST00000481353 1120 No protein -
PDCD4-204 ENST00000462577 789 No protein -
PDCD4-209 ENST00000489049 547 No protein -
PDCD4-207 ENST00000483595 531 No protein -
PDCD4-211 ENST00000498367 975 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000150593

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000150593homo_sapiensENSP0000028015497.441496.162nomascus_leucogenysENSNLEP0000001891297.23495.9574
ENSG00000150593homo_sapiensENSP0000028015410099.5736pan_paniscusENSPPAP0000003650410099.5736
ENSG00000150593homo_sapiensENSP0000028015499.786898.9339pongo_abeliiENSPPYP0000000308699.786898.9339
ENSG00000150593homo_sapiensENSP0000028015410099.5736pan_troglodytesENSPTRP0000008051810099.5736
ENSG00000150593homo_sapiensENSP0000028015499.786899.3603gorilla_gorillaENSGGOP0000004145299.786899.3603
ENSG00000150593homo_sapiensENSP0000028015495.522490.6183ornithorhynchus_anatinusENSOANP0000003612497.816692.7948
ENSG00000150593homo_sapiensENSP0000028015497.867893.8166sarcophilus_harrisiiENSSHAP0000004417192.91589.0688
ENSG00000150593homo_sapiensENSP0000028015459.275157.9957notamacropus_eugeniiENSMEUP0000000140078.753577.0538
ENSG00000150593homo_sapiensENSP0000028015484.221782.7292choloepus_hoffmanniENSCHOP0000000676284.582483.0835
ENSG00000150593homo_sapiensENSP0000028015498.720797.2281dasypus_novemcinctusENSDNOP0000000735998.510697.0213
ENSG00000150593homo_sapiensENSP0000028015454.797453.7313erinaceus_europaeusENSEEUP0000001064754.797453.7313
ENSG00000150593homo_sapiensENSP0000028015491.471289.339echinops_telfairiENSETEP0000001059491.471289.339
ENSG00000150593homo_sapiensENSP0000028015499.360398.2942callithrix_jacchusENSCJAP0000003498699.360398.2942
ENSG00000150593homo_sapiensENSP0000028015499.573698.081cercocebus_atysENSCATP0000002204199.573698.081
ENSG00000150593homo_sapiensENSP0000028015499.573698.2942macaca_mulattaENSMMUP0000005148899.573698.2942
ENSG00000150593homo_sapiensENSP0000028015497.228196.162macaca_nemestrinaENSMNEP0000004077996.815395.7537
ENSG00000150593homo_sapiensENSP0000028015499.573698.2942papio_anubisENSPANP0000003379999.573698.2942
ENSG00000150593homo_sapiensENSP0000028015497.441495.9488mandrillus_leucophaeusENSMLEP0000002386897.23495.7447
ENSG00000150593homo_sapiensENSP0000028015493.17791.0448tursiops_truncatusENSTTRP0000000659593.17791.0448
ENSG00000150593homo_sapiensENSP0000028015497.654696.3753vulpes_vulpesENSVVUP0000001068879.513978.4722
ENSG00000150593homo_sapiensENSP0000028015498.507596.8017mus_spretusMGP_SPRETEiJ_P005115598.507596.8017
ENSG00000150593homo_sapiensENSP0000028015497.654696.162equus_asinusENSEASP0000505657995.615994.1545
ENSG00000150593homo_sapiensENSP0000028015498.720797.0149capra_hircusENSCHIP0000002558090.253488.694
ENSG00000150593homo_sapiensENSP0000028015493.603490.4051loxodonta_africanaENSLAFP0000002175793.404390.2128
ENSG00000150593homo_sapiensENSP0000028015499.147197.8678panthera_leoENSPLOP0000001420699.147197.8678
ENSG00000150593homo_sapiensENSP0000028015499.360397.6546ailuropoda_melanoleucaENSAMEP0000002293799.360397.6546
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885bos_indicus_hybridENSBIXP0000501132998.720796.5885
ENSG00000150593homo_sapiensENSP0000028015498.507596.162oryctolagus_cuniculusENSOCUP0000003056794.093791.8534
ENSG00000150593homo_sapiensENSP0000028015497.654696.162equus_caballusENSECAP0000001836995.615994.1545
ENSG00000150593homo_sapiensENSP0000028015498.933997.8678canis_lupus_familiarisENSCAFP0084504036999.570898.4979
ENSG00000150593homo_sapiensENSP0000028015499.147197.8678panthera_pardusENSPPRP0000001703899.147197.8678
ENSG00000150593homo_sapiensENSP0000028015499.147198.081marmota_marmota_marmotaENSMMMP0000000233799.147198.081
ENSG00000150593homo_sapiensENSP0000028015498.933997.2281balaenoptera_musculusENSBMSP0001002806598.933997.2281
ENSG00000150593homo_sapiensENSP0000028015498.08195.5224cavia_porcellusENSCPOP0000002582698.08195.5224
ENSG00000150593homo_sapiensENSP0000028015499.147197.6546felis_catusENSFCAP0000001103799.147197.6546
ENSG00000150593homo_sapiensENSP0000028015497.014994.6695ursus_americanusENSUAMP0000003272795.991693.6709
ENSG00000150593homo_sapiensENSP0000028015498.720795.3092monodelphis_domesticaENSMODP0000001302798.720795.3092
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885bison_bison_bisonENSBBBP0000002867098.720796.5885
ENSG00000150593homo_sapiensENSP0000028015495.309293.3902monodon_monocerosENSMMNP0001502065695.106493.1915
ENSG00000150593homo_sapiensENSP0000028015498.933997.4414sus_scrofaENSSSCP0000004422998.933997.4414
ENSG00000150593homo_sapiensENSP0000028015499.573698.081microcebus_murinusENSMICP0000002425699.573698.081
ENSG00000150593homo_sapiensENSP0000028015498.08195.5224octodon_degusENSODEP0000001275198.08195.5224
ENSG00000150593homo_sapiensENSP0000028015498.08196.5885jaculus_jaculusENSJJAP0000002191798.08196.5885
ENSG00000150593homo_sapiensENSP0000028015495.948894.2431ovis_aries_rambouilletENSOARP0002002131591.463489.8374
ENSG00000150593homo_sapiensENSP0000028015499.360398.081ursus_maritimusENSUMAP0000003294999.360398.081
ENSG00000150593homo_sapiensENSP0000028015499.147197.0149ochotona_princepsENSOPRP0000001409899.147197.0149
ENSG00000150593homo_sapiensENSP0000028015498.720796.8017delphinapterus_leucasENSDLEP0000001641698.720796.8017
ENSG00000150593homo_sapiensENSP0000028015499.147197.2281physeter_catodonENSPCTP0000502028799.147197.2281
ENSG00000150593homo_sapiensENSP0000028015498.294296.3753mus_caroliMGP_CAROLIEiJ_P004914198.294296.3753
ENSG00000150593homo_sapiensENSP0000028015498.507596.8017mus_musculusENSMUSP0000007397598.507596.8017
ENSG00000150593homo_sapiensENSP0000028015499.147197.8678dipodomys_ordiiENSDORP0000001692699.147197.8678
ENSG00000150593homo_sapiensENSP0000028015499.573698.2942mustela_putorius_furoENSMPUP0000000204499.573698.2942
ENSG00000150593homo_sapiensENSP0000028015499.573698.5075aotus_nancymaaeENSANAP0000002797499.573698.5075
ENSG00000150593homo_sapiensENSP0000028015499.360398.5075saimiri_boliviensis_boliviensisENSSBOP0000001972599.360398.5075
ENSG00000150593homo_sapiensENSP0000028015498.720796.8017vicugna_pacosENSVPAP0000000162498.720796.8017
ENSG00000150593homo_sapiensENSP0000028015499.786898.2942chlorocebus_sabaeusENSCSAP0000000147299.786898.2942
ENSG00000150593homo_sapiensENSP0000028015491.897790.1919tupaia_belangeriENSTBEP0000000031091.897790.1919
ENSG00000150593homo_sapiensENSP0000028015499.360397.6546mesocricetus_auratusENSMAUP0000001119599.360397.6546
ENSG00000150593homo_sapiensENSP0000028015498.720796.8017phocoena_sinusENSPSNP0000001816598.720796.8017
ENSG00000150593homo_sapiensENSP0000028015498.933997.2281camelus_dromedariusENSCDRP0000500830698.933997.2281
ENSG00000150593homo_sapiensENSP0000028015499.573698.7207carlito_syrichtaENSTSYP0000003412999.573698.7207
