RBP Type	Non-canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000148090	Gene ID	549	Accession	890
Symbol	AUH	Alias	NA	Full Name	AU RNA binding methylglutaconyl-CoA hydratase
Status	Confidence	Length	148104 bases	Strand	Minus strand
Position	9 : 91213815 - 91361918	RNA binding domain	N.A.
Summary	This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
18221507	Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency.	Alena Cízková	2008-01-25	BMC genomics
24598254	A bifunctional protein regulates mitochondrial protein synthesis.	R Tara Richman	2014-05-01	Nucleic acids research
7892223	AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity.	J Nakagawa	1995-03-14	Proceedings of the National Academy of Sciences of the United States of America
25695250	Whole cell formaldehyde cross-linking simplifies purification of mitochondrial nucleoids and associated proteins involved in mitochondrial gene expression.	Nina Rajala	2015-01-01	PloS one
31106228	De Novo Interstitial Deletion of 9q in a Pediatric Patient With Global Developmental Delay.	Dennis Keselman	2019-01-01	Child neurology open
24989451	EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.	Veronika Boczonadi	2014-07-03	Nature communications
22904065	p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.	Mikako Yagi	2012-10-01	Nucleic acids research
34221536	Large-scale analysis of the position-dependent binding and regulation of human RNA binding proteins.	Jianan Lin	2020-06-01	Quantitative biology (Beijing, China)
33193737	KPNA2-Associated Immune Analyses Highlight the Dysregulation and Prognostic Effects of GRB2, NRAS, and Their RNA-Binding Proteins in Hepatocellular Carcinoma.	Xiuzhi Zhang	2020-01-01	Frontiers in genetics
26189680	A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.	Oren Parnas	2015-07-30	Cell
11738050	Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase.	K Kurimoto	2001-12-01	Structure (London, England : 1993)
19196430	Mutant copper-zinc superoxide dismutase associated with amyotrophic lateral sclerosis binds to adenine/uridine-rich stability elements in the vascular endothelial growth factor 3'-untranslated region.	Xuelin Li	2009-02-01	Journal of neurochemistry
21909410	Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes.	Maija Wessman	2011-01-01	PloS one
16640564	Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism.	Matthias Mack	2006-05-01	The FEBS journal
12434311	3-Methylglutaconic aciduria type I is caused by mutations in AUH.	Lodewijk IJlst	2002-12-01	American journal of human genetics
11343630	Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability.	G Chen	2001-03-01	The international journal of neuropsychopharmacology
21150874	A genome-wide association study for diabetic nephropathy genes in African Americans.	W Caitrin McDonough	2011-03-01	Kidney international

Name	Transcript ID	bp	Protein	Translation ID
AUH-202	ENST00000375731	1574	339aa	ENSP00000364883
AUH-201	ENST00000303617	1490	310aa	ENSP00000307334
AUH-203	ENST00000473695	632	No protein	-
AUH-205	ENST00000478465	751	No protein	-
AUH-204	ENST00000475023	641	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
422	Respiratory Function Tests	1.22718160066294E-7	17903307
8264	Electrocardiography	2.65392231829385E-10	17903306
13307	Lupus Erythematosus, Systemic	2.37E-6	18204446
14987	Myocardial Infarction	5.3662451E-004	-
15154	Myocardial Infarction	8.0106382E-004	-
29903	Triglycerides	9.5590000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000148090	homo_sapiens	ENSP00000401751	44.5183	27.2425	homo_sapiens	ENSP00000364883	39.528	24.1888
ENSG00000148090	homo_sapiens	ENSP00000476295	24.7036	13.4387	homo_sapiens	ENSP00000364883	36.8732	20.059
ENSG00000148090	homo_sapiens	ENSP00000301729	39.7351	22.8477	homo_sapiens	ENSP00000364883	35.3982	20.354
ENSG00000148090	homo_sapiens	ENSP00000352706	34.715	19.4301	homo_sapiens	ENSP00000364883	39.528	22.1239
ENSG00000148090	homo_sapiens	ENSP00000368517	42.2442	24.7525	homo_sapiens	ENSP00000364883	37.7581	22.1239
ENSG00000148090	homo_sapiens	ENSP00000302968	21.6607	11.1913	homo_sapiens	ENSP00000364883	35.3982	18.2891
ENSG00000148090	homo_sapiens	ENSP00000250838	22.7357	11.8299	homo_sapiens	ENSP00000364883	36.2832	18.8791
ENSG00000148090	homo_sapiens	ENSP00000371844	22.5926	11.8519	homo_sapiens	ENSP00000364883	35.9882	18.8791
ENSG00000148090	homo_sapiens	ENSP00000372319	22.7357	11.8299	homo_sapiens	ENSP00000364883	36.2832	18.8791
ENSG00000148090	homo_sapiens	ENSP00000380718	22.9779	13.0515	homo_sapiens	ENSP00000364883	36.8732	20.944
ENSG00000148090	homo_sapiens	ENSP00000221418	42.0732	25	homo_sapiens	ENSP00000364883	40.708	24.1888
ENSG00000148090	homo_sapiens	ENSP00000360577	72.2603	52.3973	homo_sapiens	ENSP00000364883	62.2419	45.1327
ENSG00000148090	homo_sapiens	ENSP00000357535	51.0345	33.1034	homo_sapiens	ENSP00000364883	43.6578	28.3186

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000148090	homo_sapiens	ENSP00000364883	75.2212	71.0914	nomascus_leucogenys	ENSNLEP00000034918	81.4697	76.9968
ENSG00000148090	homo_sapiens	ENSP00000364883	76.1062	74.6313	pan_paniscus	ENSPPAP00000031480	64.8241	63.5678
ENSG00000148090	homo_sapiens	ENSP00000364883	98.8201	98.5251	pongo_abelii	ENSPPYP00000021702	98.8201	98.5251
ENSG00000148090	homo_sapiens	ENSP00000364883	99.705	99.115	pan_troglodytes	ENSPTRP00000079432	99.705	99.115
ENSG00000148090	homo_sapiens	ENSP00000364883	99.705	99.41	gorilla_gorilla	ENSGGOP00000003756	99.705	99.41
ENSG00000148090	homo_sapiens	ENSP00000364883	75.8112	64.6018	ornithorhynchus_anatinus	ENSOANP00000036804	58.0135	49.4357
ENSG00000148090	homo_sapiens	ENSP00000364883	82.3009	73.4513	sarcophilus_harrisii	ENSSHAP00000040885	84.0361	75
ENSG00000148090	homo_sapiens	ENSP00000364883	82.5959	76.1062	notamacropus_eugenii	ENSMEUP00000004179	85.6269	78.8991
ENSG00000148090	homo_sapiens	ENSP00000364883	81.7109	78.1711	choloepus_hoffmanni	ENSCHOP00000012397	81.7109	78.1711
ENSG00000148090	homo_sapiens	ENSP00000364883	57.8171	55.4572	dasypus_novemcinctus	ENSDNOP00000034547	97.5124	93.5323
ENSG00000148090	homo_sapiens	ENSP00000364883	87.6106	83.7758	erinaceus_europaeus	ENSEEUP00000010265	88.3929	84.5238
ENSG00000148090	homo_sapiens	ENSP00000364883	97.9351	96.1652	callithrix_jacchus	ENSCJAP00000010488	97.9351	96.1652
ENSG00000148090	homo_sapiens	ENSP00000364883	89.9705	87.0207	callithrix_jacchus	ENSCJAP00000089264	92.4242	89.3939
ENSG00000148090	homo_sapiens	ENSP00000364883	95.2802	94.3953	cercocebus_atys	ENSCATP00000037999	97.5831	96.6767
ENSG00000148090	homo_sapiens	ENSP00000364883	99.115	98.2301	macaca_fascicularis	ENSMFAP00000051155	88.8889	88.0952
ENSG00000148090	homo_sapiens	ENSP00000364883	98.8201	97.9351	macaca_mulatta	ENSMMUP00000020756	88.6243	87.8307
ENSG00000148090	homo_sapiens	ENSP00000364883	99.115	98.2301	macaca_nemestrina	ENSMNEP00000042683	99.115	98.2301
ENSG00000148090	homo_sapiens	ENSP00000364883	98.8201	98.2301	papio_anubis	ENSPANP00000019399	98.8201	98.2301
ENSG00000148090	homo_sapiens	ENSP00000364883	66.9617	65.1917	mandrillus_leucophaeus	ENSMLEP00000032773	91.9028	89.4737
ENSG00000148090	homo_sapiens	ENSP00000364883	67.2566	64.8968	tursiops_truncatus	ENSTTRP00000011785	67.8571	65.4762
ENSG00000148090	homo_sapiens	ENSP00000364883	93.2153	88.7906	vulpes_vulpes	ENSVVUP00000030588	92.6686	88.2698
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	87.6106	mus_spretus	MGP_SPRETEiJ_P0036000	96.4968	94.586
ENSG00000148090	homo_sapiens	ENSP00000364883	93.8053	89.9705	equus_asinus	ENSEASP00005035976	94.9254	91.0448
ENSG00000148090	homo_sapiens	ENSP00000364883	92.6254	89.0855	capra_hircus	ENSCHIP00000016884	92.6254	89.0855
ENSG00000148090	homo_sapiens	ENSP00000364883	84.0708	78.4661	loxodonta_africana	ENSLAFP00000014279	91.0543	84.984
ENSG00000148090	homo_sapiens	ENSP00000364883	90.2655	84.9557	panthera_leo	ENSPLOP00000015623	75	70.5882
ENSG00000148090	homo_sapiens	ENSP00000364883	93.5103	90.8555	ailuropoda_melanoleuca	ENSAMEP00000035255	93.5103	90.8555
ENSG00000148090	homo_sapiens	ENSP00000364883	71.6814	67.5516	bos_indicus_hybrid	ENSBIXP00005045481	92.7481	87.4046
ENSG00000148090	homo_sapiens	ENSP00000364883	92.9204	89.3805	bos_indicus_hybrid	ENSBIXP00005010930	92.9204	89.3805
ENSG00000148090	homo_sapiens	ENSP00000364883	77.8761	75.2212	oryctolagus_cuniculus	ENSOCUP00000006425	78.3383	75.6677
ENSG00000148090	homo_sapiens	ENSP00000364883	81.7109	74.3363	equus_caballus	ENSECAP00000073616	82.4405	75
ENSG00000148090	homo_sapiens	ENSP00000364883	93.8053	89.0855	canis_lupus_familiaris	ENSCAFP00845024861	93.5294	88.8235
ENSG00000148090	homo_sapiens	ENSP00000364883	93.5103	89.9705	panthera_pardus	ENSPPRP00000002129	93.5103	89.9705
ENSG00000148090	homo_sapiens	ENSP00000364883	32.4484	30.9735	marmota_marmota_marmota	ENSMMMP00000025052	88	84
ENSG00000148090	homo_sapiens	ENSP00000364883	92.6254	89.3805	balaenoptera_musculus	ENSBMSP00010006995	92.6254	89.3805
ENSG00000148090	homo_sapiens	ENSP00000364883	74.6313	72.8614	cavia_porcellus	ENSCPOP00000000963	96.1977	93.9164
ENSG00000148090	homo_sapiens	ENSP00000364883	91.1504	85.5457	felis_catus	ENSFCAP00000060298	62.5506	58.7045
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	86.4307	ursus_americanus	ENSUAMP00000032001	91.5408	88.5196
ENSG00000148090	homo_sapiens	ENSP00000364883	77.2861	71.0914	monodelphis_domestica	ENSMODP00000057758	63.9024	58.7805
ENSG00000148090	homo_sapiens	ENSP00000364883	68.4366	64.3068	bison_bison_bison	ENSBBBP00000003921	86.5672	81.3433
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	86.4307	bison_bison_bison	ENSBBBP00000002856	89.3805	86.4307
ENSG00000148090	homo_sapiens	ENSP00000364883	89.6755	87.3156	monodon_monoceros	ENSMMNP00015030214	89.6755	87.3156
ENSG00000148090	homo_sapiens	ENSP00000364883	91.4454	89.0855	monodon_monoceros	ENSMMNP00015016468	90.379	88.0466
ENSG00000148090	homo_sapiens	ENSP00000364883	92.0354	88.4956	sus_scrofa	ENSSSCP00000010238	92.3077	88.7574
ENSG00000148090	homo_sapiens	ENSP00000364883	95.8702	94.3953	microcebus_murinus	ENSMICP00000040577	95.8702	94.3953
ENSG00000148090	homo_sapiens	ENSP00000364883	80.826	75.2212	octodon_degus	ENSODEP00000001181	84.0491	78.2209
ENSG00000148090	homo_sapiens	ENSP00000364883	89.0855	87.3156	jaculus_jaculus	ENSJJAP00000011740	92.0732	90.2439
ENSG00000148090	homo_sapiens	ENSP00000364883	92.9204	89.3805	ovis_aries_rambouillet	ENSOARP00020000503	92.9204	89.3805
ENSG00000148090	homo_sapiens	ENSP00000364883	73.1563	70.5015	ursus_maritimus	ENSUMAP00000022632	79.7428	76.8489
ENSG00000148090	homo_sapiens	ENSP00000364883	70.7965	68.7316	ochotona_princeps	ENSOPRP00000000063	76.9231	74.6795
ENSG00000148090	homo_sapiens	ENSP00000364883	68.4366	66.6667	delphinapterus_leucas	ENSDLEP00000026499	88.5496	86.2595
ENSG00000148090	homo_sapiens	ENSP00000364883	87.0207	84.6608	delphinapterus_leucas	ENSDLEP00000025446	89.6657	87.234
ENSG00000148090	homo_sapiens	ENSP00000364883	92.0354	89.0855	physeter_catodon	ENSPCTP00005015282	92.0354	89.0855
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	87.3156	mus_caroli	MGP_CAROLIEiJ_P0034367	96.4968	94.2675
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	87.3156	mus_musculus	ENSMUSP00000021913	96.4968	94.2675
ENSG00000148090	homo_sapiens	ENSP00000364883	85.5457	83.1858	dipodomys_ordii	ENSDORP00000017267	91.195	88.6792
ENSG00000148090	homo_sapiens	ENSP00000364883	66.3717	64.3068	mustela_putorius_furo	ENSMPUP00000006792	97.8261	94.7826
ENSG00000148090	homo_sapiens	ENSP00000364883	97.9351	96.4602	aotus_nancymaae	ENSANAP00000007202	97.9351	96.4602
ENSG00000148090	homo_sapiens	ENSP00000364883	97.3451	95.8702	saimiri_boliviensis_boliviensis	ENSSBOP00000012545	97.3451	95.8702
ENSG00000148090	homo_sapiens	ENSP00000364883	61.0619	59.882	vicugna_pacos	ENSVPAP00000000148	82.4701	80.8765
ENSG00000148090	homo_sapiens	ENSP00000364883	98.5251	97.9351	chlorocebus_sabaeus	ENSCSAP00000003541	98.2353	97.6471
ENSG00000148090	homo_sapiens	ENSP00000364883	50.1475	48.6726	tupaia_belangeri	ENSTBEP00000008023	72.3404	70.2128
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	86.7257	mesocricetus_auratus	ENSMAUP00000008034	96.4968	93.6306
ENSG00000148090	homo_sapiens	ENSP00000364883	72.2714	68.7316	phocoena_sinus	ENSPSNP00000007746	87.8136	83.5125
ENSG00000148090	homo_sapiens	ENSP00000364883	91.7404	89.3805	phocoena_sinus	ENSPSNP00000001309	91.7404	89.3805
ENSG00000148090	homo_sapiens	ENSP00000364883	53.6873	52.2124	camelus_dromedarius	ENSCDRP00005024850	93.8144	91.2371
ENSG00000148090	homo_sapiens	ENSP00000364883	72.8614	70.7965	carlito_syrichta	ENSTSYP00000003775	72.8614	70.7965
ENSG00000148090	homo_sapiens	ENSP00000364883	71.9764	69.9115	panthera_tigris_altaica	ENSPTIP00000007845	71.9764	69.9115
ENSG00000148090	homo_sapiens	ENSP00000364883	89.0855	87.3156	rattus_norvegicus	ENSRNOP00000015786	95.873	93.9683
ENSG00000148090	homo_sapiens	ENSP00000364883	94.9853	92.3304	prolemur_simus	ENSPSMP00000036839	94.9853	92.3304
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	87.9056	microtus_ochrogaster	ENSMOCP00000014114	96.4968	94.9045
ENSG00000148090	homo_sapiens	ENSP00000364883	55.1622	52.8024	sorex_araneus	ENSSARP00000002615	74.502	71.3147
ENSG00000148090	homo_sapiens	ENSP00000364883	89.9705	88.2006	peromyscus_maniculatus_bairdii	ENSPEMP00000012318	97.1338	95.2229
ENSG00000148090	homo_sapiens	ENSP00000364883	38.3481	35.1032	bos_mutus	ENSBMUP00000009000	87.8378	80.4054
ENSG00000148090	homo_sapiens	ENSP00000364883	76.6962	74.6313	mus_spicilegus	ENSMSIP00000008242	84.1424	81.877
ENSG00000148090	homo_sapiens	ENSP00000364883	88.7906	86.7257	cricetulus_griseus_chok1gshd	ENSCGRP00001014719	95.2532	93.038
ENSG00000148090	homo_sapiens	ENSP00000364883	90.2655	85.8407	pteropus_vampyrus	ENSPVAP00000004541	90.8012	86.3502
ENSG00000148090	homo_sapiens	ENSP00000364883	14.7493	13.5693	myotis_lucifugus	ENSMLUP00000002869	96.1538	88.4615
ENSG00000148090	homo_sapiens	ENSP00000364883	82.3009	76.1062	vombatus_ursinus	ENSVURP00010008871	84.0361	77.7108
ENSG00000148090	homo_sapiens	ENSP00000364883	91.7404	87.0207	rhinolophus_ferrumequinum	ENSRFEP00010018550	92.2849	87.5371
ENSG00000148090	homo_sapiens	ENSP00000364883	74.0413	71.0914	neovison_vison	ENSNVIP00000020046	88.3803	84.8592
ENSG00000148090	homo_sapiens	ENSP00000364883	37.7581	31.8584	bos_taurus	ENSBTAP00000068994	66.3212	55.9585
ENSG00000148090	homo_sapiens	ENSP00000364883	73.7463	70.2065	bos_taurus	ENSBTAP00000067281	90.9091	86.5455
ENSG00000148090	homo_sapiens	ENSP00000364883	40.118	37.1681	heterocephalus_glaber_female	ENSHGLP00000042062	83.9506	77.7778
ENSG00000148090	homo_sapiens	ENSP00000364883	98.8201	98.2301	rhinopithecus_bieti	ENSRBIP00000009555	99.1124	98.5207
ENSG00000148090	homo_sapiens	ENSP00000364883	86.7257	80.826	canis_lupus_dingo	ENSCAFP00020008352	88.0239	82.0359
ENSG00000148090	homo_sapiens	ENSP00000364883	39.233	35.6932	sciurus_vulgaris	ENSSVLP00005009428	65.5172	59.6059
ENSG00000148090	homo_sapiens	ENSP00000364883	75.8112	65.7817	phascolarctos_cinereus	ENSPCIP00000047590	59.0805	51.2644
ENSG00000148090	homo_sapiens	ENSP00000364883	63.1268	60.767	procavia_capensis	ENSPCAP00000014700	63.1268	60.767
ENSG00000148090	homo_sapiens	ENSP00000364883	89.3805	86.4307	nannospalax_galili	ENSNGAP00000007744	96.4968	93.3121
ENSG00000148090	homo_sapiens	ENSP00000364883	36.2832	35.6932	bos_grunniens	ENSBGRP00000014154	91.791	90.2985
ENSG00000148090	homo_sapiens	ENSP00000364883	81.7109	79.056	chinchilla_lanigera	ENSCLAP00000000854	96.1806	93.0556
ENSG00000148090	homo_sapiens	ENSP00000364883	92.9204	89.0855	cervus_hanglu_yarkandensis	ENSCHYP00000014983	92.9204	89.0855
ENSG00000148090	homo_sapiens	ENSP00000364883	92.6254	87.9056	catagonus_wagneri	ENSCWAP00000001747	92.8994	88.1657
ENSG00000148090	homo_sapiens	ENSP00000364883	67.2566	63.7168	ictidomys_tridecemlineatus	ENSSTOP00000024366	85.3933	80.8989
ENSG00000148090	homo_sapiens	ENSP00000364883	94.9853	92.0354	otolemur_garnettii	ENSOGAP00000010512	95.8333	92.8571
ENSG00000148090	homo_sapiens	ENSP00000364883	96.7552	94.9853	cebus_imitator	ENSCCAP00000002723	96.7552	94.9853
ENSG00000148090	homo_sapiens	ENSP00000364883	93.2153	90.2655	moschus_moschiferus	ENSMMSP00000017877	93.2153	90.2655
ENSG00000148090	homo_sapiens	ENSP00000364883	92.6254	91.4454	rhinopithecus_roxellana	ENSRROP00000031798	92.0821	90.9091
ENSG00000148090	homo_sapiens	ENSP00000364883	89.0855	87.3156	mus_pahari	MGP_PahariEiJ_P0040975	96.1783	94.2675
ENSG00000148090	homo_sapiens	ENSP00000364883	97.0501	95.2802	propithecus_coquereli	ENSPCOP00000019109	97.0501	95.2802
ENSG00000148090	homo_sapiens	ENSP00000364883	58.1121	41.5929	caenorhabditis_elegans	F56B3.5.1	68.6411	49.1289
ENSG00000148090	homo_sapiens	ENSP00000364883	61.9469	48.0826	drosophila_melanogaster	FBpp0086993	70.2341	54.515
ENSG00000148090	homo_sapiens	ENSP00000364883	60.177	47.1976	ciona_intestinalis	ENSCINP00000005607	67.7741	53.1561
ENSG00000148090	homo_sapiens	ENSP00000364883	50.7375	37.4631	petromyzon_marinus	ENSPMAP00000003770	66.9261	49.4163
ENSG00000148090	homo_sapiens	ENSP00000364883	64.8968	50.4425	eptatretus_burgeri	ENSEBUP00000012565	72.3684	56.25
ENSG00000148090	homo_sapiens	ENSP00000364883	71.3864	58.9971	callorhinchus_milii	ENSCMIP00000028277	72.6727	60.0601
ENSG00000148090	homo_sapiens	ENSP00000364883	59.587	50.1475	latimeria_chalumnae	ENSLACP00000008049	71.6312	60.2837
ENSG00000148090	homo_sapiens	ENSP00000364883	73.4513	62.8319	lepisosteus_oculatus	ENSLOCP00000009963	74.7748	63.964
ENSG00000148090	homo_sapiens	ENSP00000364883	71.3864	58.4071	clupea_harengus	ENSCHAP00000043036	74.4615	60.9231
ENSG00000148090	homo_sapiens	ENSP00000364883	73.4513	58.7021	danio_rerio	ENSDARP00000063092	76.6154	61.2308
ENSG00000148090	homo_sapiens	ENSP00000364883	69.6165	56.0472	carassius_auratus	ENSCARP00000081056	73.9812	59.5611
ENSG00000148090	homo_sapiens	ENSP00000364883	70.7965	58.4071	astyanax_mexicanus	ENSAMXP00000052532	76.6773	63.2588
ENSG00000148090	homo_sapiens	ENSP00000364883	71.6814	57.8171	ictalurus_punctatus	ENSIPUP00000037313	66.0326	53.2609
ENSG00000148090	homo_sapiens	ENSP00000364883	63.7168	49.5575	esox_lucius	ENSELUP00000037258	63.9053	49.7041
ENSG00000148090	homo_sapiens	ENSP00000364883	67.5516	56.9322	electrophorus_electricus	ENSEEEP00000041889	66.3768	55.942
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	57.5221	oncorhynchus_kisutch	ENSOKIP00005117754	73.9264	59.816
ENSG00000148090	homo_sapiens	ENSP00000364883	63.4218	51.0324	oncorhynchus_mykiss	ENSOMYP00000126669	42.0744	33.8552
ENSG00000148090	homo_sapiens	ENSP00000364883	70.7965	57.8171	salmo_salar	ENSSSAP00000106453	68.5714	56
ENSG00000148090	homo_sapiens	ENSP00000364883	71.6814	58.4071	salmo_trutta	ENSSTUP00000059212	67.313	54.8476
ENSG00000148090	homo_sapiens	ENSP00000364883	69.9115	57.2271	gadus_morhua	ENSGMOP00000055617	73.6025	60.2484
ENSG00000148090	homo_sapiens	ENSP00000364883	34.8083	24.7788	fundulus_heteroclitus	ENSFHEP00000013749	57.8431	41.1765
ENSG00000148090	homo_sapiens	ENSP00000364883	52.8024	41.8879	fundulus_heteroclitus	ENSFHEP00000028945	66.0517	52.3985
ENSG00000148090	homo_sapiens	ENSP00000364883	69.0266	57.2271	poecilia_reticulata	ENSPREP00000006396	73.3542	60.815
ENSG00000148090	homo_sapiens	ENSP00000364883	69.0266	58.7021	xiphophorus_maculatus	ENSXMAP00000016170	72.8972	61.9938
