RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000148730	Gene ID	1979	Accession	3289
Symbol	EIF4EBP2	Alias	4EBP2;PHASII	Full Name	eukaryotic translation initiation factor 4E binding protein 2
Status	Confidence	Length	24474 bases	Strand	Plus strand
Position	10 : 70404145 - 70428618	RNA binding domain	eIF_4EBP
Summary	This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000362314	eIF_4EBP	PF05456	6.1e-46	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
EIF4EBP2-201	ENST00000373218	7491	120aa	ENSP00000362314

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0006412	involved_in translation	1	TAS	Homo_sapiens(9606)	Process
GO:0007613	involved_in memory	1	ISS	Homo_sapiens(9606)	Process
GO:0008190	enables eukaryotic initiation factor 4E binding	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0008286	involved_in insulin receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0030371	enables translation repressor activity	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0031929	involved_in TOR signaling	1	ISS	Homo_sapiens(9606)	Process
GO:0035176	involved_in social behavior	1	ISS	Homo_sapiens(9606)	Process
GO:0043232	is_active_in intracellular non-membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0045947	involved_in negative regulation of translational initiation	3	IBA,IDA,ISS	Homo_sapiens(9606)	Process
GO:0048167	involved_in regulation of synaptic plasticity	1	ISS	Homo_sapiens(9606)	Process
GO:0050804	involved_in modulation of chemical synaptic transmission	1	ISS	Homo_sapiens(9606)	Process
GO:0071598	is_active_in neuronal ribonucleoprotein granule	1	IDA	Homo_sapiens(9606)	Component
GO:0098794	located_in postsynapse	1	IEA	Homo_sapiens(9606)	Component