RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000143374	Gene ID	80222	Accession	30740
Symbol	TARS2	Alias	thrRS;TARSL1;COXPD21	Full Name	threonyl-tRNA synthetase 2, mitochondrial
Status	Confidence	Length	20189 bases	Strand	Plus strand
Position	1 : 150487414 - 150507602	RNA binding domain	HGTP_anticodon , tRNA_SAD , tRNA-synt_2b
Summary	This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000358060	tRNA_SAD	PF07973	2.3e-08	1
ENSP00000358060	tRNA-synt_2b	PF00587	7.8e-33	2
ENSP00000358060	HGTP_anticodon	PF03129	2.1e-18	3
ENSP00000475847	tRNA_SAD	PF07973	5.5e-07	1
ENSP00000475847	tRNA-synt_2b	PF00587	6.1e-33	2
ENSP00000475847	HGTP_anticodon	PF03129	1.8e-18	3
ENSP00000358050	tRNA-synt_2b	PF00587	5.6e-33	1
ENSP00000358050	HGTP_anticodon	PF03129	1.5e-18	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TARS2-203	ENST00000369054	1998	588aa	ENSP00000358050
TARS2-204	ENST00000369064	2727	718aa	ENSP00000358060
TARS2-213	ENST00000606933	2162	636aa	ENSP00000475847
TARS2-202	ENST00000369053	628	No protein	-
TARS2-201	ENST00000369051	2106	135aa	ENSP00000358047
TARS2-210	ENST00000479372	850	No protein	-
TARS2-209	ENST00000467982	1855	143aa	ENSP00000475551
TARS2-208	ENST00000466989	427	No protein	-
TARS2-211	ENST00000480070	832	No protein	-
TARS2-207	ENST00000463555	852	No protein	-
TARS2-205	ENST00000460794	568	No protein	-
TARS2-206	ENST00000462578	609	No protein	-
TARS2-212	ENST00000483046	311	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
71400	Cerebrospinal Fluid	2E-10	28031287

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000143374	homo_sapiens	ENSP00000360327	37.2632	20.6316	homo_sapiens	ENSP00000358060	24.6518	13.649
ENSG00000143374	homo_sapiens	ENSP00000338093	61.2219	47.3815	homo_sapiens	ENSP00000358060	68.3844	52.9248
ENSG00000143374	homo_sapiens	ENSP00000265112	67.7732	51.4523	homo_sapiens	ENSP00000358060	68.2451	51.8106
ENSG00000143374	homo_sapiens	ENSP00000284967	38.7574	21.5976	homo_sapiens	ENSP00000358060	18.2451	10.1671

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000143374	homo_sapiens	ENSP00000358060	99.1643	98.1894	nomascus_leucogenys	ENSNLEP00000012029	99.1643	98.1894
ENSG00000143374	homo_sapiens	ENSP00000358060	99.5822	99.5822	pan_paniscus	ENSPPAP00000038656	99.5822	99.5822
ENSG00000143374	homo_sapiens	ENSP00000358060	99.4429	98.7465	pongo_abelii	ENSPPYP00000041602	99.4429	98.7465
ENSG00000143374	homo_sapiens	ENSP00000358060	99.8607	99.8607	pan_troglodytes	ENSPTRP00000002129	99.8607	99.8607
ENSG00000143374	homo_sapiens	ENSP00000358060	85.376	85.2368	gorilla_gorilla	ENSGGOP00000006177	99.6748	99.5122
ENSG00000143374	homo_sapiens	ENSP00000358060	44.1504	36.7688	ornithorhynchus_anatinus	ENSOANP00000048351	39.477	32.8767
ENSG00000143374	homo_sapiens	ENSP00000358060	82.0334	73.3983	sarcophilus_harrisii	ENSSHAP00000024350	82.6087	73.913
ENSG00000143374	homo_sapiens	ENSP00000358060	77.1588	69.3593	notamacropus_eugenii	ENSMEUP00000012991	77.0515	69.2629
ENSG00000143374	homo_sapiens	ENSP00000358060	48.3287	45.2646	choloepus_hoffmanni	ENSCHOP00000000707	75.7642	70.9607
