Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000149311 Gene ID 472 Accession 795
Symbol ATM Alias AT1;ATA;ATC;ATD;ATE;ATDC;TEL1;TELO1 Full Name ATM serine/threonine kinase
Status Confidence Length 146036 bases Strand Plus strand
Position 11 : 108223067 - 108369102 RNA binding domain N.A.
Summary The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25030905 DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal. Sébastien Britton 2014-08-01 Nucleic acids research
23791529 DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Guohui Wan 2013-06-27 Cell reports
36879298 PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression. Liang Chen 2023-03-06 Cell & bioscience
21209379 ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. Krystyna Mazan-Mamczarz 2011-02-24 Blood
36010841 DNA Damage Regulates the Functions of the RNA Binding Protein Sam68 through ATM-Dependent Phosphorylation. Venturina Stagni 2022-08-09 Cancers
36138131 METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Xiangyu Zeng 2022-09-01 Nature cancer
35200138 Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome. Wouter Huiting 2022-02-24 eLife

Transcripts

Name Transcript ID bp Protein Translation ID
ATM-243 ENST00000683488 5020 No protein -
ATM-241 ENST00000683174 13130 No protein -
ATM-229 ENST00000675843 12915 3056aa ENSP00000501606
ATM-212 ENST00000527805 9287 1545aa ENSP00000435747
ATM-228 ENST00000675595 9309 1545aa ENSP00000502563
ATM-242 ENST00000683468 4908 112aa ENSP00000508178
ATM-217 ENST00000532931 481 93aa ENSP00000432318
ATM-214 ENST00000530958 5718 168aa ENSP00000483338
ATM-203 ENST00000452508 12954 3056aa ENSP00000388058
ATM-246 ENST00000683914 442 112aa ENSP00000507649
ATM-240 ENST00000683150 593 112aa ENSP00000507125
ATM-226 ENST00000639953 587 112aa ENSP00000492487
ATM-227 ENST00000640388 578 112aa ENSP00000492354
ATM-225 ENST00000639240 498 112aa ENSP00000491585
ATM-201 ENST00000278616 12717 3056aa ENSP00000278616
ATM-209 ENST00000526567 560 112aa ENSP00000480205
ATM-234 ENST00000682430 993 No protein -
ATM-222 ENST00000601453 582 135aa ENSP00000469471
ATM-235 ENST00000682465 2862 112aa ENSP00000508284
ATM-230 ENST00000682147 1344 No protein -
ATM-247 ENST00000684029 1374 168aa ENSP00000508010
ATM-238 ENST00000682956 2353 No protein -
ATM-251 ENST00000684179 2243 No protein -
ATM-249 ENST00000684061 2529 No protein -
ATM-248 ENST00000684037 3020 357aa ENSP00000508245
ATM-236 ENST00000682516 3011 No protein -
ATM-223 ENST00000638443 2146 112aa ENSP00000491957
ATM-239 ENST00000683100 5156 No protein -
ATM-245 ENST00000683605 2884 No protein -
ATM-205 ENST00000525012 258 No protein -
ATM-218 ENST00000533526 234 No protein -
ATM-202 ENST00000419286 302 No protein -
ATM-232 ENST00000682289 1337 No protein -
ATM-220 ENST00000533733 2565 No protein -
ATM-204 ENST00000524792 5912 No protein -
ATM-215 ENST00000531525 1513 155aa ENSP00000434327
ATM-244 ENST00000683524 6870 No protein -
ATM-250 ENST00000684152 7062 No protein -
ATM-219 ENST00000533690 3354 No protein -
ATM-213 ENST00000529588 502 77aa ENSP00000435524
ATM-231 ENST00000682286 6403 No protein -
ATM-206 ENST00000525056 3608 No protein -
ATM-233 ENST00000682302 6064 No protein -
ATM-216 ENST00000532765 610 No protein -
ATM-253 ENST00000684447 8139 No protein -
ATM-211 ENST00000527389 401 No protein -
ATM-208 ENST00000525537 1799 No protein -
ATM-224 ENST00000638786 4344 No protein -
ATM-252 ENST00000684180 4120 No protein -
ATM-221 ENST00000533979 705 No protein -
ATM-207 ENST00000525178 880 No protein -
ATM-210 ENST00000527181 740 No protein -
ATM-237 ENST00000682569 3013 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
65964Melanoma3E-921983787
100853Melanoma3E-928212542

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000149311homo_sapiensENSP0000040251519.69419.88801homo_sapiensENSP0000050160623.592911.8455
ENSG00000149311homo_sapiensENSP0000031342024.612411.7975homo_sapiensENSP0000050160633.246115.9359
ENSG00000149311homo_sapiensENSP0000035455824.754811.7693homo_sapiensENSP0000050160620.64799.81675
ENSG00000149311homo_sapiensENSP0000034374133.396417.0197homo_sapiensENSP0000050160628.89414.7251
ENSG00000149311homo_sapiensENSP0000039464522.902110.4312homo_sapiensENSP0000050160629.024913.2199

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000149311homo_sapiensENSP0000050160699.41198.7565nomascus_leucogenysENSNLEP0000000882399.443598.7889
ENSG00000149311homo_sapiensENSP0000050160699.803799.5746pan_paniscusENSPPAP0000000905899.803799.5746
ENSG00000149311homo_sapiensENSP0000050160699.443798.8874pongo_abeliiENSPPYP0000000440399.443798.8874
ENSG00000149311homo_sapiensENSP0000050160699.738299.4437pan_troglodytesENSPTRP0000005421699.738299.4437
ENSG00000149311homo_sapiensENSP0000050160698.396697.9385gorilla_gorillaENSGGOP0000001014499.470799.0076
ENSG00000149311homo_sapiensENSP0000050160688.219978.3377ornithorhynchus_anatinusENSOANP0000004152487.475777.6768
ENSG00000149311homo_sapiensENSP0000050160689.430680.6283sarcophilus_harrisiiENSSHAP0000001266189.197180.4178
ENSG00000149311homo_sapiensENSP0000050160653.53447.9712notamacropus_eugeniiENSMEUP0000000183754.715749.0301
ENSG00000149311homo_sapiensENSP0000050160672.218667.8992choloepus_hoffmanniENSCHOP0000000625874.4169.9595
ENSG00000149311homo_sapiensENSP0000050160694.044589.1361dasypus_novemcinctusENSDNOP0000000894693.921689.0196
ENSG00000149311homo_sapiensENSP0000050160673.854769.4044erinaceus_europaeusENSEEUP0000000716474.21969.7468
ENSG00000149311homo_sapiensENSP0000050160670.28865.2487echinops_telfairiENSETEP0000001171770.31165.2701
ENSG00000149311homo_sapiensENSP0000050160697.480494.928callithrix_jacchusENSCJAP0000001884497.480494.928
ENSG00000149311homo_sapiensENSP0000050160698.396697.1859cercocebus_atysENSCATP0000003272297.852396.6482
ENSG00000149311homo_sapiensENSP0000050160698.920297.8076macaca_fascicularisENSMFAP0000002239098.920297.8076
ENSG00000149311homo_sapiensENSP0000050160698.952997.873macaca_mulattaENSMMUP0000000556198.952997.873
ENSG00000149311homo_sapiensENSP0000050160698.003996.7277macaca_nemestrinaENSMNEP0000000115098.779797.4934
ENSG00000149311homo_sapiensENSP0000050160698.920297.8403papio_anubisENSPANP0000001052198.920297.8403
ENSG00000149311homo_sapiensENSP0000050160695.680694.6008mandrillus_leucophaeusENSMLEP0000002376198.617297.5042
ENSG00000149311homo_sapiensENSP0000050160689.332585.4712tursiops_truncatusENSTTRP0000000573589.714185.8363
ENSG00000149311homo_sapiensENSP0000050160693.946389.3325vulpes_vulpesENSVVUP0000002082693.823589.2157
ENSG00000149311homo_sapiensENSP000005016066.348175.85733mus_spretusMGP_SPRETEiJ_P00914719789.5
ENSG00000149311homo_sapiensENSP0000050160625.392724.1165equus_asinusENSEASP0000501536696.517491.6667
ENSG00000149311homo_sapiensENSP000005016065.497385.26832equus_asinusENSEASP0000506033794.38290.4494
ENSG00000149311homo_sapiensENSP0000050160694.502689.6597capra_hircusENSCHIP0000001636394.440889.601
ENSG00000149311homo_sapiensENSP0000050160695.026290.216loxodonta_africanaENSLAFP0000000687195.057390.2455
ENSG00000149311homo_sapiensENSP0000050160692.408487.3037panthera_leoENSPLOP0000003015193.914288.7263
ENSG00000149311homo_sapiensENSP0000050160693.946388.9071ailuropoda_melanoleucaENSAMEP0000001770193.884988.8489
ENSG00000149311homo_sapiensENSP0000050160694.306389.8233bos_indicus_hybridENSBIXP0000503718194.36889.8821
ENSG00000149311homo_sapiensENSP0000050160693.979188.9725oryctolagus_cuniculusENSOCUP0000001263893.979188.9725
ENSG00000149311homo_sapiensENSP0000050160694.829890.4123equus_caballusENSECAP0000002589393.999489.6205
ENSG00000149311homo_sapiensENSP0000050160693.979189.5288canis_lupus_familiarisENSCAFP0084500493593.979189.5288
ENSG00000149311homo_sapiensENSP0000050160693.782788.6453panthera_pardusENSPPRP0000000537393.75288.6163
ENSG00000149311homo_sapiensENSP0000050160689.528884.5877marmota_marmota_marmotaENSMMMP0000000076294.70489.4773
ENSG00000149311homo_sapiensENSP0000050160695.189891.0013balaenoptera_musculusENSBMSP0001000772895.158790.9715
ENSG00000149311homo_sapiensENSP0000050160692.081286.322cavia_porcellusENSCPOP0000000988592.840687.034
ENSG00000149311homo_sapiensENSP0000050160693.913688.8416felis_catusENSFCAP0000002592893.668488.6097
ENSG00000149311homo_sapiensENSP000005016063.468593.23953ursus_americanusENSUAMP0000000882395.495589.1892
ENSG00000149311homo_sapiensENSP0000050160650.032747.3168ursus_americanusENSUAMP0000000496490.153385.2594
ENSG00000149311homo_sapiensENSP000005016063.534033.20681monodelphis_domesticaENSMODP0000005987996.428687.5
ENSG00000149311homo_sapiensENSP0000050160694.404489.8887bison_bison_bisonENSBBBP0000002798694.466389.9476
ENSG00000149311homo_sapiensENSP0000050160695.124390.9359monodon_monocerosENSMMNP0001502907695.24991.055
ENSG00000149311homo_sapiensENSP0000050160693.651888.449sus_scrofaENSSSCP0000001593193.621288.42