ENSG00000150593homo_sapiensENSP0000028015499.147197.8678panthera_tigris_altaicaENSPTIP0000000967299.147197.8678
ENSG00000150593homo_sapiensENSP0000028015498.720796.8017rattus_norvegicusENSRNOP0000007636698.720796.8017
ENSG00000150593homo_sapiensENSP0000028015499.360397.8678prolemur_simusENSPSMP0000002423899.360397.8678
ENSG00000150593homo_sapiensENSP0000028015499.147196.8017microtus_ochrogasterENSMOCP0000002628499.147196.8017
ENSG00000150593homo_sapiensENSP0000028015490.405188.4861sorex_araneusENSSARP0000000745190.405188.4861
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885peromyscus_maniculatus_bairdiiENSPEMP0000000238098.720796.5885
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885bos_mutusENSBMUP0000002357998.720796.5885
ENSG00000150593homo_sapiensENSP0000028015495.948894.2431mus_spicilegusENSMSIP0000003757998.468396.7177
ENSG00000150593homo_sapiensENSP0000028015498.507596.8017cricetulus_griseus_chok1gshdENSCGRP0000100555898.507596.8017
ENSG00000150593homo_sapiensENSP0000028015498.294296.5885pteropus_vampyrusENSPVAP0000001532798.504396.7949
ENSG00000150593homo_sapiensENSP0000028015498.933996.3753myotis_lucifugusENSMLUP0000001255698.933996.3753
ENSG00000150593homo_sapiensENSP0000028015498.720795.5224vombatus_ursinusENSVURP0001003284898.720795.5224
ENSG00000150593homo_sapiensENSP0000028015499.360398.081rhinolophus_ferrumequinumENSRFEP0001001779999.360398.081
ENSG00000150593homo_sapiensENSP0000028015499.360398.081neovison_visonENSNVIP0000000994199.360398.081
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885bos_taurusENSBTAP0000002588698.720796.5885
ENSG00000150593homo_sapiensENSP0000028015498.507595.7356heterocephalus_glaber_femaleENSHGLP0000001494598.507595.7356
ENSG00000150593homo_sapiensENSP0000028015496.801795.7356rhinopithecus_bietiENSRBIP0000002428897.424996.3519
ENSG00000150593homo_sapiensENSP0000028015499.573698.5075canis_lupus_dingoENSCAFP0002001479099.573698.5075
ENSG00000150593homo_sapiensENSP0000028015499.147198.081sciurus_vulgarisENSSVLP0000500177299.147198.081
ENSG00000150593homo_sapiensENSP0000028015498.720795.3092phascolarctos_cinereusENSPCIP0000000018898.720795.3092
ENSG00000150593homo_sapiensENSP0000028015486.353984.0085procavia_capensisENSPCAP0000001323486.353984.0085
ENSG00000150593homo_sapiensENSP0000028015498.720796.8017nannospalax_galiliENSNGAP0000002385598.720796.8017
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885bos_grunniensENSBGRP0000002842498.720796.5885
ENSG00000150593homo_sapiensENSP0000028015498.720796.3753chinchilla_lanigeraENSCLAP0000000151598.720796.3753
ENSG00000150593homo_sapiensENSP0000028015498.720797.0149cervus_hanglu_yarkandensisENSCHYP0000001278798.720797.0149
ENSG00000150593homo_sapiensENSP0000028015498.507597.4414catagonus_wagneriENSCWAP0000002857498.507597.4414
ENSG00000150593homo_sapiensENSP0000028015498.933997.6546ictidomys_tridecemlineatusENSSTOP0000002953998.933997.6546
ENSG00000150593homo_sapiensENSP0000028015498.933997.6546otolemur_garnettiiENSOGAP0000001127298.933997.6546
ENSG00000150593homo_sapiensENSP0000028015499.360398.5075cebus_imitatorENSCCAP0000002700299.360398.5075
ENSG00000150593homo_sapiensENSP0000028015498.933997.8678urocitellus_parryiiENSUPAP0001002948098.933997.8678
ENSG00000150593homo_sapiensENSP0000028015498.720796.5885moschus_moschiferusENSMMSP0000002857298.720796.5885
ENSG00000150593homo_sapiensENSP0000028015497.867897.0149rhinopithecus_roxellanaENSRROP0000003813597.659696.8085
ENSG00000150593homo_sapiensENSP0000028015498.720797.2281mus_pahariMGP_PahariEiJ_P002210998.720797.2281
ENSG00000150593homo_sapiensENSP0000028015490.831688.9126propithecus_coquereliENSPCOP0000001847494.666792.6667
ENSG00000150593homo_sapiensENSP0000028015462.260142.2175drosophila_melanogasterFBpp030410057.367438.8998
ENSG00000150593homo_sapiensENSP0000028015456.2939.0192ciona_intestinalisENSCINP0000002434356.53139.1863
ENSG00000150593homo_sapiensENSP0000028015481.449968.2303callorhinchus_miliiENSCMIP0000004551981.10467.9406
ENSG00000150593homo_sapiensENSP0000028015487.846575.0533latimeria_chalumnaeENSLACP0000001508288.41275.5365
ENSG00000150593homo_sapiensENSP0000028015485.501172.7079lepisosteus_oculatusENSLOCP0000001514785.319172.5532
ENSG00000150593homo_sapiensENSP0000028015482.942469.936clupea_harengusENSCHAP0000001246881.551468.7631
ENSG00000150593homo_sapiensENSP0000028015483.795369.7228danio_rerioENSDARP0000000242083.61769.5745
ENSG00000150593homo_sapiensENSP0000028015482.942469.936carassius_auratusENSCARP0000010784168.126157.4431
ENSG00000150593homo_sapiensENSP0000028015483.582169.2964carassius_auratusENSCARP0000006417783.404369.1489
ENSG00000150593homo_sapiensENSP0000028015483.155670.1493astyanax_mexicanusENSAMXP0000000463782.978770
ENSG00000150593homo_sapiensENSP0000028015481.876368.2303ictalurus_punctatusENSIPUP0000001580682.22768.5225
ENSG00000150593homo_sapiensENSP0000028015481.663171.6418esox_luciusENSELUP0000004926674.368965.2427
ENSG00000150593homo_sapiensENSP0000028015482.51666.5245electrophorus_electricusENSEEEP0000002168482.340466.383
ENSG00000150593homo_sapiensENSP0000028015482.942471.6418oncorhynchus_kisutchENSOKIP0000506409880.538369.5652
ENSG00000150593homo_sapiensENSP0000028015449.680243.0704oncorhynchus_kisutchENSOKIP0000505037682.332271.3781
ENSG00000150593homo_sapiensENSP0000028015483.795372.7079oncorhynchus_mykissENSOMYP0000002054583.262772.2458
ENSG00000150593homo_sapiensENSP0000028015483.582172.4947oncorhynchus_mykissENSOMYP0000012925983.050872.0339
ENSG00000150593homo_sapiensENSP0000028015483.368972.2814salmo_salarENSSSAP0000001487776.968566.7323
ENSG00000150593homo_sapiensENSP0000028015481.449970.7889salmo_salarENSSSAP0000002439180.421169.8947
ENSG00000150593homo_sapiensENSP0000028015483.155672.4947salmo_truttaENSSTUP0000010412876.771766.9291
ENSG00000150593homo_sapiensENSP0000028015483.368972.4947salmo_truttaENSSTUP0000008351176.968566.9291
ENSG00000150593homo_sapiensENSP0000028015461.833752.0256gadus_morhuaENSGMOP0000001573082.386469.3182
ENSG00000150593homo_sapiensENSP0000028015481.449968.6567fundulus_heteroclitusENSFHEP0000001158378.278765.9836
ENSG00000150593homo_sapiensENSP0000028015480.810268.2303poecilia_reticulataENSPREP0000000038376.720664.7773
ENSG00000150593homo_sapiensENSP0000028015477.825265.6716xiphophorus_maculatusENSXMAP0000002893974.948763.2444
ENSG00000150593homo_sapiensENSP0000028015475.906262.4733oryzias_latipesENSORLP0000001916280.909166.5909
ENSG00000150593homo_sapiensENSP0000028015480.810266.951cyclopterus_lumpusENSCLMP0000500133480.638366.8085
ENSG00000150593homo_sapiensENSP0000028015482.942469.7228oreochromis_niloticusENSONIP0000002873981.894768.8421
ENSG00000150593homo_sapiensENSP0000028015482.302869.5096haplochromis_burtoniENSHBUP0000001489581.434668.7764
ENSG00000150593homo_sapiensENSP0000028015482.302869.5096astatotilapia_callipteraENSACLP0000003800781.434668.7764
ENSG00000150593homo_sapiensENSP0000028015480.383868.2303sparus_aurataENSSAUP0001003080579.368467.3684
ENSG00000150593homo_sapiensENSP0000028015482.089669.5096lates_calcariferENSLCAP0001002316480.208367.9167
ENSG00000150593homo_sapiensENSP0000028015486.993672.7079xenopus_tropicalisENSXETP0000008425684.297570.4545
ENSG00000150593homo_sapiensENSP0000028015495.095987.8465chrysemys_picta_belliiENSCPBP0000001753495.299188.0342
ENSG00000150593homo_sapiensENSP0000028015491.897784.435sphenodon_punctatusENSSPUP0000000574292.489384.9785
ENSG00000150593homo_sapiensENSP0000028015494.029987.8465crocodylus_porosusENSCPRP0000501620894.230888.0342
ENSG00000150593homo_sapiensENSP0000028015493.17785.2878laticauda_laticaudataENSLLTP0000000662393.17785.2878
ENSG00000150593homo_sapiensENSP0000028015492.537384.8614notechis_scutatusENSNSUP0000000475492.537384.8614
ENSG00000150593homo_sapiensENSP0000028015493.17785.7143pseudonaja_textilisENSPTXP0000000408293.17785.7143
ENSG00000150593homo_sapiensENSP0000028015493.17785.5011anas_platyrhynchos_platyrhynchosENSAPLP0000000265493.57685.8672
ENSG00000150593homo_sapiensENSP0000028015490.191981.8763gallus_gallusENSGALP0001002622188.679280.5031
ENSG00000150593homo_sapiensENSP0000028015492.750584.435meleagris_gallopavoENSMGAP0000001129293.147884.7966
ENSG00000150593homo_sapiensENSP0000028015492.963885.9275serinus_canariaENSSCAP0000002192493.562286.4807
ENSG00000150593homo_sapiensENSP0000028015492.963885.9275parus_majorENSPMJP0000000608793.562286.4807
ENSG00000150593homo_sapiensENSP0000028015492.537384.2217anolis_carolinensisENSACAP0000001552792.73584.4017
ENSG00000150593homo_sapiensENSP0000028015482.51669.7228neolamprologus_brichardiENSNBRP0000000420981.473768.8421
ENSG00000150593homo_sapiensENSP0000028015493.390285.9275naja_najaENSNNAP0000001436493.390285.9275
ENSG00000150593homo_sapiensENSP0000028015493.390284.2217podarcis_muralisENSPMRP0000000435593.589784.4017
ENSG00000150593homo_sapiensENSP0000028015492.963885.9275geospiza_fortisENSGFOP0000000594493.562286.4807
ENSG00000150593homo_sapiensENSP0000028015492.963885.7143taeniopygia_guttataENSTGUP0000001594193.562286.2661
ENSG00000150593homo_sapiensENSP0000028015486.353971.6418erpetoichthys_calabaricusENSECRP0000000931287.096872.2581
ENSG00000150593homo_sapiensENSP0000028015481.023568.2303kryptolebias_marmoratusENSKMAP0000002744679.664667.086
ENSG00000150593homo_sapiensENSP0000028015492.324182.7292salvator_merianaeENSSMRP0000001442792.521482.906
ENSG00000150593homo_sapiensENSP0000028015478.67865.2452oryzias_javanicusENSOJAP0000000290279.01565.5246
ENSG00000150593homo_sapiensENSP0000028015481.876368.6567amphilophus_citrinellusENSACIP0000002116282.22768.9508
ENSG00000150593homo_sapiensENSP0000028015480.810268.0171dicentrarchus_labraxENSDLAP0000500479274.606362.7953
ENSG00000150593homo_sapiensENSP0000028015482.729269.0832amphiprion_perculaENSAPEP0000000797281.856568.3544
ENSG00000150593homo_sapiensENSP0000028015464.818852.8785oryzias_sinensisENSOSIP0000002920079.373464.752
ENSG00000150593homo_sapiensENSP0000028015494.029986.3539pelodiscus_sinensisENSPSIP0000001115294.230886.5385
ENSG00000150593homo_sapiensENSP0000028015493.17785.5011gopherus_evgoodeiENSGEVP0000501965790.103182.6804
