RBP Type
Non-canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
N.A.
Localizations
Stress granucle
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000147889 Gene ID
1029 Accession
1787
Symbol
CDKN2A
Alias
ARF;MLM;P14;P16;P19;CMM2;INK4;MTS1;TP16;CDK4I;CDKN2;INK4A;MTS-1;P14ARF;P19ARF;P16INK4;P16INK4A;P16-INK4A
Full Name
cyclin dependent kinase inhibitor 2A
Status
Confidence
Length
27550 bases
Strand
Minus strand
Position
9 : 21967752 - 21995301
RNA binding domain
N.A.
Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
CDKN2A-201
ENST00000304494
978
156aa
ENSP00000307101
CDKN2A-214
ENST00000579755
1052
132aa
ENSP00000462950
CDKN2A-213
ENST00000579122
666
138aa
ENSP00000464202
CDKN2A-212
ENST00000578845
678
105aa
ENSP00000467390
CDKN2A-210
ENST00000530628
748
132aa
ENSP00000432664
CDKN2A-208
ENST00000498124
880
167aa
ENSP00000418915
CDKN2A-209
ENST00000498628
926
105aa
ENSP00000467857
CDKN2A-203
ENST00000380151
794
116aa
ENSP00000369496
CDKN2A-206
ENST00000494262
989
105aa
ENSP00000464952
CDKN2A-205
ENST00000479692
544
121aa
ENSP00000466887
CDKN2A-211
ENST00000577854
442
No protein
-
CDKN2A-202
ENST00000380150
493
No protein
-
CDKN2A-207
ENST00000497750
565
104aa
ENSP00000468510
CDKN2A-204
ENST00000470819
856
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
30394 Basophils 3.1110000E-005 - 32180 Gastrointestinal Neoplasms 7.0100000E-006 23504502 56346 Glioma 1.0590000E-005 - 73307 Platelet Count 6E-14 22139419 93996 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma 2E-8 23996088
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000147889 homo_sapiens ENSP00000276925 81.1594 78.2609 homo_sapiens ENSP00000307101 71.7949 69.2308
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000147889 homo_sapiens ENSP00000307101 91.0256 89.1026 nomascus_leucogenys ENSNLEP00000037509 89.3082 87.4214 ENSG00000147889 homo_sapiens ENSP00000307101 92.9487 91.0256 pongo_abelii ENSPPYP00000021479 91.195 89.3082 ENSG00000147889 homo_sapiens ENSP00000307101 97.4359 96.7949 gorilla_gorilla ENSGGOP00000031035 91.018 90.4192 ENSG00000147889 homo_sapiens ENSP00000307101 50.641 49.359 choloepus_hoffmanni ENSCHOP00000008324 91.8605 89.5349 ENSG00000147889 homo_sapiens ENSP00000307101 32.0513 19.2308 echinops_telfairi ENSETEP00000016003 27.027 16.2162 ENSG00000147889 homo_sapiens ENSP00000307101 91.6667 89.7436 cercocebus_atys ENSCATP00000002225 89.9371 88.0503 ENSG00000147889 homo_sapiens ENSP00000307101 90.3846 88.4615 macaca_nemestrina ENSMNEP00000044681 88.125 86.25 ENSG00000147889 homo_sapiens ENSP00000307101 91.0256 88.4615 mandrillus_leucophaeus ENSMLEP00000018034 89.3082 86.7924 ENSG00000147889 homo_sapiens ENSP00000307101 52.5641 51.2821 tursiops_truncatus ENSTTRP00000000147 95.3488 93.0233 ENSG00000147889 homo_sapiens ENSP00000307101 79.4872 76.2821 equus_asinus ENSEASP00005006347 57.9439 55.6075 ENSG00000147889 homo_sapiens ENSP00000307101 81.4103 77.5641 capra_hircus ENSCHIP00000031674 80.8917 77.0701 ENSG00000147889 homo_sapiens ENSP00000307101 79.4872 75.641 ailuropoda_melanoleuca ENSAMEP00000036384 51.2397 48.7603 ENSG00000147889 homo_sapiens ENSP00000307101 83.9744 81.4103 bos_indicus_hybrid ENSBIXP00005023233 81.875 79.375 ENSG00000147889 homo_sapiens ENSP00000307101 81.4103 78.8462 oryctolagus_cuniculus ENSOCUP00000021423 39.1975 37.963 ENSG00000147889 homo_sapiens ENSP00000307101 80.1282 76.2821 equus_caballus ENSECAP00000054966 58.4112 55.6075 ENSG00000147889 homo_sapiens ENSP00000307101 51.2821 50 panthera_pardus ENSPPRP00000020552 97.561 95.1219 ENSG00000147889 homo_sapiens ENSP00000307101 83.3333 80.7692 panthera_pardus ENSPPRP00000027614 85.5263 82.8947 ENSG00000147889 homo_sapiens ENSP00000307101 75.641 71.1538 marmota_marmota_marmota ENSMMMP00000010787 86.7647 81.6176 ENSG00000147889 homo_sapiens ENSP00000307101 56.4103 53.8462 marmota_marmota_marmota ENSMMMP00000010775 72.7273 69.4215 ENSG00000147889 homo_sapiens ENSP00000307101 73.7179 66.6667 balaenoptera_musculus ENSBMSP00010003475 68.0473 61.5385 ENSG00000147889 homo_sapiens ENSP00000307101 76.2821 69.2308 cavia_porcellus ENSCPOP00000016421 88.806 80.597 ENSG00000147889 homo_sapiens ENSP00000307101 82.0513 76.9231 bison_bison_bison ENSBBBP00000023484 81.5287 76.4331 ENSG00000147889 homo_sapiens ENSP00000307101 88.4615 83.3333 monodon_monoceros ENSMMNP00015021539 88.4615 83.3333 ENSG00000147889 homo_sapiens ENSP00000307101 85.8974 81.4103 sus_scrofa ENSSSCP00000033144 84.2767 79.8742 ENSG00000147889 homo_sapiens ENSP00000307101 83.3333 81.4103 microcebus_murinus ENSMICP00000020117 87.8378 85.8108 ENSG00000147889 homo_sapiens ENSP00000307101 72.4359 68.5897 jaculus_jaculus ENSJJAP00000015013 84.3284 79.8507 ENSG00000147889 homo_sapiens ENSP00000307101 85.2564 82.0513 ovis_aries_rambouillet ENSOARP00020009518 88.6667 85.3333 ENSG00000147889 homo_sapiens ENSP00000307101 82.0513 76.9231 delphinapterus_leucas ENSDLEP00000028944 82.5806 77.4194 ENSG00000147889 homo_sapiens ENSP00000307101 88.4615 84.6154 physeter_catodon ENSPCTP00005023360 88.4615 84.6154 ENSG00000147889 homo_sapiens ENSP00000307101 50 46.7949 dipodomys_ordii ENSDORP00000011352 86.6667 81.1111 ENSG00000147889 homo_sapiens ENSP00000307101 79.4872 74.359 mustela_putorius_furo ENSMPUP00000015870 81.5789 76.3158 ENSG00000147889 homo_sapiens ENSP00000307101 89.1026 86.5385 aotus_nancymaae ENSANAP00000015331 86.3354 83.8509 ENSG00000147889 homo_sapiens ENSP00000307101 89.7436 87.8205 saimiri_boliviensis_boliviensis ENSSBOP00000027576 85.8896 84.0491 ENSG00000147889 homo_sapiens ENSP00000307101 77.5641 66.6667 mesocricetus_auratus ENSMAUP00000003146 77.0701 66.242 ENSG00000147889 homo_sapiens ENSP00000307101 87.8205 83.9744 phocoena_sinus ENSPSNP00000001626 87.8205 83.9744 ENSG00000147889 homo_sapiens ENSP00000307101 88.4615 83.9744 carlito_syrichta ENSTSYP00000018210 80.7018 76.6082 ENSG00000147889 homo_sapiens ENSP00000307101 82.6923 79.4872 prolemur_simus ENSPSMP00000016203 81.1321 77.9874 ENSG00000147889 homo_sapiens ENSP00000307101 75 66.6667 microtus_ochrogaster ENSMOCP00000014360 70.0599 62.2754 ENSG00000147889 homo_sapiens ENSP00000307101 73.7179 68.5897 peromyscus_maniculatus_bairdii ENSPEMP00000009584 73.7179 68.5897 ENSG00000147889 homo_sapiens ENSP00000307101 71.1538 61.5385 cricetulus_griseus_chok1gshd ENSCGRP00001016035 69.8113 60.3774 ENSG00000147889 homo_sapiens ENSP00000307101 71.7949 67.3077 myotis_lucifugus ENSMLUP00000021909 85.4962 80.1527 ENSG00000147889 homo_sapiens ENSP00000307101 80.1282 76.2821 rhinolophus_ferrumequinum ENSRFEP00010010968 79.6178 75.7962 ENSG00000147889 homo_sapiens ENSP00000307101 69.2308 64.1026 heterocephalus_glaber_female ENSHGLP00000051152 83.7209 77.5194 ENSG00000147889 homo_sapiens ENSP00000307101 76.9231 71.1538 sciurus_vulgaris ENSSVLP00005029617 82.7586 76.5517 ENSG00000147889 homo_sapiens ENSP00000307101 52.5641 49.359 nannospalax_galili ENSNGAP00000024340 80.3922 75.4902 ENSG00000147889 homo_sapiens ENSP00000307101 73.0769 66.0256 chinchilla_lanigera ENSCLAP00000002298 88.3721 79.845 ENSG00000147889 homo_sapiens ENSP00000307101 82.6923 78.2051 catagonus_wagneri ENSCWAP00000017697 78.6585 74.3902 ENSG00000147889 homo_sapiens ENSP00000307101 82.6923 74.359 otolemur_garnettii ENSOGAP00000007067 82.6923 74.359 ENSG00000147889 homo_sapiens ENSP00000307101 88.4615 86.5385 cebus_imitator ENSCCAP00000032234 86.7924 84.9057 ENSG00000147889 homo_sapiens ENSP00000307101 85.8974 82.0513 moschus_moschiferus ENSMMSP00000000952 83.75 80 ENSG00000147889 homo_sapiens ENSP00000307101 91.6667 89.7436 rhinopithecus_roxellana ENSRROP00000026898 89.9371 88.0503 ENSG00000147889 homo_sapiens ENSP00000307101 83.9744 80.7692 propithecus_coquereli ENSPCOP00000026289 86.1842 82.8947 ENSG00000147889 homo_sapiens ENSP00000307101 49.359 41.6667 astatotilapia_calliptera ENSACLP00000031360 58.7786 49.6183 ENSG00000147889 homo_sapiens ENSP00000307101 52.5641 41.0256 xenopus_tropicalis ENSXETP00000012023 65.6 51.2 ENSG00000147889 homo_sapiens ENSP00000307101 60.8974 51.9231 chrysemys_picta_bellii ENSCPBP00000010127 69.8529 59.5588 ENSG00000147889 homo_sapiens ENSP00000307101 61.5385 52.5641 chrysemys_picta_bellii ENSCPBP00000010124 67.6056 57.7465 ENSG00000147889 homo_sapiens ENSP00000307101 54.4872 49.359 sphenodon_punctatus ENSSPUP00000004129 62.963 57.037 ENSG00000147889 homo_sapiens ENSP00000307101 55.1282 50 sphenodon_punctatus ENSSPUP00000004142 64.1791 58.209 ENSG00000147889 homo_sapiens ENSP00000307101 35.2564 21.1538 crocodylus_porosus ENSCPRP00005021907 21.4008 12.8405 ENSG00000147889 homo_sapiens ENSP00000307101 55.1282 45.5128 laticauda_laticaudata ENSLLTP00000007949 49.1429 40.5714 ENSG00000147889 homo_sapiens ENSP00000307101 57.6923 46.1538 notechis_scutatus ENSNSUP00000009398 67.1642 53.7313 ENSG00000147889 homo_sapiens ENSP00000307101 54.4872 44.2308 pseudonaja_textilis ENSPTXP00000026816 61.1511 49.6403 ENSG00000147889 homo_sapiens ENSP00000307101 57.0513 48.7179 anas_platyrhynchos_platyrhynchos ENSAPLP00000025869 62.6761 53.5211 ENSG00000147889 homo_sapiens ENSP00000307101 58.3333 51.2821 anas_platyrhynchos_platyrhynchos ENSAPLP00000025322 66.9118 58.8235 ENSG00000147889 homo_sapiens ENSP00000307101 57.0513 50 gallus_gallus ENSGALP00010001152 64.0288 56.1151 ENSG00000147889 homo_sapiens ENSP00000307101 55.1282 46.7949 parus_major ENSPMJP00000004884 61.8705 52.518 ENSG00000147889 homo_sapiens ENSP00000307101 57.0513 48.0769 parus_major ENSPMJP00000004879 36.7769 30.9917 ENSG00000147889 homo_sapiens ENSP00000307101 52.5641 45.5128 naja_naja ENSNNAP00000019880 59.854 51.8248 ENSG00000147889 homo_sapiens ENSP00000307101 51.2821 44.2308 podarcis_muralis ENSPMRP00000033110 29.8507 25.7463 ENSG00000147889 homo_sapiens ENSP00000307101 58.3333 51.2821 taeniopygia_guttata ENSTGUP00000001569 30.9524 27.2109 ENSG00000147889 homo_sapiens ENSP00000307101 55.1282 48.7179 taeniopygia_guttata ENSTGUP00000001568 64.6617 57.1429 ENSG00000147889 homo_sapiens ENSP00000307101 51.9231 43.5897 kryptolebias_marmoratus ENSKMAP00000001588 65.3226 54.8387 ENSG00000147889 homo_sapiens ENSP00000307101 42.9487 40.3846 salvator_merianae ENSSMRP00000027138 63.8095 60 ENSG00000147889 homo_sapiens ENSP00000307101 60.8974 54.4872 pelodiscus_sinensis ENSPSIP00000017335 68.3453 61.1511 ENSG00000147889 homo_sapiens ENSP00000307101 62.1795 51.9231 gopherus_evgoodei ENSGEVP00005018246 71.3235 59.5588 ENSG00000147889 homo_sapiens ENSP00000307101 59.6154 52.5641 gopherus_evgoodei ENSGEVP00005018329 57.764 50.9317 ENSG00000147889 homo_sapiens ENSP00000307101 60.8974 51.9231 chelonoidis_abingdonii ENSCABP00000001171 69.8529 59.5588 ENSG00000147889 homo_sapiens ENSP00000307101 58.3333 