ENSG00000149311homo_sapiensENSP0000050160695.058991.5576microcebus_murinusENSMICP0000001253295.214791.7076
ENSG00000149311homo_sapiensENSP0000050160690.314183.5079octodon_degusENSODEP0000002128391.694484.784
ENSG00000149311homo_sapiensENSP0000050160693.226486.7147jaculus_jaculusENSJJAP0000002222593.195986.6863
ENSG00000149311homo_sapiensENSP0000050160694.568189.7251ovis_aries_rambouilletENSOARP0002001456094.6389.7839
ENSG00000149311homo_sapiensENSP0000050160694.011889.0052ursus_maritimusENSUMAP0000001113293.858288.8598
ENSG00000149311homo_sapiensENSP0000050160663.350858.8024ochotona_princepsENSOPRP0000001561464.684360.0401
ENSG00000149311homo_sapiensENSP0000050160695.353491.1322delphinapterus_leucasENSDLEP0000001110395.322291.1024
ENSG00000149311homo_sapiensENSP0000050160695.124390.9359physeter_catodonENSPCTP0000500729295.093290.9061
ENSG00000149311homo_sapiensENSP0000050160691.492183.606mus_caroliMGP_CAROLIEiJ_P008786891.16483.3062
ENSG00000149311homo_sapiensENSP0000050160691.62384.195mus_musculusENSMUSP0000015634491.324283.9204
ENSG00000149311homo_sapiensENSP0000050160693.291987.9581dipodomys_ordiiENSDORP0000001287593.35388.0157
ENSG00000149311homo_sapiensENSP0000050160693.586488.7107mustela_putorius_furoENSMPUP0000000592093.555888.6817
ENSG00000149311homo_sapiensENSP0000050160697.676795.5825aotus_nancymaaeENSANAP0000001132097.676795.5825
ENSG00000149311homo_sapiensENSP0000050160697.316894.9607saimiri_boliviensis_boliviensisENSSBOP0000002747597.316894.9607
ENSG00000149311homo_sapiensENSP0000050160682.362678.5013vicugna_pacosENSVPAP0000000298893.429889.0497
ENSG00000149311homo_sapiensENSP0000050160698.952997.9712chlorocebus_sabaeusENSCSAP0000001507198.952997.9712
ENSG00000149311homo_sapiensENSP0000050160671.891468.0956tupaia_belangeriENSTBEP0000000764475.810971.8081
ENSG00000149311homo_sapiensENSP0000050160690.44583.3115mesocricetus_auratusENSMAUP0000001116791.705484.4725
ENSG00000149311homo_sapiensENSP0000050160695.157191.0995phocoena_sinusENSPSNP0000001130795.281891.2189
ENSG00000149311homo_sapiensENSP0000050160694.469990.3469camelus_dromedariusENSCDRP0000503215894.469990.3469
ENSG00000149311homo_sapiensENSP0000050160694.404489.6597carlito_syrichtaENSTSYP0000000888394.404489.6597
ENSG00000149311homo_sapiensENSP0000050160693.717388.6126panthera_tigris_altaicaENSPTIP0000000964293.686688.5836
ENSG00000149311homo_sapiensENSP0000050160691.753984.1623rattus_norvegicusENSRNOP0000004552991.514483.9426
ENSG00000149311homo_sapiensENSP0000050160695.942492.3757prolemur_simusENSPSMP0000001611196.162792.5877
ENSG00000149311homo_sapiensENSP0000050160691.557683.7042microtus_ochrogasterENSMOCP0000002443291.948784.0618
ENSG00000149311homo_sapiensENSP0000050160680.530175.4254sorex_araneusENSSARP0000000046780.76875.6482
ENSG00000149311homo_sapiensENSP000005016063.861263.50131peromyscus_maniculatus_bairdiiENSPEMP0000003051393.650884.9206
ENSG00000149311homo_sapiensENSP0000050160692.539385.3403peromyscus_maniculatus_bairdiiENSPEMP0000001418592.539385.3403
ENSG00000149311homo_sapiensENSP000005016069.718599.12958bos_mutusENSBMUP0000001214993.103487.4608
ENSG00000149311homo_sapiensENSP0000050160691.688584.0641mus_spicilegusENSMSIP0000000322091.389483.79
ENSG00000149311homo_sapiensENSP0000050160692.342985.4058cricetulus_griseus_chok1gshdENSCGRP0000102082892.312785.3778
ENSG00000149311homo_sapiensENSP0000050160675.163671.3024pteropus_vampyrusENSPVAP0000001548075.286871.4192
ENSG00000149311homo_sapiensENSP0000050160666.197662.2055myotis_lucifugusENSMLUP0000001025992.290186.7244
ENSG00000149311homo_sapiensENSP0000050160632.657130.9882myotis_lucifugusENSMLUP0000002269992.151487.4423
ENSG00000149311homo_sapiensENSP0000050160689.561580.9882vombatus_ursinusENSVURP0001001847789.327780.7768
ENSG00000149311homo_sapiensENSP0000050160694.731790.0851rhinolophus_ferrumequinumENSRFEP0001001453594.669790.0262
ENSG00000149311homo_sapiensENSP0000050160693.259288.2853neovison_visonENSNVIP0000003180393.228788.2565
ENSG00000149311homo_sapiensENSP0000050160694.306389.8233bos_taurusENSBTAP0000003988494.36889.8821
ENSG00000149311homo_sapiensENSP0000050160693.684687.8599heterocephalus_glaber_femaleENSHGLP0000005989093.745987.9175
ENSG00000149311homo_sapiensENSP0000050160697.938596.7277rhinopithecus_bietiENSRBIP0000002033898.909597.6867
ENSG00000149311homo_sapiensENSP0000050160693.946389.4633canis_lupus_dingoENSCAFP0002000898793.823589.3464
ENSG00000149311homo_sapiensENSP0000050160695.451689.7251sciurus_vulgarisENSSVLP0000502738295.514189.7839
ENSG00000149311homo_sapiensENSP000005016064.057593.73037phascolarctos_cinereusENSPCIP0000000335494.656587.0229
ENSG00000149311homo_sapiensENSP000005016063.599483.3377phascolarctos_cinereusENSPCIP0000005470597.345190.2655
ENSG00000149311homo_sapiensENSP0000050160673.069468.7173procavia_capensisENSPCAP0000000610074.607470.1637
ENSG00000149311homo_sapiensENSP0000050160693.030186.4202nannospalax_galiliENSNGAP0000000946592.575785.998
ENSG00000149311homo_sapiensENSP0000050160694.33989.7906bos_grunniensENSBGRP0000002251694.400889.8494
ENSG00000149311homo_sapiensENSP0000050160692.833887.0419chinchilla_lanigeraENSCLAP0000001729092.864287.0704
ENSG00000149311homo_sapiensENSP0000050160694.469989.5615cervus_hanglu_yarkandensisENSCHYP0000000474694.531889.6202
ENSG00000149311homo_sapiensENSP0000050160693.913688.8743catagonus_wagneriENSCWAP0000000640593.944488.9034
ENSG00000149311homo_sapiensENSP0000050160678.30572.9058ictidomys_tridecemlineatusENSSTOP0000000402991.405785.1031
ENSG00000149311homo_sapiensENSP0000050160693.7589.6597otolemur_garnettiiENSOGAP0000001545093.903689.8066
ENSG00000149311homo_sapiensENSP0000050160695.680693.5209cebus_imitatorENSCCAP0000002160797.466795.2667
ENSG00000149311homo_sapiensENSP0000050160694.469988.9725urocitellus_parryiiENSUPAP0001001056594.43988.9434
ENSG00000149311homo_sapiensENSP0000050160694.469989.9542moschus_moschiferusENSMMSP0000002156194.531890.0131
ENSG00000149311homo_sapiensENSP000005016065.857335.33377moschus_moschiferusENSMMSP0000002562195.212886.7021
ENSG00000149311homo_sapiensENSP0000050160698.985697.8403rhinopithecus_roxellanaENSRROP0000003154398.985697.8403
ENSG00000149311homo_sapiensENSP0000050160692.375784.4895mus_pahariMGP_PahariEiJ_P002351792.194684.324
ENSG00000149311homo_sapiensENSP0000050160681.577278.2068propithecus_coquereliENSPCOP0000001740694.61190.7021
ENSG00000149311homo_sapiensENSP000005016064.712042.68325ciona_intestinalisENSCINP0000003621761.276634.8936
ENSG00000149311homo_sapiensENSP0000050160625.818120.1898petromyzon_marinusENSPMAP0000000715471.597155.9891
ENSG00000149311homo_sapiensENSP000005016069.685866.47906eptatretus_burgeriENSEBUP0000000125965.631943.9024
ENSG00000149311homo_sapiensENSP000005016063.664922.38874eptatretus_burgeriENSEBUP0000002408863.636441.4773
ENSG00000149311homo_sapiensENSP0000050160675.850860.5366callorhinchus_miliiENSCMIP0000001936077.602961.9351
ENSG00000149311homo_sapiensENSP0000050160659.162346.3351latimeria_chalumnaeENSLACP0000000540776.126359.6211
ENSG00000149311homo_sapiensENSP0000050160672.840355.5301lepisosteus_oculatusENSLOCP0000000156372.721355.4394
ENSG00000149311homo_sapiensENSP0000050160669.175453.7958clupea_harengusENSCHAP0000003535569.039853.6904
ENSG00000149311homo_sapiensENSP0000050160670.811554.4175danio_rerioENSDARP0000001516770.009753.8014
ENSG00000149311homo_sapiensENSP0000050160670.746154.9411carassius_auratusENSCARP0000009925869.877254.2663
ENSG00000149311homo_sapiensENSP0000050160670.87754.3521astyanax_mexicanusENSAMXP0000004442370.87754.3521
ENSG00000149311homo_sapiensENSP0000050160670.222553.4031ictalurus_punctatusENSIPUP0000001223869.765953.0559
ENSG00000149311homo_sapiensENSP0000050160671.433255.1374esox_luciusENSELUP0000001943472.500855.9615
ENSG00000149311homo_sapiensENSP0000050160666.62350.4908electrophorus_electricusENSEEEP0000003231067.32851.0251
ENSG00000149311homo_sapiensENSP0000050160672.709456.1518oncorhynchus_kisutchENSOKIP0000505814472.685656.1335
ENSG00000149311homo_sapiensENSP0000050160671.793255.072oncorhynchus_mykissENSOMYP0000007485672.194855.3801
ENSG00000149311homo_sapiensENSP0000050160673.23356.25salmo_salarENSSSAP0000004539872.450655.6491
ENSG00000149311homo_sapiensENSP000005016062.585081.70157salmo_truttaENSSTUP0000009225964.227642.2764
ENSG00000149311homo_sapiensENSP0000050160671.956855.5628salmo_truttaENSSTUP0000011218472.454755.9473
ENSG00000149311homo_sapiensENSP0000050160668.553751.4071gadus_morhuaENSGMOP0000006255869.786852.3318
ENSG00000149311homo_sapiensENSP000005016064.286653.37042fundulus_heteroclitusENSFHEP0000003485175.722559.5376
ENSG00000149311homo_sapiensENSP000005016063.370422.58508fundulus_heteroclitusENSFHEP0000002083375.735358.0882
ENSG00000149311homo_sapiensENSP0000050160671.040654.3521poecilia_reticulataENSPREP0000002438870.236253.7367
ENSG00000149311homo_sapiensENSP0000050160667.670251.9306xiphophorus_maculatusENSXMAP0000001697871.930455.2
ENSG00000149311homo_sapiensENSP000005016067.166235.07199oryzias_latipesENSORLP0000002761968.224348.2866
ENSG00000149311homo_sapiensENSP000005016063.92673.14136oryzias_latipesENSORLP0000002626681.632765.3061
ENSG00000149311homo_sapiensENSP0000050160670.713353.3704cyclopterus_lumpusENSCLMP0000500806071.226153.7574
ENSG00000149311homo_sapiensENSP0000050160671.335154.7448oreochromis_niloticusENSONIP0000000690670.436254.0549
ENSG00000149311homo_sapiensENSP000005016064.64663.46859haplochromis_burtoniENSHBUP0000000504880.22659.887
ENSG00000149311homo_sapiensENSP000005016063.534032.68325haplochromis_burtoniENSHBUP0000000506275.524557.3427
ENSG00000149311homo_sapiensENSP000005016063.370422.58508astatotilapia_callipteraENSACLP0000000408774.100756.8345
ENSG00000149311homo_sapiensENSP000005016064.64663.46859astatotilapia_callipteraENSACLP0000000413180.22659.887
ENSG00000149311homo_sapiensENSP0000050160670.353454.0903sparus_aurataENSSAUP0001006117470.770254.4108
ENSG00000149311homo_sapiensENSP0000050160679.777565.0851xenopus_tropicalisENSXETP0000006871479.673265
ENSG00000149311homo_sapiensENSP0000050160685.700373.9202chrysemys_picta_belliiENSCPBP0000003091985.756473.9686
ENSG00000149311homo_sapiensENSP000005016069.947649.29319sphenodon_punctatusENSSPUP0000002287392.401286.3222
ENSG00000149311homo_sapiensENSP000005016064.024873.14136sphenodon_punctatusENSSPUP0000002283582.550364.4295
ENSG00000149311homo_sapiensENSP0000050160613.350811.6165sphenodon_punctatusENSSPUP0000002286087.93176.5086
ENSG00000149311homo_sapiensENSP000005016065.988225.07199sphenodon_punctatusENSSPUP0000002284483.181870.4545
ENSG00000149311homo_sapiensENSP000005016065.23564.48298sphenodon_punctatusENSSPUP0000000633185.561573.262
ENSG00000149311homo_sapiensENSP000005016063.370422.84686sphenodon_punctatusENSSPUP0000002281791.964377.6786
ENSG00000149311homo_sapiensENSP000005016062.552361.79974sphenodon_punctatusENSSPUP000000228257855
ENSG00000149311homo_sapiensENSP000005016063.075922.68325sphenodon_punctatusENSSPUP0000002285490.384678.8462
ENSG00000149311homo_sapiensENSP0000050160684.19572.1531crocodylus_porosusENSCPRP0000502019284.443772.3663
ENSG00000149311homo_sapiensENSP000005016068.376966.38089laticauda_laticaudataENSLLTP000000002858060.9375
ENSG00000149311homo_sapiensENSP0000050160677.846962.6636notechis_scutatusENSNSUP0000002283480.344564.6741
ENSG00000149311homo_sapiensENSP000005016063.435862.68325pseudonaja_textilisENSPTXP0000002359078.947461.6541
ENSG00000149311homo_sapiensENSP000005016064.253933.37042pseudonaja_textilisENSPTXP0000002359284.967367.3203
ENSG00000149311homo_sapiensENSP0000050160680.791967.5065anas_platyrhynchos_platyrhynchosENSAPLP0000001264083.215469.5315
ENSG00000149311homo_sapiensENSP0000050160682.820769.4372gallus_gallusENSGALP0001000635182.44369.1205
ENSG00000149311homo_sapiensENSP0000050160624.149222.1204meleagris_gallopavoENSMGAP0000001606587.857180.4762
ENSG00000149311homo_sapiensENSP0000050160683.37769.6662serinus_canariaENSSCAP0000000585383.132169.4617
ENSG00000149311homo_sapiensENSP0000050160683.409769.5026parus_majorENSPMJP0000002417583.71169.7537
ENSG00000149311homo_sapiensENSP0000050160662.434649.4437anolis_carolinensisENSACAP0000003967673.66858.3398
ENSG00000149311homo_sapiensENSP000005016063.075922.38874neolamprologus_brichardiENSNBRP0000000189581.739163.4783
ENSG00000149311homo_sapiensENSP000005016063.501312.71597neolamprologus_brichardiENSNBRP0000000188676.428659.2857
ENSG00000149311homo_sapiensENSP000005016063.141362.55236naja_najaENSNNAP0000001101385.714369.6429
ENSG00000149311homo_sapiensENSP000005016062.977752.35602naja_najaENSNNAP0000001099481.2564.2857
ENSG00000149311homo_sapiensENSP0000050160679.973866.8848podarcis_muralisENSPMRP0000000390580.7467.5256
ENSG00000149311homo_sapiensENSP0000050160682.984369.5681geospiza_fortisENSGFOP0000001130283.311469.8423
ENSG00000149311homo_sapiensENSP0000050160661.092952.2579taeniopygia_guttataENSTGUP0000001300183.872471.743
ENSG00000149311homo_sapiensENSP0000050160675.719958.4097erpetoichthys_calabaricusENSECRP0000001010575.30158.0866
ENSG00000149311homo_sapiensENSP000005016063.206812.51963kryptolebias_marmoratusENSKMAP0000000046779.674862.6016
ENSG00000149311homo_sapiensENSP000005016063.435862.71597kryptolebias_marmoratusENSKMAP0000000050780.769263.8462
ENSG00000149311homo_sapiensENSP0000050160680.66166.1976salvator_merianaeENSSMRP0000001402880.713866.241
ENSG00000149311homo_sapiensENSP000005016063.599482.84686amphilophus_citrinellusENSACIP0000001576871.895456.8627
ENSG00000149311homo_sapiensENSP000005016063.370422.51963amphilophus_citrinellusENSACIP0000001578379.230859.2308
ENSG00000149311homo_sapiensENSP0000050160666.753950.1963dicentrarchus_labraxENSDLAP0000504198469.910952.5703
ENSG00000149311homo_sapiensENSP0000050160670.157153.7304amphiprion_perculaENSAPEP0000002903970.572754.0487
ENSG00000149311homo_sapiensENSP000005016064.515713.23953oryzias_sinensisENSOSIP0000001066765.402846.9194
ENSG00000149311homo_sapiensENSP0000050160684.19572.5131pelodiscus_sinensisENSPSIP0000000682284.057572.3946
ENSG00000149311homo_sapiensENSP0000050160685.471273.4293gopherus_evgoodeiENSGEVP0000501808785.053773.0707
ENSG00000149311homo_sapiensENSP000005016063.861263.27225chelonoidis_abingdoniiENSCABP0000002731990.076376.3359
ENSG00000149311homo_sapiensENSP000005016065.071994.48298chelonoidis_abingdoniiENSCABP0000002732193.373582.5301
ENSG00000149311homo_sapiensENSP0000050160670.091653.534seriola_dumeriliENSSDUP0000001592571.423854.5515
ENSG00000149311homo_sapiensENSP0000050160667.702951.7997cottoperca_gobioENSCGOP0000002098771.517554.7183
ENSG00000149311homo_sapiensENSP0000050160684.358671.9241struthio_camelus_australisENSSCUP0000002347384.386371.9476
ENSG00000149311homo_sapiensENSP0000050160681.871768.3573anser_brachyrhynchusENSABRP0000001922382.792969.1264
ENSG00000149311homo_sapiensENSP000005016067.755245.66099gasterosteus_aculeatusENSGACP0000000927175.238154.9206
ENSG00000149311homo_sapiensENSP0000050160670.222553.1086gasterosteus_aculeatusENSGACP0000000926269.114352.2705
ENSG00000149311homo_sapiensENSP0000050160669.240852.5851cynoglossus_semilaevisENSCSEP0000000310669.331652.654
ENSG00000149311homo_sapiensENSP0000050160670.942454.2539poecilia_formosaENSPFOP0000000616870.366853.8137
ENSG00000149311homo_sapiensENSP0000050160669.633553.8285myripristis_murdjanENSMMDP0000502812369.95454.0763
ENSG00000149311homo_sapiensENSP0000050160670.058953.4031sander_luciopercaENSSLUP0000004551871.942254.8387
ENSG00000149311homo_sapiensENSP0000050160680.66167.3757strigops_habroptilaENSSHBP0000501634583.220869.5138
ENSG00000149311homo_sapiensENSP000005016063.075922.51963strigops_habroptilaENSSHBP0000501638083.928668.75
ENSG00000149311homo_sapiensENSP0000050160670.320753.8613amphiprion_ocellarisENSAOCP0000001965571.419154.7026
ENSG00000149311homo_sapiensENSP0000050160685.569473.8547terrapene_carolina_triunguisENSTMTP0000001435485.485573.7823
ENSG00000149311homo_sapiensENSP000005016062.290581.76702hucho_huchoENSHHUP0000004205968.627452.9412
ENSG00000149311homo_sapiensENSP0000050160671.989555.9882hucho_huchoENSHHUP0000007140872.871856.6744
ENSG00000149311homo_sapiensENSP0000050160670.451654.1558betta_splendensENSBSLP0000005159569.586353.4906
ENSG00000149311homo_sapiensENSP0000050160671.236954.7448pygocentrus_nattereriENSPNAP0000000647970.681854.3182
ENSG00000149311homo_sapiensENSP0000050160668.815452.9123anabas_testudineusENSATEP0000005361771.384954.888
ENSG00000149311homo_sapiensENSP000005016068.475136.90445ciona_savignyiENSCSAVP0000000686267.447954.9479
ENSG00000149311homo_sapiensENSP0000050160670.746154.0249seriola_lalandi_dorsalisENSSLDP0000002268971.212154.3808
ENSG00000149311homo_sapiensENSP0000050160669.731753.2068labrus_bergyltaENSLBEP0000001573170.586353.8589
ENSG00000149311homo_sapiensENSP0000050160670.451654.0576pundamilia_nyerereiENSPNYP0000001479070.56754.1462
ENSG00000149311homo_sapiensENSP0000050160670.484353.4686mastacembelus_armatusENSMAMP0000000549570.231553.2768
ENSG00000149311homo_sapiensENSP0000050160670.418853.8613stegastes_partitusENSSPAP0000002248770.603754.0026
ENSG00000149311homo_sapiensENSP0000050160672.774956.25oncorhynchus_tshawytschaENSOTSP0000502790672.703556.1948
ENSG00000149311homo_sapiensENSP0000050160670.124353.2395acanthochromis_polyacanthusENSAPOP0000002836270.819653.7673
ENSG00000149311homo_sapiensENSP000005016064.810213.89398aquila_chrysaetos_chrysaetosENSACCP0002001078085.465169.186
ENSG00000149311homo_sapiensENSP000005016063.763093.14136aquila_chrysaetos_chrysaetosENSACCP0002001076388.461573.8462
ENSG00000149311homo_sapiensENSP0000050160670.353453.5013nothobranchius_furzeriENSNFUP0001503167469.941453.188