ENSG00000143374	homo_sapiens	ENSP00000358060	93.0362	87.7437	dasypus_novemcinctus	ENSDNOP00000004603	93.4266	88.1119
ENSG00000143374	homo_sapiens	ENSP00000358060	69.7772	65.1811	erinaceus_europaeus	ENSEEUP00000000160	69.6801	65.0904
ENSG00000143374	homo_sapiens	ENSP00000358060	32.312	30.2228	erinaceus_europaeus	ENSEEUP00000011533	63.2153	59.1281
ENSG00000143374	homo_sapiens	ENSP00000358060	85.2368	79.2479	echinops_telfairi	ENSETEP00000006966	85.4749	79.4693
ENSG00000143374	homo_sapiens	ENSP00000358060	96.5181	94.5682	callithrix_jacchus	ENSCJAP00000011960	96.5181	94.5682
ENSG00000143374	homo_sapiens	ENSP00000358060	95.4039	94.2897	cercocebus_atys	ENSCATP00000022463	97.9971	96.8526
ENSG00000143374	homo_sapiens	ENSP00000358060	96.1003	94.2897	macaca_fascicularis	ENSMFAP00000014628	94.9106	93.1224
ENSG00000143374	homo_sapiens	ENSP00000358060	98.3287	97.0752	macaca_mulatta	ENSMMUP00000008230	98.3287	97.0752
ENSG00000143374	homo_sapiens	ENSP00000358060	79.9443	77.0195	macaca_nemestrina	ENSMNEP00000038134	86.3158	83.1579
ENSG00000143374	homo_sapiens	ENSP00000358060	98.1894	96.6574	papio_anubis	ENSPANP00000011899	98.1894	96.6574
ENSG00000143374	homo_sapiens	ENSP00000358060	98.0501	96.9359	mandrillus_leucophaeus	ENSMLEP00000012071	98.0501	96.9359
ENSG00000143374	homo_sapiens	ENSP00000358060	61.9777	59.4708	tursiops_truncatus	ENSTTRP00000010074	75.5518	72.4958
ENSG00000143374	homo_sapiens	ENSP00000358060	91.5042	87.1866	vulpes_vulpes	ENSVVUP00000015643	91.1234	86.8239
ENSG00000143374	homo_sapiens	ENSP00000358060	89.1365	83.9833	mus_spretus	MGP_SPRETEiJ_P0061590	88.5201	83.4025
ENSG00000143374	homo_sapiens	ENSP00000358060	93.3148	88.8579	equus_asinus	ENSEASP00005059355	92.9265	88.4882
ENSG00000143374	homo_sapiens	ENSP00000358060	92.4791	87.883	capra_hircus	ENSCHIP00000019635	92.4791	87.883
ENSG00000143374	homo_sapiens	ENSP00000358060	91.7827	87.3259	loxodonta_africana	ENSLAFP00000004164	91.4008	86.9626
ENSG00000143374	homo_sapiens	ENSP00000358060	91.5042	87.1866	panthera_leo	ENSPLOP00000026457	92.1459	87.798
ENSG00000143374	homo_sapiens	ENSP00000358060	91.5042	87.883	ailuropoda_melanoleuca	ENSAMEP00000001673	91.5042	87.883
ENSG00000143374	homo_sapiens	ENSP00000358060	87.1866	82.8691	bos_indicus_hybrid	ENSBIXP00005023943	78.6432	74.7487
ENSG00000143374	homo_sapiens	ENSP00000358060	92.4791	87.883	oryctolagus_cuniculus	ENSOCUP00000046284	92.4791	87.883
ENSG00000143374	homo_sapiens	ENSP00000358060	93.454	89.1365	equus_caballus	ENSECAP00000012043	93.0652	88.7656
ENSG00000143374	homo_sapiens	ENSP00000358060	91.3649	87.1866	canis_lupus_familiaris	ENSCAFP00845024349	91.3649	87.1866
ENSG00000143374	homo_sapiens	ENSP00000358060	91.6435	87.3259	panthera_pardus	ENSPPRP00000027855	92.2861	87.9383
ENSG00000143374	homo_sapiens	ENSP00000358060	93.7326	87.6045	marmota_marmota_marmota	ENSMMMP00000022113	93.7326	87.6045
ENSG00000143374	homo_sapiens	ENSP00000358060	92.7577	89.8329	balaenoptera_musculus	ENSBMSP00010020294	92.7577	89.8329
ENSG00000143374	homo_sapiens	ENSP00000358060	36.7688	33.4262	cavia_porcellus	ENSCPOP00000009506	91.0345	82.7586
ENSG00000143374	homo_sapiens	ENSP00000358060	91.7827	87.6045	felis_catus	ENSFCAP00000001577	92.4264	88.2188
ENSG00000143374	homo_sapiens	ENSP00000358060	76.6017	73.2591	ursus_americanus	ENSUAMP00000031269	89.7227	85.8075
ENSG00000143374	homo_sapiens	ENSP00000358060	82.5905	73.8162	monodelphis_domestica	ENSMODP00000023437	82.7057	73.9191
ENSG00000143374	homo_sapiens	ENSP00000358060	92.0613	87.7437	bison_bison_bison	ENSBBBP00000015860	92.0613	87.7437
ENSG00000143374	homo_sapiens	ENSP00000358060	92.7577	89.6936	monodon_monoceros	ENSMMNP00015006193	92.7577	89.6936
ENSG00000143374	homo_sapiens	ENSP00000358060	92.7577	88.9972	sus_scrofa	ENSSSCP00000022087	92.7577	88.9972
ENSG00000143374	homo_sapiens	ENSP00000358060	90.9471	86.351	microcebus_murinus	ENSMICP00000007312	92.1016	87.4471
ENSG00000143374	homo_sapiens	ENSP00000358060	89.415	83.1476	octodon_degus	ENSODEP00000016137	88.5517	82.3448
ENSG00000143374	homo_sapiens	ENSP00000358060	90.2507	84.9582	jaculus_jaculus	ENSJJAP00000021600	90.1252	84.8401
ENSG00000143374	homo_sapiens	ENSP00000358060	92.4791	87.7437	ovis_aries_rambouillet	ENSOARP00020010615	92.4791	87.7437
ENSG00000143374	homo_sapiens	ENSP00000358060	92.2006	88.4401	ursus_maritimus	ENSUMAP00000004595	92.2006	88.4401
ENSG00000143374	homo_sapiens	ENSP00000358060	79.2479	73.8162	ochotona_princeps	ENSOPRP00000009323	79.2479	73.8162
ENSG00000143374	homo_sapiens	ENSP00000358060	91.5042	86.2117	delphinapterus_leucas	ENSDLEP00000013167	55.2565	52.0606
ENSG00000143374	homo_sapiens	ENSP00000358060	90.8078	87.7437	physeter_catodon	ENSPCTP00005028565	93.6782	90.5172
ENSG00000143374	homo_sapiens	ENSP00000358060	89.415	83.9833	mus_caroli	MGP_CAROLIEiJ_P0059214	88.7967	83.4025
ENSG00000143374	homo_sapiens	ENSP00000358060	89.2758	84.1226	mus_musculus	ENSMUSP00000029752	88.6584	83.5408
ENSG00000143374	homo_sapiens	ENSP00000358060	72.4234	66.4345	dipodomys_ordii	ENSDORP00000007099	86.3787	79.2359
ENSG00000143374	homo_sapiens	ENSP00000358060	92.3398	88.7187	mustela_putorius_furo	ENSMPUP00000004756	91.9556	88.3495
ENSG00000143374	homo_sapiens	ENSP00000358060	97.2145	95.1254	aotus_nancymaae	ENSANAP00000003567	97.2145	95.1254
ENSG00000143374	homo_sapiens	ENSP00000358060	88.0223	85.9332	saimiri_boliviensis_boliviensis	ENSSBOP00000000346	96.6361	94.3425
ENSG00000143374	homo_sapiens	ENSP00000358060	65.4596	62.6741	vicugna_pacos	ENSVPAP00000005042	68.314	65.407
ENSG00000143374	homo_sapiens	ENSP00000358060	98.468	97.3538	chlorocebus_sabaeus	ENSCSAP00000014094	98.468	97.3538
ENSG00000143374	homo_sapiens	ENSP00000358060	70.8914	66.8524	tupaia_belangeri	ENSTBEP00000003458	71.2885	67.2269
ENSG00000143374	homo_sapiens	ENSP00000358060	90.1114	84.1226	mesocricetus_auratus	ENSMAUP00000006188	89.4882	83.5408
ENSG00000143374	homo_sapiens	ENSP00000358060	92.3398	88.9972	phocoena_sinus	ENSPSNP00000002590	92.3398	88.9972
ENSG00000143374	homo_sapiens	ENSP00000358060	92.4791	88.3008	camelus_dromedarius	ENSCDRP00005024755	92.4791	88.3008
ENSG00000143374	homo_sapiens	ENSP00000358060	95.5432	91.922	carlito_syrichta	ENSTSYP00000023531	95.5432	91.922
ENSG00000143374	homo_sapiens	ENSP00000358060	89.9721	85.6546	panthera_tigris_altaica	ENSPTIP00000006181	90.6031	86.2553
ENSG00000143374	homo_sapiens	ENSP00000358060	89.1365	83.0084	rattus_norvegicus	ENSRNOP00000072886	88.5201	82.4343
ENSG00000143374	homo_sapiens	ENSP00000358060	95.6824	91.7827	prolemur_simus	ENSPSMP00000030630	95.6824	91.7827
ENSG00000143374	homo_sapiens	ENSP00000358060	90.9471	85.376	microtus_ochrogaster	ENSMOCP00000020899	90.3181	84.7856
ENSG00000143374	homo_sapiens	ENSP00000358060	85.9332	78.9694	sorex_araneus	ENSSARP00000011874	87.642	80.5398
ENSG00000143374	homo_sapiens	ENSP00000358060	90.5293	85.0975	peromyscus_maniculatus_bairdii	ENSPEMP00000014384	89.779	84.3923
ENSG00000143374	homo_sapiens	ENSP00000358060	92.0613	88.0223	bos_mutus	ENSBMUP00000031618	91.6782	87.656
ENSG00000143374	homo_sapiens	ENSP00000358060	89.2758	83.9833	mus_spicilegus	ENSMSIP00000008003	88.6584	83.4025
ENSG00000143374	homo_sapiens	ENSP00000358060	90.8078	84.9582	cricetulus_griseus_chok1gshd	ENSCGRP00001026117	90.1798	84.3707
ENSG00000143374	homo_sapiens	ENSP00000358060	87.6045	82.8691	pteropus_vampyrus	ENSPVAP00000004108	87.6045	82.8691
ENSG00000143374	homo_sapiens	ENSP00000358060	92.8969	88.1616	myotis_lucifugus	ENSMLUP00000011941	92.5104	87.7947
ENSG00000143374	homo_sapiens	ENSP00000358060	82.5905	74.0947	vombatus_ursinus	ENSVURP00010000610	82.7057	74.198
ENSG00000143374	homo_sapiens	ENSP00000358060	82.7298	74.0947	vombatus_ursinus	ENSVURP00010019924	82.6147	73.9917
ENSG00000143374	homo_sapiens	ENSP00000358060	88.1616	83.844	rhinolophus_ferrumequinum	ENSRFEP00010031138	86.1225	81.9048
ENSG00000143374	homo_sapiens	ENSP00000358060	92.4791	88.4401	neovison_vison	ENSNVIP00000021453	92.4791	88.4401
ENSG00000143374	homo_sapiens	ENSP00000358060	91.922	87.883	bos_taurus	ENSBTAP00000004948	91.922	87.883
ENSG00000143374	homo_sapiens	ENSP00000358060	89.5543	82.5905	heterocephalus_glaber_female	ENSHGLP00000012895	89.9301	82.9371
ENSG00000143374	homo_sapiens	ENSP00000358060	89.5543	87.883	rhinopithecus_bieti	ENSRBIP00000042513	92.1203	90.4011
ENSG00000143374	homo_sapiens	ENSP00000358060	91.3649	87.1866	canis_lupus_dingo	ENSCAFP00020024978	91.3649	87.1866
ENSG00000143374	homo_sapiens	ENSP00000358060	94.0111	87.7437	sciurus_vulgaris	ENSSVLP00005001328	94.0111	87.7437
ENSG00000143374	homo_sapiens	ENSP00000358060	82.5905	74.234	phascolarctos_cinereus	ENSPCIP00000010986	82.7057	74.3375
ENSG00000143374	homo_sapiens	ENSP00000358060	72.9805	68.9415	procavia_capensis	ENSPCAP00000015582	78.6787	74.3243
ENSG00000143374	homo_sapiens	ENSP00000358060	18.5237	17.688	nannospalax_galili	ENSNGAP00000026713	93.662	89.4366
ENSG00000143374	homo_sapiens	ENSP00000358060	92.0613	88.0223	bos_grunniens	ENSBGRP00000001188	90.7967	86.8132
ENSG00000143374	homo_sapiens	ENSP00000358060	88.1616	83.0084	chinchilla_lanigera	ENSCLAP00000025157	90.0427	84.7795
ENSG00000143374	homo_sapiens	ENSP00000358060	92.4791	88.9972	cervus_hanglu_yarkandensis	ENSCHYP00000017991	92.4791	88.9972
ENSG00000143374	homo_sapiens	ENSP00000358060	92.3398	88.5794	catagonus_wagneri	ENSCWAP00000011251	92.3398	88.5794
ENSG00000143374	homo_sapiens	ENSP00000358060	91.5042	85.7939	ictidomys_tridecemlineatus	ENSSTOP00000007459	92.6657	86.8829
ENSG00000143374	homo_sapiens	ENSP00000358060	80.0836	74.6518	otolemur_garnettii	ENSOGAP00000004796	83.5756	77.907
ENSG00000143374	homo_sapiens	ENSP00000358060	96.3788	94.2897	cebus_imitator	ENSCCAP00000032597	96.3788	94.2897
ENSG00000143374	homo_sapiens	ENSP00000358060	93.3148	87.4652	urocitellus_parryii	ENSUPAP00010002672	93.3148	87.4652
ENSG00000143374	homo_sapiens	ENSP00000358060	91.922	87.6045	moschus_moschiferus	ENSMMSP00000026661	91.922	87.6045
ENSG00000143374	homo_sapiens	ENSP00000358060	98.3287	97.2145	rhinopithecus_roxellana	ENSRROP00000013429	98.3287	97.2145
ENSG00000143374	homo_sapiens	ENSP00000358060	89.2758	83.4262	mus_pahari	MGP_PahariEiJ_P0070182	88.6584	82.8492
ENSG00000143374	homo_sapiens	ENSP00000358060	96.1003	91.6435	propithecus_coquereli	ENSPCOP00000011471	96.1003	91.6435
ENSG00000143374	homo_sapiens	ENSP00000358060	62.9526	46.6574	caenorhabditis_elegans	C47D12.6a.1	62.3448	46.2069
ENSG00000143374	homo_sapiens	ENSP00000358060	23.9554	12.2563	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.1463
ENSG00000143374	homo_sapiens	ENSP00000358060	67.2702	49.5822	drosophila_melanogaster	FBpp0312095	64.6586	47.6573
ENSG00000143374	homo_sapiens	ENSP00000358060	6.26741	2.92479	petromyzon_marinus	ENSPMAP00000000155	21.2264	9.90566
ENSG00000143374	homo_sapiens	ENSP00000358060	21.5877	11.4206	eptatretus_burgeri	ENSEBUP00000026111	29.4677	15.5894
ENSG00000143374	homo_sapiens	ENSP00000358060	8.21727	3.76045	lepisosteus_oculatus	ENSLOCP00000020757	27.4419	12.5581
ENSG00000143374	homo_sapiens	ENSP00000358060	11.9777	8.07799	erpetoichthys_calabaricus	ENSECRP00000025700	62.3188	42.029
ENSG00000143374	homo_sapiens	ENSP00000358060	64.2061	47.0752	ciona_savignyi	ENSCSAVP00000006647	64.2957	47.1409
ENSG00000143374	homo_sapiens	ENSP00000358060	63.9276	45.2646	saccharomyces_cerevisiae	YIL078W	62.5341	44.2779
ENSG00000143374	homo_sapiens	ENSP00000358060	28.273	15.1811	saccharomyces_cerevisiae	YHR020W	29.5058	15.843
ENSG00000143374	homo_sapiens	ENSP00000358060	25.0696	13.2312	poecilia_latipinna	ENSPLAP00000018447	27.907	14.7287
ENSG00000143374	homo_sapiens	ENSP00000358060	7.52089	3.48189	tetraodon_nigroviridis	ENSTNIP00000004410	23.6842	10.9649

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002161	enables aminoacyl-tRNA editing activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004829	enables threonine-tRNA ligase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005575	is_active_in cellular_component	1	ND	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	IEA	Homo_sapiens(9606)	Component
GO:0006435	involved_in threonyl-tRNA aminoacylation	1	IBA	Homo_sapiens(9606)	Process
GO:0042803	enables protein homodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0070159	involved_in mitochondrial threonyl-tRNA aminoacylation	1	TAS	Homo_sapiens(9606)	Process
GO:0106074	involved_in aminoacyl-tRNA metabolism involved in translational fidelity	1	IEA	Homo_sapiens(9606)	Process