RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-OC43DengueZika
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000147649	Gene ID	92140	Accession	29608
Symbol	MTDH	Alias	3D3;AEG1;AEG-1;LYRIC;LYRIC/3D3	Full Name	metadherin
Status	Confidence	Length	86077 bases	Strand	Plus strand
Position	8 : 97644184 - 97730260	RNA binding domain	N.A.
Summary	Enables NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum; nuclear lumen; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
No data available in table

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29431736	RICK_PMID29431736_Hela_human	Hela	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	eRIC_PMID30352994_Jurkat_human	Jurkat	Joel I Perez-Perri?	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8

Showing 1 to 10 of 26 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
22199357	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	Xiangbing Meng	2012-02-10	The Journal of biological chemistry
25940628	Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.	Lit-Yeen Tan	2015-06-23	Nucleic acids research
26221589	Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling.	A Dmitry Chistiakov	2015-01-01	BioMed research international
28341852	Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer.	Katharina Anna Seitz	2017-03-24	Scientific reports
31054476	Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-κB-Mediated Signaling.	Li Zhang	2019-06-01	Translational oncology
31477281	MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy.	Jianling Bi	2019-11-01	Gynecologic oncology
31527591	Metadherin enhances vulnerability of cancer cells to ferroptosis.	Jianling Bi	2019-09-17	Cell death & disease
31979093	Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin.	Thi-Kim Yen Nguyen	2020-01-22	Cancers
33962073	TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.	Shunjie Xia	2021-01-01	Cellular and molecular gastroenterology and hepatology
34244458	Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules.	R Jessica Child	2021-10-01	RNA (New York, N.Y.)

Showing 1 to 10 of 11 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
MTDH-201	ENST00000336273	7662	582aa	ENSP00000338235
MTDH-202	ENST00000519293	629	60aa	ENSP00000429289
MTDH-203	ENST00000519934	2184	526aa	ENSP00000428168
MTDH-204	ENST00000521933	565	188aa	ENSP00000429642
MTDH-205	ENST00000522104	486	No protein	-
MTDH-206	ENST00000522313	672	224aa	ENSP00000428703

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Gene Model

Click here to download ENSG00000147649's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
37339	Platelet Function Tests	2.4367200E-005	-
37345	Platelet Function Tests	3.6370200E-005	-
37351	Platelet Function Tests	2.6556900E-005	-
37371	Platelet Function Tests	2.4367200E-005	-
37377	Platelet Function Tests	3.6370200E-005	-
37383	Platelet Function Tests	2.6556900E-005	-
39684	Platelet Function Tests	1.3747600E-005	-
39690	Platelet Function Tests	1.4674900E-005	-
39693	Platelet Function Tests	1.5596500E-005	-
39694	Platelet Function Tests	1.7476900E-005	-

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000147649	rs149211171	8	97708529	Mean corpuscular hemoglobin	29403010	0.02684	EFO_0004527
ENSG00000147649	rs2468024	8	97652425	Red cell distribution width	28957414	0.0721306	EFO_0005192
ENSG00000147649	rs2449511	8	97723714	Red cell distribution width	30595370		EFO_0005192
ENSG00000147649	rs2468024	8	97652425	Mean corpuscular hemoglobin	30595370		EFO_0004527

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000147649's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000147649	homo_sapiens	ENSP00000324175	30.6024	15.6627	homo_sapiens	ENSP00000338235	21.8213	11.1684

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000147649	homo_sapiens	ENSP00000338235	99.4845	99.1409	nomascus_leucogenys	ENSNLEP00000004519	99.4845	99.1409
ENSG00000147649	homo_sapiens	ENSP00000338235	97.4227	96.2199	pan_paniscus	ENSPPAP00000012488	100	98.7654
ENSG00000147649	homo_sapiens	ENSP00000338235	99.4845	98.9691	pongo_abelii	ENSPPYP00000021053	99.6558	99.1394
ENSG00000147649	homo_sapiens	ENSP00000338235	100	99.4845	pan_troglodytes	ENSPTRP00000034960	100	99.4845
ENSG00000147649	homo_sapiens	ENSP00000338235	99.8282	99.6564	gorilla_gorilla	ENSGGOP00000035388	94.9346	94.7712
ENSG00000147649	homo_sapiens	ENSP00000338235	69.244	59.1065	ornithorhynchus_anatinus	ENSOANP00000005841	70.2091	59.9303
ENSG00000147649	homo_sapiens	ENSP00000338235	84.1924	75.2577	sarcophilus_harrisii	ENSSHAP00000035884	74.8092	66.8702
ENSG00000147649	homo_sapiens	ENSP00000338235	44.1581	38.488	notamacropus_eugenii	ENSMEUP00000014547	45.2465	39.4366
ENSG00000147649	homo_sapiens	ENSP00000338235	89.5189	87.457	choloepus_hoffmanni	ENSCHOP00000007361	89.673	87.6076
ENSG00000147649	homo_sapiens	ENSP00000338235	93.4708	91.0653	dasypus_novemcinctus	ENSDNOP00000033679	88.4553	86.1789

Showing 1 to 10 of 129 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0051059	enables NF-kappaB binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0001650	located_in fibrillar center	1	IDA	Homo_sapiens(9606)	Component
GO:0003712	enables transcription coregulator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0003713	enables transcription coactivator activity	1	IMP	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003725	enables double-stranded RNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component

Showing 1 to 10 of 29 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression