RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000147853	Gene ID	50808	Accession	17376
Symbol	AK3	Alias	AK6;FIX;AK3L1;AKL3L;AKL3L1	Full Name	adenylate kinase 3
Status	Confidence	Length	32488 bases	Strand	Minus strand
Position	9 : 4709556 - 4742043	RNA binding domain	ADK_lid
Summary	The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000352948	ADK_lid	PF05191	4.1e-16	1
ENSP00000482308	ADK_lid	PF05191	4.1e-16	1
ENSP00000413933	ADK_lid	PF05191	5.4e-16	1
ENSP00000371230	ADK_lid	PF05191	7.4e-16	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
27078856	Novel Biomarker Proteins in Chronic Lymphocytic Leukemia: Impact on Diagnosis, Prognosis and Treatment.	Lee Admoni-Elisha	2016-01-01	PloS one

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
AK3-202	ENST00000381809	4219	227aa	ENSP00000371230
AK3-204	ENST00000611749	4029	157aa	ENSP00000482308
AK3-201	ENST00000359883	1536	157aa	ENSP00000352948
AK3-203	ENST00000447596	705	187aa	ENSP00000413933

Gene Model

Click here to download ENSG00000147853's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
33675	Body Mass Index	4.4956882E-005	-
46436	Platelet Function Tests	1.9871700E-005	-
50134	Child Development Disorders, Pervasive	2.2051000E-006	-
50167	Child Development Disorders, Pervasive	1.1212000E-005	-
50270	Autistic Disorder	2.3181000E-005	-
66239	Platelet Count	9E-17	19820697
81773	Platelet Count	3E-49	22139419
87026	Platelet Count	3E-13	20139978
87585	Platelet Count	3E-13	20139978
89663	Platelet Count	5E-6	26805783

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000147853's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004017	NOT enables adenylate kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005525	enables GTP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0005759	is_active_in mitochondrial matrix	3	IBA,ISS,TAS	Homo_sapiens(9606)	Component
GO:0006172	involved_in ADP biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0007596	involved_in blood coagulation	1	TAS	Homo_sapiens(9606)	Process
GO:0009142	involved_in nucleoside triphosphate biosynthetic process	1	IBA	Homo_sapiens(9606)	Process
GO:0016310	involved_in phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0046033	involved_in AMP metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0046039	involved_in GTP metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046041	involved_in ITP metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046051	involved_in UTP metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046899	enables nucleoside triphosphate adenylate kinase activity	3	EXP,IBA,IDA	Homo_sapiens(9606)	Function

Expression