ENSG00000150593homo_sapiensENSP0000028015494.456386.9936chelonoidis_abingdoniiENSCABP0000000175594.658187.1795
ENSG00000150593homo_sapiensENSP0000028015481.449968.4435seriola_dumeriliENSSDUP0000001388880.590767.7215
ENSG00000150593homo_sapiensENSP0000028015482.729269.2964cottoperca_gobioENSCGOP0000000178082.029668.7104
ENSG00000150593homo_sapiensENSP0000028015493.390285.9275struthio_camelus_australisENSSCUP0000001364493.790286.2955
ENSG00000150593homo_sapiensENSP0000028015493.17785.2878anser_brachyrhynchusENSABRP0000000687993.57685.6531
ENSG00000150593homo_sapiensENSP0000028015480.810266.5245gasterosteus_aculeatusENSGACP0000002472180.126865.9619
ENSG00000150593homo_sapiensENSP0000028015479.957466.7377cynoglossus_semilaevisENSCSEP0000001894879.957466.7377
ENSG00000150593homo_sapiensENSP0000028015481.023568.4435poecilia_formosaENSPFOP0000000507379.664667.2956
ENSG00000150593homo_sapiensENSP0000028015484.008570.3625myripristis_murdjanENSMMDP0000503584383.122469.6203
ENSG00000150593homo_sapiensENSP0000028015481.023566.5245sander_luciopercaENSSLUP0000003397479.497965.272
ENSG00000150593homo_sapiensENSP0000028015492.324186.1407strigops_habroptilaENSSHBP0000500855692.918586.6953
ENSG00000150593homo_sapiensENSP0000028015482.729269.0832amphiprion_ocellarisENSAOCP0000001381881.856568.3544
ENSG00000150593homo_sapiensENSP0000028015457.569351.5991terrapene_carolina_triunguisENSTMTP0000000721792.465882.8767
ENSG00000150593homo_sapiensENSP0000028015478.038467.8038hucho_huchoENSHHUP0000002430370.114960.9195
ENSG00000150593homo_sapiensENSP0000028015483.155672.4947hucho_huchoENSHHUP0000006659482.627172.0339
ENSG00000150593homo_sapiensENSP0000028015482.51669.5096betta_splendensENSBSLP0000001576081.818268.9218
ENSG00000150593homo_sapiensENSP0000028015483.368970.5757pygocentrus_nattereriENSPNAP0000001259283.191570.4255
ENSG00000150593homo_sapiensENSP0000028015478.67866.7377anabas_testudineusENSATEP0000004996080.74468.4902
ENSG00000150593homo_sapiensENSP0000028015454.797439.0192ciona_savignyiENSCSAVP0000000842455.869639.7826
ENSG00000150593homo_sapiensENSP0000028015481.449968.4435seriola_lalandi_dorsalisENSSLDP0000001548780.590767.7215
ENSG00000150593homo_sapiensENSP0000028015481.023565.8849labrus_bergyltaENSLBEP0000003337080.338365.3277
ENSG00000150593homo_sapiensENSP0000028015482.302869.5096pundamilia_nyerereiENSPNYP0000000264581.434668.7764
ENSG00000150593homo_sapiensENSP0000028015481.023567.8038mastacembelus_armatusENSMAMP0000006315877.55164.898
ENSG00000150593homo_sapiensENSP0000028015482.942469.0832stegastes_partitusENSSPAP0000000669682.067568.3544
ENSG00000150593homo_sapiensENSP0000028015479.317768.0171oncorhynchus_tshawytschaENSOTSP0000505451481.938370.2643
ENSG00000150593homo_sapiensENSP0000028015482.51668.8699acanthochromis_polyacanthusENSAPOP0000000895681.645668.1435
ENSG00000150593homo_sapiensENSP0000028015492.750586.5672aquila_chrysaetos_chrysaetosENSACCP0002000963693.347687.1245
ENSG00000150593homo_sapiensENSP0000028015477.611965.2452nothobranchius_furzeriENSNFUP0001502186676.150664.0167
ENSG00000150593homo_sapiensENSP0000028015481.236767.1642cyprinodon_variegatusENSCVAP0000001846680.549766.5962
ENSG00000150593homo_sapiensENSP0000028015480.59767.3774denticeps_clupeoidesENSDCDP0000001128979.746866.6667
ENSG00000150593homo_sapiensENSP0000028015481.663169.0832larimichthys_croceaENSLCRP0000504975581.316368.7898