ENSG00000149311homo_sapiensENSP000005016063.664922.84686cyprinodon_variegatusENSCVAP0000001175877.241460
ENSG00000149311homo_sapiensENSP000005016063.043192.38874cyprinodon_variegatusENSCVAP0000001175578.151361.3445
ENSG00000149311homo_sapiensENSP0000050160665.641450.8835denticeps_clupeoidesENSDCDP0000005361171.822455.6749
ENSG00000149311homo_sapiensENSP0000050160669.764453.5013larimichthys_croceaENSLCRP0000500882570.572754.1212
ENSG00000149311homo_sapiensENSP0000050160670.058952.4869takifugu_rubripesENSTRUP0000008834869.355451.9598
ENSG00000149311homo_sapiensENSP0000050160682.558969.0445ficedula_albicollisENSFALP0000000046482.61369.0897
ENSG00000149311homo_sapiensENSP000005016067.657075.5301hippocampus_comesENSHCOP0000000919375.241254.3408
ENSG00000149311homo_sapiensENSP000005016063.468592.65052hippocampus_comesENSHCOP0000000918062.721947.929
ENSG00000149311homo_sapiensENSP0000050160670.811554.9084cyprinus_carpio_carpioENSCCRP0000018171469.941854.234
ENSG00000149311homo_sapiensENSP0000050160682.591668.9463coturnix_japonicaENSCJPP0000500317782.917269.2181
ENSG00000149311homo_sapiensENSP0000050160667.670252.0615poecilia_latipinnaENSPLAP0000001228671.905455.3199
ENSG00000149311homo_sapiensENSP0000050160664.692449.6073sinocyclocheilus_grahamiENSSGRP0000009311969.637253.3991
ENSG00000149311homo_sapiensENSP000005016064.64663.46859maylandia_zebraENSMZEP0000501653080.22659.887
ENSG00000149311homo_sapiensENSP000005016063.403142.6178maylandia_zebraENSMZEP0000501654874.820157.554
ENSG00000149311homo_sapiensENSP0000050160612.20558.60602tetraodon_nigroviridisENSTNIP0000000591969.589649.0672
ENSG00000149311homo_sapiensENSP0000050160653.174139.9869tetraodon_nigroviridisENSTNIP0000000611870.255152.8318
ENSG00000149311homo_sapiensENSP0000050160670.28855.1702paramormyrops_kingsleyaeENSPKIP0000003252870.914555.6619
ENSG00000149311homo_sapiensENSP0000050160670.615255.7264scleropages_formosusENSSFOP0001501632471.150756.149
ENSG00000149311homo_sapiensENSP0000050160680.366564.7251leptobrachium_leishanenseENSLLEP0000001152979.869964.3252
ENSG00000149311homo_sapiensENSP0000050160667.604751.3089scophthalmus_maximusENSSMAP0000006984869.538952.7768
ENSG00000149311homo_sapiensENSP000005016063.435862.81414oryzias_melastigmaENSOMEP0000000415478.947464.6617
ENSG00000149311homo_sapiensENSP000005016064.155763.27225oryzias_melastigmaENSOMEP0000000413872.159156.8182

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000077involved_in DNA damage checkpoint signaling2IBA,IDAHomo_sapiens(9606)Process
GO:0000425involved_in pexophagy1IDAHomo_sapiens(9606)Process
GO:0000723involved_in telomere maintenance1IBAHomo_sapiens(9606)Process
GO:0000724involved_in double-strand break repair via homologous recombination1IEAHomo_sapiens(9606)Process
GO:0000781colocalizes_with chromosome, telomeric region1IDAHomo_sapiens(9606)Component
GO:0001541involved_in ovarian follicle development1IEAHomo_sapiens(9606)Process
GO:0001666involved_in response to hypoxia1IEAHomo_sapiens(9606)Process
GO:0001756involved_in somitogenesis1IEAHomo_sapiens(9606)Process
GO:0002331involved_in pre-B cell allelic exclusion1ISSHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0004677enables DNA-dependent protein kinase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1ISSHomo_sapiens(9606)Component
GO:0005782is_active_in peroxisomal matrix2IDA,TASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1ISSHomo_sapiens(9606)Component
GO:0005819located_in spindle1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006302involved_in double-strand break repair1TASHomo_sapiens(9606)Process
GO:0006303involved_in double-strand break repair via nonhomologous end joining1TASHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response3IDA,IMPHomo_sapiens(9606)Process
GO:0006977involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1TASHomo_sapiens(9606)Process
GO:0007094involved_in mitotic spindle assembly checkpoint signaling1IMPHomo_sapiens(9606)Process
GO:0007095involved_in mitotic G2 DNA damage checkpoint signaling1IMPHomo_sapiens(9606)Process
GO:0007131involved_in reciprocal meiotic recombination1TASHomo_sapiens(9606)Process
GO:0007140involved_in male meiotic nuclear division1IEAHomo_sapiens(9606)Process
GO:0007143involved_in female meiotic nuclear division1IEAHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007420involved_in brain development1IEAHomo_sapiens(9606)Process
GO:0007507involved_in heart development1IEAHomo_sapiens(9606)Process
GO:0008340involved_in determination of adult lifespan1IEAHomo_sapiens(9606)Process
GO:0008630involved_in intrinsic apoptotic signaling pathway in response to DNA damage1IBAHomo_sapiens(9606)Process
GO:0009791involved_in post-embryonic development1IEAHomo_sapiens(9606)Process
GO:0010212involved_in response to ionizing radiation1IDAHomo_sapiens(9606)Process
GO:0010506involved_in regulation of autophagy1IMPHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0016303enables 1-phosphatidylinositol-3-kinase activity1IMPHomo_sapiens(9606)Function
GO:0018105involved_in peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0030335involved_in positive regulation of cell migration1IMPHomo_sapiens(9606)Process
GO:0030889involved_in negative regulation of B cell proliferation1IMPHomo_sapiens(9606)Process
GO:0031410located_in cytoplasmic vesicle1IEAHomo_sapiens(9606)Component
GO:0032210involved_in regulation of telomere maintenance via telomerase1IGIHomo_sapiens(9606)Process
GO:0032212involved_in positive regulation of telomere maintenance via telomerase1ISSHomo_sapiens(9606)Process
GO:0033151involved_in V(D)J recombination1IEAHomo_sapiens(9606)Process
GO:0034614involved_in cellular response to reactive oxygen species1IDAHomo_sapiens(9606)Process
GO:0035264involved_in multicellular organism growth1IEAHomo_sapiens(9606)Process
GO:0036092involved_in phosphatidylinositol-3-phosphate biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0036289acts_upstream_of_or_within peptidyl-serine autophosphorylation1IMPHomo_sapiens(9606)Process
GO:0042159involved_in lipoprotein catabolic process1IEAHomo_sapiens(9606)Process
GO:0042770involved_in signal transduction in response to DNA damage2IDA,IMPHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042981involved_in regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0043517involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator1IMPHomo_sapiens(9606)Process
GO:0043525involved_in positive regulation of neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0044877enables protein-containing complex binding1IDAHomo_sapiens(9606)Function
GO:0045141involved_in meiotic telomere clustering1IEAHomo_sapiens(9606)Process
GO:0045785involved_in positive regulation of cell adhesion1ISSHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0048538involved_in thymus development1IEAHomo_sapiens(9606)Process
GO:0048599involved_in oocyte development1IEAHomo_sapiens(9606)Process
GO:0051402involved_in neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1IMPHomo_sapiens(9606)Process
GO:0051972NOT involved_in regulation of telomerase activity1IMPHomo_sapiens(9606)Process
GO:0071044involved_in histone mRNA catabolic process1IDAHomo_sapiens(9606)Process
GO:0071300involved_in cellular response to retinoic acid1ISSHomo_sapiens(9606)Process
GO:0071480involved_in cellular response to gamma radiation1IDAHomo_sapiens(9606)Process
GO:0071481involved_in cellular response to X-ray1IDAHomo_sapiens(9606)Process
GO:0071500involved_in cellular response to nitrosative stress1IDAHomo_sapiens(9606)Process
GO:0090398involved_in cellular senescence1TASHomo_sapiens(9606)Process
GO:0090399involved_in replicative senescence1IMPHomo_sapiens(9606)Process
GO:0097694involved_in establishment of RNA localization to telomere1IMPHomo_sapiens(9606)Process
GO:0097695involved_in establishment of protein-containing complex localization to telomere1IMPHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1900034involved_in regulation of cellular response to heat1TASHomo_sapiens(9606)Process
GO:1901796involved_in regulation of signal transduction by p53 class mediator1TASHomo_sapiens(9606)Process
GO:1903626involved_in positive regulation of DNA catabolic process1IEAHomo_sapiens(9606)Process
GO:1903978involved_in regulation of microglial cell activation1IEAHomo_sapiens(9606)Process
GO:1904262involved_in negative regulation of TORC1 signaling2IBA,IMPHomo_sapiens(9606)Process
GO:1904354involved_in negative regulation of telomere capping1IMPHomo_sapiens(9606)Process
GO:1904358involved_in positive regulation of telomere maintenance via telomere lengthening1IMPHomo_sapiens(9606)Process
GO:1904884involved_in positive regulation of telomerase catalytic core complex assembly1IMPHomo_sapiens(9606)Process
GO:1990391part_of DNA repair complex1IDAHomo_sapiens(9606)Component

Expression