ENSG00000148090	homo_sapiens	ENSP00000364883	71.6814	59.882	oryzias_latipes	ENSORLP00000025083	75.2322	62.8483
ENSG00000148090	homo_sapiens	ENSP00000364883	69.3215	58.4071	cyclopterus_lumpus	ENSCLMP00005048141	71.4286	60.1824
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	58.1121	oreochromis_niloticus	ENSONIP00000032766	64.2667	52.5333
ENSG00000148090	homo_sapiens	ENSP00000364883	56.6372	46.3127	oreochromis_niloticus	ENSONIP00000028816	73.8462	60.3846
ENSG00000148090	homo_sapiens	ENSP00000364883	70.7965	57.8171	oreochromis_niloticus	ENSONIP00000014128	73.1707	59.7561
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	57.8171	haplochromis_burtoni	ENSHBUP00000004955	73.4756	59.7561
ENSG00000148090	homo_sapiens	ENSP00000364883	69.3215	56.9322	astatotilapia_calliptera	ENSACLP00000012188	76.7974	63.0719
ENSG00000148090	homo_sapiens	ENSP00000364883	70.5015	57.8171	astatotilapia_calliptera	ENSACLP00000030630	76.8489	63.0225
ENSG00000148090	homo_sapiens	ENSP00000364883	57.2271	46.0177	astatotilapia_calliptera	ENSACLP00000033980	69.7842	56.1151
ENSG00000148090	homo_sapiens	ENSP00000364883	69.6165	57.8171	sparus_aurata	ENSSAUP00010057396	71.7325	59.5745
ENSG00000148090	homo_sapiens	ENSP00000364883	70.2065	58.1121	lates_calcarifer	ENSLCAP00010025366	72.561	60.061
ENSG00000148090	homo_sapiens	ENSP00000364883	76.9911	64.0118	xenopus_tropicalis	ENSXETP00000107486	81.0559	67.3913
ENSG00000148090	homo_sapiens	ENSP00000364883	81.1209	72.2714	chrysemys_picta_bellii	ENSCPBP00000028854	85.6698	76.324
ENSG00000148090	homo_sapiens	ENSP00000364883	79.056	70.7965	sphenodon_punctatus	ENSSPUP00000014127	84.0125	75.2351
ENSG00000148090	homo_sapiens	ENSP00000364883	79.351	70.2065	crocodylus_porosus	ENSCPRP00005014769	84.0625	74.375
ENSG00000148090	homo_sapiens	ENSP00000364883	23.3038	17.6991	laticauda_laticaudata	ENSLLTP00000018101	61.7188	46.875
ENSG00000148090	homo_sapiens	ENSP00000364883	74.6313	64.0118	notechis_scutatus	ENSNSUP00000019069	80.3175	68.8889
ENSG00000148090	homo_sapiens	ENSP00000364883	77.5811	67.8466	pseudonaja_textilis	ENSPTXP00000017914	82.1875	71.875
ENSG00000148090	homo_sapiens	ENSP00000364883	80.531	71.9764	anas_platyrhynchos_platyrhynchos	ENSAPLP00000002887	83.2317	74.3902
ENSG00000148090	homo_sapiens	ENSP00000364883	81.7109	71.9764	gallus_gallus	ENSGALP00010012926	79.1429	69.7143
ENSG00000148090	homo_sapiens	ENSP00000364883	46.9027	39.823	meleagris_gallopavo	ENSMGAP00000006664	58.0292	49.2701
ENSG00000148090	homo_sapiens	ENSP00000364883	75.5162	66.3717	serinus_canaria	ENSSCAP00000019191	80.5031	70.7547
ENSG00000148090	homo_sapiens	ENSP00000364883	65.7817	60.767	parus_major	ENSPMJP00000002949	94.4915	87.2881
ENSG00000148090	homo_sapiens	ENSP00000364883	60.177	54.2773	anolis_carolinensis	ENSACAP00000024888	77.2727	69.697
ENSG00000148090	homo_sapiens	ENSP00000364883	21.5339	16.5192	anolis_carolinensis	ENSACAP00000041464	59.3496	45.5285
ENSG00000148090	homo_sapiens	ENSP00000364883	55.1622	43.0678	neolamprologus_brichardi	ENSNBRP00000008621	67.509	52.7076
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	57.5221	neolamprologus_brichardi	ENSNBRP00000003219	63.9257	51.7241
ENSG00000148090	homo_sapiens	ENSP00000364883	24.1888	21.5339	naja_naja	ENSNNAP00000000802	85.4167	76.0417
ENSG00000148090	homo_sapiens	ENSP00000364883	22.7139	17.4041	naja_naja	ENSNNAP00000000823	60.6299	46.4567
ENSG00000148090	homo_sapiens	ENSP00000364883	79.351	69.3215	podarcis_muralis	ENSPMRP00000025264	78.4257	68.5131
ENSG00000148090	homo_sapiens	ENSP00000364883	67.5516	60.472	geospiza_fortis	ENSGFOP00000004576	87.7395	78.5441
ENSG00000148090	homo_sapiens	ENSP00000364883	82.0059	73.1563	taeniopygia_guttata	ENSTGUP00000024966	84.4985	75.3799
ENSG00000148090	homo_sapiens	ENSP00000364883	71.3864	58.9971	erpetoichthys_calabaricus	ENSECRP00000021772	71.5976	59.1716
ENSG00000148090	homo_sapiens	ENSP00000364883	70.5015	58.4071	kryptolebias_marmoratus	ENSKMAP00000015971	73.3129	60.7362
ENSG00000148090	homo_sapiens	ENSP00000364883	79.941	69.3215	salvator_merianae	ENSSMRP00000024934	80.6548	69.9405
ENSG00000148090	homo_sapiens	ENSP00000364883	71.3864	59.292	oryzias_javanicus	ENSOJAP00000008352	74.9226	62.2291
ENSG00000148090	homo_sapiens	ENSP00000364883	67.2566	54.5723	amphilophus_citrinellus	ENSACIP00000013420	69.7248	56.5749
ENSG00000148090	homo_sapiens	ENSP00000364883	69.3215	58.7021	amphiprion_percula	ENSAPEP00000018783	73.2087	61.9938
ENSG00000148090	homo_sapiens	ENSP00000364883	54.2773	44.2478	oryzias_sinensis	ENSOSIP00000002523	85.9813	70.0935
ENSG00000148090	homo_sapiens	ENSP00000364883	63.7168	58.7021	pelodiscus_sinensis	ENSPSIP00000013400	93.913	86.5217
ENSG00000148090	homo_sapiens	ENSP00000364883	81.1209	72.2714	gopherus_evgoodei	ENSGEVP00005005269	85.6698	76.324
ENSG00000148090	homo_sapiens	ENSP00000364883	28.0236	22.1239	chelonoidis_abingdonii	ENSCABP00000017566	67.8571	53.5714
ENSG00000148090	homo_sapiens	ENSP00000364883	62.8319	53.0973	chelonoidis_abingdonii	ENSCABP00000004175	61.7391	52.1739
ENSG00000148090	homo_sapiens	ENSP00000364883	70.2065	58.9971	seriola_dumerili	ENSSDUP00000025175	72.3404	60.7903
ENSG00000148090	homo_sapiens	ENSP00000364883	69.0266	57.2271	cottoperca_gobio	ENSCGOP00000043990	71.3415	59.1463
ENSG00000148090	homo_sapiens	ENSP00000364883	65.4867	61.3569	struthio_camelus_australis	ENSSCUP00000023409	94.4681	88.5106
ENSG00000148090	homo_sapiens	ENSP00000364883	81.1209	72.5664	anser_brachyrhynchus	ENSABRP00000001165	82.8313	74.0964
ENSG00000148090	homo_sapiens	ENSP00000364883	67.5516	56.9322	gasterosteus_aculeatus	ENSGACP00000024665	77.1044	64.9832
ENSG00000148090	homo_sapiens	ENSP00000364883	61.9469	50.7375	cynoglossus_semilaevis	ENSCSEP00000015296	68.6274	56.2092
ENSG00000148090	homo_sapiens	ENSP00000364883	66.9617	56.3422	poecilia_formosa	ENSPFOP00000000514	78.0069	65.6357
ENSG00000148090	homo_sapiens	ENSP00000364883	70.7965	59.587	myripristis_murdjan	ENSMMDP00005025165	73.3945	61.7737
ENSG00000148090	homo_sapiens	ENSP00000364883	70.5015	58.4071	sander_lucioperca	ENSSLUP00000043984	71.988	59.6386
ENSG00000148090	homo_sapiens	ENSP00000364883	80.531	72.5664	strigops_habroptila	ENSSHBP00005022369	84.2593	75.9259
ENSG00000148090	homo_sapiens	ENSP00000364883	69.9115	58.7021	amphiprion_ocellaris	ENSAOCP00000031507	73.8318	61.9938
ENSG00000148090	homo_sapiens	ENSP00000364883	81.1209	72.8614	terrapene_carolina_triunguis	ENSTMTP00000022648	85.6698	76.947
ENSG00000148090	homo_sapiens	ENSP00000364883	71.3864	57.2271	hucho_hucho	ENSHHUP00000003796	74.2331	59.5092
ENSG00000148090	homo_sapiens	ENSP00000364883	69.6165	56.9322	betta_splendens	ENSBSLP00000004568	72.1713	59.0214
ENSG00000148090	homo_sapiens	ENSP00000364883	69.9115	57.5221	betta_splendens	ENSBSLP00000006201	72.2561	59.4512
ENSG00000148090	homo_sapiens	ENSP00000364883	71.9764	59.882	pygocentrus_nattereri	ENSPNAP00000014182	77.9553	64.8562
ENSG00000148090	homo_sapiens	ENSP00000364883	68.7316	56.3422	anabas_testudineus	ENSATEP00000015224	71.4724	58.589
ENSG00000148090	homo_sapiens	ENSP00000364883	62.5369	48.0826	ciona_savignyi	ENSCSAVP00000015534	70.1987	53.9735
ENSG00000148090	homo_sapiens	ENSP00000364883	69.0266	58.1121	seriola_lalandi_dorsalis	ENSSLDP00000022048	73.125	61.5625
ENSG00000148090	homo_sapiens	ENSP00000364883	68.7316	56.0472	labrus_bergylta	ENSLBEP00000032435	73.2704	59.7484
ENSG00000148090	homo_sapiens	ENSP00000364883	68.7316	56.0472	labrus_bergylta	ENSLBEP00000020457	73.2704	59.7484
ENSG00000148090	homo_sapiens	ENSP00000364883	63.1268	49.5575	pundamilia_nyererei	ENSPNYP00000005061	70.6271	55.4455
ENSG00000148090	homo_sapiens	ENSP00000364883	69.9115	57.2271	mastacembelus_armatus	ENSMAMP00000033857	72.0365	58.9666
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	58.7021	stegastes_partitus	ENSSPAP00000009460	75.0779	61.9938
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	57.5221	oncorhynchus_tshawytscha	ENSOTSP00005088616	73.9264	59.816
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	59.587	acanthochromis_polyacanthus	ENSAPOP00000003286	75.0779	62.9283
ENSG00000148090	homo_sapiens	ENSP00000364883	75.5162	66.9617	aquila_chrysaetos_chrysaetos	ENSACCP00020016084	77.5758	68.7879
ENSG00000148090	homo_sapiens	ENSP00000364883	69.9115	57.8171	nothobranchius_furzeri	ENSNFUP00015007460	65.651	54.2936
ENSG00000148090	homo_sapiens	ENSP00000364883	46.6077	38.3481	cyprinodon_variegatus	ENSCVAP00000012076	74.8815	61.6114
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	58.9971	denticeps_clupeoides	ENSDCDP00000006852	80.3333	66.6667
ENSG00000148090	homo_sapiens	ENSP00000364883	70.5015	57.2271	larimichthys_crocea	ENSLCRP00005061623	66.205	53.7396
ENSG00000148090	homo_sapiens	ENSP00000364883	65.7817	55.7522	takifugu_rubripes	ENSTRUP00000024191	72.8758	61.7647
ENSG00000148090	homo_sapiens	ENSP00000364883	41.5929	35.3982	ficedula_albicollis	ENSFALP00000022492	67.7885	57.6923
ENSG00000148090	homo_sapiens	ENSP00000364883	31.2684	27.4336	ficedula_albicollis	ENSFALP00000029276	89.0756	78.1513
ENSG00000148090	homo_sapiens	ENSP00000364883	70.7965	58.9971	hippocampus_comes	ENSHCOP00000024626	73.3945	61.1621
ENSG00000148090	homo_sapiens	ENSP00000364883	65.7817	51.0324	cyprinus_carpio_carpio	ENSCCRP00000101585	54.9261	42.6108
ENSG00000148090	homo_sapiens	ENSP00000364883	23.8938	20.649	cyprinus_carpio_carpio	ENSCCRP00000118936	84.375	72.9167
ENSG00000148090	homo_sapiens	ENSP00000364883	76.6962	66.9617	coturnix_japonica	ENSCJPP00005011102	71.8232	62.7072
ENSG00000148090	homo_sapiens	ENSP00000364883	60.767	49.5575	poecilia_latipinna	ENSPLAP00000020892	67.3203	54.902
ENSG00000148090	homo_sapiens	ENSP00000364883	69.9115	56.0472	sinocyclocheilus_grahami	ENSSGRP00000040980	76.4516	61.2903
ENSG00000148090	homo_sapiens	ENSP00000364883	70.5015	58.1121	maylandia_zebra	ENSMZEP00005038062	76.8489	63.3441
ENSG00000148090	homo_sapiens	ENSP00000364883	61.0619	48.9676	maylandia_zebra	ENSMZEP00005014626	69.2308	55.5184
ENSG00000148090	homo_sapiens	ENSP00000364883	63.1268	51.9174	maylandia_zebra	ENSMZEP00005003466	64.6526	53.1722
ENSG00000148090	homo_sapiens	ENSP00000364883	69.3215	56.9322	maylandia_zebra	ENSMZEP00005030008	76.7974	63.0719
ENSG00000148090	homo_sapiens	ENSP00000364883	69.0266	56.6372	tetraodon_nigroviridis	ENSTNIP00000009904	76.7213	62.9508
ENSG00000148090	homo_sapiens	ENSP00000364883	72.2714	59.882	paramormyrops_kingsleyae	ENSPKIP00000003430	71.2209	59.0116
ENSG00000148090	homo_sapiens	ENSP00000364883	71.0914	59.587	scleropages_formosus	ENSSFOP00015011752	73.7003	61.7737
ENSG00000148090	homo_sapiens	ENSP00000364883	74.6313	63.4218	leptobrachium_leishanense	ENSLLEP00000000207	78.0864	66.358
ENSG00000148090	homo_sapiens	ENSP00000364883	69.0266	56.9322	scophthalmus_maximus	ENSSMAP00000011804	78.2609	64.5485
ENSG00000148090	homo_sapiens	ENSP00000364883	71.6814	59.587	oryzias_melastigma	ENSOMEP00000005867	75.2322	62.5387

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003730	enables mRNA 3-UTR binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004300	enables enoyl-CoA hydratase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0004490	enables methylglutaconyl-CoA hydratase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005739	is_active_in mitochondrion	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0006552	involved_in leucine catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006635	involved_in fatty acid beta-oxidation	1	IBA	Homo_sapiens(9606)	Process
GO:0050011	enables itaconyl-CoA hydratase activity	1	IEA	Homo_sapiens(9606)	Function