RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	SARS-COV-OC43FlavivirusesSARS-COV-2SINVDengueZika
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	TF
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000146676	Gene ID	5814	Accession	9702
Symbol	PURB	Alias	PURBETA	Full Name	purine rich element binding protein B
Status	Confidence	Length	9232 bases	Strand	Minus strand
Position	7 : 44876299 - 44885530	RNA binding domain	PurA
Summary	This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

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Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000379051	PurA	PF04845	1.1e-97	1

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RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
28431233	RIC_PMID28431233_Hs_microRNA		Thomas Treiber	2017 Apr 20	doi: 10.1016/j.molcel.2017.03.014
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	eRIC_PMID30352994_Jurkat_human	Jurkat	Joel I Perez-Perri?	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
27261479	Something Old, Something New, Something Borrowed, Something Fused: Novel EGFR Rearrangements in Lung Adenocarcinomas.	K Paul Paik	2016-06-01	Cancer discovery
36768582	Neuromuscular and Neuromuscular Junction Manifestations of the PURA-NDD: A Systematic Review of the Reported Symptoms and Potential Treatment Options.	Magdalena Mroczek	2023-01-23	International journal of molecular sciences

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
PURB-201	ENST00000395699	9232	312aa	ENSP00000379051

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Gene Model

Click here to download ENSG00000146676's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000146676's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000146676	homo_sapiens	ENSP00000332706	72.3602	64.9068	homo_sapiens	ENSP00000379051	74.6795	66.9872
ENSG00000146676	homo_sapiens	ENSP00000466881	59.0778	49.2795	homo_sapiens	ENSP00000379051	65.7051	54.8077

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000146676	homo_sapiens	ENSP00000379051	98.3974	98.3974	pan_paniscus	ENSPPAP00000000385	99.6753	99.6753
ENSG00000146676	homo_sapiens	ENSP00000379051	99.6795	99.6795	pongo_abelii	ENSPPYP00000019707	99.6795	99.6795
ENSG00000146676	homo_sapiens	ENSP00000379051	99.6795	99.6795	pan_troglodytes	ENSPTRP00000086097	99.6795	99.6795
ENSG00000146676	homo_sapiens	ENSP00000379051	99.6795	99.6795	pan_troglodytes	ENSPTRP00000060793	99.6795	99.6795
ENSG00000146676	homo_sapiens	ENSP00000379051	99.359	99.359	gorilla_gorilla	ENSGGOP00000026772	99.359	99.359
ENSG00000146676	homo_sapiens	ENSP00000379051	96.1538	93.5897	ornithorhynchus_anatinus	ENSOANP00000036385	86.9565	84.6377
ENSG00000146676	homo_sapiens	ENSP00000379051	91.3462	89.7436	dasypus_novemcinctus	ENSDNOP00000022890	93.75	92.1053
ENSG00000146676	homo_sapiens	ENSP00000379051	99.6795	99.6795	cercocebus_atys	ENSCATP00000006910	99.6795	99.6795
ENSG00000146676	homo_sapiens	ENSP00000379051	99.6795	99.6795	macaca_fascicularis	ENSMFAP00000032701	99.6795	99.6795
ENSG00000146676	homo_sapiens	ENSP00000379051	99.6795	99.6795	macaca_mulatta	ENSMMUP00000051922	99.6795	99.6795

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0000977	enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	1	IBA	Homo_sapiens(9606)	Function
GO:0001227	enables DNA-binding transcription repressor activity, RNA polymerase II-specific	1	IEA	Homo_sapiens(9606)	Function
GO:0003697	enables single-stranded DNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression