RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000147596	Gene ID	63978	Accession	14001
Symbol	PRDM14	Alias	PFM11	Full Name	PR/SET domain 14
Status	Confidence	Length	20043 bases	Strand	Minus strand
Position	8 : 70051651 - 70071693	RNA binding domain	N.A.
Summary	This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
28423353	Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.	Hiroaki Taniguchi	2017-07-18	Oncotarget

Name	Transcript ID	bp	Protein	Translation ID
PRDM14-201	ENST00000276594	2269	571aa	ENSP00000276594
PRDM14-202	ENST00000426346	422	99aa	ENSP00000408653

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
76695	Testicular Neoplasms	5E-8	23666240

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0000902	involved_in cell morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0000977	enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0001708	involved_in cell fate specification	1	IEA	Homo_sapiens(9606)	Process
GO:0001827	involved_in inner cell mass cell fate commitment	1	IEA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0007281	involved_in germ cell development	1	IEA	Homo_sapiens(9606)	Process
GO:0007566	involved_in embryo implantation	1	IEA	Homo_sapiens(9606)	Process
GO:0008168	enables methyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0008543	involved_in fibroblast growth factor receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0009566	involved_in fertilization	1	IEA	Homo_sapiens(9606)	Process
GO:0030718	involved_in germ-line stem cell population maintenance	1	IEA	Homo_sapiens(9606)	Process
GO:0031490	enables chromatin DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0034972	involved_in histone H3-R26 methylation	1	IBA	Homo_sapiens(9606)	Process
GO:0040037	involved_in negative regulation of fibroblast growth factor receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0044030	involved_in regulation of DNA methylation	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0048873	involved_in homeostasis of number of cells within a tissue	1	IEA	Homo_sapiens(9606)	Process
GO:0060817	involved_in inactivation of paternal X chromosome	1	IEA	Homo_sapiens(9606)	Process
GO:1902093	involved_in positive regulation of flagellated sperm motility	1	IEA	Homo_sapiens(9606)	Process
GO:1902459	involved_in positive regulation of stem cell population maintenance	1	IEA	Homo_sapiens(9606)	Process