RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000150347	Gene ID	84159	Accession	17362
Symbol	ARID5B	Alias	MRF2;DESRT;MRF-2	Full Name	AT-rich interaction domain 5B
Status	Confidence	Length	195261 bases	Strand	Plus strand
Position	10 : 61901684 - 62096944	RNA binding domain	N.A.
Summary	This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
37129704	1H, 13C, 15N backbone chemical shift assignments of the extended ARID domain in human AT-rich interactive domain protein 5a (Arid5a).	Julian J von	2023-06-01	Biomolecular NMR assignments

Name	Transcript ID	bp	Protein	Translation ID
ARID5B-203	ENST00000644638	1439	254aa	ENSP00000494412
ARID5B-205	ENST00000681100	7468	1180aa	ENSP00000506119
ARID5B-201	ENST00000279873	7492	1188aa	ENSP00000279873
ARID5B-204	ENST00000647323	565	No protein	-
ARID5B-202	ENST00000309334	3141	945aa	ENSP00000308862

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
3253	Cholesterol, HDL	7.76709167912896E-9	17903299
3264	Cholesterol, HDL	1.40273447063472E-10	17903299
3272	Cholesterol, HDL	1.60812710421038E-6	17903299
5241	Cholesterol, HDL	7.42707324121716E-15	17903299
7127	Receptors, Tumor Necrosis Factor, Type II	2.79924841823139E-6	17903293
72044	Corneal Topography	6E-10	23291589
75529	Lupus Erythematosus, Systemic	5E-11	23273568
82429	Immunoglobulins	1E-6	23382691
83199	Haloperidol	1E-6	24751813
83200	Psychotic Disorders	1E-6	24751813
85621	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	5E-54	23996088
87250	Arthritis, Rheumatoid	6E-18	22446963
93111	Precursor Cell Lymphoblastic Leukemia-Lymphoma	1E-15	19684603
95136	Lupus Erythematosus, Systemic	1E-6	27399966
95359	Precursor Cell Lymphoblastic Leukemia-Lymphoma	7E-19	19684604
95583	Arthritis, Rheumatoid	5E-22	24390342
95597	Arthritis, Rheumatoid	3E-15	24390342
96026	Arthritis, Rheumatoid	1E-8	24390342
97434	Lupus Erythematosus, Systemic	1E-10	26502338
98467	Immunoglobulins	2E-6	23382691
100605	Precursor Cell Lymphoblastic Leukemia-Lymphoma	2E-9	25310577
101467	Precursor Cell Lymphoblastic Leukemia-Lymphoma	6E-46	23512250
105426	Precursor Cell Lymphoblastic Leukemia-Lymphoma	4E-15	22076464
106623	Precursor Cell Lymphoblastic Leukemia-Lymphoma	1E-11	22076464

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0000976	enables transcription cis-regulatory region binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0001822	involved_in kidney development	1	IEA	Homo_sapiens(9606)	Process
GO:0001889	involved_in liver development	1	TAS	Homo_sapiens(9606)	Process
GO:0003677	enables DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003713	enables transcription coactivator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006807	involved_in nitrogen compound metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0008584	involved_in male gonad development	1	IEA	Homo_sapiens(9606)	Process
GO:0008585	involved_in female gonad development	1	IEA	Homo_sapiens(9606)	Process
GO:0009791	involved_in post-embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0010761	involved_in fibroblast migration	1	IEA	Homo_sapiens(9606)	Process
GO:0030325	involved_in adrenal gland development	1	IEA	Homo_sapiens(9606)	Process
GO:0035264	involved_in multicellular organism growth	1	IEA	Homo_sapiens(9606)	Process
GO:0045444	involved_in fat cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	TAS	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0048008	involved_in platelet-derived growth factor receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0048468	involved_in cell development	1	IEA	Homo_sapiens(9606)	Process
GO:0048644	involved_in muscle organ morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0048705	involved_in skeletal system morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0051091	involved_in positive regulation of DNA-binding transcription factor activity	1	IDA	Homo_sapiens(9606)	Process
GO:0060021	involved_in roof of mouth development	1	IEA	Homo_sapiens(9606)	Process
GO:0060325	involved_in face morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0060612	involved_in adipose tissue development	1	ISS	Homo_sapiens(9606)	Process
GO:0060613	involved_in fat pad development	1	IEA	Homo_sapiens(9606)	Process
GO:1990830	involved_in cellular response to leukemia inhibitory factor	1	IEA	Homo_sapiens(9606)	Process