ENSG00000150593homo_sapiensENSP0000028015479.744165.6716takifugu_rubripesENSTRUP0000001897479.237365.2542
ENSG00000150593homo_sapiensENSP0000028015489.978782.516ficedula_albicollisENSFALP0000002826790.170982.6923
ENSG00000150593homo_sapiensENSP0000028015481.023569.936hippocampus_comesENSHCOP0000000083780.338369.3446
ENSG00000150593homo_sapiensENSP0000028015478.67866.3113cyprinus_carpio_carpioENSCCRP000001431638269.1111
ENSG00000150593homo_sapiensENSP0000028015483.368969.0832cyprinus_carpio_carpioENSCCRP0000017397183.191568.9362
ENSG00000150593homo_sapiensENSP0000028015493.17785.0746coturnix_japonicaENSCJPP0000502553593.57685.439
ENSG00000150593homo_sapiensENSP0000028015481.023568.4435poecilia_latipinnaENSPLAP0000000794980.168867.7215
ENSG00000150593homo_sapiensENSP0000028015482.942469.5096sinocyclocheilus_grahamiENSSGRP0000005641182.76669.3617
ENSG00000150593homo_sapiensENSP0000028015481.449968.2303sinocyclocheilus_grahamiENSSGRP0000009978280.590767.5106
ENSG00000150593homo_sapiensENSP0000028015482.302869.5096maylandia_zebraENSMZEP0000500389881.434668.7764
ENSG00000150593homo_sapiensENSP0000028015478.67865.4584tetraodon_nigroviridisENSTNIP0000001349478.343965.1805
ENSG00000150593homo_sapiensENSP0000028015484.861472.2814paramormyrops_kingsleyaeENSPKIP0000004055585.042772.4359
ENSG00000150593homo_sapiensENSP0000028015484.221769.2964scleropages_formosusENSSFOP0001501258684.582469.5931
ENSG00000150593homo_sapiensENSP0000028015487.633375.693leptobrachium_leishanenseENSLLEP0000004636888.577676.5086
ENSG00000150593homo_sapiensENSP0000028015480.383867.5906scophthalmus_maximusENSSMAP0000000218879.535966.8776
ENSG00000150593homo_sapiensENSP0000028015480.59766.951oryzias_melastigmaENSOMEP0000002560079.915466.3848

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus3IBA,IMP,ISSHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IMPHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0009725involved_in response to hormone1IEAHomo_sapiens(9606)Process
GO:0030509involved_in BMP signaling pathway1IDAHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043279involved_in response to alkaloid1IEAHomo_sapiens(9606)Process
GO:0043508involved_in negative regulation of JUN kinase activity1ISSHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription2IDA,ISSHomo_sapiens(9606)Process
GO:0050729involved_in positive regulation of inflammatory response1ISSHomo_sapiens(9606)Process
GO:0060940involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development1ISSHomo_sapiens(9606)Process
GO:0071222involved_in cellular response to lipopolysaccharide1ISSHomo_sapiens(9606)Process
GO:1900016involved_in negative regulation of cytokine production involved in inflammatory response1ISSHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:1904706involved_in negative regulation of vascular associated smooth muscle cell proliferation1IMPHomo_sapiens(9606)Process
GO:1904761involved_in negative regulation of myofibroblast differentiation1IMPHomo_sapiens(9606)Process
GO:1905064involved_in negative regulation of vascular associated smooth muscle cell differentiation1IDAHomo_sapiens(9606)Process
GO:1905461involved_in positive regulation of vascular associated smooth muscle cell apoptotic process1IMPHomo_sapiens(9606)Process
GO:2000353involved_in positive regulation of endothelial cell apoptotic process1IMPHomo_sapiens(9606)Process

Expression