49.359 anser_brachyrhynchus ENSABRP00000016662 20.9677 17.7419 ENSG00000147889 homo_sapiens ENSP00000307101 60.8974 53.2051 strigops_habroptila ENSSHBP00005023125 63.3333 55.3333 ENSG00000147889 homo_sapiens ENSP00000307101 57.6923 50 strigops_habroptila ENSSHBP00005023127 67.1642 58.209 ENSG00000147889 homo_sapiens ENSP00000307101 60.2564 52.5641 terrapene_carolina_triunguis ENSTMTP00000032308 59.1195 51.5723 ENSG00000147889 homo_sapiens ENSP00000307101 60.8974 53.2051 terrapene_carolina_triunguis ENSTMTP00000032028 66.4336 58.042 ENSG00000147889 homo_sapiens ENSP00000307101 60.8974 51.2821 terrapene_carolina_triunguis ENSTMTP00000032309 66.4336 55.9441 ENSG00000147889 homo_sapiens ENSP00000307101 57.6923 50.641 terrapene_carolina_triunguis ENSTMTP00000032029 64.7482 56.8345 ENSG00000147889 homo_sapiens ENSP00000307101 59.6154 51.2821 aquila_chrysaetos_chrysaetos ENSACCP00020019179 62.8378 54.0541 ENSG00000147889 homo_sapiens ENSP00000307101 54.4872 45.5128 aquila_chrysaetos_chrysaetos ENSACCP00020019147 58.6207 48.9655 ENSG00000147889 homo_sapiens ENSP00000307101 58.3333 50 coturnix_japonica ENSCJPP00005006427 49.4565 42.3913 ENSG00000147889 homo_sapiens ENSP00000307101 56.4103 44.2308 leptobrachium_leishanense ENSLLEP00000000937 53.6585 42.0732
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000079 involved_in regulation of cyclin-dependent protein serine/threonine kinase activity 1 IBA Homo_sapiens(9606) Process GO:0001953 involved_in negative regulation of cell-matrix adhesion 1 IMP Homo_sapiens(9606) Process GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0004861 enables cyclin-dependent protein serine/threonine kinase inhibitor activity 2 IBA,IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005737 is_active_in cytoplasm 2 IBA,IDA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 1 TAS Homo_sapiens(9606) Component GO:0007049 involved_in cell cycle 1 IEA Homo_sapiens(9606) Process GO:0007265 involved_in Ras protein signal transduction 1 IEP Homo_sapiens(9606) Process GO:0008285 involved_in negative regulation of cell population proliferation 3 IBA,IDA,IMP Homo_sapiens(9606) Process GO:0019901 enables protein kinase binding 2 IBA,IPI Homo_sapiens(9606) Function GO:0030308 involved_in negative regulation of cell growth 1 IDA Homo_sapiens(9606) Process GO:0032088 involved_in negative regulation of NF-kappaB transcription factor activity 1 IDA Homo_sapiens(9606) Process GO:0034393 involved_in positive regulation of smooth muscle cell apoptotic process 1 ISS Homo_sapiens(9606) Process GO:0035985 part_of senescence-associated heterochromatin focus 1 IDA Homo_sapiens(9606) Component GO:0042326 involved_in negative regulation of phosphorylation 1 IDA Homo_sapiens(9606) Process GO:0045736 acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity 2 IDA Homo_sapiens(9606) Process GO:0045892 involved_in negative regulation of DNA-templated transcription 1 IMP Homo_sapiens(9606) Process GO:0051059 enables NF-kappaB binding 1 IDA Homo_sapiens(9606) Function GO:0051726 involved_in regulation of cell cycle 2 IDA,IMP Homo_sapiens(9606) Process GO:0090398 involved_in cellular senescence 1 IMP Homo_sapiens(9606) Process GO:0090399 involved_in replicative senescence 1 IMP Homo_sapiens(9606) Process GO:2000045 involved_in regulation of G1/S transition of mitotic cell cycle 2 IBA,IDA Homo_sapiens(9606) Process GO:2000111 involved_in positive regulation of macrophage apoptotic process 1 ISS Homo_sapiens(9606) Process
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